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Cetyltrimethylammonium chloride(CTAC)catalyzed one-pot synthesis of novel coumarin-4H-pyran conjugates in aqueous media

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Chinese Chemical Letters 2017年第5期28卷 976-980页

作者： adil omar Keyume Ablajan Mawjvda Hamdulla Key Laboratory of Oil&Gas Fine Chemicals Ministry of Education&Xinjiang Uyghur Autonomous RegionCollege of Chemistry and Chemical EngineeringXinjiang UniversityUrumqi 830046China

Novel fluorescent coumarin-4H-pyran conjugates were achieved by three-component reactions of various synthetic β-ketoesters with aldehydes and malononitrile in aqueous *** mild reaction conditions,operational simplicity,absence of tedious separation procedures,using of inexpensive and nontoxic commercially available cationic surfactant cetyltrimethylammonium chloride（CTAC） as a catalyst are the prominent advantage of this method.

关键词： Coumarin 4H-Pyran Multicomponent reaction CTAC Aqueous media Surfactant catalyzed

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One-pot, three-component reaction of aldehyde/ketone, thiosemicarbazide and carboxylic ester derivatives

One-pot, three-component reaction of aldehyde/ketone, thiose...

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中国化学会第九届全国有机化学学术会议

作者： Xiabing Ma Mamateli Obul adil omar Keyume Ablajan Key Laboratory of Oil ＆ Gas Fine Chemicals Ministry of Education ＆ Xinjiang Uyghur Autonomous Region College of Chemistry and Chemical Engineering Xinjiang University

＜正＞Heterocyclic compound are widespread in nature with many different kinds and large number,such as some alkaloids,vitamins,antibiotics,*** to the differences among the species and the number of heteroatoms,ring m...

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Convenient one-pot, four component synthesis of multi-subsitituted pyrano[2,3-c]pyrazole-benzoic acid containing dicarboxylates

Convenient one-pot, four component synthesis of multi-subsit...

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中国化学会第九届全国有机化学学术会议

作者： Mamateli Obul Xiabing Ma adil omar Keyume Ablajan Key Laboratory of Oil & Gas Fine Chemicals Ministry of Education & Xinjiang Uyghur Autonomous Region College of Chemistry and Chemical Engineering Xinjiang University

The synthesis and design of biologically active molecules in a single operation without isolation of intermediates is the main challenges in medicinal ***,MCRs have attracted much attention for the construction of bio...

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Pregnancy with Gastric Stromal Tumor

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Case Reports in Clinical Medicine 2014年第11期3卷 571-576页

作者： Iliass Charif Najat Khalil Abdelmalek Ousadden El Bachir Benjelloun Ouafae Slimani Fatima Zahra Fdili Alaoui Fatima Zahra Hijri omar Mesbahi adil Ibrahimi Ihsane Mellouki Hepatogastroenterology Service Hassan II University Hospital. Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco Visceral Surgery Service Hassan II University Hospital. Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco Gynecology Obstetrics Service Hassan II University Hospital. Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco Medical Oncology Service Hassan II University Hospital. Faculty of Medicine and Pharmacy of Fez Sidi Mohammed Ben Abdellah University Fez Morocco

Background: Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. GIST are rare during pregnancy. We report here the case of a patient who was admitted in our university hospital for GIST discovered during the second trimester of pregnancy. She was 42 years old, in the fifth months of pregnancy. She was admitted for biliary colic pain with vomiting. On abdominal examination, we objectified a distended abdomen with uterine height of 18 cm and epigastric mass of 10 cm. Abdominal ultrasound and magnetic resonance imaging (MRI) showed a hepatic, tissue and cystic mass, developing at the expense of the left liver. Endoscopy objectified an aspect of extrinsic compression at the front of the stomach. A cesarean was scheduled at the 35th month of pregnancy for fetal extraction and rescue. Exploration of the peritoneal cavity during surgery has objectified a hepatic highly vascularised mass reaching up to the umbilicus. This mass was unresectable. A postoperative CT scan revealed a large bilobed epigastric mass adhering to the stomach and the left liver. Histological and immunohistochemical study of hepatic process showed a gastrointestinal stromal tumor of high risk of malignancy. Conclusion: few cases have been reported in the literature on GIST during pregnancy showing the rarity of the condition that requires multidisciplinary care.

关键词： GIST Pregnancy Imatinib

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