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Testing discrete symmetries at a super τ-charm factory

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Frontiers of physics 2016年第1期11卷 17-25页

作者： adrian john Bevan Particle Physics Research Centre Queen Mary University of London Mile End Road London E1 4NS UK

Tests of discrete symmetry violation have played an important role in understanding the structure of weak interactions in the Standard Model of particle physics. Historically, these measurements have been extensively performed in experiments with large samples of K and B mesons. A high luminosity τ-charm facility presents physicists with the opportunity to comprehensively explore discrete symmetry violation and test the Standard Model using τ leptons, charm mesons, and charmed baryons. This paper discusses several possible measurements for a future T-charm factory.

关键词： discrete symmetries P C T CP CPT violation

Analysis of the Sedimentary Characteristics of a Modern Distributive Fluvial System:A Case Study of the Great Halten River in the Sugan Lake Basin,Qinghai,China

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Journal of Earth Science 2023年第4期34卷 1249-1262页

作者： Xianghui Zhang Changmin Zhang adrian hartley Qinghai Xu Wenjie Feng Taiju Yin Rui Zhu School of Geosciences Yangtze UniversityWuhan 430100China Department of Geology and Petroleum Geology School of GeosciencesUniversity of AberdeenAberdeen AB243UEUK

Understanding controls on river planform changes can help to build predictive models for distributive fluvial systems,and then guide the oil and gas *** do this we have undertaken a detailed investigation of the modern Great Halten River distributive fluvial system from the Sugan Lake Basin,Qinghai,*** aerial vehicle(UAV) photography,satellite remote sensing data and elemental analysis were used to determine differences in the sedimentary characteristics of the distributive fluvial *** the apex to the toe,the changes in the slope,river morphology,sedimentary characteristics and element content in different regions were determined and three facies belts:“proximal”,“medial” and “distal” were *** found that the sedimentary structure and elemental content characteristics of each facies differ *** compare the large-scale evolution of rivers from braided to meandering rivers,and the fine description of sedimentary characteristics in combination with each observation,we strengthen our overall understanding of the modern DFS from macro to micro *** the same time,we summarize the sedimentation model of the Great Halten River DFS,and our study provides a reference for establishing the sedimentary model in continental petroliferous basins.

关键词： Sugan Lake Basin distributive fluvial system river morphology sedimentary model sedimentary structure sedimentology.

Antifragility Analysis and Measurement Framework for Systems of Systems

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International Journal of Disaster Risk Science 2013年第4期4卷 159-168页

作者： john johnson adrian V.Gheorghe Engineering Management and Systems Engineering Department Old Dominion University Norfolk VA 23529 USA

The twenty-first century is defined by the social and technical hazards we face.A hazardous situation is a condition,or event,that threatens the well-being of people,organizations,societies,environments,and *** most extreme of the hazards are considered X-Events and are an exogenous source of extreme stress to a system.X-Events can also be the unintended outputs of a system with both positive(serendipitous) and negative(catastrophic) *** can vary in their ability to withstand these stress *** ability exists on a continuum of fragility that ranges from fragile(degrading with stress),to robust(unchanged by stress),to antifragile(improving with stress).The state of the art does not include a method for analyzing or measuring *** that “what we measure we will improve,” the absence of a measurement approach limits the effectiveness of governance in making our systems less fragile and more robust if not *** authors present an antifragile system simulation model,and propose a framework for analyzing and measuring antifragility based on system of systems *** framework reduces a multidimensional concept of fragility into a two-dimensional continuous interval scale.

关键词： extreme unchanged consequences

Adjuvant therapy in pancreatic cancer

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World Journal of Gastroenterology 2001年第4期7卷 482-489页

作者： Paula Ghaneh john Slavin Robert Sutton Mark hartley john P Neoptolemos Department of Surgery.University of Liverpool 5~(th)Floor UCD Building.Daulby StreetLiverpool.L69 3GA.UK

The outlook for patients with pancreatic cancer has been grim. There have been major advances in the surgical treatment of pancreatic cancer, leading to a dramatic reduction in post-operative mortality from the development of high volume specialized centres. This stimulated the study of adjuvant and neoadjuvant treatments in pancreatic cancer including chemoradiotherapy and chemotherapy. Initial protocols have been based on the original but rather small GITSG study first reported in 1985. There have been two large European trials totalling over 600 patients (EORTC and ESPAC-1) that do not support the use of chemoradiation as adjuvant therapy. A second major finding from the ESPAC-1 trial (541 patients randomized) was some but not conclusive evidence for a survival benefit associated with chemotherapy. A third major finding from the ESPAC-1 trial was that the quality of life was not affected by the use of adjuvant treatments compared to surgery alone. The ESPAC-3 trial aims to assess the definitive use of adjuvant chemotherapy in a randomized controlled trial of 990 patients.

关键词： Pancreatic Neoplasms Antineoplastic Agents Combined Modality Therapy Humans Research Support, Non-U.S. Gov't

CHIM-geoelectrochemical method in search of concealed mineralisation in China and Australia

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Chinese Journal Of Geochemistry 2008年第2期27卷 198-202页

作者： LUO Xianrong HOU Baohong WEN Meilanna ZENG Nanshi john Keeling Roger Fidler adrian Fabris Guilin University of Technology Guilin 541004 China CRC LEME Primary Industries ＆ Resources South Australia （PIRSA） SA 5000 Australia

A version of the geoelectrochemical prospecting technique developed in China was demonstrated in China and Australia to test its suitability under both Chinese and Australian *** paper briefly describes the mechanism and effectiveness of the technique applied to search of concealed mineralisation through regolith cover,based on both experimental and field *** paer deals with three main aspects of the method: a) how metallic ions are released from orebodies by electrochemical dissolution;b)how these ions migrate to the collector and are deposited as elements by electrochemical extraction in the presence of an electric field; and c) the effectiveness of the method illustrated by some case studies.

关键词：地球化学矿化作用中国澳大利亚

Management of necrotizing pancreatitis

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World Journal of Gastroenterology 2001年第4期7卷 476-481页

作者： john Slavin Paula Ghaneh Robert Sutton Mark hartley Peter Rowlands Conall Garvey Mark Hughes john Neoptolemos Departments of Surgery Royal Liverpool University Hospital Departments of Radiology Royal Liverpool University Hospital

Infection complicating pancreatic necrosis leads to persisting sepsis, multiple organ dysfunction syndrome and accounts for about half the deaths that occur following acute pancreatitis. Severe cases due to gallstones require urgent endoscopic sphincterotomy. Patients with pancreatic necrosis should be followed with serial contrast enhanced computed tomography (CE-CT) and if infection is suspected fine needle aspiration of the necrotic area for bacteriology (FNAB) should be undertaken. Treatment of sterile necrosis should initially be non-operative. In the presence of infection necrosectomy is indicated. Although traditionally this has been by open surgery, minimally invasive procedures are a promising new alternative. There are many unresolved issues in the management of pancreatic necrosis. These include, the use of antibiotic prophylaxis, the precise indications for and frequency of repeat CE-CT and FNAB,and the role of enteral feeding.

关键词： Humans Pancreatitis, Acute Necrotizing Surgical Procedures, Minimally Invasive

Comprehensive Clinical Hepatology

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2006年

作者： Emeritus Editor Peter D Howdle Edited by Bruce R Bacon john G O'Grady adrian M Di Bisceglie john R Lake

ISBN: (纸本)9780323036757

Authoritative and highly illustrated in full color, this comprehensive resource is the result of a joint effort of four experienced senior clinicians and educators. It focuses on the medical aspects of transplantation, offers an oasis of knowledge on key topics for clinical practice and examination, and discusses the newest developments in the field, including NASH and chronic viral hepatitis.

关键词： LiverDiseases.

来源：畅想之星图书光盘版（南... 评论

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分支河流体系分类初探

岩性油气藏 2023年第4期35卷 1-15页

作者：张昌民张祥辉 adrian J.hartley 冯文杰尹太举尹艳树朱锐长江大学地球科学学院武汉430100 阿伯丁大学地球科学学院英国阿伯丁AB243UE

通过综述国内外分支河流体系(DFS)的研究进展,总结了DFS的地貌特征和主要类型,并探讨了DFS形成和发育的控制因素。研究结果表明:(1)DFS不是新的或者特殊的河道类型,而是多种河道有规律的集合,地貌特征表现为水系网络从一点呈放射状展布... 详细信息

通过综述国内外分支河流体系(DFS)的研究进展,总结了DFS的地貌特征和主要类型,并探讨了DFS形成和发育的控制因素。研究结果表明:(1)DFS不是新的或者特殊的河道类型,而是多种河道有规律的集合,地貌特征表现为水系网络从一点呈放射状展布,多种河型共同发育,河道几何形态变化大,沉积环境包括河道和河道间区域,沉积体系复杂;主要类型包括冲积扇、河流扇和巨型扇。(2)以DFS半径为关键指标,面积和坡度为辅助指标将DFS分为小型(冲积扇)、大型(河流扇)和巨型(巨型扇),小型DFS扇体半径小于30 km,面积小于100 km2,坡度大于1.0°;大型DFS半径为30~100 km,面积为100~1 000 km2,坡度小于1.0°;巨型DFS扇体半径大于100 km,面积大于1 000 km2,坡度小于0.5°,3种类型的分布范围有一定的交叉和重复,还需结合DFS的沉积水动力过程和沉积特征进行判别。(3)构造背景和气候是控制DFS形成与分布的最根本因素;流域面积、母岩性质直接影响DFS中沉积物供给总量、供给速率及成分和结构;地形坡度作为间接因素,与河流流量、流速等自生因素相结合,控制河道形态以及河道的分汊和决口,进而控制了DFS表面的沉积环境和沉积相分布。

关键词：分支河流体系冲积扇河流扇巨型扇辫状河曲流河扇体半径

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Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

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Journal of Pharmaceutical Analysis 2018年第6期8卷 407-412页

作者： Jayesh A.Dhanani Suzanne L.Parker Jeffrey Lipman Steven C.Wallis Jeremy Cohen john Fraser adrian Barnett Michelle Chew Jason A.Roberts Burns Trauma and Critical Care Research Centre The University of Queensland UQ Centre for Clinical Research Department of Intensive Care Medicine Royal Brisbane & Women's Hospital Faculty of Health Queensland University of Technology Critical Care Research Group The University of Queensland Institute of Health and Biomedical Innovation & School of Public Health and Social Work Queensland University of Technology Department of Anaesthesiology and Intensive Care and Department of Medical and Health Sciences Link?ping University School of Pharmacy The University of Queensland Department of Pharmacy Royal Brisbane & Women's Hospital

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. Comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/mL and flow rate of 1.0μL/min had the best recovery. A concentration of 5.0μg/mL and flow rate of 1.0μL/min yielded maximal recovery for vancomycin. Large molecular size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. Low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations.

关键词： Microdialysis Combination antibiotic therapy Relative recovery rate Pharmacokinetics Anti-infectives Protein binding