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A reduced-Form rapid Economic Consequence Estimating Model:Application to Property Damage from U.S. Earthquakes

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International Journal of Disaster risk Science 2013年第1期4卷 20-32页

作者： Nathaniel Heatwole adam rose National Center for risk and Economic Analysis of Terrorism Events(CrEATE) University of Southern CaliforniaLos AngelesCA 90089USA Price School of Public Policy University of Southern CaliforniaLos AngelesCA 90089USA

Modeling the economic consequences of disasters has reached a high level of maturity and accuracy in recent years. Methods for providing reasonably accurate rapid estimates of economic losses, however, are still limited. This article presents the case for “reduced-form” models for rapid economic consequence estimation for disasters, and specifies and statistically estimates a regression equation for property damage from significant U.S. earthquakes. Explanatory variables are of two categories:(1) hazard-related variables pertaining to earthquake characteristics;and(2) exposure-related variables pertaining to socioeconomic conditions. Comparisons to other available earthquake damage estimates indicate that our reduced-Form Model yields reasonably good results, including several statistically significant variables that are consistent with a priori hypotheses. The article concludes with a discussion of how the research can be enhanced through the collection of data on additional variables, and of the potential for the extension of the reduced-form modeling approach to other hazard types.

关键词： earthquake hazard maturity

Expanding roles for pectins in plant development

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Journal of Integrative Plant Biology 2018年第10期60卷 910-923页

作者： adam M.Saffer Department of Molecular Cellular and Developmental BiologyYale University

Pectins are complex cell wall polysaccharides important for many aspects of plant development. recent studies have discovered extensive physical interactions between pectins and other cell wall components,implicating pectins in new molecular functions. Pectins are often localized in spatially-restricted patterns, and some of these non-uniform pectin distributions contribute to multiple aspects of plant development, including the morphogenesis of cells and organs. Furthermore, a growing number of mutants affecting cell wall composi- tion have begun to reveal the distinct contributions of different pectins to plant development. This review discusses the interactions of pectins with other cell wall components, the functions of pectins in controlling cellular morphology, and how non-uniform pectin composition can be an important determinant of developmental processes.

关键词： Expanding roles for pectins in plant development

Sharp Heat Kernel Estimates in the Fourier–Bessel Setting for a Continuous range of the Type Parameter

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Acta Mathematica Sinica,English Series 2014年第3期30卷 437-444页

作者： adam NOWAK Luz rONCAL Instytut Matematyczny Polska Akademia Nauk Departamento de Matemáticas y Computación Universidad de La Rioja

The heat kernel in the setting of classical Fourier-Bessel expansions is defined by an os- cillatory series which cannot be computed explicitly. We prove qualitatively sharp estimates of this kernel. Our method relies on establishing a connection with a situation of expansions based on Jacobi polynomials and then transferring known sharp bounds for the related Jacobi heat kernel.

关键词： Fourier-Bessel expansions heat kernel Bessel process transition density

Hepatocellular carcinoma:Defining the place of surgery in an era of organ shortage

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World Journal of Gastroenterology 2008年第28期14卷 4445-4453页

作者： adam Bartlett Nigel Heaton Institute of Liver Studies Kings College School of Medicine at Kings College HospitalDenmark HillCamberwellLondonSE5 9RSUnited Kingdom

Liver resection (Lr) and transplantation offer the only potential chance of cure for patients with hepatocellular carcinoma (HCC). Historically, all patients were treated by hepatic resection. With the advent of liver transplantation (LT) patients with HCC were preferentially placed on the waiting list for LT. However, early experience with LT was associated with a high rate of tumour recurrence and poor long-term survival. The increasing scarcity of donor livers resulted in restrictions being placed on tumour size, and an improvement in patient survival. To date there have been no randomised clinical trials comparing Lr to LT. We review the evidence supporting Lr and/or LT for HCC and discuss the role of neoadjuvant therapy. The decision of whether to resect or transplant remains debatable and is often determined by centre experience, availability of LT and donor organs.

关键词： Hepatocellular carcinoma Liver transplantation Liver resection Adjuvant therapy Salvage liver transplantation radiofrequency ablation Transarterial chemoembolization

Discovery of the inhibitor of DNA binding 1 as a novel marker for radioresistance in pancreatic cancer using genome-wide rNA-seq

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Cancer Drug resistance 2022年第4期5卷 926-938页

作者： scar Zuniga Stephanie Byrum adam r.Wolfe Department of radiation Oncology University of Arkansas for Medical SciencesLittle RockAR 72205USA Department of Biochemistry and Molecular Biology University of Arkansas for Medical SciencesLittle RockAR 72205USA

Purpose/Objective(s): Discovery of genetic drivers of radioresistance is critical for developing novel therapeuticstrategies to combine with radiotherapy of radioresistant PDAC. In this study, we used genome-wide rNA-seq toidentify genes upregulated in generated radioresistant PDAC cell lines and discovered the Inhibitor of DNA Binding1 (ID1) gene as a potential regulator of radioresistance in ***/Methods: radioresistant clones of the PDAC cell lines MIA PaCa-2 and PANC-1 were generated bydelivering daily ionizing irradiation (Ir) (2 Gy/day) in vitro over two weeks (total 20 Gy) followed by standardclonogenic assays following one week from the end of Ir. The generated rr and parental cell lines were submittedfor rNA-seq analysis to identify differentially expressed genes. The Limma r package was used to calculatedifferential expression among genes. Log2 fold change values were calculated for each sample compared to thecontrol. Genes with an absolute fold change > 1 were considered significant. rNA sequencing expression data fromthe Cancer Genome Atlas (TCGA) database was analyzed through the online databases GEPIA, cBioPortal, and theHuman Protein ***: Following exposure to two weeks of 2 Gy daily Ir in vitro, the two PDAC cell lines showed significantlygreater clonogenic cell survival than their parental cell lines, indicating enhanced rr in these cells. rNA-seqanalysis comparing parental and rr cell lines found upregulated seven genes (TNS4, ZDHHC8P1, APLNr, AQP3,SPP1, ID1, ID2) and seven genes downregulated (PTX3, ITGB2, EPS8L1, ALDH1L2, KCNT2, ArHGAP9, IFI16) in bothrr cell lines. Western blotting confirmed increased expression of the ID1 protein in the rr cell lines compared totheir parental cell lines. We found that ID1 mrNA was significantly higher in PDAC tumors compared to matchednormal and high ID1 expression correlated with significantly worse disease-free survival (DFS) in PDAC patients(Hr = 2.2, log rank P = 0.009). ID1 mrNA express

关键词： Pancreatic cancer radiation resistance ID1 rNA-seq

Proper Holomorphic Maps from Domains in C2 with Transverse Circle Action

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Chinese Annals of Mathematics,Series B 2007年第5期28卷 533-542页

作者： adam COFFMAN Yifei PAN Department of Mathematical Sciences Indiana University - Purdue University Fort Wayne Fort Wayne IN 46805-1499 USA. Department of Mathematical Sciences Indiana University - Purdue University Fort Wayne Fort Wayne IN 46805-1499 USA College of Mathematics and Information Sciences Jiangxi Normal University Nanchang 330022 China.

The authors consider proper holomorphic mappings between smoothly bounded pseudoconvex regions in complex 2-space,where the domain is of finite type and admits a transverse circle *** main result is that the closure of each irreducible component of the branch locus of such a map intersects the boundary of the domain in the union of finitely many orbits of the group action.

关键词： Proper holomorphic map Pseudoconvex domain

The (e_(g)■e_(u))■E_(g) product Jahn-Teller effect in the neutral group-Ⅳ vacancy quantum bits in diamond

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npj Computational Materials 2019年第1期5卷 1002-1007页

作者： GergőThiering adam Gali Wigner research Centre for Physics Hungarian Academy of SciencesPO Box 49Budapest 1525Hungary Department of Atomic Physics Budapest University of Technology and EconomicsBudafokiút 8.Budapest 1111Hungary

The product Jahn-Teller effect may occur for such coupled electron-phonon systems in solids where single electrons occupy double degenerate *** propose that the excited state of the neutral XV split-vacancy complex in diamond,where X and V labels a group-Ⅳ impurity atom of X=Si,Ge,Sn,Pb and the vacancy,respectively,is such a system with e_(g) and e_(u) double degenerate orbitals and E_(g) quasi-localized *** develop and apply ab initio theory to quantify the strength of electron–phonon coupling for neutral XV complexes in diamond,and find a significant impact on the corresponding optical properties of these *** results show good agreement with recent experimental data on the prospective SiV(0)quantum bit,and reveals the complex nature of the excited states of neutral XV color centers in diamond.

关键词： neutral vacancy quantum

POTENTIAL OPErATOrS AND LAPLACE TYPE MULTIPLIErS ASSOCIATED WITH THE TWISTED LAPLACIAN

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Acta Mathematica Scientia 2017年第1期37卷 280-292页

作者： adam NOWAK Krzysztof STEMPAK Instytut Matematyczny Polska Akademia NaukSniadeckich 800-656 WarszawaPoland Wydziat Matematyki Politechnika WroctawskaWyb.Wyspianskiego 2750-370 WroclawPoland

We study potential operators and,more generally,Laplace-Stieltjes and Laplace type multipliers associated with the twisted *** characterize those 1 ≤ p,q ≤ ∞,for which the potential operators are Lp—Lq *** result is a sharp analogue of the classical Hardy-Littlewood-Sobolev fractional integration theorem in the context of special Hermite *** also investigate Lp mapping properties of the Laplace-Stieltjes and Laplace type multipliers.

关键词： twisted Laplacian special Hermite expansion negative power potential op-erator fractional integral potential kernel spectral multiplier singular oscil-latory integral

Inhibition of translation and immune responses by the virulence factor Nsp1 of SArS-CoV-2

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Signal Transduction and Targeted Therapy 2020年第1期5卷 487-489页

作者： Kendra r.Vann adam H.Tencer Tatiana G.Kutateladze Department of Pharmacology University of Colorado School of MedicineAuroraCO 80045USA

Structural analysis of SArS-CoV-2 virulence factors is crucial for the development of vaccines and anti-viral *** cryo-EM structures of the viral protein Nsp1 bound to the human ribosomal machinery shed light onto the... 详细信息

关键词： immune shutdown vaccines