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Efficacy of Silene arenosa extract on acetylcholinesterase in Bungarus sindanus(krait) venom

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Journal of Traditional Chinese Medicine 2021年第3期41卷 349-354页

作者： adil shah Mushtaq Ahmed Naila Sher Nadia Mushtaq Rahmat Ali Khan Fozia Midrarullah Department of Biotechnology Faculty of Biological SciencesUniversity of Science&TechnologyBannu 28100KPK-Pakistan Department of Botany Faculty of Biological SciencesUniversity of Science&TechnologyBannu 28100KPK-Pakistan Department of Biochemistry KMU Institute of Medical SciencesKohat 26000Pakistan Department of Biotechnology Saheed Benazir Bhutto UniversitySheringalDir UpperKPK-Pakistan

OBJECTIVE:To examine the efficacy of Silene arenosa extract on acetylcholinesterase (AChE) of krait (Bungarus Sindanus) snake ***:The present project designed to evaluate the inhibition of AChE by following standard ***:Statistical analysis of the results showed that Silene arenosa exerted 73%inhibition against the krait venom acetylcholinesterase at fixed substrate acetylcholine (ACh) concentration (0.5 mM).Kinetic analysis using the Lineweaver Burk plot revealed that Silene arenosa caused a competitive type of inhibition i.e.K_(m) values increased from 26.6 to 93.3 mM (26.6%to 93.3%) and V_(max)remained constant in a concentration-dependent *** arenosa competes with the substrate to bind at the active site of the *** K_(mapp)of venom AChE for Silene arenosa increased from 60%to 81.6%and the V_(maxapp)remains constant.K_(i)(inhibition constant was estimated to be 48μg for snake venom);while the K_(m)(Michaelis-Menten constant of AChE-substrate into AChE and product) was estimated to be 0.5 *** IC_(50)of AchE calculated for Silene arenosa was 67μ***:The present results suggest that Silene arenosa extract can be considered as an inhibitor of snake venom AChE.

关键词： acetylcholinesterase snake venoms silene arenosa competitive inhibition

Lumbar Hernia: An Unusual Presentation of Bear Maul

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International Journal of Clinical Medicine 2013年第10期4卷 451-454页

作者： Mubashir Ahmad shah Aakib Hamid Charag adil Pervaiz shah Haroon Rashid Zargar Department of General & Minimal Access Surgery Sher-I-Kashmir Institute of Medical Sciences Srinagar India Department ofPlastic & Reconstructive Surgery Sher-I-Kashmir Institute of Medical Sciences Srinagar India

Introduction: Typical lumbar hernias are very rare surgical conditions. Lumbar hernias can be congenital or acquired. About 25% of all lumbar hernias have a traumatic etiology. Case-Report: We here reported a case of a 55-year-old male who was mauled by a bear. The patient developed an atypical lumbar hernia after 6 months of sustaining craniofacial and abdominal trauma. Open hernioplasty, which was a very challenging job, was done in this patient. Conclusion: Post traumatic lumbar hernias have been reported but till today no case of lumbar hernia following an attack by a bear has been reported in literature. Both acute and long-standing post-traumatic lumbar hernias are rare but challenging conditions. The corrective surgical procedure becomes more complex as hernial defect enlarges. Reconstruction is a challenging aspect of lumbar hernia surgery.

关键词： Lumbar Hernia Trauma Bear Maul

Acute iatrogenic Budd-Chiari syndrome following hepatectomy for hepatolithiasis:A report of two cases

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World Journal of Gastroenterology 2013年第34期19卷 5763-5768页

作者： Xue-Li Bai Yi-Wen Chen Qi Zhang Long-Yun Ye Yuan-Liang Xu Liang Wang Chun-Hui Cao Shun-Liang Gao Mohamed adil shah Khoodoruth Bibi Zaina Ramjaun Ai-Qiang Dong Ting-Bo Liang Department of Hepatobiliary-Pancreatic Surgery Second Affiliated HospitalSchool of MedicineZhejiang University Department of Cardiothoracic Surgery Second Affiliated HospitalSchool of MedicineZhejiang University

Budd-Chiari syndrome(BCS)is defined as hepatic venous outflow obstruction at any level from the small hepatic veins to the junction of the inferior vena cava(IVC)and the right atrium,regardless of the cause of *** present two cases of acute iatrogenic BCS and our clinical management of these *** first case was a 43-year-old woman who developed acute BCS following the implantation of an IVC stent for the correction of stenosis in the IVC after hepatectomy for *** second case was a61-year-old woman with complete obstruction of the outflow of hepatic veins during bilateral hepatectomy for *** iatrogenic BCS should be con-sidered a rare complication following hepatectomy for *** of potential hepatic outflow obstructions and timely management are critical to avoid poor outcomes when performing hepatectomy for hepatolithiasis.

关键词： Acute iatrogenic Budd-Chiari syndrome Hepatolithiasis Hepatectomy Inferior vena cava

Sex and racial disparities in non-alcoholic fatty liver disease-related cardiovascular events: National inpatient sample analysis (2019)

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World Journal of Cardiology 2024年第3期16卷 137-148页

作者： Rupak Desai Ali Tariq Alvi Advait Vasavada Yashwitha Sai Pulakurthi Bhavin Patel adil Sarvar Mohammed Shreyans Doshi Ikechukwu Ogbu Independent Researcher AtlantaGA 30079United States Department of Internal Medicine HCA Florida Westside HospitalPlantationFL 33324United States Department of Internal Medicine M.P.Shah Medical CollJamnagar 361008India Department of Internal Medicine Saint Michael Medical CenterNewarkNJ 07102United States Department of Internal Medicine Trinity Health Oakland HospitalPontiacMI 48341United States Department of Internal Medicine Central Michigan University College of MedicineSaginawMI 48602United States Department of Internal Medicine UCF College of Medicine HCA GME ConsortiumGainesvilleFL 32605United States Department of Internal Medicine Mountainview HospitalLas VegasNV 89108United States

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)increases cardiovascular disease(CVD)risk irrespective of other risk ***,large-scale cardiovascular sex and race differences are poorly *** To investigate the relationship between NAFLD and major cardiovascular and cerebrovascular events(MACCE)in subgroups using a nationally representative United States inpatient *** We examined National Inpatient Sample(2019)to identify adult hospitalizations with NAFLD by age,sex,and race using ICD-10-CM *** and demographic characteristics,comorbidities,and MACCE-related mortality,acute myocardial infarction(AMI),cardiac arrest,and stroke were compared in NAFLD cohorts by sex and *** regression analyses were adjusted for sociodemographic characteristics,hospitalization features,and *** We examined 409130 hospitalizations[median 55(IQR 43-66)years]with *** was more common in females(1.2%),Hispanics(2%),and Native Americans(1.9%)than *** often reported non-elective admissions,Medicare enrolment,the median age of 55(IQR 42-67),and poor *** had higher obesity and uncomplicated diabetes but lower hypertension,hyperlipidemia,and complicated diabetes than *** had a median age of 48(IQR 37-60),were Medicaid enrollees,and had non-elective *** had greater diabetes and obesity rates than whites but lower hypertension and ***,all-cause mortality,AMI,cardiac arrest,and stroke were all greater in elderly individuals(P<0.001).MACCE,AMI,and cardiac arrest were more common in men(P<0.001).Native Americans(aOR 1.64)and Asian Pacific Islanders(aOR 1.18)had higher all-cause death risks than *** Increasing age and male sex link NAFLD with adverse MACCE outcomes;Native Americans and Asian Pacific Islanders face higher mortality,highlighting a need for tailored interventions and care.

关键词： Non-alcoholic fatty liver disease Cardiovascular disease Major cardiovascular and cerebrovascular events Sex/gender disparities Mortality

Extraction of protein from churpi of yak milk origin:Size reduction,nutraceutical potential and as a wall material for resveratrol

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Food Bioscience 2022年第2期46卷 900-911页

作者： Asir Gani Nairah Noor adil Gani Jenno Joseph-Leenose-Helen Asima shah Zanoor ul Ashraf Laboratory of Functional Food and Nutraceuticals Department of Food Science and TechnologyUniversity of KashmirSrinagar190006India

Resveratrol is a known anti-oxidant and anti-cancer *** low bioavailability and poor water solubility of resveratrol is a major barrier that restricts its usage in food *** overcome these problems,the study presents micro and nano encapsulation of resveratrol in casein micelles extracted from Himalayan cheese(Churpi).Resveratrol loaded casein microparticles(CS-rm)were obtained using emulsion-freeze ***,resveratrol loaded casein nanoparticles(CS-rn)were obtained using *** were characterized using dynamic light scattering(DLS),scanning electron microscopy(SEM)and attenuated total reflectance-fourier transform infrared spectroscopy(ATR-FTIR).DLS revealed hydrodynamic diameter of 71.24μm and 387.023 nm and zeta potential of-22.62 and-28.08 mV for CS-rm and *** confirmed the characteristic peaks of resveratrol at 965.4,1380.86,1586.66 and 1607 cm-1 confirmed successful micro and ***-rm displayed high encapsulation efficiency(52.32%)and swelling power(77.90 at pH 3 and 68.65 at pH 7.5)than *** micro and nanoencapsulation protected resveratrol in gastric conditions,however,CS-rn showed high release of resveratrol then CS-rm in simulated intestinal *** anti-oxidant and anti-cancer activity of resveratrol under simulated gastric and intestinal conditions(SGID)was significantly higher(p≤0.05)for CS-rn,showing that nanoencapsulation improved release and nutraceutical profile of *** loaded nano and micro casein particles can be used a source of fortified protein supplement in growing food and nutraceutical industry.

关键词： Casein Encapsulation efficiency In vitro release Anti-cancer

Deposition and electrical properties of cadmium telluride thin films by thermal vacuum evaporation technique

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材料科学与工程（中英文版） 2009年第10期3卷 11-17,34页

作者： Nazar Abbas shah Manzar Abbas Muhammad Bashir Waqar Ahmad adil Syed Muhammad Ashraf Atta Department of Physics COMSA TS Institute of Information Technology Islamabad 45320 Pakistan