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Chinese Journal of Traumatology 2022年第5期25卷 272-276页

作者： Nils Muhlenfeld Philipp Stormann Ingo Marzi Felix Rosenow adam strzelczyk Rene D.Verboket Laurent M.Willems Department of Traurma Hand and Reconstructive SurgeryGoethe University FrankfurtFrankfurt Am MainGermany Epilepsy Center Frankfurt Rhine-Main Department of NeurologyGoethe University FrankfurlFrankfurt Am MainGermany LOEWE Center for Personalized Translational Epilepsy Research(CePTER) Goethe-Universitat FrankfurtFrankfurt Am MainGermany Department of Neurology and Epilepsy Center Hessen Philipps-University MarburgMarburg(Lahn)Germany

Purpose: Epileptic seizures frequently result in distinct physical injuries, fractures, traumatic brain injuries and minor trauma. The aim of this study was to retrospectively determine the frequent injury patterns due to seizure episode and to analyze consecutive acute medical care. Methods: This retrospective mono-center study was conducted at Frankfurt University Hospital, Frankfurt am Main, Germany between January 2007 and December 2017. Epilepsy patients with seizure-related fractures admitted to the emergency department were identified via a retrospective systematic query in the hospital information system using the ICD-10 German modification codes G40.0—G40.9. Patients with an unclear diagnosis of epilepsy were excluded. Sociodemographic as well as disease specific aspects were analyzed. Descriptive and Kruskal—Wallis one-way analysis of variance were used for statistical analysis. Results: A total number of 62 epilepsy patients were included. The mean age was 58.1 years. Fractures concerned the upper extremity most frequently (43.5%,n= 20), and 70.0% (14/20) were humerus fractures. Admission to intensive care unit for acute trauma care was necessary in 29.0% patients (n = 18), and surgery in 45.2% patients (n = 28). Twenty-five patients (26.6%) showed clinical or radiological signs of traumatic brain injury. Provoking factors were identified in 20 patients (32.3%), i.e., acute withdrawal or excess of alcohol (n = 15), relevant sleep deprivation (n = 2), and intoxication or withdrawal of other illegal drugs or trivial infect (n = 1 for each) and non-compliance with anti-seizure drugs (n = 1). A decreased T-score (-1.04 ± 1.15) and Z-score (-0.84 ± 0.75) compared to healthy subjects were found. Conclusion: Fractures in upper extremities, trunk and craniocerebral trauma occur frequently as seizure-induced injuries. Alcohol excess and withdrawal are important provoking factors and should be targeted with preventive measurements to avoid seizure related injuries

关键词： Epilepsy Wounds and injuries Falls Quality of life

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拉科酰胺在癫痫持续状态中的应用--针对现有证据的系统评价

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癫痫杂志 2018年第5期4卷 446-460页

作者： adam strzelczyk Johann Philipp Zollner Laurent M Willems 肖英凤童馨慕洁 Julie Jost Esther Paule Susanne Schubert-Bast Felix Rosenow Sebastian Bauer

拉科酰胺(Lacosamide,LCM)的静脉制剂具有良好的耐受性和安全性,促使其在癫痫持续状态(Status Epilepticus,SE)中得到应用。本项系统评价的目的是确定和评估LCM在SE中的使用情况。在电子数据库中用联合检索方式对2008年—2016年10月的... 详细信息

拉科酰胺(Lacosamide,LCM)的静脉制剂具有良好的耐受性和安全性,促使其在癫痫持续状态(Status Epilepticus,SE)中得到应用。本项系统评价的目的是确定和评估LCM在SE中的使用情况。在电子数据库中用联合检索方式对2008年—2016年10月的文献进行了系统检索,并使用标准化的评估表格从各项研究中将有关研究设计、方法框架、数据源、有效性和LCM引起的不良反应的信息进行提取并系统地报告。研究共评估了522次SE发作,其中包括486例成人和36例儿童及青少年发作,女性占51.7%。LCM的总体效力为57%。LCM对非惊厥性(57%,82/145)和全面痉挛性(61%,30/49,P=0.68)SE的效力相似,但对局灶运动性SE的总体有效率更高(92%,34/39,P<0.001)。而LCM在用药次序靠后时其疗效从100%下降到20%。治疗期间的主要不良反应是眩晕,视力异常,复视和共济失调。总体而言,LCM具有良好的耐受性,并且没有具临床意义的药物相互作用。现有数据表明LCM在SE中的使用是有前景的,有效率为57%。LCM的优势在于没有潜在的药物相互作用,并且在紧急情况需迅速增加剂量时可静脉使用。

关键词：拉科酰胺癫痫持续状态痫性发作癫痫电压门控钠通道

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Gastrojejunostomy in patients with unresectable pancreatic head cancer-the use of Roux loop significantly shortens the hospital length of stay

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World Journal of Gastroenterology 2013年第45期19卷 8321-8325页

作者： Dariusz Szymanski adam Durczynski Michal Nowicki Janusz strzelczyk Department of General and Transplant Surgery Barlicki University Hospital Medical University of Lodz 0-153 Lodz Poland

AIM:To evaluate the use of the Roux loop on the postoperative course in patients submitted for gastroenteroanastomosis(GE).METHODS:Non-jaundiced patients(n=41)operated on in the Department of General and Transplant Surgery in Lodz,between January 2010 and December 2011 were *** tumor was considered unresectable when liver metastases or major vascular involvement were *** were randomized to receive Roux(n=21)or conventional GE(n=20)on a prophylactic ***:The mean time to nasogastric tube withdrawal in Roux GE group was shorter(1.4±0.75 vs2.8±1.1,P<0.001).Time to starting oral liquids,soft diet and regular diet were decreased(2.3±0.86 vs 3.45±1.19;P<0.001;3.3±0.73 vs 4.4±1.23,P<0.001and 4.5±0.76 vs 5.6±1.42,P=0.002;respectively).The Roux GE group had a lower use of prokinetics(10mg thrice daily for 2.2±1.8 d vs 3.7±2.6 d,P=0.044;total 62±49 mg vs 111±79 mg,P=0.025).The mean hospitalization time following Roux GE was shorter(7.7 d vs 9.6 d,P=0.006).Delayed gastric emptying(DGE)was confirmed in 20%after conventional GE but in none of the patients following Roux ***:Roux gastrojejunostomy during open abdomen exploration in patients with unresectable pancreatic cancer is easy to perform,decreases the incidence of DGE and lowers hospitalization time.

关键词： Unresectable pancreatic cancer Roux and conventional gastroeneteroanastomosis Gastroenteroanastomosis Delayed gastric emptying Hospital length of stay

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Preoperative high level of D-dimers predicts unresectability of pancreatic head cancer

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World Journal of Gastroenterology 2014年第36期20卷 13167-13171页

作者： adam Durczynski Anna Kumor Piotr Hogendorf Dariusz Szymanski Piotr Grzelak Janusz strzelczyk Department of General and Transplant Surgery Medical University of Lodz 90-153 Lodz Poland Department of Allergology and Pulmonary Diseases Medical University of Lodz 90-153 Lodz Poland Department of Radiology and Diagnostic Imaging Medical University of Lodz 90-153 Lodz Poland

AIM: To assess the value of D-dimer level in determining resectability of pancreatic cancer.

关键词： Pancreatic cancer D-dimers Portal blood Peripheral blood Bile Urine Pancreatic cancer respectability

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Impact of environmental variables on spatial and seasonal internal phosphorus loading in a mesoeutrophic lake

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International Journal of Sediment Research 2019年第1期34卷 14-26页

作者： Katarzyna Kowalczewska-Madura Ryszard Go?dyn Julia Bogucka Katarzyna strzelczyk Department of Water Protection Faculty of BiologyAdam Mickiewicz University

Strzeszynskie Lake was formerly a slightly eutrophic（meso-eutrophic） water body. The aim of the current research was to define variables on both spatial and seasonal internal phosphorus loading from bottom sediments at five stations located in zones varying in depth, oxygenation, macrophyte presence,and uses of the neighboring catchment area. Ex situ experiments done with the use of intact bottom sediment cores have shown that the highest phosphorus release occurred in the deepest part of the lake and reached 3.6 mg P/m2d under anoxic conditions during summer thermal stratification. In turn, the internal loading from littoral sediments, which were well aerated all year round, was clearly ***, phosphorus accumulation in the bottom sediment was observed to reach a maximum of 1.45 mg P/m2d in autumn. A comparison of the internal loading intensity in lake zones with different land uses of the neighboring catchment area has shown slightly higher values at stations adjacent to the forest catchment area than those used for recreation. Changes in the land use of the catchment area of Strzeszynskie Lake, especially the increase in impermeable surfaces, have led to an increased inflow of external loads after heavy rains, resulting in deterioration in water quality and a delayed increase in internal loading.

关键词： Bottom sediments Interstitial water Bottom water Internal loading Sediment-water interface

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