检索结果-南通市图书馆

Evaluation of the Strategy and Efficacy of Treatment of Chronic Viral Hepatitis C with the Sofosbuvir/Daclatasvir Combination in a Resource-Limited Country

引用

Open Journal of Gastroenterology 2024年第7期14卷 233-240页

作者： Mayanna Habkreo Ali Mahamat Moussa adama ahmed ngare Abdraman Kossou Tahir Mahamat Saleh Maire Dehainsala Mahamat Ali Hachim Mahamat Ali Bolti Oumaima Djarma Joseph Madtoingue Service de Gastroentrologie/Mdecine Interne du Centre Hospitalier Universitaire la Rfrence Nationale NDjamena Chad Service de Gastroentrologie du Centre Hospitalier Universitaire la Renaissance NDjamena Chad Service de Maladies Infectieuses du Centre Hospitalier Universitaire la Renaissance NDjamena Chad Service de Maladies Infectieuses du Centre Hospitalier Universitaire la Rfrence Nationale NDjamena Chad

Introduction: The treatment of viral hepatitis C (HCV), a major public health problem, has evolved considerably since the introduction of direct-acting anti-virals (DAAs). The aim of this study was to evaluate the strategy for initiating treatment with Sofosbuvir/Daclatasvir, and also to assess its efficacy. Patients and Methods: Included were patients aged at least 15 years, with detectable hepatitis C viremia and treated with a pan-genotypic Sofosbuvir/Daclatasvir regimen at the Centre “Hospitalier Universitaire la Référence Nationale de N’Djamena” between October 2019 and October 2023. The APRI score was used to assess fibrosis. Cure was defined by an undetectable viral load 12 weeks after the end of treatment. Results: A total of 835 patients were included (sex ratio 1.55, mean age 50.5 ± 13.73, extremes 20 and 84 years). The 60 - 69 age group was the most represented. The mean APRI score was 0.42 ± 0.29, with extremes of 0.019 and 1.84. The mean viral load was 2,316,193.086 IU/mL. All subjects had good renal function. Cytolysis was absent in 70% of cases. Without genotyping, a pan-genotypic regimen was used in all patients: Sofosbuvir (400 mg)/Daclatasvir (60 mg). The cure rate was 99.4%, with good tolerability. However, four cases of failure were recorded out of the 668 patients who underwent follow-up HCV-PCR testing after 12 weeks of treatment. Conclusion: The Sofosbuvir/Daclatasvir regimen is highly effective, with an excellent safety profile. However, the still high cost of these molecules limits their accessibility to a large proportion of patients.

关键词： Efficacy Tolerance Sofosbuvir/Daclatasvir HCV Chad

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and Predictors of Viral Hepatitis D Co-Infection in Chronic HbsAg Carriers

引用

Open Journal of Gastroenterology 2022年第9期12卷 213-220页

作者： Ali Mahamat Moussa Tahir Mahamat Saleh Mayanna Habkreo Bessimbaye Nadlaou adama ahmed ngare Doffou Adjeka Stanislas Assi Constant Service de Medecine Interne & Gastroentérologie CHU La Référence Nationale N’Djamena Tchad Service de Medecine Interne CHU La Renaissance N’Djamena Tchad Service de Laboratoire CHU La Référence Nationale N’Djamena Tchad

The characteristics of viral hepatitis B and D co-infection are poorly documented in Chad. The aim of our study was to determine the prevalence of HBV/HDV co-infection and the characteristics of this co-infection. Materials and Methods: This was a retrospective study including all patients with chronic HBsAg carriers referred in our department from January 2014 to December 2018. Non-inclusion criteria were: absence of anti-HDV testing, presence of anti-viral hepatitis C or Human Immunodeficiency Virus antibodies or excessive alcohol consumption. The variables studied were age, sex, blood transaminase level, HBV DNA level, HDV RNA level, and liver fibrosis and activity score (Actitest Fibrotest). The prevalence of HDV and the characteristics of HDV/HBV co-infection were determined. Results: During the study period, 403 patients were seen in these two hospitals for chronic HBsAg carriage. Of these, 378 (75%) had performed the anti HDV assay. Anti-HDV antibodies were positive in 53 patients (14%). In multivariate analysis, HBV/HDV co-infected patients were less frequently HBeAg positive (5.4% vs. 28.1%;p = 0.0001), older (35 years vs. 32 years;p = 0.001), and more frequently had significant necrotic-inflammatory activity (3.9% vs. 3.2%;p = 0.031) compared with mono infected patients. Neither gender (76.9% male vs. 77.4% male;p = ns), nor viral load (median 530 IU/ml vs. 195 IU/ml;p = ns), nor significant liver fibrosis (35.1% vs. 47.1%;p = ns), nor transaminases (median 26 vs. 32 IU/ml) were different with mono infected patients. Conclusion: VHD is common in Chad. It is associated with increased hepatic necrotic-inflammatory activity.

关键词： Viral Hepatitis D (Anti VHD Ac) Prevalence Favouring Factors Necrotic-Inflammatory Activity Chad

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Analysis of the Characteristics of Materials Obtained by Recycling Scrap Metal in Guinea

引用

材料科学与工程（中英文A版） 2024年第1期14卷 1-10页

作者： Alpha Issa Diallo Jean ahmed Kourouma adama Moussa Sakho Alexandre Lucien Richard Mechanical Laboratory Higher Institute of Technology of MamouMamou 063Republic of Guinea Materials Laboratory of Gamal Abdel Nasser University ConakryMamou1147Republic of Guinea Department of Laboratory Technology Higher Institute of Technology of MamouMamou 063Republic of Guinea

The aim of this study was to determine the quality of rebar produced from recycled scrap metal collected throughout the country,and imported rebar sold in the Republic of *** do this,the samples were subjected to various mechanical tests involving traction,bending and microscopic *** the Lambanyi and Casse Sonfonia samples,all the tensile strength values for diameters 12,14 and 16 were above 550 ***,the iron samples from Baillobaye and the 10 mm diameters of the samples from Casse Sonfonio and Lambanyi have less appreciable *** limits of elasticity were *** various values found vary more or less from the conventional yield strength of the NF A35-016 reference supplied by CBITEC,which is 500 *** analysis gives us an insight into the internal structure of the iron samples *** study may provide the company and the vendors with an alternative for their improvements.

关键词： Steel in construction recycled scrap strength test traction bending.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Postpartum Eclampsia in the Department of Obstetrics Gynecology and Reproductive Medicine of the Souro Sanou University Hospital;Burkina Faso: About 76 Cases

引用

Open Journal of Obstetrics and Gynecology 2024年第8期14卷 1176-1184页

作者： Yaméogo Rélwendé Barnabé Sawadogo Amidou Kaboré ahmed Komboigo Béwendin Evelyne Dembélé adama Somé Der Adolphe Souro Sanou University Hospital Bobo Dioulasso Burkina Faso Public Health Department of Joseph Ki-Zerbo University Ouagadougou Burkina Faso

Background: Postpartum eclampsia is a life-threatening obstetric emergency. Its management is multidisciplinary. Despite measures taken to accelerate the reduction of maternal, fetal and infant mortality in Burkina Faso, maternal deaths related to postpartum eclampsia persist. The aim of the study was to investigate the epidemiological, clinical and prognostic aspects of postpartum eclampsia in the obstetrics department of the Sourô Sanou University Hospital in Bobo-Dioulasso. Method: This was a descriptive cross-sectional study with retrospective data collection covering the period from June 1, 2018 to May 31, 2019. We included 76 patients in the study;the variables studied were the epidemiological, clinical and prognostic aspects. The data collected were entered on a microcomputer and analyzed with the EPI info version 7.2 software. Results: The prevalence of postpartum eclampsia was 0.87% compared to admissions to the obstetrics department. The average age of the patients was 23 years old with the extremes of 15 and 39 years old. Primiparas accounted for 39.47%, housewives 53%, and home births accounted for 15.79%. Seizures accounted for 55% of the reasons for admission, the average time to onset of these seizures postpartum was 3.8 days with extremes of 1 and 30 days with 45% of seizures occurring postpartum immediately. Maternal complications were noted in 42.10% of cases with 5 cases of Hellp syndrome, 3 cases of renal failure, and 3 cases of acute pulmonary edema. We recorded 4 cases of maternal death, representing a case fatality rate of 5.2%. Conclusion: Postpartum eclampsia is common in the obstetrics department of the Souro Sanou University Hospital Center with a significant case fatality rate. Emphasis should be placed on monitoring and prevention, especially women at risk of developing postpartum eclampsia for better maternal prognosis.

关键词： Eclampsia Postpartum Epidemiology Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prevalence and Predictors of Viral Hepatitis D Co-Infection in Chronic HbsAg Carriers

引用

Open Journal of Gastroenterology（肠胃病学期刊） 2022年第9期

作者： ali mahamat moussa tahir mahamat saleh mayanna habkreo bessimbaye nadlaou adama ahmed ngare doffou adjeka stanislas assi constant

来源：博看期刊评论

在线全文

博看期刊

学校读者我要写书评

暂无评论

Why Do Pregnant Women Choose a Planned Caesarean Section in Burkina Faso? A Qualitative Study

引用

Open Journal of Obstetrics and Gynecology 2022年第5期12卷 408-416页

作者： Nestor Bationo Noufou G. Nana adama Ouattara Patrice A. Ngangue Dieudonné Soubeiga ahmed Kabore Maxime Drabo Institut de Formation et de Recherche Interdisciplinaires en Sciences de la Santé et de l’Education Ouagadougou Burkina-Faso Université Joseph Ki-ZERBO Ouagadougou Burkina-Faso Centre National pour la Recherche Scientifique et Technologique Ouagadougou Burkina-Faso

Despite the complications related to the caesarean section, some couples choose it by desirability. This study aimed to understand the reasons for maternal requests for a planned caesarean section in Burkina Faso, in the absence of obstetric indications. A qualitative descriptive study was conducted in March 2019, consisting of twelve semi-structured interviews with women requesting caesarean section at Tingandogo Teaching Hospital in Burkina Faso. The operative reports were also examined. Thematic analysis based on Braun and Clarke approach was performed with QDA Miner software. Twelve patients were involved in the study. The mean age was 33 years. The majority had a higher level of education. Half were employees. The mean stay duration was 72 hours, with an estimated cost of CFA 300.000 (457,347 EUR). The choice of a planned caesarean was motivated by fear of birth (tokophobia), the positive feeling associated to the surgical technology, the doctor-patient relationship and the confidence in the quality of healthcare services such as reception and hygiene. Maternal reasons for requesting a planned caesarean section in Burkina Faso are multifactorial. Information, education and communication and shared decision-making strategies concerning the different modes of delivery and complications at the end of pregnancy, may contribute to reducing this problem.

关键词： Caesarean Section Maternal Request Qualitative Study Tokophobia Burkina-Faso

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Changes in Vegetation and Rainfall over West Africa during the Last Three Decades (1981-2010)

引用

Atmospheric and Climate Sciences 2015年第4期5卷 367-379页

作者： adama Bamba Bastien Dieppois Abdourahamane Konaré Thierry Pellarin ahmed Balogun Nadine Dessay Bamory Kamagaté Issiaka Savané Arona Diédhiou WASCAL/Department of Meteorology and Climate Science Federal University of Technology Akure Nigeria Centre for Agroecology Water and Resilience (CAWR) Coventry University Coventry UK Université Félix Houphouët Boigny de Cocody Abidjan C&#244te d’Ivoire IRD/LTHE Université Joseph Fourier Grenoble France Maison de la Télédétection Montpellier France Université Nangui Abrogoua Abidjan C&#244te d’Ivoire

The decadal variability of rainfall and vegetation over West Africa have been studied over the last three decades, 1981-1990, 1991-2000 and 2001-2010 denoted as 1980s, 1990s and 2000s, respectively. Climate Research Unit (CRU) monthly precipitation and Normalized Difference Vegetation Index (NDVI) from the National Oceanic and Atmosphere Administration (NOAA), all covering the period 1981-2010 have been used. This study aimed to assess the changes in the land surface condition and the spatio-temporal distribution of rainfall over West Africa region. The relationship between rainfall and vegetation indices over this region was determined using Pearson’s correlation. Also, the decadal comparison between rainfall and NDVI over the region was based on the significant t-test and the Pearson’s correlation. Results showed that significant return to wet conditions is observed between decade 1980s and decade 1990s over West Africa, and also during decade 2000s with the exception of central Benin and the western Nigeria. Meanwhile, a regreening of the central Sahel and Sudano-Sahel regions is noted. From 1990s to 2000s, this regreening belt is located in the South and the coastal areas: the Guinea Coast, Sudano-Guinea and western Sahel regions. A northward displacement of this re-greening belt is also detected. Thus, a linear relationship occurs between rainfall and NDVI in the Sudanian savannah region, but it is not the case in the rest of West Africa. This may suggest that the re-growth of vegetation in the Sudanian savannah region may be linked to rainfall supplies. Therefore, re-greening over Sahel region in 1990s is related to rainfall recovery. However, this re-greening was not sustained in the decade 2000s due to a slight decrease in rainfall.

关键词： Decadal Variability NDVI Re-Greening Rainfall Recovery Significant t-Test

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drivers of the Chemical Quality of Market Gardening Soils in the Urban and Peri-Urban Environment of Bobo-Dioulasso (Burkina Faso): Impact of Fertilizers Sources and Sites Location

引用

Journal of Agricultural Chemistry and Environment 2023年第1期12卷 1-15页

作者： Fabèkourè Cédric Kambire Sheick ahmed Khalil S. B. Sangare R. Adèle Ouedraogo adama Zanga Ouattara Institute for Research in Applied Sciences and Technologies (IRSAT)/National Centre for Scientific and Technological Research (CNRST) Bobo-Dioulasso Burkina Faso Nazi Boni University/Laboratory of Study and Research on Soil Fertility (LERF) Bobo-Dioulasso Burkina Faso

Urban and peri-urban agriculture plays a key role by providing many goods and services. In particular, it provides diversified food and employment for vulnerable groups (youth and women). However, it often involves negative externalities due to non-conventional soils fertility management practices. This study aimed to investigate the chemical quality of soils over six (06) sites of the market gardening area of Bobo-Dioulasso (Burkina Faso) as affected by fertilizers uses and sites location. Thirty (30) representative market gardening farms, located in urban, semi-urban and rural areas, were randomly selected from a baseline survey database. Within each farm, composite soil samples made up of 3 individual cores were taken over the 0 - 15 cm soil depth for determining soils carbon, total nitrogen, available phosphorus contents and pH-water. These data were normalized and summarized to compute a synthetic Soil Fertility Index (SFI). The data processing was focused on a Principal Component Analysis and an Ascendant Hierarchical Classification in order to make a typology of the vegetable farms. Fertilizers management effects on soils quality were compared through Variance Analysis (ANOVA) following a GLM procedure in Rstudio software. As main results, soils chemical parameters, except for available K, were affected by the location of the sites. Soils in urban farms are less acidic (on average pH = 6.9), while semi-urban and rural sites (Samadeni, Nakaguana) have more acidic soils. However, the latter site had the highest values of C and N. Moreover, the long-term application of organic matter sources results in improving of the chemical quality of the market garden soil. The SFI is positively correlated with the rate of applied organic fertilizers, and the cultivation duration. On the other hand, soil quality tends to decrease with the expansion of the area, due to a dilution effect of the organic fertilizer doses. All these results suggest that there is a real scope to

关键词： Gardening Soil Fertility Index Chemical Fertility Bobo-Dioulasso

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genesis and magma fertility of gold associated high-K granites:LA-ICP-MS zircon trace element and REEs constraint from Bakoshi–Gadanya granites in NW Nigeria

引用

Acta Geochimica 2022年第3期41卷 351-366页

作者： Safiyanu Muhammad Elatikpo Huan Li Yuanlin Chen Hafizullah Abba ahmed Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China Department of Geology Ahmadu Bello UniversityZariaNigeria Department of Geology Modibbo Adama University of TechnologyP.M.B.2076YolaNigeria

High-K granites dominate the rock units in the Bakoshi and Gadanya areas located in the northwestern Nigerian subshield,part of the Trans-Saharan Belt,West *** this contribution,the LA-ICP-MS zircon trace element revealed the fertility of magma responsible for the high-K granites that hosts the Bakoshi–Gadanya gold *** likely metallogenic granites types are 1)Gadanya alkali granite,with high Ce^(4+)/Ce^(3+)(mean 1485)and limited range of Eu anomalies may likely be associated with the gold mineralization,and 2)Bakoshi porphyritic granite,Jaulere biotite granite,Shanono coarsegrained granite,and Yettiti granite,all have low Ce^(4+)/Ce^(3+) ratios(mean\100,except second Bakoshi granite D2-1)with wider ranges of Eu/Eu^(*) values,thus are considered reduced *** reduced granites have oxygen fugacity values and Eu anomalies comparable to reduced granites associated with tin belts in Myanmar and Zaaiplaats granites in Bushveld Complex,South ***-inZircon thermometric study revealed two thermal regimes during the crystallization of the Bakoshi–Gadanya granites:the high temperature(746–724℃):Shanono coarsegrained granite,Bakoshi granite D2-1,and Jaulere biotite granite;and relatively low temperature(705–653℃):Bakoshi porphyritic granite D1-1,Yettiti medium-grained granite,and Gadanya alkali *** trace elements including U,Yb,Y,Nb,and Sc ratios constraint the magma source of Bakoshi–Gadanya granites to an enriched mantle metasomatized during the subduction process before its *** for Gadanya alkali granite,fractionation of titanite and apatite dominate the magma evolution with limited amphibole *** that crystallized Gadanya alkali granite is rather saturated in zircon without accessory titanite or apatite.

关键词： Bakoshi–Gadanya area Zircon trace element Europium anomalies Gold mineralization Oxygen fugacity Cerium ratio

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Risk Factors of Liver Cirrhosis in Chad: Large Proportion of Cases without Clear Etiology

引用

Open Journal of Gastroenterology 2023年第11期13卷 339-350页

作者： Ali Mahamat Moussa Pascal Pineau Mayanna Habkreo Moussa Hassan Elefi Tahir Mahamat Saleh Maire Dehainsala Mahamat Ali Hachim adama ahmed N’Gare Adoum Abderrazak Fouda Bessimbaye Nadlaou Adawaye Chatté Service de Médecine Interne et Gastroentérologie Centre Hospitalier Universitaire La Référence Nationale Ndjamena Tchad Unité “Organisation Nucléaire et Oncogenèse” Institut National de la Santé et de la Recherche Médicale U993 Paris France Service de Medecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad Programme de Lutte contre le VIH et SIDA Hépatites et Infectins Sexuellement Transmissibles Ministère de la Santé Publique N’Djamena Tchad Service de Laboratoire Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad

Background: In comparison to other forms of chronic liver diseases, cirrhosis is generally poorly studied in sub Saharan Africa. In Chad, more particularly, no data are available despite the burden of liver diseases considered as the first cause of hospitalizations in the country. Methods: We conducted a retrospective analysis of 268 patients with liver cirrhosis attending care at the University Reference Hospital between 2007 and 2016. Results: This series of liver cirrhoses was characterized by a weak mal predominance (M:F = 1.7). The age of onset occurs significantly earlier in women than in men (40.6 ± 12.0 vs. 44.4 ± 13.4, p = 0.0171). The principal risk factor was persistent infection with hepatitis B virus (49% of cases) followed distantly by infection with hepatitis C virus (13%) and excessive alcohol consumption (10%). Men were more frequently carrying HBV surface antigen than women (65.6% vs 35.9% p = 0.0019). HBV-associated liver cirrhosis was overall more severe than diseases from other causes. A large proportion of cirrhosis (30%), observed primarily in women (48.1% vs 24.1%, p = 0.0036), was considered are cryptogenic. Conclusions: The etiological spectrum of liver cirrhosis remains to be properly defined in Chad. This lack of knowledge prevents the implementation of an efficient policy of prevention. A significant effort should be secured to characterize hitherto neglected infectious, lifestyle or genetic risk factors responsible of this form of terminal disease and improve subsequently liver health of local populations.

关键词： Chad Liver Cirrhosis Hepatitis Viruses Alcohol Cryptogenic

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：