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Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review

World Journal of Gastroenterology 2016年第40期22卷 9012-9021页

作者： Berrie Meijer Chris JJ Mulder Godefridus J Peters adriaan a van bodegraven Nanne KH de Boer Department of Gastroenterology and Hepatology VU University Medical Center Department of Medical Oncology VU University Medical Center Department of Gastroenterology Geriatrics Internal and Intensive Care Medicine (Co-MIK) Zuyderland Medical Center

AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity *** A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords "thioguanine", "6-TG", "thioguanine", "inflammatory bowel disease", "IBD", "Crohn's disease", "Ulcerative colitis" and "effectiveness" in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not *** A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients.

关键词： Thiopurines Thioguanine Inflammatory bowel disease Crohn’s disease Ulcerative colitis

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How I treat my inflammatory bowel disease-patients with thiopurines?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 524-530页

作者： Berrie Meijer Chris JJ Mulder adriaan a van bodegraven Nanne KH de Boer Department of Gastroenterology and Hepatology VU University Medical Center Department of Gastroenterology GeriatricsInternal and Intensive Care Medicine (Co-MIK)Zuyderland Medical Center

Thiopurines are essential drugs to maintain remission in patients with inflammatory bowel disease(IBD).Thiopurines used in IBD are azathioprine(2.0-2.5 mg/kg),mercaptopurine(1.0-1.5 mg/kg) and thioguanine(0.2-0.3 mg/kg).However,mainly due to numerous adverse events associated with thiopurine use,almost 50% of the patients have to discontinue conventional thiopurine *** monitoring and the application of several treatment strategies,such as split-dose administration,co-administration with allopurinol or dose reduction/increase,may increase the chance of successful *** this review,we provide practical information on how thiopurines are initiated and maintained in two thiopurine research centers in The *** provide clinical information concerning safety issues,indications and management of therapy that may serve as a guide for the administration of thiopurines in IBD patients in daily practice.

关键词： Thiopurines Azathioprine Mercaptopurine Thioguanine Inflammatory bowel disease Therapeutic drug monitoring Pregnancy Metabolites

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Diarrhoea in a patient with metastatic melanoma:Ipilimumab ileocolitis treated with infliximab

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2013年第3期4卷 80-82页

作者： Rob ME Slangen Alfonsus JM van den Eertwegh adriaan a van bodegraven Nanne KH de Boer Department of Gastroenterology and Hepatology HagaZiekenhuis2545 CH Den HaagThe Netherlands Department of Medical Oncology VU University Medical Centre1007 MB AmsterdamThe Netherlands Department of Gastroenterology and Hepatology VU University Medical Centre1007 MB AmsterdamThe Netherlands

Administration of ipilimumab,a cytotoxic T-lymphocyte associated antigen-4-blocking monoclonal antibody,leads to enhancement of the anti-tumor T-cell respons and as a result shows a significant survival benefit in metastatic melanoma *** patients are currently receiving this promising therapy as a secondline ***,by activation of the T-cell immune reponse,ipilimumab therapy may lead to an unwanted induction of different autoimmune *** and colitis occur in up to one third of *** we present a case of ipilimumab induced ileocolitis which was successfully treated with infliximab,an anti-tumor necrosis factor monoclonal antibody,after corticosteroid therapy *** formal trials are lacking,recently publicated series suggest that infusional therapy of infliximab is effective in ipilimumab induced ileocolitis.

关键词： Melanoma Ipilimumab Colitis Infliximab Cytotoxic T-lymphocyte associated antigen-4

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Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population

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World Journal of Gastroenterology 2008年第20期14卷 3183-3187页

作者： Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea adriaan a van bodegraven Department of Gastroenterology VUmcUniversity Medical Center Department of Pathology VUmc University MedicalCenter

AIM： To describe the characteristics of Dutch patients with *** bowel disease （IBD） first diagnosed above 60 years of age-a disease also known as old-age colitis （OAC） and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease （SCAD）. METHODS： A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS： Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 （50） [median age 82 years （range 64-101）; 25 male （42%）] were identified. These patients were diagnosed with ulcerative colitis （n = 37, 61%）, Crohn＇s disease （n = 14, 24%）, and indeterminate colitis （n = 8, 15%）. Remission was induced in 40 （68%） patients within a median interval of 6 mo （range 1-21） and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five （8%） patients. CONCLUSION： OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical features suggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli.

关键词： Inflammatory bowel disease Old-age colitis Segmental colitis

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Clinical nutrition in the hepatogastroenterology curriculum

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World Journal of Gastroenterology 2016年第5期22卷 1729-1735页

作者： Chris JJ Mulder Geert JA Wanten Carol E Semrad Palle B Jeppesen Hinke M Kruizenga Nicolette J Wierdsma Matthijs E Grasman adriaan a van bodegraven Department of Gastroenterology and Hepatology VU University Medical Center Amsterdam1007 MD AmsterdamThe Netherlands Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical Center6500 HB NijmegenThe Netherlands Department of Medicine GI Section The University of ChicagoChicagoIL 60637United States Department of Medical Gastroenterology Rigshospitalet University Hospital of Copenhagen2100 KHB CopenhagenDenmark Department of Dietetic VU University Medical Center Amsterdam1081 HZ AmsterdamThe Netherlands Department of Internal Medicine Gastroenterologyand GeriatricsORBIS Medical Center6130 MB Sittard-GeleenThe Netherlands

Gastroenterology(GE) used to be considered a subspecialty of internal medicine. Today, GE is generally recognized as a wide-ranging specialty incorporating capacities, such as hepatology, oncology and interventional endoscopy, necessitating GEexpert differentiation. Although the European Board of Gastroenterology and Hepatology has defined specific expertise areas in Advanced endoscopy, hepatology, digestive oncology and clinical nutrition, training for the latter topic is lacking in the current hepatogastroenterology(HGE) curriculum. Given its relevance for HGE practice, and being at the core of gastrointestinal functioning, there is an obvious need for training in nutrition and related issues including the treatment of disease-related malnutrition and obesity and its associated metabolic derangements. This document aims to be a starting point for the integration of nutritional expertise in the HGE curriculum, allowing a central role in the management of malnutrition and obesity. We suggest minimum endpoints for nutritional knowledge and expertise in the standard curriculum and recommend a focus period of training in nutrition issues in order to produce well-trained HGE specialists. This article provides a road map for the organization of such a training program. We would highly welcome the World Gastroenterology Organisation, the European Board of Gastroenterology and Hepatology, the American Gastroenterology Association and other(inter)national Gastroenterology societies support the necessary certifications for this item in the HGE-curriculum.

关键词： Gastroenterology Training Clinical nutrition Malnutrition Metabolism Curriculum Targeted therapy Enteral feeding Parenteral feeding Obesity

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Crop type mapping using LiDAR,Sentinel-2 and aerial imagery with machine learning algorithms

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Geo-Spatial Information Science 2021年第2期24卷 215-227,I0003页

作者： adriaan Jacobus Prins adriaan van Niekerk Department of Geography&Environmental Studies Stellenbosch UniversityStellenboschSouth Africa

LiDAR data are becoming increasingly available,which has opened up many new *** such application is crop type *** crop type maps are critical for monitoring water use,estimating harvests and in precision *** traditional approach to obtaining maps of cultivated fields is by manually digitizing the fields from satellite or aerial imagery and then assigning crop type labels to each field-often informed by data collected during ground and aerial ***,manual digitizing and labeling is time-consuming,expensive and subject to human *** remote sensing methods is a cost-effective alternative,with machine learning gaining popularity for classifying crop *** study evaluated the use of LiDAR data,Sentinel-2 imagery,aerial imagery and machine learning for differentiating five crop types in an intensively cultivated *** combinations of the three datasets were evaluated along with ten machine *** classification results were interpreted by comparing overall accuracies,kappa,standard deviation and *** was found that LiDAR data successfully differentiated between different crop types,with XGBoost providing the highest overall accuracy of 87.8%.Furthermore,the crop type maps produced using the LiDAR data were in general agreement with those obtained by using Sentinel-2 data,with LiDAR obtaining a mean overall accuracy of 84.3%and Sentinel-2 a mean overall accuracy of 83.6%.However,the combination of all three datasets proved to be the most effective at differentiating between the crop types,with RF providing the highest overall accuracy of 94.4%.These findings provide a foundation for selecting the appropriate combination of remotely sensed data sources and machine learning algorithms for operational crop type mapping.

关键词： LiDAR multispectral imagery sentinel-2 machine learning crop type classification per-pixel classification

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Indications for 5-aminosalicylate in inflammatory bowel disease:Is the body of evidence complete?

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World Journal of Gastroenterology 2006年第38期12卷 6115-6123页

作者： Ad A van bodegraven Chris JJ Mulder Section of Inflammatory Bowel Diseases VU University medical centre Amsterdam The Netherlands Department of Gastroenterology VU University medical centre Amsterdam The Netherlands

Mesalazine is a safe drug, although adverse events may be seen in a minority of patients. This applies also to pregnant women and children. The role of mesalazine in combination therapy to improve efficacy and con- comitant drug pharmacokinetics, or in chemoprevention against inflammatory bowel disease (IBD)-related co- lonic carcinoma has not yet been completely elucidated. Therapeutic success of mesalazine may be optimized by a combination of high dose and low frequency of dos- age to improve compliance. Therefore, due to its supe- rior safety profile and pharmacokinetic characteristics, mesalazine is preferable to sulphasalazine. This paper reviews the literature concerning mechanisms of action, indications and off-label use, pharmacokinetic properties and formulations, therapeutic efficacy, compliance, pae- diatric indications, chemoprevention, and safety issues and adverse event profile of mesalazine treatment versus sulphasalazine. It also highlights these controversies in order to clarify the potential benefits of mesalazines in IBD therapy and evidence for its use.

关键词： Mesalazine Sulphasalazine Review Ulcerative colitis Crohn's disease Treatment Chemoprevention Pregnancy Adverse events

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INVESTIGATIONS ON VINYLENE CARBONATE Ⅰ. PREPARATION AND PROPERTIES OF POLY-(VINYLENEC ARBONATE)

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Chinese Journal of Polymer Science 1990年第3期8卷 197-203页

作者：黄家贤陈国华 EDDY TIJSMA LEEN van DER DOES adriaan BANTJES Nankai University Department of Chemistry Tianjin People's Republic of China Department of Chemical Technology Biomaterials Section Twente University P. O. Box 217 7500 AE Enschede The Netherlands

Bulk polymerization of vinylene carbonate using t-butylperoxypivalate at 40℃gave colourless, high molecular weight poly(vinylene carbonate) (PVCA). Solutions of PVCA in acetone and DMF are not stable at 25℃and this ... 详细信息

关键词： Vinylene carbonate Polymerization High Molecular Weight Degradation Mark-Houwink Equation.

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Outcome of direct-acting antiviral treatment for patients with chronic hepatitis C virus infection: clinical benefit proven?

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 257-259页

作者： Raoel Maan adriaan J.van der Meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamthe Netherlands

The highly effective direct-acting antivirals(DAAs)for the treatment of chronic hepatitis C virus(HCV)infection were well-received by both patients and physicians as sustained virological response(SVR)was associated with an improved overall survival in patients with stable liver disease,even in case of cirrhosis(1).Yet,at that time these results were derived from retrospective cohort studies with long-term follow-up after interferon-based *** patients with compensated liver disease there is confidence that SVR is a clinically relevant endpoint based on consistent positive results with smart use of statistics in numerous cohort ***,however,there remains a need for long-term follow-up data showing a clinical benefit of DAA-induced SVR,preferably with high-quality prospective *** results from the French ANRS CO22 Hepather cohort,as published by *** and colleagues in the April issue of the Lancet,thus bring an important contribution to the field(2).It’s the first prospective cohort study with reasonable follow-up time to assess all-cause mortality after DAA therapy.

关键词： patients infection clinical

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Hepatocellular carcinoma (HCC) risk stratification after virological cure for hepatitis C virus (HCV)-induced cirrhosis: time to refine predictive models

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 385-387页

作者： Raoel Maan adriaan J.van der Meer Department of Gastroenterology and Hepatology Erasmus MC University Medical Center RotterdamRotterdamThe Netherlands

Direct-acting antivirals(DAAs)have revolutionized antiviral treatment for chronic hepatitis C virus(HCV)infection,especially with the interferon-free regimens of the past 5 *** a cure for a virus that has been identified(only)30 years ago is unique in medical ***,even in case of advanced liver disease,cohort studies showed that patients attaining a sustained virological response(SVR)have a 3-to 4-fold reduced risk of hepatocellular carcinoma(HCC)(1-3).

关键词： sustained interferon hepatitis

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