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Convolutional Neural Network for Histopathological Osteosarcoma Image Classification

Computers, Materials & Continua 2021年第12期69卷 3365-3381页

作者： Imran Ahmed Humaira Sardar Hanan Aljuaid Fakhri alam khan Muhammad Nawaz Adnan Awais Center of Excellence in Information Technology Institute of Management SciencesPeshawarPakistan Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman University(PNU)RiyadhSaudi Arabia

Osteosarcoma is one of the most widespread causes of bone cancer globally and has a high mortality *** diagnosis may increase the chances of treatment and survival however the process is time-consuming(reliability and complexity involved to extract the hand-crafted features)and largely depends on pathologists’*** Neural Network(CNN—an end-to-end model)is known to be an alternative to overcome the aforesaid ***,this work proposes a compact CNN architecture that has been rigorously explored on a Small Osteosarcoma histology Image Dataaseet(a high-class imbalanced dataset).Though,during training,class-imbalanced data can negatively affect the performance of ***,an oversampling technique has been proposed to overcome the aforesaid issue and improve generalization *** this process,a hierarchical CNN model is designed,in which the former model is non-regularized(due to dense architecture)and the later one is regularized,specifically designed for small histopathology ***,the regularized model is integrated with CNN’s basic architecture to reduce *** results demonstrate that oversampling might be an effective way to address the imbalanced class problem during *** training and testing accuracies of the non-regularized CNN model are 98%&78%with an imbalanced dataset and 96%&81%with a balanced dataset,*** regularized CNN model training and testing accuracies are 84%&75%for an imbalanced dataset and 87%&86%for a balanced dataset.

关键词： Convolutional neural network histopathological image classification osteosarcoma computer-aided diagnosis

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Options and Opportunities for Energy Management in Malaysian Grid Systems-Putrajaya as a Case Study

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Journal of Electronic Science and Technology 2018年第4期16卷 316-324页

作者： Aravind CV Umashankar Subramaniam MD Shahrukh Adnan khan Md. Ibrahim Ibne alam School of Engineering Taylor’s University Subang Jaya 47500 Malaysia Department of Energy and Power Electronics VIT University Vellore 632014 India University of Asia Pacific Dhaka 1205 Bangladesh

This paper presents an opportunity for energy management with an integrated photovoltaic and wind farm for the energy and economic aspects of the commercial area located in Putrajaya. The energy economy accession conforming to the wind speed, temperature, solar irradiation, and energy consumption on a daily basis is taken into consideration. Design analysis is done through the industry standard numerical tool. From the result analysis, the recommended ratio of renewable share minimizing stress to the electric grid is proposed. According to the solutions obtained from the numerical design tool, photovoltaic is recommended to be more energy efficient and economically viable in comparison of the fully crowded wind farm. From the proposed solutions, the photovoltaic is able to provide 51% of the energy consumed and it costs RM 0.365 per kW/h.

关键词： Cost grid Homer Pro photovoltaic park wind turbine farm

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Petrography and geochemistry of Jumara Dome sediments, Kachchh Basin: Implications for provenance, tectonic setting and weathering intensity

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Chinese Journal Of Geochemistry 2014年第1期33卷 9-23页

作者： Ahmad A.H.M Noufal K.N Masroor alam M Tavheed khan Department of Geology Department of civil Engineering ZH College of Engineering and Technology

In the Kachchh Mainland, the Jumara Dome mixed carbonate-siliciclastic succession is represented by the Jhurio and Patcham formations and siliciclastic-dominating Chari Formation(Bathonian to Oxfordian). The Jumara Dome sediments were deposited during sea-level fluctuating, and were interrupted by storms in the shallow marine environment. The sandstones are generally medium-grained, moderately sorted, subangular to subrounded and of low sphericity. The sandstones are mineralogically mature and mainly composed of quartzarenite and subarkose. The plots of petrofacies in the Qt-F-L, Qm-F-Lt, Qp-Lv-Ls and Qm-P-K ternary diagrams suggest mainly the basement uplift source(craton interior) in rifted continental margin basin setting. The sandstones were cemented by carbonate, iron oxide and silica overgrowth. The Chemical Index of Alteration values(73% sandstone and 81% shale) indicate high weathering conditions in the source area. Overall study suggests that such strong chemical weathering conditions are of unconformity with worldwide humid and warm climates during the Jurassic period. Positive correlations between Al2O3 and Fe2O3, TiO2, Na2O, MgO, K2O are evident. A high correlation coefficient between Al2O3 and K2O in shale samples suggests that clay minerals control the major oxides. The analogous contents of Si, Al, Ti, LREE and TTE in the shale to PAAS with slightly depleted values of other elements ascribe a PAAS like source(granitic gneiss and minor mafics) to the present study. The petrographic and geochemical data strongly suggest that the studied sandstones/shales were deposited on a passive margin of the stable intracratonic basin.

关键词：大陆边缘盆地地球化学数据沉积物岩相学风化强度构造背景源区圆顶

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Adaptive Runtime Monitoring of Service Level Agreement Violations in Cloud Computing

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Computers, Materials & Continua 2022年第6期71卷 4199-4220页

作者： Sami Ullah khan Babar Nazir Muhammad Hanif Akhtar Ali Sardar alam Usman Habib Department of Computer Science COMSATS UniversityAbbottabad CampusPakistan Faculty of Computer Science and Engineering Ghulam Ishaq Khan(GIK)Institute of Engineering Sciences and Technology TopiPakistan IFahja Pvt Limited PeshawarPakistan Department of Computer Science National University of Computer and Emerging Sciences IslamabadChiniot-Faisalabad CampusPakistan

The cloud service level agreement(SLA)manage the relationship between service providers and consumers in cloud *** is an integral and critical part of modern era IT vendors and communication *** to low cost and flexibility more and more consumers delegate their tasks to cloud providers,the SLA emerges as a key aspect between the consumers and *** monitoring of Quality of Service(QoS)attributes is required to implement SLAs because of the complex nature of cloud *** other factors,such as user reliability,satisfaction,and penalty on violations are also taken into ***,there is no such policy of cloud SLA monitoring to minimize SLA *** this work,we have proposed a cloud SLA monitoring policy by dividing a monitoring session into two parts,for critical and non-critical *** critical and non-critical parameters will be decided on the interest of the consumer during SLA *** will help to shape a new comprehensive SLA based Proactive Resource Allocation Approach(RPAA)which will monitor SLA at runtime,analyze the SLA parameters and try to find the possibility of SLA *** also have implemented an adaptive system for allocating cloud IT resources based on SLA violations and *** have defined two main components of SLA-PRAA i.e.,(a)Handler and(b)Accounting and Billing *** have also described the function of both components through *** experimental results validate the performance of our proposed method in comparison with state-of-the-art cloud SLA policies.

关键词： Energy consumption penalty calculation proactive resource allocation service level agreement(SLA)monitoring SLA violation detection

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Eslicarbazepine acetate:A therapeutic agent of paramount importance in acute anticonvulsant therapy

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Journal of Acute Disease 2017年第6期6卷 245-254,253页

作者： Farah Iram Shah alam khan aftab Ahmad Anees A.Siddiqui Asif Husain Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia Hamdard(Hamdard University)New Delhi-110062India Department of Pharmacy Oman Medical CollegeMuscatSultanate of Oman Health Information Technology Department Jeddah Community CollegeKing Abdulaziz UniversityP.O.Box-80283Jeddah-21589Kingdom of Saudi Arabia

Eslicarbazepine acetate (ESL) is a new, once daily, orally administered, third generation antiepileptic drug which is indicated in the treatment of partial-onset seizures. ESL is known to exert it's anticonvulsant effect by blocking the voltage-gated sodium channels. Several clinical trials and pharmacological studies have revealed that seizure control was better with ESL monotherapy (1 200 or 1 600 mg once daily) following a switch from other antiepileptic drugs in comparison with pseudo-placebo patients. The studies have indicated the ESL to be well tolerated and produced only mild to moderate emergent adverse events with the therapy. Being a dibenzazepine family member, structure and chemistry of ESL resembles more or less to carbamazepine and oxcarbazepine. ESL differs structurally from carbamazepine and oxcarbazepine at the 10, 11 position of dibenazepine nucleus. This molecular variation results in differences in metabolism and thus helps to prevent the formation of toxic epoxide metabolites. ESL following oral administration is rapidly metabolised to active metabolite namely S-licarbazepine which is responsible for its pharmacological activity. ESL exhibits acceptable pharmacokinetic profile and shows insignificant drug-drug interactions. In phase III clinical program, ESL was found to be efficacious and well tolerated in adult patients with partial onset seizures previously not controlled with treatment with one or two other antiepileptic drugs.

关键词： Eslicarbazepine acetate Partial-onset seizures Epilepsy Antiepileptic drugs Drug interactions

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Condition Monitoring and Maintenance Management with Grid-Connected Renewable Energy Systems

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Computers, Materials & Continua 2022年第8期72卷 3999-4017页

作者： Md.Mottahir alam Ahteshamul Haque Mohammed Ali khan Nebras M.Sobahi Ibrahim Mustafa Mehedi Asif Irshad khan Department of Electrical and Computer Engineering(ECE) King Abdulaziz UniversityJeddah 21589Saudi Arabia Advance Power Electronics Research Lab Department of Electrical EngineeringJamia Millia IslamiaNew Delhi 110025India Department of Electrical Power Engineering Faculty of Electrical Engineering and CommunicationBrno University of TechnologyBrno 61600Czech Republic Center of Excellence in Intelligent Engineering Systems(CEIES) King Abdulaziz UniversityJeddah 21589Saudi Arabia Computer Science Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah 21589Saudi Arabia

The shift towards the renewable energy market for carbon-neutral power generation has encouraged different governments to come up with a plan of *** with the endorsement of renewable energy for harsh environmental conditions like sand dust and snow,monitoring and maintenance are a few of the prime *** problems were addressed widely in the literature,but most of the research has drawbacks due to long detection time,and high misclassification *** to overcome these drawbacks,and to develop an accurate monitoring approach,this paper is motivated toward the understanding of primary failure concerning a grid-connected photovoltaic(PV)system and highlighted along with a brief overview on existing fault detection *** on the drawback a data-driven machine learning approach has been used for the identification of fault and indicating the maintenance unit regarding the operation and maintenance ***,the system was tested with a 4 kWp grid-connected PV system,and a decision tree-based algorithm was developed for the identification of a *** results identified 94.7%training accuracy and 14000 observations/sec prediction speed for the trained classifier and improved the reliability of fault detection nature of the grid-connected PV operation.

关键词： Fault detection machine learning fault ride through

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A comparative in vitro study on the effect of SGLT2 inhibitors on chemosensitivity to doxorubicin in MCF-7 breast cancer cells

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Oncology Research 2024年第5期32卷 817-830页

作者： SHAHID KARIM ALANOUD NAHER ALGHANMI MAHA JAMAL HUDA ALKREATHY alam JAMAL HIND A.ALKHATABI MOHAMMED BAZUHAIR aftab AHMAD Department of Clinical Pharmacology Faculty of MedicineKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry Faculty of ScienceKing Abdulaziz UniversityJeddahSaudi Arabia Department of Biochemistry College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Health Information Technology Department The Applied CollegeKing Abdulaziz UniversityJeddahSaudi Arabia Pharmacovigilance and Medication Safety Unit Center of Research Excellence for Drug Research and Pharmaceutical IndustriesKing Abdulaziz UniversityJeddahSaudi Arabia

Cancer frequently develops resistance to the majority of chemotherapy *** study aimed to examine the synergistic cytotoxic and antitumor effects of SGLT2 inhibitors,specifically Canagliflozin(CAN),Dapagliflozin(DAP),Empagliflozin(EMP),and Doxorubicin(DOX),using in vitro *** precise combination of CAN+DOX has been found to greatly enhance the cytotoxic effects of doxorubicin(DOX)in MCF-7 ***,it was shown that cancer cells exhibit an increased demand for glucose and ATP in order to support their ***,when these medications were combined with DOX,there was a considerable inhibition of glucose consumption,as well as reductions in intracellular ATP and lactate ***,this effect was found to be dependent on the dosages of the *** addition to effectively inhibiting the cell cycle,the combination of CAN+DOX induces substantial modifications in both cell cycle and apoptotic gene *** work represents the initial report on the beneficial impact of SGLT2 inhibitor medications,namely CAN,DAP,and EMP,on the responsiveness to the anticancer properties of *** underlying molecular mechanisms potentially involve the suppression of the function of SGLT2.

关键词： SGLT2 Cancer Cytotoxicity ATP Cell cycle

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Ethnobotany,phytochemistry and pharmacological potential of Vitex negundo L.(five-leaved chaste tree):An updated review

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Journal of Coastal Life Medicine 2015年第10期 826-833页

作者： Lubna Abidin aftab Ahmad Shokat Rasool Mir Mohd Mujeeb Shah alam khan Department of Pharmacognosy and Phytochemistry Faculty of PharmacyJamia HamdardNew Delhi 110062India Health Information Technology Department Jeddah Community CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia Department of Pharmacy Oman Medical CollegePO Box 620PC 130MuscatSultanate of Oman

In the past two decades,a shift in paradigm has been observed in the development of new drugs from the plants for the treatment of *** scientists are focusing on the evidence based use of medicinal plants to develop pharmacotherapy for various human *** important medicinal plant that has caught the attention of researchers all over the globe is Vitex negundo *** plant is commonly used in various traditional systems of medicine like Ayurveda,Chinese,Siddha and Unani to treat various diseases and has been the subject of extensive research studies *** roots and leaves are widely used in various disorders and illnesses such as skin eczema,ringworm,liver disorders,spleen enlargement,rheumatic pain,gout,abscess,backache *** are also used as folklore medicine in bronchitis,eye disorders,female reproductive disorders,cold,dropsy,malarial fever and as *** current article is an effort to compile an updated review to disseminate knowledge and information among the scientific fraternity covering the progress made in the pharmacology and phytochemistry of this useful medicinal *** review on a very important traditional medicine,Vitex negundo *** serve as a reference to the scientific community for their future research on this plant.

关键词： Vitex negundo Verbenaceae Traditional systems of medicine Medicinal plant

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Petrographical and geochemical signatures of Jurassic rocks of Chari Formation, Western India： implications for provenance and tectonic setting

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Acta Geochimica 2016年第2期35卷 184-202页

作者： Shaista khan A. H. M. Ahmad M. Masroor alam Adnan Quasim Department of Geology Aligarh Muslim University AligarhUP. India Geology Section Civil Engineering Z.H. College of Engineering and Technology Aligarh Muslim UniversityAligarh UP India

members The sandstones of the Ridge and Athleta of Chari Formation （Callovian-Oxfordian） exposed at Jara have been analyzed for their petrographical and geochemical studies. Texturally, these sandstones are medium to coarse grained, poorly to well sorted, sub-an- gular to sub-rounded, and show low to medium sphericity. These sandstones were derived from a mixed provenance including granites, granite-gneisses, low and high-grade metamorphic, and some basic rocks of Aravalli range and Nagarparkar massif. The petrofacies analysis reveals that these sandstones belong to the continental block and recycled orogen tectonic regime. The studied sandstones are modified by paleoclimate, distance of transport, and diagenesis. Mineralogically and geochemically, sandstones are classified as quartzarenite, subarkose, arkose, sublithic arenite, and wacke, respectively. The A-CN-K ternary plot and CIA, CIW, PIA, and ICV values suggest that the similar source rocks suffered moderate to high chemical weathering under a hot-humid climate in an acidic envi- ronment with higher Pco2. Generally good to strong cor- relations between AI2O3 and other oxides in these sediments indicate clay mineral control. The K2O/Na2O versus SiO2 diagram indicates that the studied samples occupy passive margin fields but the SiO2/A12O3 versus K2O/Na20 plot suggests that the Athleta Sandstone and Ridge Sandstone fall within the passive margin field, while Ridge Shale falls within the active continental margin field.

关键词： Petrography Geochemistry Jurassic rocks Chari Formation Kachchh Gujarat

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Usability Evaluation Through Fuzzy AHP-TOPSIS Approach: Security Requirement Perspective

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Computers, Materials & Continua 2021年第7期68卷 1203-1218页

作者： Yoosef BAbushark Asif Irshad khan Fawaz Jaber Alsolami Abdulmohsen Almalawi Md Mottahir alam Alka Agrawal Rajeev Kumar Raees Ahmad khan Department of Computer Science Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Electrical and Computer Engineering Faculty of EngineeringKing Abdulaziz UniversityJeddah21589Saudi Arabia Department of Information Technology Babasaheb Bhimrao Ambedkar UniversityLucknow226025India Department of Computer Application Shri Ramswaroop Memorial UniversityBarabanki225003India

Most of the security strategies today are primarily designed to provide security protection,rather than to solve one of the basic security issues related to adequate software product *** models,frameworks and methodologies have been introduced by the researchers for a secure and sustainable software development life *** it is important to assess the usability of the popular security requirements engineering(SRE)approaches.A significant factor in the management and handling of successful security requirements is the assessment of security requirements engineering method *** assessment will allow changes to the engineering process of security *** consistency of security requirements depends heavily on the usability of security requirements *** SRE approaches are available for use and each approach takes into account several factors of usability but does not cover every element of *** seems to be no realistic implementation of such models because the concept of usability is not *** paper aims at specifying the different taxonomy of usability and design hierarchical usability *** taxonomy takes into account the common quality assessment parameters that combine variables,attributes,and characteristics identified in different approaches used for security requirements *** multiple-criteria decision-making(MCDM)model used in this paper for usability evaluation is called the fuzzy AHP-TOPSIS model which can conveniently be incorporated into the current approach of software *** significant usability criteria are identified and used to evaluate the six different *** strategies are graded as per their expected values of usability.

关键词： Security requirements engineering cyber-security usability fuzzy logic MCDM

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