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Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

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Cellular & Molecular Immunology 2024年第1期21卷 33-46页

作者： Anja Meyer Stephanie R.Zack Wes Nijim adel Burgos Vishwa Patel Brian Zanotti Michael V.Volin M.Asif Amin Myles J.Lewis Costantino Pitzalis Shiva Arami Joseph A.Karam Nadera J.Sweiss Shiva Shahrara Jesse Brown VA Medical Center ChicagoILUSA Department of Medicine Division of RheumatologyThe University of Illinois at ChicagoChicagoILUSA Department of Microbiology and Immunology Midwestern UniversityDowners GroveILUSA Division of Rheumatology and Clinical Autoimmunity Center of Excellence University of MichiganAnn ArborMIUSA Centre for Experimental Medicine and Rheumatology William Harvey Research InstituteBarts and The London School of Medicine and DentistryQueen Mary University of LondonLondonUnited Kingdom Centre for Experimental Medicine&Rheumatology William Harvey Research InstituteQueen Mary University of London and Barts NIHR BRC&NHS TrustLondonUK Department of Biomedical Sciences Humanitas Universityand Humanitas Research HospitalMilanItaly Department of Orthopedic Surgery the University of Illinois at ChicagoChicagoILUSA

A novel rheumatoid arthritis(RA)synovial fluid protein,Syntenin-1,and its receptor,Syndecan-1(SDC-1),are colocalized on RA synovial tissue endothelial cells and fibroblast-like synoviocytes(FLS).Syntenin-1 exacerbates the inflammatory landscape of endothelial cells and RA FLS by upregulating transcription of IRF1/5/7/9,IL-1β,IL-6,and CCL2 through SDC-1 ligation and HIF1α,or mTOR ***,Syntenin-1 orchestrates RA FLS and endothelial cell invasion via SDC-1 and/or mTOR *** Syntenin-1 reprogrammed endothelial cells,the dynamic expression of metabolic intermediates coincides with escalated glycolysis along with unchanged oxidative factors,AMPK,PGC-1α,citrate,and inactive oxidative ***,RA FLS rewired by Syntenin-1 displayed a modest glycolytic-ATP accompanied by a robust mitochondrial-ATP *** enriched mitochondrial-ATP detected in Syntenin-1 reprogrammed RA FLS was coupled with mitochondrial fusion and fission recapitulated by escalated Mitofusin-2 and DRP1 *** found that VEGFR1/2 and Notch1 networks are responsible for the crosstalk between Syntenin-1 rewired endothelial cells and RA FLS,which are also represented in RA *** to RA explants,morphological and transcriptome studies authenticated the importance of VEGFR1/2,Notch1,RAPTOR,and HIF1αpathways in Syntenin-1 arthritic mice and their obstruction in SDC-1 deficient ***,dysregulation of SDC-1,mTOR,and HIF1αnegated Syntenin-1 inflammatory phenotype in RA explants,while inhibition of HIF1αimpaired synovial angiogenic imprint amplified by *** conclusion,since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood,targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.

关键词： Syntenin-1 Syndecan-1 RA FLS RA explants immunometabolism

Calibration of CO and CO₂ Monitors Used in Periodic Inspection of Vehicles at Fixed Stations for Environmental Control

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Green and Sustainable Chemistry 2024年第2期14卷 29-41页

作者： adel Bassuoni Shehata Abdulrahman Rashed Al Askar Najjy Hamad Al Yami Abdullah Suleiman Al Owaysi Sultan K. Alharbi Chemistry Department National Measurement and Calibration Center (NMCC) Saudi Standards Metrology and Quality Organization (SASO) Riyadh Kingdom of Saudi Arabia

Global efforts for environmental cleanliness through the control of gaseous emissions from vehicles are gaining momentum and attracting increasing attention. Calibration plays a crucial role in these efforts by ensuring the quantitative assessment of emissions for informed decisions on environmental treatments. This paper describes a method for the calibration of CO/CO2 monitors used for periodic inspections of vehicles in cites. The calibration was performed in the selected ranges: 900 - 12,000 µmol/mol for CO and 2000 - 20,000 µmol/mol for CO2. The traceability of the measurement results to the SI units was ensured by using certified reference materials from CO/N2 and CO2/N2 primary gas mixtures. The method performance was evaluated by assessing its linearity, accuracy, precision, bias, and uncertainty of the calibration results. The calibration data exhibited a strong linear trend with R² values close to 1, indicating an excellent fit between the measured values and the calibration lines. Precision, expressed as relative standard deviation (%RSD), ranged from 0.48 to 4.56% for CO and from 0.97 to 3.53% for CO2, staying well below the 5% threshold for reporting results at a 95% confidence level. Accuracy measured as percent recovery, was consistently high (≥ 99.1%) for CO and ranged from 84.90% to 101.54% across the calibration range for CO2. In addition, the method exhibited minimal bias for both CO and CO2 calibrations and thus provided a reliable and accurate approach for calibrating CO/CO2 monitors used in vehicle inspections. Thus, it ensures the effectiveness of exhaust emission control for better environment.

关键词： Monitors Periodic Inspection CO/CO2 Calibration Linearity Precision Accuracy

Potential Benefits and Obstacles of the Use of Internet of Things in Saudi Universities: Empirical Study

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Advances in Internet of Things 2024年第1期14卷 1-20页

作者： Najmah adel Fallatah Fahad Mahmoud Ghabban Omair Ameerbakhsh Ibrahim Alfadli Wael Ghazy Alheadary Salem Sulaiman Alatawi Ashwaq Hasen Al-Shehri College of Computer Science and Engineering Taibah University Madinah Saudi Arabia Ministry of Education in Al-Madinah Al-Munawwarah Region Madinah Saudi Arabia

Internet of Things (IoT) among of all the technology revolutions has been considered the next evolution of the internet. IoT has become a far more popular area in the computing world. IoT combined a huge number of things (devices) that can be connected through the internet. The purpose: this paper aims to explore the concept of the Internet of Things (IoT) generally and outline the main definitions of IoT. The paper also aims to examine and discuss the obstacles and potential benefits of IoT in Saudi universities. Methodology: the researchers reviewed the previous literature and focused on several databases to use the recent studies and research related to the IoT. Then, the researchers also used quantitative methodology to examine the factors affecting the obstacles and potential benefits of IoT. The data were collected by using a questionnaire distributed online among academic staff and a total of 150 participants completed the survey. Finding: the result of this study reveals there are twelve factors that affect the potential benefits of using IoT such as reducing human errors, increasing business income and worker’s productivity. It also shows the eighteen factors which affect obstacles the IoT use, for example sensors’ cost, data privacy, and data security. These factors have the most influence on using IoT in Saudi universities.

关键词： Internet of Things (IoT) M2M Factors Obstacles Potential Benefits Universities

Planning Target Volume Margin in Linac-Based Stereotactic Radiosurgery for Brain Metastases

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Journal of Cancer Therapy 2024年第7期15卷 265-272页

作者： Hany S. Attallah Radwa M. Hamed Khaled M. EL-Shahat Aliaa Mahmoud Mahmoud Abdallah Ibraheem Haggag Emad Moustafa adel Yassin Department of Radiation Oncology International Medical Center (IMC) Cairo Egypt Department of Radiation Oncology Armed Forces Medical Collogue (AFCM) Cairo Egypt Department of Medical Physics Al Azhar University Cairo Egypt Department of Medical Physics International Medical Center (IMC) Cairo Egypt Department of Medical Physics Department of Clinical Oncology Faculty of Medicine Zagazig University Zagazig Egypt

Background: The treatment of brain metastases with radiotherapy has shifted to the use of Stereotactic Radio-surgery (SRS). The technical issue of expanding the treatment volume around the Gross Tumor Volume (GTV) is a current debate. Radiotherapy centers use variable GTV-PTV margins, ranging from one to 2 mm. Material and Methods: We performed a dosimetric comparison in plans of twenty patients using three margins: PTV zero, PTV1, and PTV2. We also developed imaginary Peel volumes. These volumes are described as follows: Peel1 = PTV1 − GTV, Peel2 = PTV2 − GTV. Results: Our results showed that the mean PTV volume differed significantly across the different margins (p = 0.000). The V12 of the brain significantly varied as a function of PTV margin (p = 0.000). The target coverage and plan quality indices were not significantly different. The Peel volume dosimetric analysis showed that the mean dose was significantly higher in the nearby normal brain tissue: Peel1 (p = 0.022) and Peel 2 (p = 0.013). Conclusion: According to our dosimetric analysis, expanding the GTV into a PTV by 1 mm margin is more convenient than 2 mm.

关键词： SRS Brain Metastases PTV

Gastrointestinal tolerability of organic infant formula compared to traditional infant formula: A systematic review

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World Journal of Clinical Pediatrics 2024年第1期13卷 125-140页

作者： Mohammed Al-Beltagi Nermin Kamal Saeed adel Salah Bediwy Reem Elbeltagi Mohamed Basiony Hamza Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 12ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlgahrbiaEgypt

BACKGROUND Infants'nutrition significantly influences their growth,development,and overall *** the increasing demand for organic infant formula driven by the perception of health benefits and growing awareness of natural feeding options,it is crucial to conduct a comparative analysis of the gastrointestinal tolerability between organic and traditional infant *** To provide a concise and precise analysis of the gastrointestinal tolerability of organic infant formula compared to traditional infant *** to limited direct comparisons,the review synthesizes available literature on each formula type,presenting insights into their potential effects on infants'digestive *** An extensive literature search was conducted,compiling studies on organic and traditional infant formulas,their compositions,and reported effects on gastrointestinal *** searched academic databases such as PubMed and Google Scholar and specialized nutrition,paediatrics,and infant health journals using relevant keywords till October 1,*** Although specific comparative studies are scarce and formula heterogeneity is a significant limitation,this systematic review provides an in-depth understanding of organic infant formulas'composition and potential *** scientific evidence directly comparing gastrointestinal tolerability is limited,organic formulas strive to use carefully selected organic ingredients to imitate breast milk *** benefits include improved lipid profiles,higher methionine content,and decreased antibiotic-resistant bacteria *** the gastrointestinal tolerability of organic and traditional infant formulas is crucial for parents and healthcare providers to make informed *** Despite limitations in direct comparisons,this systematic review provides insights into the composition and potential benefits of organic infant *** emphasizes the need for further research to eluci

关键词： Organic infant formula Traditional infant formula Gastrointestinal tolerability Formula ingredients Digestive health Infant nutrition Organic farming

Validation of a Method for Characterization of Ethanol in Water by HS-GC-FID to Serve the Traceability of Halal Measurements

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Green and Sustainable Chemistry 2024年第2期14卷 17-28页

作者： adel B. Shehata Abdulrahman R. Al Askar Mohammed A. Al Rasheed Abdulrahman M. Al Zahrany Fahd A. Al Kharraa Sowailem A. Al Sowailem Chemistry Department/National Measurement and Calibration Center (NMCC) Saudi Standards Metrology and Quality Organization (SASO) Riyadh Kingdom of Saudi Arabia

The determination of the ethanol content in food products is of fundamental importance for HALAL certification. In this work, an analytical method for the determination of ethanol in water by headspace gas chromatography with flame ionization detector (HS-GC-FID) has been developed and validated for the use in characterization of ethanol reference materials. The validation study was carried out in the linear calibration range 100 - 1500 mg/kg using the NIST SRM 2900, nominal 95.6%. The studied performance characteristics of the method were the limit of detection, LOD, the limit of quantification LOQ, selectivity, linearity, precision, recovery and bias. The validation results showed that the method is selective, precise, accurate and free from any significant bias. The LOD and LOQ were 1.27 and 3.86 mg/kg respectively and the estimated expanded uncertainty was 2% indicating that the method is fit for the purpose of certification of ethanol in water reference materials.

关键词： Ethanol HS-GC-FID Validation Linearity Precision Bias

Energy-Efficient Static Data Collector-based Scheme in Smart Cities

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Computers, Materials & Continua 2022年第7期72卷 2077-2092页

作者： adel D.Rajab College of Computer Science and Information Systems Najran UniversityNajran61441Saudi Arabia

In the Internet of Things(IoT)-based smart city applications,employing the Data Collectors(DC)as the data brokers between the nodes and Base Station(BS)can be a promising solution to enhance the energy efficiency of energy-constrained IoT sensor *** are several schemes that utilize mobile DCs to collect the data packets from sensor ***,moving DCs along the hundreds of thousands of sensors sparsely distributed across a smart city is considered a design challenge in such *** concern lies in how these mobile DCs are being ***,to overcome these limitations,we exploit multiple energy-limited Static Data Collectors(SDC)which are deployed at the locations optimized so that the energy consumption of both nodes and SDCs is ***,anUnmannedAerial Vehicle(UAV)-enabled wireless power transfer is considered for sustaining the SDCs to avoid their energy depletion and data packet *** sustainable charging process operates periodically in each cycle so that the UAV flies from a charging station and after recharging the SDCs,it comes back to the station to be *** this study,we formulate a problem to optimize the movement trajectory and charging time of UAV so that sustainable operation of SDCs during a cycle can be *** the prior studies,our proposed scheme determines the optimal trajectory and charging time at the beginning of each cycle which leads to increase accuracy in comparison with long-term optimization-based *** outcomes of simulation experiments show that the proposed scheme achieves improved network performance in terms of data delivery ratio(12.5%);system throughput(6.6%);total energy consumption(59.19%);and network lifetime(58%)as compared to previous related works.

关键词： Smart city wireless sensor network power constraint energy efficiency

Integrated Random Early Detection for Congestion Control at the Router Buffer

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Computer Systems Science & Engineering 2022年第2期40卷 719-734页

作者： Ahmad adel Abu-Shareha The World Islamic Sciences and Education University(WISE) AmmanJordan

This paper proposed an Integrated Random Early Detection(IRED)method that aims to resolve the problems of the queue-based AQM and loadbased AQM and gain the benefits of both using indicators from both *** arrival factor(e.g.,arrival rate,queue and capacity)and the departure factors are used to estimate the congestion through two integrated *** utilized indicators are mathematically calculated and integrated to gain unified and coherent congestion ***,IRED is built based on a new dropping calculation approach that fits the utilized congestion indicators while maintaining the intended buffer management criteria,avoiding global synchronization and enhancing the *** results showed that IRED,compared to RED,BLUE,ERED,FLRED,EnRED and DcRED,decreased packet delay and loss under various network ***,the results showed that in heavy and moderate traffic,the proposed IRED method outperformed the state-of-the-art methods in loss and delay by 18% and 10.6%,respectively.

关键词： Congestion random early detection active queue management

Finite Generation of Lie Derived Powers of Skew Lie Algebras

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Algebra Colloquium 2022年第2期29卷 217-220页

作者： adel Alahmadi Fawziah Alharthi Department of Mathematics Research Group of Algebraic Structures and Applications Deanship of Scientific ResearchKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics College of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Mathematics College of ScienceQassim University Buraydah 51482Saudi Arabia

Let A be a finitely generated associative algebra over a field of characteristic different from *** asked when the Lie algebra[A,A]is finitely ***,it was shown that for a finitely generated nil algebra A all derived powers of A are finitely generated Lie *** K be the Lie algebra of skew-symmetric elements of an associative algebra with *** consider all derived powers of the Lie algebra K and prove that for any finitely generated associative nil algebra with an involution,all derived powers of K are finitely generated Lie algebras.

关键词： associative algebra Lie subalgebra finitely generated