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Burden and factors associated with schistosomiasis and soil-transmitted helminth infections among school-age children in Huambo,Uige and Zaire provinces,Angola

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Infectious Diseases of Poverty 2022年第3期11卷 99-100页

作者： adam w.bartlett Jose C.Sousa-Figueiredo Roelofje Cvan Goor Paul Monaghan warren Lancaster Rukaaka Mugizi Elsa P.Mendes Susana Vaz Nery Sergio Lopes 不详 The Mentor Initiative 4Th Floor(South Suite)Burns HouseHarlands RoadHaywards HeathR161PGUK

Background:Schistosomiasis and soil-transmitted helminths(STHs)contribute high disease burdens amongst the neglected tropical diseases(NTDs)and are public health problems in *** study reports the prevalence,intensity and risk factors for schistosomiasis and STH infection in Huambo,Uige and Zaire provinces,Angola,to inform a school-based preventive chemotherapy ***:A two-stage cluster design was used to select schools and schoolchildren to participate in parasitological and water,sanitation and hygiene(wASH)surveys across Huambo,Uige,and Zaire ***-of-care circulating cathodic antigen and urinalysis rapid diagnostic tests(RDTs)were used to determine the prevalence of Schistosoma mansoni and ***,***-Katz was used to identify and quantify STH species and quantify and compare with RDTs for *** filtration was used to quantify and compare with RDTs for *** statistics were used for prevalence and infection intensity of schistosomiasis and STH *** of RDTs was assessed through specificity and Cohen’s Kappa agreement with microscopy.A multivariate regression analysis was used to determine demographic and wASH factors associated with schistosomiasis and STH ***:A total 575 schools and 17,093 schoolchildren participated in the schistosomiasis survey,of which 121 schools and 3649 schoolchildren participated in the STH *** prevalence of *** was 21.2%(municipality range 0.9–74.8%)and *** 13.6%(range 0–31.2%),with an overall prevalence of schistosomiasis of 31.4%(range 5.9–77.3%).Overall prevalence of Ascaris lumbricoides was 25.1%(range 0–89.7%),hookworm 5.2%(range 0–42.6%),and Trichuris trichiura 3.6%(range 0–24.2%),with an overall prevalence of STH infection of 29.5%(range 0.8–89.7%).Ecological zone and ethnicity were factors associated with schistosomiasis and STH infection,with older age and female sex additional risk factors for S

关键词： Schistosomiasis Soil-transmitted helminths Circulating cathodic antigen Rapid diagnostic test water,sanitation and hygiene

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‘New’unintentionally produced PCBs in the Arctic

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Emerging Contaminants 2019年第1期5卷 9-14页

作者： Paul w.bartlett Elisabeth Isaksson Mark H.Hermanson Fordham University 113 West 60th Street-Rm 813mNew YorkNY10023USA John Jay College of Criminal Justice City University of New York524 West 59th St.Rm.NB 9.63.25New YorkNY10019USA Norwegian Polar Institute Fram Centre Postboks 6066NO-9296TromsøNorway Hermanson&Associates LLC 2000W.53rd St.MinneapolisMN55419USA

Contamination of the Arctic by legacy polychlorinated biphenyls(PCB)is well documented,but the more recent discovery of unintentionally produced(UP)PCBs in the Arctic is a cause for *** PCBs are covered by existing international conventions and regular monitoring,and the UP congeners are covered by the Stockholm Convention and the *** Substances Control Act,but systematic monitoring and regulatory enforcement of UP-PCBs are *** of UP-PCB are by-products of manufacturing(***)and from thermal sources(***).Estimates of PCB emissions in China now show UP-PCB eclipsing emissions of legacy *** we discuss the 209 PCB-congener results from surface snow samples from Lomonosovfonna in 2010 and 2014,a glacial site on Svalbard which,in 2014,shows presence of PCB5,PCB11,and an unusually high amount of *** PCB5 and PCB11 may not be found in legacy PCB mixtures,PCB52 is in many PCB mixtures,yet dominates none of them as in the 2014 snow *** it possible that these congeners are from UP-PCB processes?A search of the literature shows that PCB5,PCB11 and PCB52 are co-synthesis products of pigment production and that PCB5 and PCB11 are found in flue gas and ash from hazardous waste *** these,PCB11 has received greater attention in the *** has recently been consistently detected in the air,snow,soil and biota in the Arctic,evidence that PCB11 and possibly other UP-PCB congeners are global *** core measurements dating from 1957 to 2009 of PCBs in Svalbard reveal PCB11 presence throughout that period,indicating historic presence in the Arctic before being a focus of research *** UP-PCB need to be more fully investigated,especially from thermal sources.

关键词： PCB Polychlorinated biphenyls Arctic PCB5 PCB11 PCB52 Emerging chemicals Assessment

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Hepatocellular carcinoma:Defining the place of surgery in an era of organ shortage

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world Journal of Gastroenterology 2008年第28期14卷 4445-4453页

作者： adam bartlett Nigel Heaton Institute of Liver Studies Kings College School of Medicine at Kings College HospitalDenmark HillCamberwellLondonSE5 9RSUnited Kingdom

Liver resection (LR) and transplantation offer the only potential chance of cure for patients with hepatocellular carcinoma (HCC). Historically, all patients were treated by hepatic resection. with the advent of liver transplantation (LT) patients with HCC were preferentially placed on the waiting list for LT. However, early experience with LT was associated with a high rate of tumour recurrence and poor long-term survival. The increasing scarcity of donor livers resulted in restrictions being placed on tumour size, and an improvement in patient survival. To date there have been no randomised clinical trials comparing LR to LT. we review the evidence supporting LR and/or LT for HCC and discuss the role of neoadjuvant therapy. The decision of whether to resect or transplant remains debatable and is often determined by centre experience, availability of LT and donor organs.

关键词： Hepatocellular carcinoma Liver transplantation Liver resection Adjuvant therapy Salvage liver transplantation Radiofrequency ablation Transarterial chemoembolization

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A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

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Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

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Fuel and vegetation changes in southwestern, unburned portions of Great Smoky Mountains National Park, USA, 2003-2019

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Journal of Forestry Research 2022年第5期33卷 1459-1470页

作者： T.adam Coates w.Mark Ford Department of Forest Resources and Environmental Conservation Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA U.S.Geological Survey Virginia Cooperative Fish and Wildlife Research UnitDepartment of Fisheries and Wildlife ConservationVirginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA

Overstory basal area,ericaceous shrub cover(Kalmia latifolia *** Rhododendron maximum L.),and fuels(i.e.,woody fuel loads and depths and O Horizon thickness) were assessed within Great Smoky Mountains National Park,USA,in *** to recent wildfire activity within the southern Appalachian Mountain region(including Great Smoky Mountains National Park),the potential spread and expansion of ericaceous shrubs,and the impacts of the hemlock woolly adelgid(Adelges tsugae Annand) on eastern hemlock(Tsuga canadensis(L.) Carrière),these same ecosystem components were again assessed in *** and moisture regime(xeric,intermediate,and mesic) were included in this assessment as potential influential *** evaluation of repeated measurements from 40 plots suggested that O Horizon thickness did not change significantly over the 16-year period,but increased as elevation increased,and moisture regime(xeric O Horizon thickness> mesic O Horizon thickness) was a significant,related *** sum of 1-,10-,and 100-h fuel loads(fuels less whereas woody fuel depth decreased over the16-year *** significant changes in 1000-h fuel lo ads(>7.6 cm diameter),total woody fuel loads,ericaceous shrub cover,total basal area,or live *** basal area were *** *** basal area decreased with increasing ***,standing *** basal area increased from 2003-2019,and that increase was most pronounced as elevation increased on xeric and intermediate ***,we found that:*** increases in total woody fuel loads and ericaceous shrub cover were not present;and *** and moisture regime were most related to observed changes in vegetation and fuel condition.

关键词： Eastern hemlock Hemlock woolly adelgid Mountain laurel Rhododendron

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof

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Dynamic modeling of a three-dimensional braided composite thin plate considering braiding directions

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 123-138页

作者： Chentong GAO Huiyu SUN Jianping GU w.M.HUANG College of Aerospace Engineering Nanjing University of Aeronautics and Astronautics School of Mechanical and Aerospace Engineering Nanyang Technological University Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology School of Materials Science and EngineeringNanjing Institute of Technology

Currently, there are a limited number of dynamic models available for braided composite plates with large overall motions, despite the incorporation of three-dimensional(3D) braided composites into rotating blade components. In this paper, a dynamic model of 3D 4-directional braided composite thin plates considering braiding directions is established. Based on Kirchhoff's plate assumptions, the displacement variables of the plate are expressed. By incorporating the braiding directions into the constitutive equation of the braided composites, the dynamic model of the plate considering braiding directions is obtained. The effects of the speeds, braiding directions, and braided angles on the responses of the plate with fixed-axis rotation and translational motion, respectively, are investigated. This paper presents a dynamic theory for calculating the deformation of 3D braided composite structures undergoing both translational and rotational motions. It also provides a simulation method for investigating the dynamic behavior of non-isotropic material plates in various applications.

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Steatotic livers are susceptible to normothermic ischemiareperfusion injury from mitochondrial Complex-Ⅰ?dysfunction

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world Journal of Gastroenterology 2016年第19期22卷 4673-4684页

作者： Michael JJ Chu Rakesh Premkumar Anthony JR Hickey Yannan Jiang Brett Delahunt Anthony RJ Phillips adam SJR bartlett Department of Surgery University of Auckland School of Biological Sciences University of Auckland Maurice wilkins Centre for Biodiscovery University of Auckland Department of Statistics University of Auckland Department of Pathology and Molecular Medicine Wellington School of Medicine University of Otago New Zealand Liver Transplant Unit Auckland City Hospital

AIM: To assess the effects of ischemic preconditioning(IPC, 10-min ischemia/10-min reperfusion) on steatotic liver mitochondrial function after normothermic ischemia-reperfusion injury(IRI).METHODS: Sixty male Sprague-Dawley rats were fed8-wk with either control chow or high-fat/high-sucrose diet inducing > 60% mixed steatosis. Three groups(n = 10/group) for each dietary state were tested:(1) the IRI group underwent 60 min partial hepatic ischemia and 4 h reperfusion;(2) the IPC group underwent IPC prior to same standard IRI; and(3) sham underwent t h e s a m e s u r g e r y w i t h o u t I R I o r I P C. H e p a t i c mitochondrial function was analyzed by oxygraphs. Mitochondrial Complex-Ⅰ, Complex-Ⅱ enzyme activity, serum alanine aminotransferase(ALT), and histological injury were ***: Steatotic-IRI livers had a greater increase in ALT(2476 ± 166 vs 1457 ± 103 IU/L, P wing IRI compared to the lean liver group. Steatotic-IRI demonstrated lower Complex-Ⅰ?activity at baseline [78.4 ± 2.5 vs 116.4 ± 6.0 nmol/(*** protein), P wing IRI [28.0 ± 6.2 vs 104.3 ± 12.6 nmol/(*** protein), P was unaffected by hepatic steatosis or IRI. Lean liver mitochondrial function was unchanged following IRI. IPC normalized ALT and histological injury in steatotic livers but had no effect on overall steatotic liver mitochondrial function or individual mitochondrial complex enzyme activities. CONCLUSION: warm IRI impairs steatotic liver Complex-Ⅰ?activity and function. The protective effects of IPC in steatotic livers may not be mediated through mitochondria.

关键词： Mitochondrial respiration Fatty liver Liver ischemia Oxidative phosphorylation Liver injury Hepatic steatosis Ischemic preconditioning

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Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

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