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World Journal of Gastroenterology 2022年第23期28卷 2633-2635页

作者： Konstantinos Argyriou adolfo parra-blanco Department of Gastroenterology University Hospital of LarisaLarisa GR41110Greece Department of Gastroenterology Nottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom

We have recently read with interest the mini-review article"Therapeutic endoscopy for the treatment of post-bariatric surgery complications".The abovementioned article is a brief overview of the different endoscopic modalities employed in the management of bariatric surgery complications and represents an important decision support tool for clinicians to improve their current *** we appreciate the endeavor of Larsen and Kozarek,based on our indepth analysis,we came across several minor issues in this article;thus,we present our comments in this *** case the authors contemplate these comments in their relevant research,we believe that their contribution would be considerable for future studies.

关键词： Endoscopic treatment Bariatric surgery Complications Obesity Sleeve gastrectomy Roux-en-Y gastric bypass

Evidence-based considerations on bowel preparation for colonoscopy

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World Journal of Gastroenterology 2022年第31期28卷 4463-4466页

作者： Konstantinos Argyriou adolfo parra-blanco Department of Gastroenterology University Hospital of LarisaLarisa GR41334Greece Department of Gastroenterology Nottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom

We recently read with interest the article,“Novel frontiers of agents for bowel cleansing for colonoscopy”.This is a practical narrative review,which could be of particular importance to clinicians in order to improve their current *** we appreciate the venture of our colleagues,based on our in-depth analysis,we came across several minor issues in the article;hence,we present our comments in this *** the authors consider these comments further in their relevant research,we believe that their contribution would be of considerable importance for future studies.

关键词： Colonoscopy Bowel preparation Polyethylene glycol Post-polypectomy syndrome Post-polypectomy complications

Endoscopic treatment of scarred polyps with a non-thermal device(Endorotor):A review of the literature

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World Journal of Gastroenterology 2024年第12期30卷 1706-1713页

作者： Mariam Zaghloul Hameed Rehman Stefano Sansone Konstantinos Argyriou adolfo parra-blanco Department of Hepatology Gastroenterology and Infectious DiseasesKafrelsheikh UniversitKafr-Elshikh 33516Egypt Department of Gastroenterology Service Nottingham City Hospital CampusNottingham University Hospitals NHS TrustNottingham NG51PBUnited Kingdom Department of Gastroenterology University Hospital of LarissaLarissa 41334Greece NIHR Nottingham Biomedical Research Centre Nottingham University Hospitals NHS Trust and University of NottinghamNottingham NG72UHUnited Kingdom

Endoscopic resection(ER)of colorectal polyps has become a daily practice in most endoscopic units providing a colorectal cancer screening program and requires the availability of local experts and high-end endoscopic *** procedures have evolved over the past few years from endoscopic mucosal resection(EMR)to more advanced techniques,such as endoscopic submucosal dissection and endo-scopic full-thickness *** resection and disease eradication are the ultimate goals of ER-based techniques,and novel devices have been developed to achieve these *** EndoRotor®Endoscopic Powered Resection System(Interscope Medical,Inc.,Northbridge,Massachusetts,United States)is one such *** EndoRotor is a powered resection tool for the removal of alimentary tract mucosa,including post-EMR persistent lesions with scarring,and has both CE Mark and FDA *** review covers available published evidence documenting the usefulness of EndoRotor for the management of recurrent colorectal polyps.

关键词： EndoRotor Scarred polyps Recurrent polyps Colorectal cancer Colorectal polyps

The timing of bowel preparation before colonoscopy determines the quality of cleansing,and is a significant factor contributing to the detection of flat lesions:A randomized study

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World Journal of Gastroenterology 2006年第38期12卷 6161-6166页

作者： adolfo parra-blanco David Nicolás-Pérez Antonio Gimeno-García Begoa Grosso Alejandro Jiménez Juan Ortega Enrique Quintero Department of Gastroenterology Hospital Universitario de Canarias La Laguna 38109 Santa Cruz de Tenerife Spain Research Unit Hospital Universitario de Canarias La Laguna 38109 Santa Cruz de Tenerife Spain

AIM： To compare the cleansing quality of polyethylene glycol electrolyte solution and sodium phosphate with different schedules of administration, and to evaluate whether the timing of the administration of bowel preparation affects the detection of polyps. METHODS： One hundred and seventy-seven consecutive outpatients scheduled for colonoscopy were randomized in one of four groups to receive polyethylene glycol electrolyte solution or oral sodium phosphate with two different timing schedules. Quality of cleansing, polyp detection, and tolerance were evaluated. RESULTS： Patients receiving polyethylene glycol or sodium phosphate on the same day as the colonoscopy, obtained good to excellent global cleansing scores more frequently than patients who received polyethylene glycol or sodium phosphate on the day prior to the procedure （P 〈 0.001）. Flat lesions, but not fiat adenomas, were more frequent in patients prepared on the same day （P = 0.02）. CONCLUSION： The quality of colonic cleansing and the detection of fiat lesions are significantly improved when the preparation is taken on the day of the colonoscopy.

关键词： Colonoscopy Preparation Polyp Flat lesion Sodium phosphate Polyethylene glycol

Achieving the best bowel preparation for colonoscopy

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World Journal of Gastroenterology 2014年第47期20卷 17709-17726页

作者： adolfo parra-blanco Alex Ruiz Manuel Alvarez-Lobos Ana Amorós Juan Cristóbal Gana Patricio Ibáez Akiko Ono Takahiro Fujii Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 833-0024Chile Department of Gastroenterology Hospital Universitario de la Candelaria38916 Santa Cruz de TenerifeSpain Gastroenterology and Nutrition Unit Division of PediatricsEscuela de MedicinaPontificia Universidad Católica de ChileSantiago 833-0024Chile Department of Gastroenterology Hospital Universitario Virgen de la Arrixaca30001 MurciaSpain TF Clinic Tokyo 197-0804Japan

Bowel preparation is a core issue in colonoscopy,as it is closely related to the quality of the *** often find that bowel preparation is the most unpleasant part of the *** is widely accepted that the quality of cleansing must be excellent to facilitate detecting neoplastic *** spite of its importance and potential implications,until recently,bowel preparation has not been the subject of much *** most commonly used agents are high-volume polyethylene glycol(PEG)electrolyte solution and sodium *** has been some confusion,even in published meta-analyses,regarding which of the two agents provides better *** is clear now that both PEG and sodium phosphate are effectivewhen administered with proper ***,the timing of administration is recognized as one of the central factors to the quality of *** bowel preparation agent should be administered,at least in part,a few hours in advance of the *** low volume agents are available,and either new or modified schedules with PEG that usually improve *** adjuvants can also be used to reduce the volume of PEG,or to improve the efficacy of other *** factors apart from the choice of agent can improve the quality of bowel *** instance,the effect of diet before colonoscopy has not been completely clarified,but an exclusively liquid diet is probably not required,and a low-fiber diet may be preferable because it improves patient satisfaction and the quality of the *** patients,such as diabetics and persons with heart or kidney disease,require modified procedures and certain *** preparation for pediatric patients is also reviewed *** such cases,PEG remains the most commonly used *** detecting neoplasia is not the main objective with these patients,less intensive preparation may *** considerations must be made for patients with inflammatory bowel disease,including

关键词： Colonoscopy Optimal preparation Polyethylene glycol Sodium phosphate Special patients Timing

Gastric endoscopic submucosal dissection:From animal model to patient

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World Journal of Gastroenterology 2013年第45期19卷 8326-8334页

作者： Nicolás González adolfo parra-blanco Miguel Villa-Gómez Alejandra Gamba Andrés Taullard Anaulina Silveira Alberto Sanguinetti Carolina Olano Henry Cohen Department of Gastroenterology Faculty of MedicineHospital de Clínicas Montevideo 11600 Uruguay Department of Gastroenterology Escuela de Medicina Pontificia Universidad Católica de Chile Santiago 6510260 Chile Department of Quantitative Methods Hospital de Clínicas Montevideo 11600 Uruguay

AIM:To assess whether the use of porcine models is useful for learning endoscopic submucosal dissection(ESD),thus contributing to its subsequent application in human ***:This study/learning process was carried out in 3 phases:PhaseⅠ:Ex vivo animal;PhaseⅡ:In vivo animal;PhaseⅢ:*** endoscopist performed 30 gastric ESDs in porcine models,and later 5gastric ESDs in 5 *** ESD was done following the method practiced at the National Cancer Center in Tokyo,*** aspects,size,time and speed of ESD,as well as complications were *** patients,their clinical,endoscopic and histologic evolution was additionally ***:Thirty en bloc ESDs were carried out in animal *** mean±SD size of the pieces was of28.4±1.2 mm,and the time of ESD was 41.7±*** time of ESD in the first 15 procedures was 43.0±3.0 min whereas in the next 15 procedures,the time was 40.3±3.9 min,P=*** speed in the first 15ESDs was 1.25±0.11 cm2/min vs 2.12±0.36 cm2/min in the remaining 15,P=*** were no *** patients,5 lesions were resected en *** size of the pieces was 25.2±5.1 mm and the time was85.0±25.6 *** and histological controls did not show evidence of residual neoplastic ***:A sequential ESD training program of a unique endoscopist,based on the practice in porcine models,contributed to learning ESD for its subsequent application in humans,yielding good results in efficacy and safety.

关键词： Endoscopic submucosal dissection Porcine models Animal models Training

Validation of Fujinon intelligent chromoendoscopy with high definition endoscopes in colonoscopy

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World Journal of Gastroenterology 2009年第42期15卷 5266-5273页

作者： adolfo parra-blanco Alejandro Jiménez Bjrn Rembacken Nicolás González David Nicolás-Pérez Antonio Z Gimeno-García Marta Carrillo-Palau Takahisa Matsuda Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Department of Gastroenterology Hospital Universitario Central de AsturiasCelestino Villamil s/n33006 OviedoPrincipado de AsturiasSpain Research Unit University Hospital of the Canary Islandsc/Ofra s/nLa Laguna 38320TenerifeSpain Centre for Digestive Diseases The General Infirmary at LeedsGreat George StLeedsLS1 3EXUnited Kingdom Department of Gastroenterology Hospital de Clínicas de MontevideoAvda.Italia s/nMontevideo 11600Uruguay Division of Endoscopy National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

AIM:To validate high definition endoscopes with Fujinon intelligent chromoendoscopy(FICE) in ***:The image quality of normal white light endoscopy(WLE),that of the 10 available FICE filters and that of a gold standard(0.2% indigo carmine dye) were ***:FICE-filter 4 [red,green,and blue(RGB) wavelengths of 520,500,and 405 nm,respectively] provided the best images for evaluating the vascular pattern compared to white *** mucosal surface was best assessed using filter ***,the views obtained were not rated significantly better than those observed with white *** "gold standard",indigo carmine(IC) dye,was found to be superior to both white light and filter *** 6(RGB wavelengths of 580,520,and 460 nm,respectively) allowed for exploration of the IC-stained *** assessing mucosal polyps,both FICE with magnification,and magnification following dye spraying were superior to the same techniques without magnification and to white light *** the presence of suboptimal bowel preparation,observation with the FICE mode was possible,and endoscopists considered it to be superior to observation with white ***:FICE-filter 4 with magnification improves the image quality of the colonic vascular patterns obtained with WLE.

关键词： Colonoscopy Computed virtual chromoendoscopy Fujinon intelligent chromoendoscopy Magnifying colonoscopy Polyp diagnosis

Endoscopic submucosal dissection training with pig models in a Western country

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World Journal of Gastroenterology 2010年第23期16卷 2895-2900页

作者： adolfo parra-blanco María Rosa Arnau David Nicolás-Pérez Antonio Z Gimeno-García Nicolás González Juan A Díaz-Acosta Alejandro Jiménez Enrique Quintero Department of Gastroenterology University Hospital of the Canary Islands Ofra s/n Endoscopy Unit Department of GastroenterologyAsturias Central University HospitalCelestino Villamil s/n Research Animal Laboratory Ofra s/nLa Laguna University Department of Gastroenterology Montevideo Clinic HospitalAvda Italia s/n Research Unit University Hospital of the Canary IslandsOfra s/n

AIM:To test a strategy for endoscopic submucosal dissection(ESD) training in animal models designed to overcome the initial learning ***:ESD was attempted in ex vivo and in vivo pig *** ESD procedures were attempted in the esophagus(n=9) or the stomach(n=21).The ex vivo model was used until initial competence was *** the in vivo model,several ESD procedures were performed in up to 3 *** following variables were analyzed:specimen size,complete and en bloc resection rate,time for circumferential incision,time for submucosal dissection,total ESD duration,and ***:Complete resection was achieved in 28 cases(en bloc 27);2 could not be completed(one perforation,one technical diff iculty).The mean ± SD time for circumferential incision was 36.2±16.8 min(range:8-87 min),and the mean±SD time for submucosal dissection was 45.1±35.7 min(range:9-196 min).The mean±SD size of the resected specimens was 45.2±17.8 *** mean±SD total resection time was signif icantly increased for the gastric cases performed in the f irst half of the study(n=13) than in the second half(n=8)(98.9±62.4 min vs 61.7±17.6 min,P=0.04),although the specimen size did not ***:Training in animal models could help endoscopists overcome the learning curve before starting ESD in humans.

关键词： Endoscopic submucosal dissection Training Animal model

Endoscopic resection techniques and ablative therapies for Barrett’s neoplasia

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World Journal of Gastrointestinal Endoscopy 2011年第9期3卷 171-182页

作者： Jacobo Ortiz-Fernández-Sordo adolfo parra-blanco Alejandro García-Varona María Rodríguez-Peláez Erika Madrigal-Hoyos Irving Waxman Luis Rodrigo Endoscopy Unit Department of GastroenterologyCentral University Hospital of AsturiasCelestino Villamil S/NOviedo 33006AsturiasSpain Center for Endoscopic Research and Therapeutics Department of MedicineSection of GastroenterologyUniversity of Chicago Medical Center5758 SMaryland AvenueChicagoIL 60637United States Department of Pathology Central University Hospital of AsturiasCelestino Villamil S/NOviedo 33006AsturiasSpain Department of Gastroenterology Central University Hospital of AsturiasCelestino Villamil S/NOviedo 33006AsturiasSpain

Esophageal adenocarcinoma is the most rapidly increas- ing cancer in western ***-grade dysplasia (HGD)arising from Barrett’s esophagus(BE)is the most important risk factor for its development,and when it is present the reported incidence is up to 10% per *** in the setting of BE develops through a well known histological sequence,from non-dysplastic Barrett’s to low grade dysplasia and then HGD and *** surveillance programs have been established to detect the presence of neo- plasia at a potentially curative *** developed endoscopic treatments have dramatically changed the therapeutic approach of *** neoplasia is confined to the mucosal layer the risk for developing lymph node metastasis is negligible and can be successfully eradi- cated by an endoscopic approach,offering a curative in- tention treatment with minimal *** therapies include resection techniques,also known as tissue-acquiring modalities,and ablation therapies or non-tissue acquiring *** aim of endoscopic treatment is to eradicate the whole Barrett’s segment,since the risk of developing synchronous and metachro- nous lesions due to the persistence of molecular aberra- tions in the residual epithelium is well established.

关键词： Barrett’s oesophagus Esophageal adenocarcinoma Endoscopic mucosal resection Endoscopic submucosal dissection Radiofrequency ablation

Effects of chlorpyrifos on enzymatic systems of Cydia pomonella （Lepidoptera： Tortricidae） adults

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Insect Science 2017年第3期24卷 455-466页

作者： Laura Beatriz parra Morales Raul adolfo Alzogaray Liliana Cichon Silvina Garrido Jimena Soleno Cristina Monica Montagna Laboratorio de Investigaciones Bioquimicas Quimicas y de Medio Ambiente Facultad de Ingenieria Universidad Nacional del ComahueBuenos Aires 1400 (Q83001BX) Neuquen Facultad de Ciencias del Ambiente y la Salud Universidad Nacional del Comahue Buenos Aires 1400 Neuquen Centro de Investigaciones de Plagas e Insecticidas (CIPEIN-UNIDEFICONICET) Villa Martelli Buenos Aires Instituto de Investigacion e Ingenieria Ambiental (3iA-UNSAM) San Martin Provincia de Buenos Aires Instituto Nacional de Tecnologia Agropecuaria Estacion Experimental Alto Valle General Roca Argentina

The control program of codling moth （Cydia pomonella L.） in the Rio Negro and Neuqu6n Valley is intended to neonate larvae. However, adults may be subjected to sublethal pesticide concentrations generating stress which might enhance both mutation rates and activity of the detoxification system. This study assessed the exposure effects of chlorpyrifos on target enzyme and, both detoxifying and antioxidant systems of surviving adults from both a laboratory susceptible strain （LSS） and a field population （FP）. The results showed that the FP was as susceptible to chlorpyrifos as the LSS and, both exhibited a similar chlorpyrifos-inhibitory concentration 50 （IC50） of acetylcholinesterase （ACHE）. The FP displayed higher carboxylesterase （CarE） and 7-ethoxycoumarine O-deethylase （ECOD） activities than LSS. Both LSS and FP showed an increase on CarE activity after the exposure to low-chlorpyrifos concentrations, followed by enzyme inhibition at higher concentrations. There were no significant differences neither in the activities of glutathione S-transferases （GST）, catalase （CAT） and superoxide dismutase （SOD） nor in the reduced glutathione （GSH） content between LSS and FP. Moreover, these enzymes were unaffected by chlorpyrifos. In conclusion, control adults from the FP exhibited higher CarE and ECOD activities than control adults from the LSS. AChE and CarE activities were the most affected by chlorpyrifos. Control strategies used for C. pomonella, such as rotations of insecticides with different modes of action, will probably delay the evolution of insecticide resistance in FPs from the study area.

关键词： acetylcholinesterase antioxidant system chlorpyrifos codling moth detoxification enzymes