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Statin, aspirin and metformin use and risk of hepatocellular carcinoma related outcomes following liver transplantation: A retrospective study

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World Journal of Transplantation 2024年第3期14卷 120-131页

作者： William Chung Kevin Wong Noel Ravindranayagam Lauren Tang Josephine Grace Darren Wong Danny Con Marie Sinclair Avik Majumdar Numan Kutaiba Samuel Hui Paul Gow Vijayaragavan Muralidharan Alexander Dobrovic adam Testro Department of Gastroenterology Austin HealthHeidelberg 3084VictoriaAustralia Victorian Liver Transplant Unit Austin HealthHeidelberg 3084VictoriaAustralia Department of Radiology Austin HealthHeidelberg 3084VictoriaAustralia Department of Gastroenterology Monash HealthClayton 3168VictoriaAustralia Department of Surgery University of MelbourneAustin HealthHeidelberg 3048VictoriaAustralia Department of Surgery Beacon LaboratoryAustin PrecinctThe University of MelbourneAustin HospitalHeidelberg 3048VictoriaAustralia

BACKGROUND Liver transplantation(LT)is a potentially curative therapy for patients with hepatocellular carcinoma(HCC).HCC-recurrence following LT is associated with reduced *** is increasing interest in chemoprophylaxis to improve HCC-related outcomes *** To investigate whether there is any benefit for the use of drugs with proposed chemoprophylactic properties against HCC,and patient outcomes following *** This was a retrospective study of adult patients who received Deceased Donor LT for HCC from 2005-2022,from a single Australian *** use was defined as statin,aspirin or metformin therapy for≥29 days,within 24 months post-LT.A cox proportional-hazards model with time-dependent covariates was used for survival *** measures were the composite-endpoint of HCC-recurrence and all-cause mortality,HCC-recurrence and HCC-related *** analysis was performed to account for immortality time bias and statin *** Three hundred and five patients were included in this study,with 253(82.95%)males with a median age of 58.90 *** of liver disease were 150(49.18%)hepatitis C,73(23.93%)hepatitis B(HBV)and 33(10.82%)non-alcoholic fatty liver disease(NAFLD).56(18.36%)took statins,51(16.72%)aspirin and 50(16.39%)*** a median follow-up time of 59.90 months,34(11.15%)developed HCC-recurrence,48(15.74%)died,17(5.57%)from HCC-related ***,aspirin or metformin use was not associated with statistically significant differences in the composite endpoint of HCC-recurrence or all-cause mortality[hazard ratio(HR):1.16,95%CI:0.58-2.30;HR:1.21,95%CI:0.28-5.27;HR:0.61,95%CI:0.27-1.36],HCC-recurrence(HR:0.52,95%CI:0.20-1.35;HR:0.51,95%CI:0.14-1.93;HR 1.00,95%CI:0.37-2.72),or HCC-related mortality(HR:0.32,95%CI:0.033-3.09;HR:0.71,95%CI:0.14-3.73;HR:1.57,95%CI:0.61-4.04)*** dosing was not associated with statist-ically significant differences in HCC-related ***

关键词： Liver transplantation Hepatocellular carcinoma Transplant oncology Statins HMG-Co-A reductase Aspirin Metformin Mammalian target of rapamycin

Of mice and men： what rodent models don＇t tell us

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Cellular & Molecular Immunology 2013年第4期10卷 284-285页

作者： adam C Drake Koch Institute for Integrative Cancer Research atMIT Cambridge MA USA

Work recently published in PNAS by The Inflammation and Host Response to Injury, Large Scale Collaborative Research Program1 compared the transcriptional responses in peripheral blood to inflammatory injuries （burns,... 详细信息

关键词： Inflammation Injury human

Improved Synergetic Current Control for Grid-connected Microgrids and Distributed Generation Systems

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Journal of Modern Power Systems and Clean Energy 2022年第5期10卷 1302-1313页

作者： A.Elnady A.Noureldin A.A.adam Department of Electrical Engineering University of SharjahSharjahUnited Arab Emirates Department of Electrical and Computer Engineering Royal Military CollegeKingstonCanada Department of Electrical and Computer Engineering Queens UniversityKingstonCanada

This paper presents the development of improved synergetic current control for the injected current of an inverter in the grid-connected microgrid and the distributed generation system(DGS). This paper introduces new formulas of the macro-variable functions for integral synergetic control(SC)and integral fast terminal SC, which both have an integral term to guarantee zero steady-state error. The proposed integral SC and integral fast terminal SC achieve a seamless performance such as the fast convergence, minimal overshoot, zero steady-state error, and chattering-free operation. To demonstrate the meritorious performance of the proposed scheme for injected current control, it is compared with the performance of a proportional-integral(PI) controller and advanced exponential sliding mode control(SMC). Finally, the practicality of the proposed scheme is justified by experimental results obtained through rapid control prototyping(RCP) using the dSPACESCALEXIO platform.

关键词： Integral synergetic control(SC) current control integral fast terminal SC advanced exponential sliding mode control(SMC) proportional-integral(PI)control microgrid distributed generation system(DGS)

Soil spatial variability impact on the behavior of a reinforced earth wall

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Frontiers of Structural and Civil Engineering 2020年第2期14卷 518-531页

作者： adam HAMROUNI Daniel DIAS Badreddine SBARTAI Laboratory InfraRES Mohammed Cherif Messaadia UniversitySoukAhras 41000Algeria School of Automotive and Transportation Engineering Hefei University of TechnologyHefei 230009China Antea Group Antony 92160France Department of Civil Engineering University of AnnabaAnnaba 23000&LMGHU LaboratoryUniversity of SkikdaSkikda 21000Algeria

This article presents the soil spatial variability effect on the performance of a reinforced earth *** serviceability limit state is considered in the *** cases of isotropic and anisotropic non-normal random fields are implemented for the soil *** K arhunen-Loeve expansion method is used for the discretization of the random *** finite difference models are considered as deterministic *** Monte Carlo simulation technique is used to obtain the deformation response variability of the reinforced soil retaining *** influences of the spatial variability response of the geotechnical system in terms of horizontal facing displacement is presented and *** results obtained show that the spatial variability has an important influence on the facing horizontal displacement as well as on the failure probability.

关键词： reinforced earth wall geosynthetic random field spatial variability Monte Carlo simulation

A Reduced-Form Rapid Economic Consequence Estimating Model:Application to Property Damage from U.S. Earthquakes

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International Journal of Disaster Risk Science 2013年第1期4卷 20-32页

作者： Nathaniel Heatwole adam Rose National Center for Risk and Economic Analysis of Terrorism Events(CREATE) University of Southern CaliforniaLos AngelesCA 90089USA Price School of Public Policy University of Southern CaliforniaLos AngelesCA 90089USA

Modeling the economic consequences of disasters has reached a high level of maturity and accuracy in recent years. Methods for providing reasonably accurate rapid estimates of economic losses, however, are still limited. This article presents the case for “reduced-form” models for rapid economic consequence estimation for disasters, and specifies and statistically estimates a regression equation for property damage from significant U.S. earthquakes. Explanatory variables are of two categories:(1) hazard-related variables pertaining to earthquake characteristics;and(2) exposure-related variables pertaining to socioeconomic conditions. Comparisons to other available earthquake damage estimates indicate that our Reduced-Form Model yields reasonably good results, including several statistically significant variables that are consistent with a priori hypotheses. The article concludes with a discussion of how the research can be enhanced through the collection of data on additional variables, and of the potential for the extension of the reduced-form modeling approach to other hazard types.

关键词： earthquake hazard maturity

CONVERGENCE RATES FOR DIFFERENCE SCHEMES FOR POLYHEDRAL NONLINEAR PARABOLIC EQUATIONS

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Journal of Computational Mathematics 2010年第4期28卷 474-488页

作者： adam M.Oberman Department of Mathematics Simon Fraser University

We build finite difference schemes for a class of fully nonlinear parabolic equations. The schemes are polyhedral and grid aligned. While this is a restrictive class of schemes, a wide class of equations are well approximated by equations from this class. For regular （C2,α） solutions of uniformly parabolic equations, we also establish of convergence rate of O（α）. A case study along with supporting numerical results is included.

关键词： Error estimates Convergence rate Viscosity solutions Finite difference schemes

Sharp Heat Kernel Estimates in the Fourier–Bessel Setting for a Continuous Range of the Type Parameter

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Acta Mathematica Sinica,English Series 2014年第3期30卷 437-444页

作者： adam NOWAK Luz RONCAL Instytut Matematyczny Polska Akademia Nauk Departamento de Matemáticas y Computación Universidad de La Rioja

The heat kernel in the setting of classical Fourier-Bessel expansions is defined by an os- cillatory series which cannot be computed explicitly. We prove qualitatively sharp estimates of this kernel. Our method relies on establishing a connection with a situation of expansions based on Jacobi polynomials and then transferring known sharp bounds for the related Jacobi heat kernel.

关键词： Fourier-Bessel expansions heat kernel Bessel process transition density

Expanding roles for pectins in plant development

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Journal of Integrative Plant Biology 2018年第10期60卷 910-923页

作者： adam M.Saffer Department of Molecular Cellular and Developmental BiologyYale University

Pectins are complex cell wall polysaccharides important for many aspects of plant development. Recent studies have discovered extensive physical interactions between pectins and other cell wall components,implicating pectins in new molecular functions. Pectins are often localized in spatially-restricted patterns, and some of these non-uniform pectin distributions contribute to multiple aspects of plant development, including the morphogenesis of cells and organs. Furthermore, a growing number of mutants affecting cell wall composi- tion have begun to reveal the distinct contributions of different pectins to plant development. This review discusses the interactions of pectins with other cell wall components, the functions of pectins in controlling cellular morphology, and how non-uniform pectin composition can be an important determinant of developmental processes.

关键词： Expanding roles for pectins in plant development

THE FEKETE-SZEG PROBLEM FOR CLOSE-TO-CONVEX FUNCTIONS WITH RESPECT TO THE KOEBE FUNCTION

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Acta Mathematica Scientia 2014年第5期34卷 1571-1583页

作者： Bogumila KOWALCZYK adam LECKO Chair of Complex Analysis University of Warmia and Mazury ul. S loneczna 5410710 Olsztyn Poland

An analytic function f in the unit disk D ：= {z ∈ C ：｜z｜〈 1}, standardly normalized, is called close-to-convex with respect to the Koebe function k（z）：= z/（1-z）2, z ∈ D, if there exists δ ∈ （-π/2,π/2） such that Re {eiδ（1-z）2f′（z）} 〉 0, z ∈ D. For the class C（k） of all close-to-convex functions with respect to k, related to the class of functions convex in the positive direction of the imaginary axis, the Fekete-Szego problem is studied.

关键词： Fekete-Szego problem close-to-convex functions close-to-convex functionswith respect to the Koebe function close-to-convex functions with argumentδ functions convex in the positive direction of the imaginary axis