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Influence of Antiretroviral Therapy on the Metabolic Profile of People Living with HIV Followed at University Hospital, Cotonou, Benin

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Open Journal of Internal Medicine 2015年第4期5卷 106-114页

作者： Djimon Marcel Zannou Angèle Azon-Kouanou Manoela Christelle Ahomadegbe Kuessi Anthelme Agbodande Jocelyn Akakpo Comlan Albert Dovonou Kuassi Daniel Amoussou-Guenou Yessoufou Tchabi Gabriel ade Fabien Houngbe Internal Medicine Department National University Hospital (CNHU-Hubert K. Maga) Cotonou Benin Ambulatory Care Center for People Living with HIV at CNHU-Hubert K. Maga Cotonou Benin Internal Medicine Department Prefectural University Hospital of Borgou Parakou Benin Endocrinology and Metabolic Diseases Department at CNHU-Hubert K. Maga Cotonou Benin Cardiology Department CNHU-Hubert K. Maga Cotonou Benin

Introduction: Since the advent of antiretroviral therapy, the vital prognosis of people living with HIV (PLWHA) has improved significantly. However, the risk of metabolic complications is high, thus making the bed of cardiovascular disease. Our objective was to compare the prevalence of metabolic abnormalities among PLWHA receiving ARVs to that observed in those who are not treated. Methods: We conducted a cross-sectional study (January to April 2010) at the PLWHA ambulatory care center of national university hospital (CNHU-Hubert K. Maga) in Cotonou, Bénin. We recruited 420 PLWHA (210 treated for at least 6 months and 210 untreated). We determined the prevalence of metabolic syndrome (MS) defined by the criteria of NCEP-ATP III, and the prevalence of abnormal glucose and lipid, and lipodystrophy. Association between metabolic syndrome and ARVs used was analyzed by binomial regression. Confidence intervals were calculated at 95% and 5% alpha level. Results: The prevalence of MS was 16% (18% of patients treated vs. 13% of non-treated, p = 0.18). That of hyperglycemia was 18% (30% of patients treated vs. 6% of untreated;p ade to the initiation of antiretroviral therapy and during the therapeutic monitoring.

关键词： Metabolic Syndrome Diabetes Dyslipidemia Antiretroviral Therapy HIV Infection

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高寒草甸地下根系生长动态对积雪变化的响应

生态学报 2017年第20期37卷 6773-6784页

作者：阿的鲁骥字洪标刘敏陈焱杨有芳王长庭西南民族大学青藏高原研究所成都610041 西南民族大学生命科学技术学院成都610041

2013年11月至2014年8月在青藏高原东缘红原县高寒草甸通过人工堆积的方法,进行了积雪量野外控制试验。以自然降雪的积雪量为对照(CK),设置了S1、S2和S3(积雪量分别为自然对照的2倍、3倍和4倍)3个处理,运用微根窗法追踪研究了积雪量改变... 详细信息

2013年11月至2014年8月在青藏高原东缘红原县高寒草甸通过人工堆积的方法,进行了积雪量野外控制试验。以自然降雪的积雪量为对照(CK),设置了S1、S2和S3(积雪量分别为自然对照的2倍、3倍和4倍)3个处理,运用微根窗法追踪研究了积雪量改变后高寒草甸植被根系生长动态,并测定了积雪变化对土壤温度的影响。结果表明:高寒草甸植被根系生长存在明显的季节性变化,随着时间的推移,根系表面积、根尖数量及现存量逐渐增加并在8—9月达到最大值;当冬季积雪量达到143.4mm(S1),对根系生长最为有利(根系表面积、根尖数量、现存量及生产量最大),根系生长旺盛期(净生产速率较高)有所提前和延长,但随着积雪量进一步增加,积雪对根系生长的正效应逐渐降低,根系生长旺盛期逐渐推迟甚至消失;研究还发现,随着积雪量增加,0—10 cm土层土壤温度逐渐降低,相似的变化规律也出现在10—20 cm土层,但在时间上有所延迟;相关性分析表明,在不同土层中,根系生长与土壤温度均呈正相关。因此,积雪变化通过改变土壤温度影响高寒草甸植物根系的生长发育,最终可能会影响高寒草甸生态系统的碳分配与碳循环过程。

关键词：高寒草甸积雪变化根系生长动态微根窗法

不同株高密花香薷光合色素含量和根际土壤酶活性的变化

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四川师范大学学报（自然科学版） 2016年第5期39卷 755-759页

作者：阿的鲁骥王长庭字洪标赵江西南民族大学青藏高原研究院四川成都610041 西南民族大学生命科学技术学院四川成都610041

密花香薷（Elsholtzia densa Benth.）是川西北高寒草甸的常见植物,为了探讨其对高寒生态环境的生理生态适应机制,分析四川省阿坝藏族羌族自治州红原县不同株高密花香薷叶面积、比叶质量、光合色素含量以及根际土壤酶活性的变化规律.结... 详细信息

密花香薷（Elsholtzia densa Benth.）是川西北高寒草甸的常见植物,为了探讨其对高寒生态环境的生理生态适应机制,分析四川省阿坝藏族羌族自治州红原县不同株高密花香薷叶面积、比叶质量、光合色素含量以及根际土壤酶活性的变化规律.结果表明：不同高度的密花香薷植株,其比叶质量和光合色素含量变化不显著（P〉0.05）,叶面积随着植株增高先增加后减小,当植株高度在40-45 cm之间的叶面积最大,此时叶绿素含量最高,且Chl a/b最大;不同株高密花香薷根际土壤的纤维素酶、蔗糖酶和酸性磷酸酶活性变化规律不明显,且与对照无明显差异.硝酸还原酶和脲酶活性大于对照,随着植株高度增加,根际硝酸还原酶和脲酶活性先增加后降低,脲酶活性与叶片Chl a的含量呈显著正相关,株高大于46 cm的植株根际脲酶活性显著大于对照（P〈0.05）.研究表明,密花香薷在生长过程中可能释放根系分泌物改变了土壤微生物活动,提高根际氮素水平以促进植物的光合作用效率.

关键词：高寒草甸密花香薷株高生理适应根际土壤酶活性

Contribution to the Study of Irritable Bowel Syndrome in Medical Students at the University of Parakou in Republic of Benin

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Open Journal of Gastroenterology 2023年第7期13卷 256-266页

作者： Khadidjatou Saké Aboudou Raimi Kpossou Adébayo Cossi Alassani Doriane Berline Magatsing Nzekou Serge ade Angelo Cossi Attinsounon Comlan Albert Dovonou Stéphane Kofi-Mensa Savi de Tovè Jean Sehonou Department of Medicine and Medical Specialties Faculty of Medicine University of Parakou Parakou Republic of Benin Department of Medicine and Medical Specialties Faculty of Medicine University of Abomey-Calavi Abomey-Calavi Republic of Benin

Introduction: Irritable bowel syndrome is the most common functional gastrointestinal disorder. The objective of this work is to contribute to improving the medical follow-up of medical students at the University of Parakou through a study of irritable bowel syndrome. Study Methods: This was a descriptive and analytical cross-sectional study with prospective data collection. Data were collected from medical students from May 2018 to July 2018 using a pre-established questionnaire. Sampling was probabilistic using a two-stage survey. The diagnostic tools were: Rome IV criteria, Bristol scale and HAD (hospital anxiety and depression) scale. Data analysis was performed using Epi Info 7.***.3.14 software. CDC. Results: Thirty-two (7.55%) of the 424 students included had irritable bowel syndrome. Out of the 32 students with IBS, 24 (75%) were female. Their average age was 21.38 ± 2.39 years. For 24 students (75%), the symptoms occurred at the same time as exam preparation or the intense course period. Of the 32 students with IBS, 1 (3.12%) was regularly physically active. In this series, 8 students (28%) consulted a doctor for their symptoms. The factors associated with this syndrome were female sex (p = 0.022), sleep disorders (p = 0.008) and the presence of a doubtful depression (p = 0.021). Absenteeism due to irritable bowel syndrome was noted in 18 (56.25%) students. Conclusion: Irritable bowel syndrome is a common condition among medical students in Parakou. Support for better management of psychological disorders could improve the quality of life of these students.

关键词： Irritable Bowel Syndrome Medical Students Parakou Republic of Benin

土荆芥化感胁迫下蚕豆叶绿体超微结构和光合关键基因表达的变化

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西南农业学报 2018年第12期31卷 2527-2532页

作者：阿的鲁骥周健李洁马丹炜四川师范大学生命科学学院四川成都610101 西南民族大学青藏高原研究所四川成都610064 四川省农业科学院农业信息与农村经济研究所四川成都610066

【目的】叶绿体结构的完整性和光合作用关键基因表达正常在光合作用中起着重要作用。为了深入探讨土荆芥化感作用机制。【方法】采用透射电镜技术和RT-PCR技术,对土荆芥挥发油及其主要成分α-萜品烯和对伞花素对蚕豆幼苗叶片叶绿体超微... 详细信息

【目的】叶绿体结构的完整性和光合作用关键基因表达正常在光合作用中起着重要作用。为了深入探讨土荆芥化感作用机制。【方法】采用透射电镜技术和RT-PCR技术,对土荆芥挥发油及其主要成分α-萜品烯和对伞花素对蚕豆幼苗叶片叶绿体超微结构和4个光合关键基因的影响进行了研究。【结果】土荆芥挥发油及其主要成分处理导致蚕豆叶片叶绿体超微结构受损,叶绿体脱离细胞壁散乱分布于细胞中央,结构紊乱,表现为肿胀、膜结构受损明显,叶绿体内部基质不均匀、基粒类囊体排列紊乱、淀粉粒消失、片层扭曲且排列松散;在光合作用过程的关键基因核酮糖羧化酶基因(Rbcs-3C)、光系统ⅡCP47蛋白基因(PsbB)、ATP合成酶β亚基基因(beta)、质体蓝素基因(PetE)的相对表达量发生了不同程度的变化。其中,挥发油处理组中4个基因均上调;对伞花素处理组Rbcs-3C和PsbB下调,beta和PetE上调;α-萜品烯处理组的PsbB下降,其他3个基因上调; 3个处理的化感综合效应由大到小依次为挥发油、α-萜品烯和对伞花素。【结论】破坏叶绿体超微结构、干扰光合关键基因表达是土荆芥化感胁迫的机制之一,土荆芥挥发油的不同成分对受体植物的化感作用具有协同性。

关键词：土荆芥挥发性化感物质叶绿体结构光合关键基因

Epidemiology of Anemia at the Internal Medicine Department in Borgou Departmental Hospital Center(DHC)in Parakou(Benin)

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Open Journal of Internal Medicine 2018年第2期8卷 123-130页

作者： Comlan Albert Dovonou Adébayo Alassani Cossi Angelo Attinsounon Serge ade Kadidjatou Sake Jivaterd Degla Séraphin Ahoui Moise adegbindin Prosper Gandaho Djimon Marcel Zannou Fabien Houngbe Isidore Zohoun Medicine Department and Medical Specialities Medical FacultyParakou UniversityParakouBenin Internal Medicine Department Borgou Departmental Teaching HospitalParakouBenin Medicine Department and Medical Specialities of Cotonou Health Science ParakouBenin

Objective: To describe clinical and biological characteristics of anemia in the Internal Medicine department of Borgou Departmental Hospital Center (DHC). Methods: This was a transversal and descriptive study for an analytic purpose. All patients hospitalized in the Internal Medicine department of Borgou DHC who had a hemogram for their care were included in the study. Anemia was defined as a hemoglobin level lower than 12 g/dL for men and lower than 11.5 g/dL for women. Results: Frequency of anemia was 61.8% (76 of 123 patients). Anemia was moderate in 47.4% of the cases and severe in 27.6% of the cases. Basing on the mean corpuscular volume, microcytic anemia accounted for 36.8%, anemia was normocytic in 46.1% and macrocytic in 17.1% of cases. According to the mean corpuscular hemoglobin concentration, normochromic anemia accounted for 81.6% of the series and hypochromic in 18.4%. The most common pathologies found in anemic patients came from digestive origin (17%), the renal causes were also found in 17% of the cases. Cardiac pathologies were responsible for anemia in 13% of cases. Malaria and pulmonary pathologies were responsible for anemia in respectively 12% and 9%. The main factors associated with anemia were young age (young adult) and neurological pathologies. Conclusion: Anemia hospital prevalence is very high in the Internal Medicine Department of Borgou DHC. Awareness of populations and practitioners for the early management of various pathologies which provide anemia could improve this presentation.

关键词： Anemia Internal Medicine Parakou

Land use impacts on parasitic infection: a cross-sectional epidemiological study on the role of irrigated agriculture in schistosome infection in a dammed landscape

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Infectious Diseases of Poverty 2021年第2期10卷 78-78页

作者： Andrea J.Lund David HRehkopf Susanne HSokolow MMoustapha Sam Nicolas Jouanard Anne-Marie Schacht Simon Senghor Assane Fall Gilles Riveau Giulio ade Leo David Lopez-Carr Emmett Interdisciplinary Program in Environment and Resources Stanford University473 Via Ortega Suite 226StanfordCAUSA 不详

Background:Water resources development promotes agricultural expansion and food *** are these benefits offset by increased infectious disease risk?Dam construction on the Senegal River in 1986 was followed by agricultural expansion and increased transmission of human *** the mechanisms linking these two processes at the individual and household levels remain *** investigated the association between household land use and schistosome infection in children.

关键词： Agriculture Exposure Livelihoods Planetary health Senegal Schistosomiasis Water contact

Primary Duodenal adenocarcinoma Revealed by Chronic Iron Deficiency Anemia:Diagnostic Difficulties in a Case Report in Internal Medicine CNHU HKM-COTONOU

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Open Journal of Internal Medicine 2015年第4期5卷 92-95页

作者： Angèle Azon-Kouanou Djimon Marcel Zannou Aboudou Raimi Kpossou Kouessi Anthelme Agbodande Roberto Dossou Torès Kouassi Prudencio Jean Sehonou Gaspard Gbessi Freddy Gnangnon Gabriel ade Fabien Houngbe Internal Medicine and Medical Oncology Department National Teaching Hospital(NTH)Hubert Koudougou Maga(HKM)CotonouBenin Hepato-Gastroenterology Department National Teaching Hospital(NTH)Hubert Koudougou Maga(HKM)CotonouBenin Visceral surgery Department National Teaching Hospital(NTH)Hubert Koudougou Maga(HKM)CotonouBenin

The location of a primary duodenal adenocarcinoma is exceptional. Only few cases have been reported in the literature. We hereby report a case of primary adenocarcinoma of the duodenum with a 60 years old patient admitted because of chronic iron deficiency anemia. Endoscopic examination revealed a budding and ulcerated process in the second duodenum. The biopsy analysis showed primary adenocarcinoma. No other primary tumor was found. The staging directed showed cephalic pancreatic invasion. The patient died in the aftermath of a surgical management.

关键词： Chronic Iron Deficit adenocarcinoma Duodenum Benin

塔里木河下游生态输水对地下水补给量影响的研究

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中国水能及电气化 2021年第11期 27-31,13页

作者：阿德·阿布拉新疆塔里木河流域干流管理局新疆库尔勒841000

文章依据塔里木河下游段现有的2000—2020年的地下水监测数据,对生态输水地下水前后水面线方程进行拟合,并在水均衡原理的基础上,对经过了21次生态输水之后的塔里木河下游段地下水埋深时空变化特征进行分析,以此对地下水的补给量进行估... 详细信息

文章依据塔里木河下游段现有的2000—2020年的地下水监测数据,对生态输水地下水前后水面线方程进行拟合,并在水均衡原理的基础上,对经过了21次生态输水之后的塔里木河下游段地下水埋深时空变化特征进行分析,以此对地下水的补给量进行估算,以更好支持后续的生态输水。

关键词：塔里木河地下水补给量生态输水时空变化