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Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation

Virologica Sinica 2024年第4期39卷 587-599页

作者： Zhenfang Yan Jiayu Yue Yaxin Zhang Zhengyang Hou Dianyu Li Yanmei Yang Xiangrong Li adi idris Huixia Li Shasha Li Jingying Xie Ruofei Feng Key Laboratory of Biotechnology and Bioengineering of State Ethnic Biomedical Research Center Northwest Minzu UniversityLanzhou730030China College of Life Science and Engineering Northwest Minzu UniversityLanzhou730030China Gansu Tech Innovation Center of Animal Cell Biomedical Research CenterNorthwest Minzu UniversityLanzhou730030China Engineering Research Center of Key Technology and Industrialization of Cell-based Vaccine Ministry of EducationBiomedical Research CenterNorthwest Minzu UniversityLanzhou730030China Centre for Immunology and Infection Control School of Biomedical SciencesQueensland University of TechnologyKelvin GroveQueensland4702Australia

Herpesviruses antagonize host antiviral responses through a myriad of molecular strategies culminating in the death of the host *** virus(PRV)is a significant veterinary pathogen in pigs,causing neurological sequalae that ultimately lead to the animal's *** is known to trigger apoptotic cell death during the late stages of *** virion host shutdown protein(VHS)encoded by UL41 plays a crucial role in the PRV infection *** this study,we demonstrate that UL41 inhibits PRV-induced activation of inflammatory cytokine and negatively regulates the cGAS-STING-mediated antiviral activity by targeting IRF3,thereby inhibiting the translocation and phosphorylation of ***,mutating the conserved amino acid sites(E192,D194,and D195)in the RNase domain of UL41 or knocking down UL41 inhibits the immune evasion of PRV,suggesting that UL41 may play a crucial role in PRV's evasion of the host immune response during *** results enhance our understanding of how PRV structural proteins assist the virus in evading the host immune response.

关键词： Pseudorabies virus(PRV) UL41 IRF3 Interferon cGAS-STING

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Salivary leptin concentrations in Bruneian secondary school children

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Asian Pacific Journal of Tropical Biomedicine 2016年第4期6卷 335-337页

作者： adi idris Ahmed Gharib Khamis Nur Basirah Ghazali Michael Steele David Koh Nik Ani Tuah PAPRSB Institute of Health Sciences Universiti Brunei Darussalam Faculty of Science Universiti Brunei Darussalam Saw Swee Hock School of Public Health National University of Singapore

Objective:To investigate the association between leptin levels and body mass index in Bruneian secondary school ***:The body mass index of Bruneian secondary school students(aged 11–18years) was determined before collecting their saliva using the passive drool *** leptin concentration was determined by ***:Correlation and partial correlation(controlled for age) analyses showed no significant differences between the levels of salivary leptin of normal weight and overweight ***:No significant increase in the salivary leptin concentration was observed in overweight compared with normal weight Bruneian secondary school students.

关键词： Obesity Saliva Leptin Brunei Adolescents Body mass index

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