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Ethanolic extracts of babandotan leaves(Ageratum conyzoides L.)prevents inflammation and proteoglycan degradation by inhibiting TNF-αand MMP-9 on osteoarthritis rats induced by monosodium iodoacetate

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 256-262页

作者： Anton Bahtiar Mutiara Nurazizah Tirza Roselina Anita Paulina Tambunan ade arsianti Faculty of Pharmacy Universitas IndonesiaKampus UIDepok 16424Indonesia Faculty of Medicine Universitas IndonesiaKampus UI Salemba Raya no 6Indonesia

Objective:To analyze the effects of Ageratum conyzoides *** the monosodium iodoacetate induced osteoarthritis ***:Thin layer chromatography was performed to analyze the constituents of the babandotan extract *** male Sprague-Dawley rats used in this study were divided into 6 groups:normal control and negative control groups,both given0.5%carboxymethyl cellulose;the positive control group that was given glucosamine and chondroitin suspension(486 mg/200 g B.W.);the 3 dose variation extract groups including dose 1,2,and 3 that were given 40,80,and 160 mg/200 g *** on day 29 *** the groups were induced with 0.05 mL monosodium iodoacetate(20 mg/mL)on day1,except normal control induced by *** of edema volume of rat knees was performed on day 0,8,15,22,29,43,and *** data was measured at day 1,29and *** was collected at day 50 to evaluate TNF-α and MMP-9 by *** histopathology was evaluated by staining with H&E and Safranin-o-fast green staining on day ***:The babandotan leaves extract dose 2(80 mg/200 g B.W.)and dose 3(160mg/200 g B.W.)could decrease the edema volume,increase the area and thickness of articular cartilage,and increase proteoglycan ***,dose 3(160 mg/200 g B.W.)of extract babandotan leaves were able to significantly decrease the number of leukocytes,lymphocytes and udem volume,and decrease TNF alpha and MMP-9 ***:Babandotan leaves extract can recover inflammation and cartilages degradation by inhibiting TNF-αin inflammation processes and MMP-9 in the collagenase reaction in the cartilages.

关键词： Inflammation Osteo arthritis Ageratum conyzoides Hematology parameters TNF-α MMP-9

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Design and Molecular Docking Study of Antimycin A<sub>3</sub>Analogues as Inhibitors of Anti-Apoptotic Bcl-2 of Breast Cancer

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Open Journal of Medicinal Chemistry 2014年第3期4卷 79-86页

作者： ade arsianti Fadilah Kusmardi Hiroki Tanimoto Tsumoru Morimoto Kiyomi Kakiuchi Department of Medical Chemistry Faculty of Medicine University of Indonesia Jakarta Indonesia Department of Anatomical Pathology Faculty of Medicine University of Indonesia JakartaIndonesia Graduate School of Materials Science Nara Institute of Science and Technology (NAIST) Nara Japan

In this paper, we report the design and moleculardocking study of analogues of antimycin A3 as inhibitors of anti-apoptotic Bcl-2 of breast cancer. Twenty designed compounds and the original antimycin A3 were docked based on their interaction with breast tumor receptor binding target Bcl-2. The docking resulted in the five top-ranked compounds, namely, compounds 11, 14, 15, 16, and 20, which have a lower G binding energy, better affinity and stronger hydrogen bonding interactions to the active site of Bcl-2 than antimycin A3. Among those five top-ranked compounds, analogue compounds 11 and 14, which have an 18-membered tetralactone core and 18-membered tetraol core, respectively, exhibited the strongest hydrogen bond interaction, formed high stability conformation, and demonstrated the greatest inhibitory activity on the catalytic site of Bcl-2.

关键词： Design Docking Antimycin A3 Analogue Bcl-2 Breast Cancer

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