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Nanomedicine: Tiny Particles and Machines, from Diagnosis to Treatment of Cardiovascular Disease, Provides Huge Achievements

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Advances in Bioscience and Biotechnology 2015年第9期6卷 613-623页

作者： Md. Ismail Md. Faruk Hossain Md. Fazlul Karim Hossain Uddin shekhar Department of Biochemistry and Molecular Biology University of Dhaka Dhaka Bangladesh Department of Biological Sciences St John’s University New York USA Department of Biological Sciences Eastern Illinois University Charleston USA

Cardiovascular disease is one of many reverberating ailments that affect and kill hundreds of thousands of people around the world. To date treatments that offer improvement in the health condition of diseased people include the most promising nanomedicine although it is in its infancy, yet attaining attention from researchers of top notch day by day. In this current review importance is given on the application of nanomedicine in the diagnosis as well as treatment of cardiovascular disease.

关键词： Nanomedicine Cardiovascular Disease Diagnosis Treatment

An Appraisal of Sexual Behaviors, STI/HIV Prevalence, and HIV Prevention Programs among Truckers in India: A Critical Literature Review

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World Journal of AIDS 2014年第2期4卷 206-218页

作者： Damodar Sahu Arvind Pandey Ram Manohar Mishra Niranjan Saggurti shekhar Setu Indra Raj Singh Family Health International New Delhi India National Institute of Medical Statistics New Delhi India Population Council New Delhi India Transport Corporation of India Foundation Gurgaon India

Background: A systematic review portraying the changing pattern of sexual behaviors, STI and HIV prevalence and key strategies curb HIV and STI among truckers in India is lacking. This paper therefore aims to present a chronological review of literature regarding sexual behaviors, STI/HIV prevalence, and various HIV prevention programs implemented among truckers in India. Methodology: Published and unpublished studies (1990-2011) were identified through electronic databases, and hand searching. Results: Most studies on sexual behaviors and STI/HIV prevalence among truckers focused only on drivers and ignored their helpers. Evidences suggest that consistent condom use by truckers with both paid and non-paid female partners has increased during the past decade. Many recent studies suggest that the HIV prevalence among truckers is about 2% and it has been declining slowly during the past decade. The HIV prevention programs among truckers which started with the aim of raising awareness about HIV during early 1990s, have grown multi-folds to encompass not only the standard strategies like mid-media events, interpersonal counselling and STI care for HIV prevention, but also innovations such as the use of business franchisee models, and integrated research and evidence based planning in the program. The possibilities of using new approaches such as male circumcision and the use of pre-exposure prophylaxes are underway. Conclusion: More studies are needed to explore helpers’ vulnerabilities to HIV. Very few studies have attempted to examine the impact of large-scale prevention programs among truckers. Efforts are required to examine the impact of different components of such programs to guide the HIV prevention efforts among truckers in India.

关键词： Truckers Sexual Behavior HIV Prevention Programs India

A Comparative Study of Dosimetric Analysis of Three Different Sets of Five Fields and Seven Fields IMRT Plans for Prostate Cancer

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2019年第3期8卷 175-192页

作者： Mukesh Kumar Zope Deepali Bhaskar Patil Angel Kuriakose Aslam Rahman Vinita Trivedi shekhar Kumar Keshri Department of Medical Physics State Cancer Institute Indira Gandhi Institute of Medical Sciences Patna India Department of Radiation Oncology Paras HMRI Hospital Patna India Department of Radiotherapy Mahavir Cancer Sansthan Patna India

The advent of Intensity Modulated Radiation Therapy (IMRT) is rapidly changing the field of Radiation Oncology. IMRT has the potential to improve clinical implementation of highly conformal non-convex dose distributions. Nonetheless, a number of IMRT approaches including coplanar and noncoplanar beam techniques with 5 to 9 beams at different angles have been used in an effort to get the best dose distribution. The purpose of this study is to compare the dose to normal tissue and dose-limiting structures, conformity index, homogeneity index, number of monitor units required for the treatment of prostate cancer in 3 sets of five and seven beam IMRT plans and thus to select the best IMRT approach for patients with prostate cancer.

关键词： Prostate Cancer MUs Conformity Index Homogeneity Index

Clinical profile and outcomes of hepatocellular carcinoma in primary Budd-Chiari syndrome

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 699-715页

作者： Ankit Agarwal Sagnik Biswas shekhar Swaroop Arnav Aggarwal Ayush Agarwal Gautam Jain Anshuman Elhence Arun Vaidya Amit Gupte Ravi Mohanka Ramesh Kumar Ashwani Kumar Mishra Shivanand Gamanagatti Shashi Bala Paul Subrat Kumar Acharya Akash Shukla Shalimar Department of Gastroenterology and Human Nutrition All India Institute of Medical SciencesNew Delhi 110029DelhiIndia Department of Gastroenterology Seth Gordhandas Sunderdas Medical College and KEM HospitalMumbai 400012MaharashtraIndia Department of Gastroenterology Sir HN Reliance Foundation HospitalMumbai 400004India Department of Liver Transplant and HPB Sir HN Reliance Foundation HospitalMumbai 400004India Department of Gastroenterology All India Institute of Medical SciencesPatna 801507India Professor of Biostatistics National Drug Dependence Treatment Centre(NDDTC)All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029DelhiIndia

BACKGROUND There is scant literature on hepatocellular carcinoma(HCC)in patients with Budd-Chiari syndrome(BCS).AIM To assess the magnitude,clinical characteristics,feasibility,and outcomes of treatment in *** A total of 904 BCS patients from New Delhi,India and 1140 from Mumbai,India were *** prevalence and incidence of HCC were determined,and among patients with BCS-HCC,the viability and outcomes of interventional therapy were *** In the New Delhi cohort of 35 BCS-HCC patients,18 had HCC at index presentation(prevalence 1.99%),and 17 developed HCC over a follow-up of 4601 person-years,[incidence 0.36(0.22-0.57)per 100 person-years].BCS-HCC patients were older when compared to patients with BCS alone(P=0.001)and had a higher proportion of inferior vena cava block,cirrhosis,and long-segment vascular *** median alpha-fetoprotein level was higher in patients with BCS-HCC at first presentation than those who developed HCC at follow-up(13029 ng/mL vs 500 ng/mL,P=0.01).Of the 35 BCS-HCC,26(74.3%)underwent radiological interventions for BCS,and 22(62.8%)patients underwent treatment for HCC[transarterial chemoembolization in 18(81.8%),oral tyrosine kinase inhibitor in 3(13.6%),and transarterial radioembolization in 1(4.5%)].The median survival among patients who underwent interventions for HCC compared with those who did not was 3.5 years vs 3.1 mo(P=0.0001).In contrast to the New Delhi cohort,the Mumbai cohort of BCS-HCC patients were predominantly males,presented with a more advanced HCC[Barcelona Clinic Liver Cancer C and D],and 2 patients underwent liver *** HCC is not uncommon in patients with *** interventions and liver transplantation are feasible in select primary BCS-HCC patients and may improve outcomes.

关键词： Budd chiari syndrome Cancer Cirrhosis Thrombosis Liver Varices Transarterial chemoembolization Hepatic venous outflow tract obstruction

Safety and Efficacy of Neoadjuvant DOF [Docetaxel, Oxaliplatin, 5-Fluorouracil] Chemotherapy Regimen in Patients with Locally Advanced Gastric and Gastro-Esophageal Junction Cancers: A Single Center Experience from India

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Journal of Cancer Therapy 2020年第5期11卷 237-250页

作者： Vishal Kulkarni Satheesh Chiradoni Thungappa shekhar Patil Vinu Sarathy Kiran Pura Krishnamurthy Rajesh Kumar Radheshyam Naik Department of Medical Oncology Health Care Global Enterprises Ltd. Bangalore India

Background:?The role of chemotherapy in Gastric Cancer is constantly evolving?with various neoadjuvant and adjuvant strategies. Several chemotherapeutic agents are used in the treatment of locally advanced gastric cancer (LAGC) namely Platinum based compounds (Cisplatin, Oxaliplatin), Fluoropyrimidines like 5-Flurouracil [(5-FU), Capecitabine)], Taxanes (Docetaxel) and Anthracyclines (Epirubicin). Various doublet and triplet combination chemotherapy regimens have been used for neo-adjuvant chemotherapy (NACT) in LAGCs. In this study we evaluated the safety and efficacy of docetaxel based triplet regimen DOF [Docetaxel, Oxaliplatin, 5-Fluorouracil] in LAGC. Material and methods:?50 Newly diagnosed patients of Locally Advanced Gastric Cancer (stage II or III) deemed fit to receive chemotherapy were included in our study. After 3 cycles of neoadjuvant chemotherapy, patients were assessed based on radiological and pathological response.?Results: 50 Patients were included in our study of which majority were male (32), median age at presentation was 55 years and 24 patients presented with a history of gastrointestinal reflux disease (GERD). The most common hematological toxicities observed in our study were anemia (61.2%), neutropenia (42.6%, febrile neutropenia constituted 6%) and thrombocytopenia (13.2%). The most common gastro-intestinal [GI] toxicities observed in our study included nausea (69.2%), vomiting (31.2%), diarrhea (34%), oral mucositis (14%) and constipation (6.6%). We found that safety profile of DOF regimen was favorable with majority of patients tolerating the regimen well. The Overall Response Rate (68%), Disease Control Rate (96%) and Resectability Rate (80%) were higher compared to western studies. Pathological CR (17.5%), ypN0?disease status (42.5%) and nodal down staging (52%), all showed positive correlations with survival outcomes. Conclusion:?DOF regimen is an effective and feasible option for neoadjuvant treatment of LAGC in an Indian population

关键词： Locally Advanced Gastric Cancer (LAGC) Neoadjuvant Chemotherapy DOF (Docetaxel Oxaliplatin 5-Fluorouracil) Safety Toxicity

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众筹平台的选择:集资门户还是经纪自营商?

金融法苑 2017年第1期 202-211页

作者： shekhar Darke 毛玮瑶何颖美国加州大学哈斯汀法学院华东政法大学互联网金融法律研究中心华东政法大学经济法学院

当前,国内的股权众筹正如火如荼地发展着,但是对众筹的法律规制却严重滞后。尤其是对于股权众筹平台应当如何定位和规制,修订中的《证券法》仍未给出清晰明确的思路,这对众筹市场的发展造成了巨大阻碍。美国JOBS法案创设了众筹登记豁免... 详细信息

当前,国内的股权众筹正如火如荼地发展着,但是对众筹的法律规制却严重滞后。尤其是对于股权众筹平台应当如何定位和规制,修订中的《证券法》仍未给出清晰明确的思路,这对众筹市场的发展造成了巨大阻碍。美国JOBS法案创设了众筹登记豁免制度,允许初创企业和小企业从普通投资者处筹集资金,这将有利于解决初创企业和小企业的融资问题。同时,法案要求进行股权众筹的众筹平台必须注册为经纪自营商或集资门户。但实践中众筹平台更倾向于以经纪自营商注册,原因在于注册为经纪自营商在灵活性、功能性、监管清晰度以及投资者保护等方面明显优于注册为集资门户的选择。

关键词： JOBS 法案众筹平台经纪自营商集资门户

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第二次读博

科学新闻 2021年第5期 62-63页

作者： shekhar Chandra 倪伟波剑桥麻省理工学院

我认为进入西方的顶尖大学,尤其是美国的顶尖大学,是通往成功的保证。我也渴望通过研究污染对全球环境的影响来帮助世界。作为一个在印度偏远村庄长大的孩子,我亲眼目睹了其中的一些影响,比如烹饪造成的室内空气污染如何导致健康问题,...

我认为进入西方的顶尖大学,尤其是美国的顶尖大学,是通往成功的保证。我也渴望通过研究污染对全球环境的影响来帮助世界。作为一个在印度偏远村庄长大的孩子,我亲眼目睹了其中的一些影响,比如烹饪造成的室内空气污染如何导致健康问题,以及不断变化的天气模式如何影响农民的庄稼。我希望自己计划从事的大气科学研究可以有助于改善我的家人和朋友,以及许多处于类似情况的其他人的生活。所以,当2007年来到美国开始攻读博士学位时,我已经准备好埋头苦干了。但在第一个学期,我开始怀疑。我的研究似乎不太可能带来自己所寻求的现实世界的改变,

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3.0动态增强MR血管成像对乳腺良恶性病变的诊断价值(英文)

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东南大学学报（医学版） 2013年第4期32卷 389-393页

作者： shekhar Kumar Mehta 刘万花东南大学附属中大医院放射科江苏南京210009

目的:回顾性评估3.0T动态增强MR血管成像(MRA)对乳腺良恶性病变的诊断价值。方法:经病理证实的108例乳腺疾病患者(52例恶性,56例良性)作为研究对象,借助3D MRA图像计算患侧血管增加(双侧差异血管数≥2)及病变邻近血管数。结果:52例乳腺... 详细信息

目的:回顾性评估3.0T动态增强MR血管成像(MRA)对乳腺良恶性病变的诊断价值。方法:经病理证实的108例乳腺疾病患者(52例恶性,56例良性)作为研究对象,借助3D MRA图像计算患侧血管增加(双侧差异血管数≥2)及病变邻近血管数。结果:52例乳腺恶性病变中41例、56例良性病变中9例出现患侧血管增加,以患侧血管增加作为诊断标准,其对乳腺恶性病变诊断的敏感性、特异性及准确度分别79%、84%及84%;52例乳腺恶性病变中46例、56例良性病变中18例出现病灶邻近血管,以病灶邻近血管作为诊断标准,其对乳腺恶性病变诊断的敏感性、特异性及准确度分别为89%、68%及76%;患侧血管增加的阳性预测值及阴性预测值分别为82%、81%,病灶邻近血管的阳性预测值及阴性预测值分别为82%、79%。结论:3D MRA能有效评估双侧乳腺血管形成。乳腺恶性病变比良性病变更容易出现患侧血管增加及病灶邻近血管。

关键词：乳腺磁共振成像增强磁共振成像磁共振血管成像患侧血管增加病灶邻近血管最大信号投影

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关于孟加拉国卡西族社会经济特点的研究

南亚研究季刊 2001年第3期 74-76页

作者： Snehangshu shekhar Changa Mohammad lsmail Hossain 孟加拉国锡尔赫特政府兽医大学 (生命科学院沙贾拉尔科技大学)基础科学系

本文提供了关于孟加拉国卡西族的原始资料。此项研究目的在于揭示孟加拉国卡西族的社会经济特点和其家庭的生活水平。锡尔赫特地区中两块区域被选作此次研究的试验地。每个区域中共有 4 0个家庭被调查取样。结果显示 38%的家庭没有自已... 详细信息

本文提供了关于孟加拉国卡西族的原始资料。此项研究目的在于揭示孟加拉国卡西族的社会经济特点和其家庭的生活水平。锡尔赫特地区中两块区域被选作此次研究的试验地。每个区域中共有 4 0个家庭被调查取样。结果显示 38%的家庭没有自已的土地 ,其中只有7%的家庭是大家庭。绝大多数的小农场主和他的家庭成员都没受过正式的教育。卡西族人家庭主要从事的都是农业 ,并且生活水平都不高。有一些卡西族人家庭是从商的。他们面临着不少问题 ,不断增加的政府发展计划正逐渐改善他的生活水平。

关键词：孟加拉国卡西族社会经济特点

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