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分支河流体系河网形态演变规律——以格尔木河流扇为例

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地质论评 2024年第3期70卷 1047-1060页

作者：王浩楠张昌民孙家惠张祥辉徐清海刘洪平 adrian John HARTLEY 长江大学地球科学学院中国武汉430100 阿伯丁大学地球科学学院英国阿伯丁AB243UE

为了探索分支河流体系河网分布规律,为创建储层建模训练图像提供知识库信息。利用Google Earth、Global Mapper、91卫图助手等现代地理信息软件,系统测量了现代格尔木河流扇表面河道分叉特征,应用Horton定律和分形方法建立了河流扇的河... 详细信息

为了探索分支河流体系河网分布规律,为创建储层建模训练图像提供知识库信息。利用Google Earth、Global Mapper、91卫图助手等现代地理信息软件,系统测量了现代格尔木河流扇表面河道分叉特征,应用Horton定律和分形方法建立了河流扇的河网形态模型。结果表明:①格尔木河流扇从顶点到入湖段共识别出26级河道,882个节点和2162个河道段,泉线上、下的河道表现出不同的河网形态;②泉线上部共发育64个节点,每级河道数目增长是上一级河道的R_(B)=1.8900倍,每级河道平均长度是下一级河道的R_(L)=1.0095倍,即河网形态特征参数R_(B)=1.8900和R_(L)=1.0095;泉线下部共发育818个节点,每级河道数目增长是上一级河道的R_(B)=1.0279倍,每级河道平均长度是下一级河道的R_(L)=0.9899倍,即河网形态特征参数是R_(B)=1.0279和R_(L)=0.9899;③河网形态特征参数受坡度影响变化较大,坡度较大则河网形态特征参数较大,坡度较小则河网形态特征参数较小。河网形态特征参数定量表征促进了分支河流体系沉积学发展,为开展陆相盆地储层建模和砂体预测提供了新的知识库信息.

关键词：分支河流体系河网形态河网模型 Horton定律格尔木河流扇

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela seplovich Yazan Bouchi Juan Pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.adrian Tyndall Binu Tharakan Firas Kobeissy Department of surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse school of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Mechanical Complications after Myocardial Infarction: A Comprehensive Review

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World Journal of Cardiovascular Diseases 2024年第1期14卷 43-60页

作者： Alexis D. Aparicio-Ortiz María Natalia Alonso-Jimenez adrian Espejel-Guzman Aldo Cabello-Ganem Javier serrano-Roman santiago Luna-Alcala Nilda Espinola-Zavaleta Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Echocardiography ABC Medical Center Mexico City Mexico

Mechanical complications of myocardial infarction are potentially fatal events that can occur after an acute myocardial infarction. While the introduction of primary percutaneous reperfusion and fibrinolysis has reduced the incidence of these complications to less than 1%. These complications pose significant hemodynamic consequences and necessitate prompt diagnosis. Echocardiography, cardiac magnetic resonance imaging, and computed tomography are valuable tools for establishing an accurate and expedited diagnosis. Consequently, it is imperative to conduct further scientific research to enhance hemodynamic stabilization techniques such as intra-aortic balloon counterpulsation and extracorporeal membrane oxygenation, in addition to exploring new surgical procedures that can reduce mortality resulting from mechanical complications. This article aims to provide a comprehensive review of mechanical complications following myocardial infarction and their correlation with multi-imaging, facilitating a better understanding of these complications.

关键词： Infarction Mechanical Complications Echocardiography Magnetic Resonance

Mechanisms of heme iron absorption:Current questions and controversies

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World Journal of Gastroenterology 2008年第26期14卷 4101-4110页

作者： adrian R West Phillip s Oates M311 Physiology School of BiomedicalBiomolecular and Chemical SciencesThe University of Western Australia35 Stirling HighwayCrawley 6009 Australia

Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis.

关键词： Iron Heme absorption Receptor mediatedendocytosis Heine transporter Heine oxygenase

Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility

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World Journal of Gastroenterology 2006年第27期12卷 4281-4295页

作者： Phillip s Oates adrian R West Physiology M311 School of Biomedical Biomolecular and Chemical SciencesUniversity of Western Australia35 Stirling HighwayNedlands 6009Australia

The gastrointestinal tract is lined by a simple epithelium that undergoes constant renewal involving cell division, differentiation and cell death. In addition, the epithelial lining separates the hostile processes of digestion and absorption that occur in the intestinal lumen from the aseptic environment of the internal milieu by defensive mechanisms that protect the epithelium from being breached. Central to these defensive processes is the synthesis of heme and its catabolism by heme oxygenase （HO）. Dietary heme is also an important source of iron for the body which is taken up intact by the enterocyte. This review describes the recent literature on the diverse properties of heme/HO in the intestine tract. The roles of heme/HO in the regulation of the cell cycle/ apoptosis, detoxification of xenobiotics, oxidative stress, inflammation, development of colon cancer, hemeiron absorption and intestinal motility are specifically examined.

关键词： Absorption Heme Uptake Release Heme oxygenase Oxidant Cytoprotection Inflammation Cancer Detoxification

Results on non-sUsY searches for physics beyond standard model in pp collisions at CMs

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Frontiers of physics 2013年第3期8卷 257-269页

作者： adrian Perieanu Physikalisches Institut B RWTH-Aachen Germany

In this paper a review of the results on searches for pnysics beyond the standard model in pp collisions with the CMs experiment at √s = 7 and 8 TeV is presented. Aspects of the analyses and their achieved limits on ... 详细信息

关键词： beyond standard model gauge bosons leptoquarks extra dimensions

Fabry Disease: Update, Focusing on Heart Disease by Multimodal Imaging

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World Journal of Cardiovascular Diseases 2024年第6期14卷 351-362页

作者： adrian Espejel-Guzman Emily Rodríguez Valente Fernandez-Badillo Javier serrano-Roman Aldo Cabello-Ganem Alexis Daniel Aparicio-Ortiz Alberto Ramon-Rios Mariali Palacios-Cruz Nilda Espinola-Zavaleta Department of Nuclear Cardiology. National Institute of Cardiology Ignacio Chavez Mexico City Mexico ABC Medical Center IAP Department of Echocardiography Mexico City Mexico

Fabry disease (FD) is a rare X-linked lysosomal accumulation disorder caused by a deficiency in the enzyme alpha-galactosidase A (Gal A), resulting in excessive storage of glycosphingolipids, particularly globotriaosylceramide (Gb3). This leads to cellular dysfunction in various organs, with cardiovascular compromise being the major cause of morbidity and mortality. This study aimed to provide a comprehensive overview of FD focusing on its genetic, epidemiological, clinical, diagnostic, and therapeutic aspects. This study explored the genetic mutations associated with FD, its epidemiology, clinical phenotypes, cardiac manifestations, diagnostic approaches, and current treatment options. Background: FD is caused by mutations in GLA on the X chromosome, with over 1000 identified variants. Neonatal screening and specific studies have shown an increased incidence of FD. The clinical presentation varies between classic and late phenotypes, with cardiac involvement being a major concern, particularly in late-onset FD. Purpose: This study aimed to summarize the current knowledge on FD, emphasizing cardiac involvement, diagnostic modalities, and treatment options. Methods: A literature review of relevant studies on FD, including genetics, epidemiology, clinical presentation, diagnostic methods, and treatment options, was conducted. Results: Cardiac manifestations of FD included left ventricular hypertrophy (LVH), heart failure, arrhythmias, and sudden death. Diagnostic approaches such as electrocardiography, echocardiography, and cardiac magnetic resonance imaging play crucial roles in the early detection and monitoring of cardiac involvement. Enzyme replacement therapy (ERT) and emerging treatments have shown promise in managing FD, although challenges remain. Conclusions: FD remains a challenging condition in cardiology, with under-diagnosis being a concern. Early detection and specific therapy are essential to improve patient outcomes. Echocardiography and cardiac MRI ar

关键词： Fabry Disease Hypertrophic Cardiomyopathy Echocardiography Cardiac Magnetic Resonance Imaging Enzyme Replacement Therapy

Numerical study of solar absorption heat storage system applied to Bucharest city

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Building simulation 2021年第3期14卷 601-616页

作者： Noureddine Cherrad adrian-Gabriel Ghiaus University Kasdi Merbah ofOuargla Faculty of Applied SciencesDepartment of Mechanical EngineeringOuarglaAlgeria Doctoral school Technical University of Civil Engineering of BucharestBucharestRomania

Buildings represent a large part in terms of fossil energy consumption,which depends on the great need for *** if the solar absorption heat storage system is possible,the performance of this system is affected by the cycle limits and the climatic *** goal of the present study is to control the thermal performance of the system cycle according to the imposed climatic conditions of Bucharest city,Romania,and therefore a numerical model was developed for this *** scheme and the thermodynamic cycle,the energy and mass balance equations,and the computational algorithm were *** results show that the cycle temperature increases at the end of desorption when the heating power supplied to the desorber is increased,which is also proportional to the drop in temperature at the beginning of the *** temperature at the end of absorption and the mass flow rates of the solution have a significant effect on the thermal power released from the absorber and used to heat the *** an average daily heat power of 1.35 kW/m^(2) and 10 hours per day of heating the building,the system with a solar collector area of 3 m^(2) has the capacity of heat supply for all the cold ***,an economic strategy remains necessary.

关键词： numerical model absorption heat storage cycle temperatures climatic conditions

Relating thermal conductivity of soil skeleton with soil texture by the concept of“local thermal conductivity fluctuation”

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第1期14卷 262-271页

作者： adrian Rózanski Faculty of Civil Engineering Wroclaw University of Science and TechnologyWybrzeze Wyspia_nskiego 2750-370WrocławPoland

The thermal conductivity of the soil skeletonλ;is an essential parameter from the point of view of the correct assessment of soil overall/effective *** work introduces the concept of“local thermal conductivity fluctuation”which characterizes the microscale variation of conductivity within the solid *** is proposed to link the“local fluctuation”of thermal conductivityλwith the soil texture-the information that is available at the scale of engineering *** was possible to relate the skeleton thermal conductivity with the grain size distribution of the ***,based on a large series of numerical simulations,the paper provides four triangle diagrams(at different organic matter contents:0%,2%,4%and 6%)relating the value ofλ;with volume fraction of individual soil *** result is extremely important from the practical point of *** can quickly evaluateλ;value provided that information on the grain size distribution and organic matter content is available.

关键词： soil skeleton Probability density function(PDF) Computational micromechanics Local fluctuation soil texture