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Double-blind evaluation of homeopathy on cocaine craving：a randomized controlled pilot study

Journal of Integrative Medicine 2018年第3期16卷 178-184页

作者： Ubiratan Cardinalli Adler Ana Carolina Acorinte Fernando Oliveira Calzavara adriano andré da silva Amarilys de Toledo Cesar Maristela Schiabel Adler Edson Zangiacomi Martinez José Carlos Fernandes Galduróz Department of Medicine Federal University of Sao Carlos Washington Luiz 235 Sao Carlos Sao Paulo 13565-905 Brazil Psychosocial Attention Center for Alcohol and Other Drugs Sao Sebastiao 3002 Soo Carlos Sao Paulo 13560-230 Brazil HN Cristiano Homeopathic Laboratory and Pharmacy Dr. Cesar 212 Sao Paulo Sao Paulo 02013-001 Brazil Department of Social Medicine Ribeirao Preto Medical School University of Sao Paulo Bandeirantes 3900. Ribeirao Preto Sao Paulo 14049-900 Brazi Department of Psychobiology Federal University of Sao Paulo Napoleao de Barros 925 Sao Paulo SP 04024-002 Brazil

Background： Brazil is among the nations with the greatest rates of annual cocaine usage. Pharmacological treatment of cocaine addiction is still limited, opening space for nonconventional *** Q-potencies of opium and Erythroxylum coca have been tested in the integrative treatment of cocaine craving among homeless addicts, but this setting had not proven feasible, due to insufficient ***： This study investigates the effectiveness and tolerability of homeopathic Q-potencies of opium and E. coca in the integrative treatment of cocaine craving in a community-based psychosocial rehabilitation ***, setting, participants, and interventions： A randomized, double-blind, placebo-controlled, parallelgroup, eight-week pilot trial was performed at the Psychosocial Attention Center for Alcohol and Other Drugs（CAPS-AD）, Sao Carlos/SP, Brazil. Eligible subjects included CAPS-AD patients between 18 and 65 years of age, with an International Classification of Diseases-10 diagnosis of cocaine dependence（F14.2）. The patients were randomly assigned to two treatment groups： psychosocial rehabilitation plus homeopathic Q-potencies of opium and E. coca（homeopathy group）, and psychosocial rehabilitation plus indistinguishable placebo（placebo group）.Main outcome measures： The main outcome measure was the percentage of cocaine-using days. Secondary measures were the Minnesota Cocaine Craving Scale and 12-Item Short-Form Health Survey *** events were reported in both ***： The study population comprised 54 patients who attended at least one post-baseline assessment,out of the 104 subjects initially enrolled. The mean percentage of cocaine-using days in the homeopathy group was 18.1%（standard deviation（SD）： 22.3%）, compared to 29.8%（SD： 30.6%） in the placebo group（P 〈0.01）. Analysis of the Minnesota Cocaine Craving Scale scores showed no between-group differences in the intensity of cravings, but results significantly favor

关键词： Homeopathy Cocaine-related disorders Clinical trial Opium Erythroxylum coca

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Gain of transcription factor binding sites is associated to changes in the expression signature of human brain and testis and is correlated to genes with higher expression breadth

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Science China(Life Sciences) 2019年第4期62卷 526-534页

作者： Vandeclécio Lira da silva andré Mauricio Ribeiro dos Santos Wilfredo Blanco Sandro José de Souza Bioinformatics Multidisciplinary Environment (BioME) Universidade Federal do Rio Grande do Norte (UFRN) Programa de Pós-Gradua??o em Genética e Biologia Molecular (PPGBM) Universidade Federal do Pará (UFPA) Department of Computer Science Universidade Estadual do Rio Grande do Norte (UERN) Brain Institute Universidade Federal do Rio Grande do Norte (UFRN)

The gain of transcription factor binding sites(TFBS) is believed to represent one of the major causes of biological *** we used strategies based on comparative genomics to identify 21,822 TFBS specific to the human lineage(TFBS-HS),when compared to chimpanzee and gorilla genomes. More than 40%(9,206) of these TFBS-HS are in the vicinity of 1,283 genes.A comparison of the expression pattern of these genes and the corresponding orthologs in chimpanzee and gorilla identified genes differentially expressed in human tissues. These genes show a more divergent expression pattern in the human testis and brain, suggesting a role for positive selection in the fixation of TFBS gains. Genes associated with TFBS-HS were enriched in gene ontology categories related to transcriptional regulation, signaling, differentiation/development and nervous ***, genes associated with TFBS-HS present a higher expression breadth when compared to genes in general. This biased distribution is due to a preferential gain of TFBS in genes with higher expression breadth rather than a shift in the expression pattern after the gain of TFBS.

关键词： TFBS transcript factor human evolution expression breadth

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Development of Junction Elements from Study of the Bionics

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Journal of Bionic Engineering 2007年第1期4卷 41-46页

作者： Wilson Kindlein Junior Luis Henrique Alves Cndido andré Canal Marques Sandra Souza dos Santos Maurício da silva Viegas Laboratory of Design and Material Selection-LdSM-Materials Department (DEMAT) School of Engineering–EE Federal University of Rio Grande do Sul-Brazil-UFRGS Brazil

The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated. These elements favor the application of Ecodesign in reference to the effectiveness of product dismount aiming the reduction of ambient impact in all its phases of use. The creation, the development and the confection of new junction elements were described, and case studies of new products developed specifically with this purpose were presented.

关键词： bionics Ecodesign junction elements

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Effectiveness of different biochars in remediating a salt-affected Luvisol in Northeast Brazil

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Biochar 2021年第2期3卷 149-159页

作者： Wallace Melo dos Santos Maria Isidoria silva Gonzaga JoséAiron da silva andréQuintão de Almeida JoséCarlos de Jesus Santos Thomas Antonio silva Gonzaga Idamar da silva Lima EloáMoura Araújo Water Resources Graduate Program Federal University of SergipeSão CristóvãoSE 49100‑000Brazil Agronomy Department Federal University of SergipeSão CristóvãoSE 49100‑000Brazil Agriculture Engineering Department Federal University of SergipeSão CristóvãoSE 49100‑000Brazil University of Notre dame Notre DameIN 46556USA Soils and Agricultural Engineering Department Federal University of ParanáCuritibaPR 80060‑000Brazil

Biochar has been proposed as a soil amendment to reclaim salt-affected ***,the evaluation of the different biochar types in these soils is essential due to the significant variation among biochar *** this study,biochars from sugarcane bagasse(SB),orange bagasse(OB),and corncob(CB)were applied alone and in the presence of gypsum(G)to test their potential to remediate a highly degraded saline-sodic soil in Brazil´s Northeast *** that,we conducted a laboratory column-leaching experiment and a greenhouse *** the column-leaching test,we analyzed the sodium adsorption ratio(SAR),the electrical conductivity of the saturation extract(ECe),the concentrations of major ions,and the exchangeable sodium percentage(ESP).Maize plants were grown in the leached soil in a ***-and corncob-derived biochars were more efficient than gypsum in reducing the soil salinity,bringing the indicators below threshold values,and optimizing soil reclamation *** ECe,SAR,and ESP were reduced to 3.42 dS m−1,1.64(mmolc dm−3)0.5 and 4.86%,respectively,in the SB treatment;and to 3.19 dS m−1,0.88(mmolc dm−3)0.5 and 2.53%,respectively,in the CB *** bagasse biochar did not effectively reduce the salinity *** biochar treatments improved seed germination and plant *** SB,CB,SBG,and CBG treatments increased plant height(478–558%),shoot mass(783–983%),and root mass(386–500%),***,the application of SB and CB is an effective alternative to remediate saline-sodic soils and to reduce the impact of soil salinity in the environment.

关键词： Biochar Soil remediation Soil salinity Corn growth

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Radiographic and tomographic description of marlin sucker Remora osteochir, Pisces: Echeneidae—preliminary data of one specimen

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Marine Life Science & Technology 2020年第3期2卷 246-251页

作者： andréLuiz Veiga Conrado Renata Stecca lunes Carlos Eduardo Malavasi Bruno Aline Tiemi Shiraishi Rocha JoséRoberto Machado Cunha da silva Laboratory of Evolutive Histophysiology Department of Cell and Developmental BiologyInstitute of Biomedical SciencesUniversity of Sao PauloAvenida ProfLineu Prestes1524Cidade UniversitariaSao Paulo 05508-000Brazil Laboratory of Immunological Techniques Applied to Morphophysiology School of Veterinary Medicine and Animal ScienceDepartment of SurgeryUniversity of Sao PauloAvenida Prof.Di.Orlando Marques de Paiva87.Cidade UniversitariaSao Paulo 05508-270Brazil

Remoras are commensal fish of various marine species,such as sharks,swordfishes,turtles,dolphins,manta rays and *** specimen of marlin sucker Remora osteochir was evaluated using computed tomography for skeletal digital reconstruction,digital radiology for general evaluation and bone counting,and the double contrast technique to distinguish coelomic *** radiographic images,it was possible to observe otoliths in the center of the neurocranium,to count 27 vertebrae,nine pairs of ribs,and to detect the presence of the hipural and epural bones near of the caudal *** double contrast images,it was possible to visualize the swim bladder,gills,heart,liver,stomach and *** the tomographic images and reconstructions,it was possible to identify the intercalar bones of the cephalic disc;the spine with vertebral bodies composed of neural arches and ventral ribs;and the pectoral girdle formed by posttemporal,cleithrum and scapulocoracoid *** was concluded that digital radiology and computed tomography were able to describe anatomical structures of marlin sucker *** without the need for dissection.

关键词： Teleost fish Double contrast Computed tomography Digital radiology Skeleton

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Evaluation of XIS-Mobile, a Domain Specific Language for Mobile Application Development

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Journal of Software Engineering and Applications 2014年第11期7卷 906-919页

作者： andré Ribeiro Alberto Rodrigues da silva INESC-ID/Instituto Superior Técnico Lisbon Portugal

The great evolution of the mobile market during the last years caused some fragmentation of the mobile platforms namely through the existence of different programming languages and software development tools for each platform. This fact can be an obstacle and increases the development complexity and costs when we want to develop mobile applications for multiple platforms. The XIS-Mobile domain specific language (defined as a UML profile) and its MDD-based framework address this problem by proposing platform-independent models to describe mobile applications and from them automatically generate the application’s source code. Many issues arose during an iterative process of evaluation which originated changes and the evolution of XIS-Mobile. This paper presents the results of the evaluation of XIS-Mobile (both the language and the companion framework) obtained through the implementation of a case study and by conducting a user session, and discusses its benefits and challenges.

关键词： Evaluation of XIS-Mobile a Domain Specific Language for Mobile Application Development

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data Modeling and data Analytics: A Survey from a Big data Perspective

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Journal of Software Engineering and Applications 2015年第12期8卷 617-634页

作者： andré Ribeiro Afonso silva Alberto Rodrigues da silva INESC-ID/Instituto Superior Técnico Lisbon Portugal

These last years we have been witnessing a tremendous growth in the volume and availability of data. This fact results primarily from the emergence of a multitude of sources (e.g. computers, mobile devices, sensors or social networks) that are continuously producing either structured, semi-structured or unstructured data. database Management Systems and data Warehouses are no longer the only technologies used to store and analyze datasets, namely due to the volume and complex structure of nowadays data that degrade their performance and scalability. Big data is one of the recent challenges, since it implies new requirements in terms of data storage, processing and visualization. Despite that, analyzing properly Big data can constitute great advantages because it allows discovering patterns and correlations in datasets. Users can use this processed information to gain deeper insights and to get business advantages. Thus, data modeling and data analytics are evolved in a way that we are able to process huge amounts of data without compromising performance and availability, but instead by “relaxing” the usual ACID properties. This paper provides a broad view and discussion of the current state of this subject with a particular focus on data modeling and data analytics, describing and clarifying the main differences between the three main approaches in what concerns these aspects, namely: operational databases, decision support databases and Big data technologies.

关键词： data Modeling data Analytics Modeling Language Big data

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Utilization of Pineapple Crown Fiber and Recycled Polypropylene for Production of Sustainable Composites

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Journal of Renewable Materials 2020年第10期8卷 1327-1341页

作者： Alexandra Augusta Reichert Mariana Ribas de Sá Gabriela Escobar Hochmuller da silva Cesar Augusto Gonçalves Beatrice andréRicardo Fajardo Amanda dantas de Oliveira Postgraduate Program in Materials Science and Engineering(PPGCEM) Federal University of Pelotas(UFPel)Pelotas96075-630Brazil Technology Development Center(CDTec) Materials EngineeringFederal University of Pelotas(UFPel)Pelotas96075-630Brazil Postgraduate Program in Materials Science and Engineering(PPGCEM) Federal University of São Carlos(UFSCar)São Carlos13565-905Brazil Laboratory of Technology and Development of Composites and Polymeric Materials Federal University of Pelotas(UFPel)Pelotas96010-900Brazil

Nowadays,the production of consumer goods is based on the use of non-renewable raw materials,which in recent years has been performing as a problem for the *** the large number of available biofibers in nature,their use in the development of polymeric composites has inevitably emerged,it is also necessary to take into account the countless discarded plastics that still have the potential to be *** this work,fibers were extracted from pineapple crown residues and utilized to compose sustainable composites using recycled polypropylene from cups discarded in the trash as a ***,it is known that for good performance,it is necessary to achieve a good chemical interaction between the fiber and the *** order to improve this interaction,alkaline mercerization treatment was carried out on the surface of the fibers removing some components incompatible with the *** this work,the effect of the mercerization treatment on the properties of the fibers was studied,as well as their interaction with the *** effect of fiber concentration on the mechanical and thermal properties of composites was also *** of 5 and 7 wt%were used for both natural and mercerized fibers.A decrease in the number of degradation stages was observed through thermogravimetry analyses(from four in natural fiber to two in mercerized fibers),showing that the mercerization performed on the fibers was *** increase in the degree of crystallinity of mercerized fibers was also observed through the results of X-ray *** techniques indicate that amorphous compounds,such as hemicellulose and lignin,were partially *** the tensile test,it could be noted that all composites presented higher values of de elastic modulus than recycled polypropylene without added load;however,there were no differences in the elastic modulus between the different types of fibers and load ***,it is interesting to use fibers as r

关键词： Recycling composites polypropylene biofibers pineapple crown

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Plant growth and metabolism of exotic and native Crotalaria species for mine land rehabilitation in the Amazon

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Journal of Forestry Research 2024年第1期35卷 143-154页

作者： Hemelyn Soares das Chagas Rafael silva Guedes Markus Gastauer Paula Godinho Ribeiro Allan Klynger da silva Lobato Cecílio Frois Caldeira Fabrício William deÁvila andréRodrigues dos Reis Silvio Junio Ramos Instituto Tecnológico Vale Rua Boaventura da Silva955BelémPA 66055-090Brazil Universidade Federal do Sul e Sudeste do Pará XinguaraPABrazil Núcleo de Pesquisa Vegetal Básica e Aplicada Universidade Federal Rural da AmazôniaParagominasPABrazil Departamento de Engenharia Florestal Universidade Estadual do Centro-Oeste/UNICENTROIratiPRBrazil School of Sciences and Engineering São Paulo State University(UNESP)TupãSP.CEP 17602-496Brazil

Despite its enormous benefits,mining is respon-sible for intense changes to vegetation and soil ***,after extraction,it is necessary to rehabilitate the mined areas,creating better conditions for the establishment of plant species which is *** study evaluated mineral and organic fertilization on the growth,and carbon and nitrogen(N)metabolism of two Crotalaria species[Cro-talaria spectabilis(exotic species)and Crotalaria maypu-rensis(native species from Carajás Mineral Province(CMP)]established on a waste pile from an iron mine in CMP.A control(without fertilizer application)and six fertilization mixtures were tested(i=NPK;ii=NPK+micronutrients;iii=NPK+micronutrients+organic compost;iv=PK;v=PK+micronutrients;vi=PK+micronutrients+organic compost).Fertilization contributed to increased growth of both species,and treatments with NPK and micronutrients had the best results(up to 257%***),while organic fertilization did not show *** Crotalaria had a greater number of nodules,higher nodule dry mass,chlorophyll a and b contents and showed free ammonium as the predominant N form,reflecting greater increments in biomass compared to native *** having lower growth,the use of this native species in the rehabilitation of mining areas should be considered,mainly because it has good development and meets current government legislation as an opportunity to restore local biodiversity.

关键词： Biological nitrogen fixation Mining Nitrogen metabolism Plant nutrition

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Biochar influences the cane fields’microbiota and the development of pre-sprouted sugarcane seedlings

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Waste Disposal and Sustainable Energy 2023年第1期5卷 75-88页

作者： Bruna Cristina Pinto Adriana Barboza Alves Osania Emerenciano Ferreira Gustavo Henrique Gravatim Costa Magno andréde Oliveira Augusto Cesar da silva Bezerra Alan Rodrigues Teixeira Machado Postgraduate Program in Environmental Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38202-436Brazil Department of Agricultural and Biological Sciences State University of Minas GeraisFrutal UnityFrutalMinas Gerais38208-436Brazil Postgraduate Program in Geotechnical Engineering Federal University of Ouro PretoOuro PretoMinas Gerais35400-000Brazil Department of Transport Engineering Federal Center for Technological Education of Minas GeraisBelo HorizonteMinas Gerais30421-169Brazil Department of Exact Sciences State University of Minas GeraisJoão Monlevade UnityJoão MonlevadeMinas Gerais35930-314Brazil

This research investigates the soil conditioning effect of sugar cane fields with biochar produced from sugarcane *** influence on the physicochemical and microbiological conditions of the soil and the agronomic performance of sugarcane seedlings was *** this end,the biochar from sugarcane bagasse was produced by pyrolysis in a double drum oven and mixed with soil at rates of 0,1%,3%,and 5%(in weight).The experiment was installed in a greenhouse with two evaluation periods(30 days and 60 days)and five *** pot received a pre-sprouted cane seedling,and the analysis of colony-forming units(bacteria and fungi),physicochemical characteristics of the soil,and growth and development of sugarcane were performed per *** biochar showed a high fixed carbon content(72%)and a specific surface area estimated by the adsorption of methylene blue of 50 m2 g−***,its structure is porous and contains important nutrients(e.g.,CaO,K2O,and P2O5).In the periods evaluated,the applications of the 3%and 5%(in weight)rates of biochar reduced most of the soil fertility ***,the chemical analyses indicated that the sugarcane field soil collected already possessed high *** microbiota was influenced,but only the application of the 3%(in weight)rate at 60 days after planting showed a significant positive effect on the number of bacteria forming units,with an increase of approximately 385%.On the other hand,no significant positive effect on sugarcane development was ***,biochar application in high-fertility sugarcane plantation soil did not result in gains for sugarcane development in the periods evaluated.

关键词： Soil Biometry Microbiology Double drum oven Biochar

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