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Why some tumours trigger neovascularisation and others don't:the story thus far

Chinese Journal of Cancer 2016年第2期35卷 69-79页

作者： Omanma Adighibe Russell D.leek Marta Fernandez-Mercado Jiangting Hu Cameron Snell Kevin C.Gatter adrian l.harris Francesco Pezzella Radcliffe Department of Medicine Nuffield Division of Laboratory ScienceJohn Radcliffe HospitalUniversity of Oxford Radcliffe Department of Medicine Leukaemia and Lymphoma Research Molecular Haematology UnitNuffield Division of Laboratory ScienceJohn Radcliffe Hospital Biodonostia Research Institute Department of Medical Oncology Molecular Oncology LaboratoriesWeatherall Institute of Molecular MedicineJohn Radcliffe Hospital

Background:Angiogenesis is not essential for tumours to develop and expand,as cancer can also grow in a nonangiogenic fashion,but why this type of growth occurs is ***,our data from mRNA transcription profiling did not show any differences in the classical angiogenic pathways,but differences were observed in mitochondrial metabolic pathways,suggesting a key role for metabolic *** then validated these results with mRNA profiling by investigating differential protein expression via immunohistochemistry in angiogenic and non-angiogenic non-small cell lung cancers(NSClCs).Methods:Immunohistochemical staining for 35 angiogenesis- and hypoxia-related biomarkers were performed on a collection of 194 angiogenic and 73 non-angiogenic NSClCs arranged on tissue *** of P53 was performed with frozen tissue samples of ***:The non-angiogenic tumours were distinguished from the angiogenic ones by having higher levels of proteins associated with ephrin pathways,mitochondria,cell biogenesis,and hypoxia-inducible factor 1(HIF1) regulation by oxygen and transcription of HIF-controlled genes but lower levels of proteins involved in the stroma,cell-cell signaling and adhesion,integrins,and Delta-Notch and epidermal growth factor(EGF)-related ***,proteins classically associated with angiogenesis were present in both types of tumours at very comparable *** expression of P53 was strongly associated with non-angiogenic tumours.A pilot investigation showed that P53 mutations were observed in 32.0%of angiogenic cases but in 71.4%of non-angiogenic ***:Our observations thus far indicate that both angiogenic and non-angiogenic tumours experience hypoxia/HIF and vascular endothelial growth factor(VEGF) pathway protein expression in a comparable ***,angiogenesis does not ensue in the non-angiogenic ***,metabolic reprogramming seems to distinguish these two types of ne

关键词： Cancer, Angiogenesis, Hypoxia, Blood vessels

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Floor dust erosion during early stages of coal dust explosion development

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International Journal of Mining Science and Technology 2019年第6期29卷 825-830页

作者： Marcia l.harris Michael J.Sapko Center for Disease Control and Prevention (CDC) National Institute for Occupational Safety and Health (NIOSH) Pittsburgh Mining Research Division (PMRD)

An ignition of methane and air can generate enough air flow to raise mixtures of combustible coal and rock *** expanding high temperature combustion products ignite the suspended dust mixture and will continue to propagate following the available combustible fuel *** the concentration of the dispersed rock dust is sufficient,the flame will stop ***-scale explosion tests were conducted within the National Institute for Occupational Safety and Health(NIOSH)lake lynn Experimental Mine(llEM)to measure the dynamic pressure history and the post-explosion dust scour *** aim of this effort is to provide quantitative data on depth of dust removal during the early stages of explosion development and its relationship to the depth of floor dust collected for assessing the incombustible content most likely to participate in the combustion *** experimental work on dust removal on is not only important for coal mine safety but also for industrial dust explosions.

关键词： Underground Coal dust Explosion Dust sampling

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Vitamin A administration at birth promotes calf growth and intramuscular fat development in Angus beef cattle

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Journal of Animal Science and Biotechnology 2018年第4期9卷 991-999页

作者： Corrine l.harris Bo Wang Jeneane M.Deavila Jan R.Busboom Martin Maquivar Steven M.Parish Brent McCann Mark l.Nelson Min Du Department of Animal Sciences Washington State University State Key laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University College of Veterinary Medicine Washington State University

Background: Marbling, or intramuscular fat, is an important factor contributing to the palatability of beef. Vitamin A, through its active metabolite, retinoic acid, promotes the formation of new fat cells(adipogenesis). As intramuscular adipogenesis is active during the neonatal stage, we hypothesized that vitamin A administration during the neonatal stage would enhance intramuscular adipogenesis and ***: Angus steer calves(n = 30), in a completely randomized design, were randomly allotted to three treatment groups at birth, receiving 0, 150,000, or 300,000 IU of vitamin A at both birth and one month of age.A biopsy of the biceps femoris muscle was collected at two months of age. After weaning at 210 d of age, steers were fed a backgrounding diet in a feedlot until 308 d of age, when they were transitioned to a high concentrate finishing diet and implanted with trenbolone/estradiol/tylosin mixture. Steers were harvested at an average of 438 d of age. All diets were formulated to meet nutrient ***: Weaning weight and weight during the backgrounding phase were linearly increased(P level, though no difference in body weight was observed at harvest. Intramuscular fat of steers at 308 d of age, measured by ultrasound, quadratically increased(P level from 4.0±0.26 % to 4.9±0.26 %.Similarly, carcass marbling score in the ribeye quadratically increased(P lusion: Administration of vitamin A at birth increased weaning weight and enhanced marbling fat ***, vitamin A administration provides a practical method for increasing marbling and early growth of beef cattle.

关键词： Beef Calf Cattle Marbling fat Quality Vitamin A

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The applications of nanoproteomic and multiplex immunoassays to accelerate drug discovery and development

The applications of nanoproteomic and multiplex immunoassays...

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第一届《药学学报》药学前沿论坛暨2015年中国药学会中药与天然药物专业委员会会议

作者： l.harris Zhang Discovery & Translational Biology NANOBIOTECLLC

Biological marker—biomarker—a characteristic that is objectively measured and evaluated as an indicator of physiologic processes,pathogenic processes or pharmacologic responses to a therapeutic *** to accurately and precisely measure biomarkers in samples of minimal amount in efficient way remains a great ***,the targets of most drugs,are otten studied through indirect DNA or RNA surrogates,as many proteins

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Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in lrp5

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Bone Research 2023年第3期11卷 595-606页

作者： Cassandra R.Diegel Ina Kramer Charles Moes Gabrielle E.Foxa Mitchell J.McDonald Zachary B.Madaj Sabine Guth Jun liu Jennifer l.harris Michaela Kneissel Bart O.Williams Department of Cell Biology Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Diseases of Aging and Regenerative Medicine Novartis Institutes for Biomedical ResearchCH-4002 BaselSwitzerland Bioinformatics and Biostatistics Core Van Andel Institute333 Bostwick Ave.NEGrand RapidsMI 49503USA Oncology Novartis Institutes for Biomedical ResearchSan DiegoCA 92121USA

Proper regulation of Wnt signaling is critical for normal bone development and *** in several Wnt signaling components,which increase the activity of the pathway in the skeleton,cause high bone mass in human subjects and mouse *** bone mass is often accompanied by severe headaches from increased intracranial pressure,which can lead to fatality and loss of vision or hearing due to the entrapment of cranial *** addition,progressive forehead bossing and mandibular overgrowth occur in almost all *** that would provide symptomatic relief in these subjects are ***-mediated palmitoylation is necessary for Wnt secretion and binding to the frizzled *** inhibition of porcupine is a highly selective method of Wnt signaling *** treated three different mouse models of high bone mass caused by aberrant Wnt signaling,including homozygosity for loss-of-function in Sost,which models sclerosteosis,and two strains of mice carrying different point mutations in lrp5(equivalent to human G171V and A214V),at 3 months of age with porcupine inhibitors for 5–6 *** significantly reduced both trabecular and cortical bone mass in all three *** demonstrates that porcupine inhibition is potentially therapeutic for symptomatic relief in subjects who suffer from these disorders and further establishes that the continued production of Wnts is necessary for sustaining high bone mass in these models.

关键词： homeostasis function mass

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数字信号处理基础 MATlAR实现影印版影印版

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2005年

作者：（美）ROBERT J.SCHIllING SANDRA l.harris

本书详细介绍了数字信号处理(DSP)的基本概念、理论和方法,重点计论了各种方法在实际信号中的应用,书中包括大量的有关音乐和语音的信号处理的实例。

ISBN: (纸本)756052107X

关键词：软件包,MATlAB 英文信号处理计算机辅助计算数字信号

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Appliced Numerical Methods for Engineers 影印

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丛书名：时代教育·国外高校优秀教材精选

2004年

作者： (美) Robert J.Schilling Sandra l.harris

本书着重介绍了解决工程实践中的各种有用的数值方法，还介绍了求解这些问题的数学软件（MATlABH和C语言）的计算机程序和结果。

ISBN: (数字)7111140109

ISBN: (纸本)7111140109

本书着重介绍了解决工程实践中的各种有用的数值方法，还介绍了求解这些问题的数学软件（MATlABH和C语言）的计算机程序和结果。

关键词： C语言

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Creation and Evaluation of a Multi-sensory Virtual Assembly Environment

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International Journal of Automation and computing 2008年第2期5卷 163-173页

作者： adrian R l Travis Department of Engineering University of Cambridge

The multi-modal information presentation, integrated into the virtual environment （VE）, has potential for stimulating different senses, improving the user＇s impression of immersion, and increasing the amount of information that is accepted and processed by the user＇s perception system. The increase of the useful feedback information may reduce the user＇s cognitive load, thus enhancing the user＇s efficiency and performance while interacting with VEs. This paper presents our creation of a multi-sensory virtual assembly environment （VAE） and the evaluation of the effects of multi-sensory feedback on the usability. The VAE brings together complex technologies such as constraint-based assembly simulation, optical motion tracking technology, and real-time 3D sound generation technology around a virtual reality workbench and a common software platform. The usability evaluation is in terms of its three attributes： efficiency of use, user satisfaction, and reliability. These are addressed by using task completion times （TCTs）, questionnaires, and human performance error rates （HPERs）, respectively. Two assembly tasks have been used to perform the experiments, using sixteen participants. The outcomes showed that the multi-sensory feedback could improve the usability. They also indicated that the integrated feedback offered better usability than either feedback used in isolation. Most participants preferred the integrated feedback to either feedback （visual or auditory） or no feedback. The participants＇ comments demonstrated that nonrealistic or inappropriate feedback had negative effects on the usability, and easily made them feel frustrated. The possible reasons behind the outcomes are also analysed by using a unifying human computer interaction framework. The implications, concluded from the outcomes of this work, can serve as useful guidelines for improving VE system design and implementation.

关键词： Usability virtual environment (VE) assembly simulation multi-sensory feedback task performance

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酒店监控实例研究

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安防科技 2003年第8期 48-49页

作者： Joanne l.harris ,于岚核工业研究生部

Cribe希尔顿酒店位于波多黎各的首府圣胡安市,坐落在一个幽静的小岛上,每年都有许多来自不同国家的人士在这里旅游或者从事商业活动。相比这个国家的其他地区而言,这里的犯罪率要低的多,即便如此,加强该酒店的安全措施也是非常必要的。

关键词：酒店摄像机同轴电缆同轴线通信电缆

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Testosterone,cardiomyopathies,and heart failure:a narrative review

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Asian Journal of Andrology 2021年第4期23卷 348-356页

作者： Rodica Diaconu Ionuţ Donoiu Oana Mirea Tudor adrian Bălşeanu Department of Cardiology University of Medicine and PharmacyCraiova 200349Romania Department of Physiology University of Medicine and PharmacyCraiova 200349Romania

Testosterone exerts an important regulation of cardiovascular function through genomic and nongenomic pathways. It produces several changes in cardiomyocytes, the main actor of cardiomyopathies, which are characterized by pathological remodeling, eventually leading to heart failure. Testosterone is involved in contractility, in the energy metabolism of myocardial cells, apoptosis, and the remodeling process. In myocarditis, testosterone directly promotes the type of inflammation that leads to fibrosis, and influences viremia with virus localization. At the same time, testosterone exerts cardioprotective effects that have been observed in different studies. There is increasing evidence that low endogenous levels of testosterone have a negative impact in some cardiomyopathies and a protective impact in others. This review focuses on the interrelationships between testosterone and cardiomyopathies and heart failure.

关键词： androgens cardiomyocytes heart disease myocardial prognosis

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