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Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation

Journal of Clinical and Translational Hepatology 2022年第2期10卷 363-373页

作者： Zhengtao Liu Jun Xu Shuping Que Lei Geng Lin Zhou adil mardinoglu Shusen Zheng Shulan International Medical College Zhejiang Shuren UniversityHangzhouZhejiangChina Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina NHC Key Laboratory of Combined Multi-organ Transplantation Key Laboratory of the diagnosis and treatment of organ TransplantationCAMSFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Key Laboratory of Organ Transplantation Zhejiang ProvinceFirst Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina DingXiang Clinics HangzhouZhejiangChina Science for Life Laboratory KTH-Royal Institute of TechnologyStockholmSweden Centre for Host-Microbiome Interactions Faculty of DentistryOral&Craniofacial SciencesKing’s College LondonLondonUK

Omics data address key issues in liver transplantation(LT)as the most effective therapeutic means for end-stage liver *** purpose of this study was to review the current application and future direction for omics in *** reviewed the use of multiomics to elucidate the pathogenesis leading to LT and *** directions with respect to the use of omics in LT are also described based on perspectives of surgeons with experience in *** molecules were identified and summarized based on omics,with a focus on post-transplant liver fibrosis,early allograft dysfunction,tumor recurrence,and graft *** emphasized the importance omics for clinicians who perform LTs and prioritized the directions that should be *** also outlined the ideal workflow for omics in *** step with advances in technology,the quality of omics data can be guaranteed using an improved algorithm at a lower *** should be addressed on the translational value of omics for better therapeutic effects in patients undergoing LT.

关键词： Multiomic analysis Transcriptomics Proteomics Metabolomics Liver transplantation EAD

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Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients:a randomised,double-blinded,placebo-controlled phase-II trial

引用

Translational Neurodegeneration 2023年第1期12卷 849-871页

作者： Burak Yulug Ozlem Altay Xiangyu Li Lutfu Hanoglu Seyda Cankaya Simon Lam Halil Aziz Velioglu Hong Yang Ebru Coskun Ezgi Idil Rahim Nogaylar Ahmet Ozsimsek Cemil Bayram Ismail Bolat Sena Oner Ozlem Ozdemir Tozlu Mehmet Enes Arslan Ahmet Hacimuftuoglu Serkan Yildirim Muhammad Arif Saeed Shoaie Cheng Zhang Jens Nielsen Hasan Turkez Jan Borén Mathias Uhlén adil mardinoglu Department of Neurology and Neuroscience Faculty of MedicineAlanya Alaaddin Keykubat UniversityAntalyaTurkey Science for Life Laboratory KTH-Royal Institute of TechnologyStockholmSweden Department of Neurology Faculty of MedicineIstanbul Medipol UniversityIstanbulTurkey Centre for Host-Microbiome Interaction’s Faculty of DentistryOral and Craniofacial SciencesKing’s College LondonLondonUK Department of Women’s and Children’s Health Karolinska InstituteStockholmSweden Functional Imaging and Cognitive-Affective Neuroscience Lab Istanbul Medipol Univer-sityIstanbulTurkey Department of Medical Pharmacology Faculty of Medi-cineAtatürk UniversityErzurumTurkey Department of Pathology Veterinary FacultyAtaturk UniversityErzurumTurkey Department of Molecular Biology and Genetics Faculty of ScienceErzurum Technical UniversityErzurumTur-key School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhouPeople’s Republic of China Department of Biology and Biological Engineering Chalmers University of TechnologyGothenburgSweden Department of Medical Biology Faculty of MedicineAtatürk UniversityErzurumTurkey Department of Molecular and Clinical Medicine University of Gothenburg and Sahlgrenska University HospitalGothenburgSweden.

Background Alzheimer’s disease(AD)is associated with metabolic abnormalities linked to critical elements of *** recently administered combined metabolic activators(CMA)to the AD rat model and observed that CMA improves the AD-associated histological parameters in the *** promotes mitochondrial fatty acid uptake from the cytosol,facilitates fatty acid oxidation in the mitochondria,and alleviates oxidative *** Here,we designed a randomised,double-blinded,placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD ***-dose CMA included 12.35 g L-serine(61.75%),1 g nicotinamide riboside(5%),2.55 g N-acetyl-L-cysteine(12.75%),and 3.73 g L-carnitine tartrate(18.65%).AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day *** primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment *** secondary aim of this study was to evaluate the safety and tolerability of CMA.A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD *** We showed a significant decrease of AD Assessment Scale-cognitive subscale(ADAS-Cog)score on day 84 vs day 0(P=0.00001,29%improvement)in the CMA ***,there was a significant decline(P=0.0073)in ADAS-Cog scores(improvement of cognitive functions)in the CMA compared to the placebo group in patients with higher ADAS-Cog *** cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging ***,the plasma levels of proteins and metabolites associated with NAD+and glutathione metabolism were significantly improved after CMA *** Our results indicate that treatment of AD patients with CMA can lead to enhanced cognit

关键词： Alzheimer’s disease Combined metabolic activators Multi-omics Systems biology Systems medicine

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