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Depth of Anesthesia Monitoring-Have we progressed in 150 years?

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Depth of Anesthesia Monitoring-Have we progressed in 150 yea...

2006年中华医学会全国麻醉学术年会

作者： adrian W Gelb Professor Department of Anesthesia ＆ Perioperative CareUniversity of California San Francisco

The challenge of adequately assessing depth of anesthesia has been with us since the earliest days of our specialty. In 1847 john Snow wrote "The question may be asked whether the medical man can always determine in what degree of etherization the patient is, and by that means estimate correctly whether or not he is liable to pain. 1 am not sure that he always can, by the mere observation of the patient. " Although much progress has been made in the intervening 153 years, especially more recently, the question and the answer remain unchanged.

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利用双处理器延长电池使用寿命

今日电子 2008年第10期 54-57页

作者： john Dixon Zack Albus adrian Valenzuela JB Fowler TI公司

向着更低功耗、更高性能的电池供电型系统发展的趋势毋庸置疑。对于电池电源而言，消费者希望便携式电子产品能够以“更低电量执行更多功能”，同时，众多工业产品也开始转而采用电池供电。

关键词：电池供电使用寿命双处理器便携式电子产品电池电源工业产品低功耗多功能

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选择铁路方式出行的阻碍因素综述

城市交通 2013年第6期11卷 80-94,65页

作者： Simon Blainey adrian Hickford john Preston 伍拾煤裴玉龙南安普顿大学交通研究小组哈尔滨工业大学交通科学与工程学院黑龙江哈尔滨150090

研究表明,即使铁路出行是最具有成本效益的出行方式,许多出行者仍然会选择其他出行方式。这表明选择铁路出行方式存在一些与费用无关的阻碍因素。本文对有关这些阻碍因素重要性的文献进行了综述,这些研究主要来自英国,但也有一部分来自... 详细信息

研究表明,即使铁路出行是最具有成本效益的出行方式,许多出行者仍然会选择其他出行方式。这表明选择铁路出行方式存在一些与费用无关的阻碍因素。本文对有关这些阻碍因素重要性的文献进行了综述,这些研究主要来自英国,但也有一部分来自于其他国家。共确认了37种不同的阻碍因素,它们可以被划分为"刚性因素"、"柔性因素"与"互补性因素"。出行者通常不会只考虑其中的单一阻碍因素,而是将这些阻碍因素看成一个整体,由此使得对最重要阻碍因素的确认十分困难。很多情况下,对于某一出行者来说,所有存在的阻碍因素都需要在出行方式转移之前解决。在思考不同阻碍因素的相对重要性后,对克服它们并实现其他出行方式向铁路转移的最有效措施提出了建议。这涉及主要的交通政策,因为它能够为有限的可利用资金确定目标市场,从而影响出行行为并提高出行方式的可持续性。

关键词：铁路出行方式转移认知一揽子政策小汽车依赖性

Early infant male circumcision:Systematic review,risk-benefit analysis,and progress in policy

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世界临床儿科杂志 2017年第1期6卷 89-102页

作者： Brian J Morris Sean E Kennedy Alex D Wodak adrian Mindel David Golovsky Leslie Schrieber Eugenie R Lumbers David J Handelsman john B Ziegler School of Medical Sciences and Bosch Institute University of Sydney School of Women’s and Children’s Health University of New South Wales St Vincent’s Hospital and Kirby Institute for Infection and Immunity in Society University of New South Wales IVF Australia Department of Medicine Sydney Medical SchoolRoyal North Shore Hospital School of Biomedical Sciences and Pharmacy Mothers and Babies Research CentreHunter Medical Research InstituteUniversity of Newcastle Department of Medicine and ANZAC Research Institute Concord Hospital Department of Immunology and Infectious Diseases Sydney Children’s Hospital

AIM To determine whether recent evidence-based United States polices on male circumcision(MC) apply to comparable Anglophone countries,Australia and New *** Articles in 2005 through 2015 were retrieved from PubM ed using the keyword "circumcision" together with 36 relevant subtopics.A further PubM ed search was performed for articles published in *** of the EMBASE and Cochrane databases did not yield additional citable *** were assessed for quality and those rated 2+ and above according to the Scottish Intercollegiate Grading System were studied *** most relevant andrepresentative of the topic were *** were examined to retrieve further key *** controlled trials,recent high quality systematic reviews or meta-analyses(level 1++ or 1+ evidence) were prioritized for inclusion.A risk-benefit analysis of articles rated for quality was *** efficiency and reliability,recent randomized controlled trials,metaanalyses,high quality systematic reviews and large welldesigned studies were used if *** searches were conducted for other relevant information,including policies and Australian data on claims under Medicare for *** Evidence-based policy statements by the American Academy of Pediatrics(AAP) and the Centers for Disease Control and Prevention(CDC) support infant and later age male circumcision(MC) as a desirable public health *** systematic review of relevant literature over the past decade yielded 140 journal articles that met our inclusion ***,these showed that early infant MC confers immediate and lifelong benefits by protecting against urinary tract infections having potential adverse long-term renal effects,phimosis that causes difficult and painful erections and "ballooning" during urination,inflammatory skin conditions,inferior penile hygiene,candidiasis,various sexually transmissible infections in both sexes,genital ulcers,and penil

关键词： Male circumcision Evidence-based policy Infants Adults Urinary tract infections Adverse events Sexually transmitted infections Genital cancers Riskbenefit analysis Cost-benefit

Mass spectrometry-based metabolomic profiling of prostate cancer - a pilot study

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Journal of Cancer Metastasis and Treatment 2019年第1期4卷 1-12页

作者： Krzysztof Ossoliński Joanna Nizioł adrian Arendowski Anna Ossolińska Tadeusz Ossoliński Jakub Kucharz PawełWiechno Tomasz Ruman Department of Urology John Paul II HospitalKolbuszowa 36-100Poland Faculty of Chemistry Rzeszów University of TechnologyRzeszów 35-959Poland Department of Urooncology Institute of OncologyWarsaw 02-781Poland

Aim:Prostate cancer(PCa)is the most commonly diagnosed non-skin cancer among *** prostate-specific antigen level is used as a standard PCa biomarker for over 20 ***,it has only 33%specificity and 86%sensitivity(for the cutoff value for prostate biopsy of>4 ng/mL).This leads to overdiagnosis and ***-depth insight into PCa metabolomics enables discovery of novel PCa ***:Metabolomic alternation in PCa serum,urine and interstitial fluid was examined using gold-nanoparticle-based laser mass spectrometry *** study included 5 patients who underwent prostate biopsy with positive result,5 patients with negative result and 10 healthy ***:Over two hundred differentiating metabolites(87 in urine,54 in serum and 78 in interstitial fluid)were ***,twenty two and ten metabolites from urine,serum and interstitial fluid respectively showed statistical significant differential abundance between cancer and control ***:Comprehensive metabolomic profile of PCa has been *** of 36 metabolites,20 were identified and should be further evaluated in clinical trials as a potential PCa *** concentration of triglyceride(12:0/20:1)showed over 10 times higher abundance in PCa samples in comparison to healthy controls and is considered the most promising potential biomarker.

关键词： Prostate cancer biomarker metabolomics mass spectrometry

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影像:揭开内在世界的面纱

英国医学杂志中文版 2014年第S1期17卷 63-64页

作者： adrian M K Thomas john Pickstone 付诗琴(译) 龚启勇(校) 不详

物理实验室中的一个偶然发现开启了对人体观测的全新视野,从骨骼到分子已是双眼可看穿,双手可触及。1895年11月8日,德国物理学家威廉·康拉德伦琴正在研究电力通过稀薄气体的结果。他惊诉地发现,一个遥远的荧光屏在黑暗中闪闪发光。让... 详细信息

物理实验室中的一个偶然发现开启了对人体观测的全新视野,从骨骼到分子已是双眼可看穿,双手可触及。1895年11月8日,德国物理学家威廉·康拉德伦琴正在研究电力通过稀薄气体的结果。他惊诉地发现,一个遥远的荧光屏在黑暗中闪闪发光。让他更惊的是当他的妻子把手置于屏幕之前,骨头的阴影图像出现了。

关键词：物理实验室稀薄气体内在世界德国物理学家康拉德在黑暗中全新视野荧光屏

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走钢丝：对现代医学中过度诊断的沟通

英国医学杂志中文版 2016年第10期19卷 541-546页

作者： McCaffery Kirsten J Jansen Jesse Scherer Laura D Thornton Hazel Hersch Jolyn Carter Stacy M Barratt Alexandra Sheridan Stacey Moynihan Ray Waller Jo Brodersen john Pickles Kristen Edwards adrian 吴东(译者) School of Public Health University of Sydney New South Wales 2006 Australia Department of Psychological Sciences University of Missouri Columbia USA Department of Health Sciences University of Leicester Leicester UK Centre for Values Ethics and the Law in MedicineUniversity of Sydney Division of General Medicine and Clinical Epidemiology School of Medicine University of North Carolina Chapel Hill USA Bond University Queensland Australia Epidemiology and Public Health University College London UK Research Unit and Section of General Practice Department of Public Health University of Copenhagen Denmark Primary Health Care Research Unit Zealand Region Denmark Division of Population Medicine School of Medicine Cardiff University UK 北京协和医院消化科

Kirsten McCaffery和同事们认为对于过度诊断进行沟通，可以促进公众、患者、医务人员、卫生管理人员从不同角度思考：怎样才能建设一个更加可持续的医疗保健系统。

关键词：现代医学过度诊断医护人员医疗卫生行业

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通过蠕变方法测试真实凝胶点的新方法

通过蠕变方法测试真实凝胶点的新方法

第十四届全国流变学学术会议

作者：杨凯 Mats Larsson john Duffy Shona Murphy adrian Hill 马尔文帕纳科(中国)公司2. Malvern Panalytical Ltd. UK

研究凝胶化过程的最常用的方法就是单频率小振幅振荡剪切,将弹性模量（G’）和粘性模量（G’’）的交点（G’=G’’）定义为凝胶点,但是对于大部分凝胶是不成立的。根据Winter等人[1]提出的凝胶点的判据,通过改变时间或温度,重复做频率... 详细信息

研究凝胶化过程的最常用的方法就是单频率小振幅振荡剪切,将弹性模量（G’）和粘性模量（G’’）的交点（G’=G’’）定义为凝胶点,但是对于大部分凝胶是不成立的。根据Winter等人[1]提出的凝胶点的判据,通过改变时间或温度,重复做频率扫描,当G’曲线和G’曲线平行且与频率无关时,即损耗因子（tanδ）与不随频率变化时,可以定义为真实凝胶点。但重复频率扫描实验特别是频率较低时耗时长,其替代方法之一就是多波测试,同时对样品施加包括基频和多个高倍频的复杂波形,虽然相对于重复频率扫描的测试时间缩短,但是由于最低频率耗时长,测试时间长的问题依然存在,而且叠加频率有限。本文提出蠕变方法测试真实凝胶点的方法,即通过蠕变柔量转化为动态模量[2],进而确定真实凝胶点。实验结果表明通过蠕变方法确定的凝胶点与多波测试结果具有良好的一致性,能够得到完成的频率谱图,大大缩短了测试时间,结果可靠性提高。

关键词：凝胶点蠕变多波测试

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井眼地震测量：超越垂直剖面

国外测井技术 2008年第6期23卷 56-69页

作者： john Blackburn john Daniels Scott Dingwall Geoffrey Hampden-Smith Scott Leaney Joel Le Calvez Les Nutt Henry Menkiti adrian Sanchez Marco Schinelli 康菲石油英国有限公司不详壳牌勘探与生产公司巴西石油公司

当前的井眼地震技术为研究井眼钻穿的地层提供了新的机会。从建井与三维盐下成像到增产措施监测和高温、高压采集，井眼地震测量都可以帮助作业公司降低作业风险，提高采收率。

关键词：地震测量井眼垂直剖面地震技术盐下成像采收率作业