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Impact of a physical activity program on plasma concentrations of adiponectin, leptin and ghrelin in overweight and obese schoolchildren: A randomized controlled trial

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Health 2013年第11期5卷 1819-1828页

作者： Andre Everton de Freitas Joel Alves Lamounier Danusa Dias Soares Thiago Henrique de Oliveira Debora Romualdo Lacerda Joyce Batista Andrade Flavia Komatsuzaki Leida Maria Botion adaliene versiani matos ferreira Camilo Adalto Mariano da Silva Dilermando Fazito Rezende Graduate Program in Child and Teenager Health Medicine SchoolFederal University of Minas GeraisBelo HorizonteBrazil Faculty of Health and Human Ecology Medicine SchoolVespasianoBrazil Graduate Program in Health Sciences Medicine SchoolFederal University of Sao Joao Del ReiCampus MidwestDivinopolisBrazil Laboratory of Exercise Physiology Federal University of Minas GeraisBelo HorizonteBrazil Laboratory of Metabolism Federal University of Minas GeraisBelo HorizonteBrazil School of Nursing Federal University of Minas GeraisBelo HorizonteBrazil School of Nutrition Federal University of Ouro PretoOuro PretoBrazil Faculty of Medicine Barbacena BarbacenaBrazil

Introduction: Child obesity has important consequences on the child’s health and is related to the risk of developing chronic diseases. That brings up the need for research assessing the impact of obesity-and overweight-reduction programs with close attention to methodology aspects and precise indicators of the impact of such programs. Goal: Assessing the impact of a physical activity program on the plasma concentrations of adiponectin, leptin, and ghrelin in overweight and obese schoolchildren. Methods: Randomized controlled trial, double-blind, with 6-to 9-year-old overweight and obese school-children. A sample of 79 schoolchildren randomly distributed into control and intervention groups was subjected to a physical activity program. The levels of adiponectin, leptin, ghrelin, body mass index, body fat percentage, anthropometry, lipid profile and glycemia were evaluated. The program’s impact was assessed through multivariate linear regression models. Result: When comparing the groups, a significant difference was found for adiponectin, which shows an increase in the proportion of subjects with higher adiponectin concentrations for the intervention group and a reduction in body mass index and body fat percentage. Conclusion: The impact of the intervention program was positive in increasing adiponectin levels associated with a reduction in body mass index and body fat percentage.

关键词： Obesity Overweight Schoolchildren Physical Activity Adipocitokines

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Changes in calcium accumulation and utilization efficiency and their impact on recycling,immobilization,and export across the oil palm cycle

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Oil Crop Science 2024年第3期9卷 143-150页

作者： Ismael de Jesus matos Viégas Luma Castro de Souza Eric Victor de Oliveira ferreira Milton Garcia Costa Glauco André dos Santos Nogueira Vitor Resende do Nascimento Candido ferreira de Oliveira Neto Capanema Campus Federal Rural University of the Amazon(UFRA)Av.Barao de CapanemaCaixa D'agua5514-6434ParaBrazil Center of Agricultural and Environmental Sciences Federal University of Maranhao(UFMA)ChapadinhaBR-222km 04SNBoa Vista65500000MaranhaoBrazilc Capitao Poço Campus Federal Rural University of the Amazon(UFRA)Tv.Pau AmareloS/n-Vila Nova68650-000Capitao PoçoParaBrazil Department of Soil Science Sao Paulo State University(Unesp)School of Agricultural and Veterinarian SciencesJaboticabalVia de Acesso Prof.Paulo Donato CastelaneCastellane-S/N-Vila Industrial14884-900Sao PauloBrazil Institute of Agricultural Sciences(ICA) Federal Rural University of the Amazon(UFRA)Estr.Principal da Ufra2150Curio-Utinga66077-580BelemParaBrazil

Effective calcium(Ca)management is crucial for optimizing oil palm cultivation and enhancing crop *** study aimed to gain insights into the dynamics of Ca concentration,accumulation,exportation,immobilization,and recycling in various oil palm organs relative to plant *** experiment was conducted at the Agropalma enterprise site in the northeastern region of Para State,Brazil,evaluating seven plant age treatments:2,3,4,5,6,7,and 8 years *** a completely randomized design with four *** results demonstrated an age-related increase in Ca concentration in petioles,rachis,arrows,male inflorescences,peduncles,and ***,Ca accumulation exhibited an upward trend in all organs with progressing plant ***,the study revealed an enhanced Ca use efficiency across all plant organs in correlation with the age of oil palm *** findings underscore the dynamic nutritional demands of oil palm,influencing Ca immobilization,cycling,and export throughout its developmental stages.

关键词： Elaeis guineensis Jacq Ca cycling Ca export Ca immobilization Ca use efficiency Plant nutrition Amazon

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Combined Oxidative Phosphorylation Deficiency-20-Exome as a Diagnostic Implement

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Journal of Biosciences and Medicines 2024年第6期12卷 7-12页

作者： Paulo Roberto matos-Neto Lucas Antonissen Lima Verde Airton ferreira da Ponte-Filho Luís Eduardo Oliveira matos Amandha Espavier Trés Paulo Roberto Lacerda Leal Gerardo Cristino-Filho Regina Coeli de Carvalho Porto Carneiro Faculty of Medicine Federal University of Cear Sobral Cear Brazil Department of Neurosurgery Federal University of Cear Sobral Cear Brazil Department of Neuropediatrics Federal University of Cear Sobral Cear Brazil

Mitochondrial disorders are phenotypically varied, with serious clinical repercussions. Among them, there is the deficiency of combined oxidative phosphorylation of type 20, which occurs due to a defect in the VARS2 gene. This article presents a case of a 2-year-old female with progressive myoclonic epilepsy and psychomotor regression, with refractoriness to multiple anticonvulsants. The diagnosis was only made after the examination was carried out. Therefore, this article highlights the aspects of this rare disease and the importance of the exome for the diagnosis of rare conditions.

关键词： Oxidative Phosphorylation Epilepsy Exome Mitochondrial Defect VARS2

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Timing of Proterozoic magmatism in the Sunsas belt, Bolivian Precambrian Shield, SW Amazonian Craton

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Geoscience Frontiers 2021年第6期12卷 277-293页

作者： Ingrid M.Nedel Reinhardt A.Fuck Amarildo S.Ruiz Gerardo R.matos-Salinas Alanielson da C.D.ferreira Instituto de Geociências Universidade de Brasília(UnB)Brasília-DFBrazil Faculdade de Geociências Universidade Federal de Mato GrossoCuiabá-MTBrazil Instituto de Investigaciones Geológicas y del Medio Ambiente Universidad Mayor de San Andrés(UMSA)Pabellón GeologíaCalle 27Campus Universitario Cota CotaLa PazBolivia Department of Earth Sciences Stellenbosch UniversityPrivate Bag X1Matieland7602 StellenboschSouth Africa

We present new U–Pb zircon and monazite ages from the Sunsas belt granitic magmatism in Bolivia, SW Amazonian Craton. The geochronological results revealed four major magmatic events recorded along the Sunsas belt domains. The older igneous event formed a granitic basement coeval to the Rio Apa Terrane(1.95–1.85 Ga) in the southern domain. The second magmatic episode is represented by 1.68 Ga granites associated to the Paraguá Terrane(1.69–1.66 Ga) in the northern domain. The 1.37–1.34 Ga granites related to San Ignacio orogeny represent the third and more pervasive magmatic event, recorded throughout the Sunsas belt. Moreover, magmatic ages of ~1.42 Ga revealed that the granitogenesis associated to the Santa Helena orogeny also affected the Sunsas belt, indicating that it was not restricted to the Jauru Terrane. Lastly, the 1.10–1.04 Ga youngest magmatism was developed during the Sunsas orogeny and represents the final magmatic evolution related to Rodinia assembly. Likewise, the 1.95–1.85 and 1.68 Ga inherited zircon cores obtained in the ~1.3 Ga and 1.0 Ga granite samples suggest strong partial melting of the Paleoproterozoic sources. The 1079 ± 14 Ma and 1018 ± 6 Ma monazite crystallization ages can be correlated to the collisional tectono-thermal event of the Sunsas orogeny, associated to reactions of medium-to high-grade metamorphism. Thus, the Sunsas belt was built by heterogeneous 1.95–1.85 Ga and 1.68 Ga crustal fragments that were reworked at 1.37–1.34 Ga and 1.10–1.04 Ga related to orogenic collages. Furthermore, the 1.01 Ga monazite age suggests that granites previously dated by zircon can bear evidence of a younger thermal history. Therefore, the geochronological evolution of the Sunsas belt may have been more complex than previously thought.

关键词： SW Amazonian Craton Sunsas belt U–Pb geochronology Zircon Monazite

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Skin models of cutaneous toxicity,transdermal transport and wound repair

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Burns & Trauma 2023年第1期11卷 393-407页

作者： Inês Vilela de Sousa Miguel J.S.ferreira Luís B.Bebiano Sandra Simões Ana Filipa matos Rúben F.Pereira Pedro L.Granja i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoRua Dr.Manuel Pereira da Silva4200-393 PortoPortugal INEB-Instituto de Engenharia Biomédica Universidade do PortoRua do Campo Alegre8234150-180 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugal FEUP-Faculdade de Engenharia da Universidade do Porto Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and Engineering&Henry Royce InstituteEngineering Building AThe University of ManchesterOxford RoadManchester M139PLUK ISEP-Instituto Superior de Engenharia do Porto Universidade do PortoRua Dr.António Bernardino de Almeida 4314200-072 PortoPortugal iMed.ULisboa Faculty of PharmacyUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal Faculty of Pharmacy Universidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive ***,the barrier properties of the skin,along with its multilayer structure,impose severe restrictions on drug transport and ***,bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin *** though in vivo research is often preferred to study biological processes involving the skin,in vitro and ex vivo strategies have been gaining increasing relevance in recent ***,there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted ***,microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin *** in miniaturization,automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust,high-throughput manner,while being compliant with regulatory issues,standards and *** this review,skin models for transdermal transport,wound repair and cutaneous toxicity will be discussed with a focus on high-throughput *** microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models,both in terms of complexity and throughput.

关键词： Skin In vitro models Ex vivo models Transdermal transport assays Wound healing assays Toxicity assays Microfluidic chip Skin-on-a-chip

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A multi-integrated approach on toxicity effects of engineered TiO2 nanoparticles

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Frontiers of Environmental Science & Engineering 2015年第5期9卷 793-803页

作者： Ana PICADO Susana M. PAIXAO Liliana MOITA Luis SILVA Mario S. DINIZ Joana LOURENCO Isabel PERES Luisa CASTRO Jose Brito CORREIA Joana PEREIRA Isabel ferreira Antonio Pedro Alves matos Pedro BARQUINHA Elsa MENDONCA LNEG-National Laboratory of Energy and Geology I.P. Lisbon 1649-038 Portugal REQUIMTE Chemistry Department Fine Chemistry and Biotechnology Center Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal IMAR-Ocean Institute Department of Sciences and Environmental Engineering Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal CENIMAT/I3N and Department of Materials Science Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal Pathological Anatomy Curry Cabml Hospital Lisbon 1069-166 Portugal CESAM Faculty of Sciences Lisbon University Lisbon 1749-016 Portugal

The new properties of engineered nanoparti- cles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organisms and ecosystems. Titanium dioxide nanoparticles have been used extensively for a wide range of applica- tions, e.g, self-cleaning surface coatings, solar cells, water treatment agents, topical sunscreens. Within this scenario increased environmental exposure can be expected but data on the ecotoxicological evaluation ofnanoparticles are still scarce. The main purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organisms, covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate model organism tissue histological and ultrastructural observations and the stress enzyme activity were also studied. TiO2 nanoparticles （Aeroxide~ P25）, two phase composition ofanatase （65%） and rutile （35%） with an average particle size value of 27.64-11 nm were used. Results on the ECs0 for the tested aquatic organisms showed toxicity for the bacteria, the algae and the crustacean, being the algae the most sensitive tested organism. The aquatic plant Lemna minor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochemical level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease （p〈0.05） after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lumen but their internalization by intestine cells could not be confirmed.

关键词： ecotoxicity enzymatic analysis histology,transmission electron microscopy (TEM) TiO2-nanoparti-cles

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Grain-size end-members and environmentally sensitive grain-size components: A comparative study in the mud shelf depocenters off southern Brazil

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International Journal of Sediment Research 2021年第2期36卷 317-327页

作者： Michel Michaelovitch de Mahiques Samara Cazzoli y Goya Maria Carolina da Silva Nogueira de matos Rodrigo Augusto Udenal de Oliveira Bianca Sung Mi Kim Paulo Alves de Lima ferreira Rubens Cesar Lopes Figueira Marcia Caruso Bícego Oceanographic Institute University of S?o Paulo Pra?a do Oceanográfico Institute of Energy and Environment University of S?o Paulo Avenida Professor Luciano Gualberto

The current study aims to do a comparative analysis of the results obtained with two End-Member(EM)grain-size modeling techniques(Analy Size and Bas EMMA) and the Environmental Sensitive Grain-Size(ESGS) modeling for sediment samples collected in the mudbelts of the southern Brazilian shelf. The methods were compared using grain-size data from the south Brazilian shelf, and the results are discussed here. It is the first time that the concept of ESGS, in its present form, is utilized outside China. The results show that despite its relative ease of use, the ESGS is not fully comparable to the EM analyses, and only two grain-size ESGS classes were recognized as analogous to EMs. The comparison of the Analy Size and Bas EMMA procedures also revealed significant differences between the techniques. A comparative analysis between the two EM techniques revealed advantages in the Bas EMMA, especially in the better correlation of the end-members with the original grain size distribution. The analysis of the geographical distribution of the EM abundances allowed point sources of sandy populations to be recognized as well as the contribution of the Rio de la Plata as a source of silty sediments to be inferred.

关键词： Grain-size End-member Environmentally sensitive Mudbelt Continental shelf

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A High-Resolution Modeling Strategy to Assess Impacts of Climate Change for Mesoamerica and the Caribbean

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American Journal of Climate Change 2016年第2期5卷 202-228页

作者： Robert Oglesby Clinton Rowe Alfred Grunwaldt Ines ferreira Franklyn Ruiz Jayaka Campbell Luis Alvarado Francisco Argenal Berta Olmedo Alejandro del Castillo Pilar Lopez Edwards matos Yosef Nava Carlos Perez Joel Perez Department of Earth and Atmospheric Sciences University of Nebraska Lincoln NE USA Climate Change and Sustainability Division Inter-American Development Bank Washington DC USA Instituto de Hidrología Meteorología y Estudios Ambientales de Colombia Bogota Colombia University of the West Indies Kingston Jamaica Instituto Meteorológico Nacional Costa Rica San Jose Costa Rica Servicio Meteorológico Nacional de Honduras Dirección General de Aeronáutica Civil Tegucigalpa Honduras Empresa de Transmisión Eléctrica Paname?a Ciudad de Panamá Panamá Water Center for the Humid Tropics of Latin America and the Caribbean (CATHALAC) Ciudad de Panamá Panamá Unidad de Análisis Meteorológico Empresa de Transmisión Eléctrica Paname?a Ciudad de Panamá Panamá Instituto Nacional de Ecología y Cambio Climático Mexico City Mexico National Weather Service MARN San Salvador El Salvador

Mesoamerica and the Caribbean are low-latitude regions at risk for the effects of climate change. Global climate models provide large-scale assessment of climate drivers, but, at a horizontal resolution of 100 km, cannot resolve the effects of topography and land use as they impact the local temperature and precipitation that are keys to climate impacts. We developed a robust dynamical downscaling strategy that used the WRF regional climate model to downscale at 4 - 12 km resolution GCM results. Model verification demonstrates the need for such resolution of topography in order to properly simulate temperatures. Precipitation is more difficult to evaluate, being highly variable in time and space. Overall, a 36 km resolution is inadequate;12 km appears reasonable, especially in regions of low topography, but the 4 km resolution provides the best match with observations. This represents a tradeoff between model resolution and the computational effort needed to make simulations. A key goal is to provide climate change specialists in each country with the information they need to evaluate possible future climate change impacts.

关键词： Regional Climate Models Dynamical Downscaling Strategy Mesoamerica and Caribbean Climate Change

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Economic Viability of Production of Tree Parica （Schizolobium amazonicum Huber ex. Ducke） of Reforestation Project in the Municipality Paragominas-PA, Brazil

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Journal of Life Sciences 2014年第12期8卷 967-971页

作者： Manoel Tavares de Paula Altem Nascimento Pontes Helio Raymundo ferreira Filho Lucy Anne Cardoso Lobao Gutierrez Ismael matos da Silva Maria da Conceicao Silva Damasceno Aline Lima de Sena Center of Natural Science and Technology University of Pare State Belem 66095-100 Para State Brazil Center of Social Sciences and Education University of Pare State Belem 66095-100 Para State Brazil

The objective of this study was to analyze the profitability of production Parica reforestation in the municipality of Paragominas-PA. The study was conducted in the municipality of Paragominas Messoregiao located in the northeast of Para. The basic data used in the economic evaluation of production of planting parica （costs and revenues） were derived from primary source through raising production cost of parica with farmers from the municipality, analyzing the period of production horizon of seven years. The discount rate chosen for economic evaluation was 10% per year. NPV （net present value） calculation IRR （internal rate of return）, BCR （benefit-cost ratio） and EP （break-even point）. To check the economic feasibility of producing parica the following criteria were used for economic analysis. The results for NPV, IRR and BC ratio were respectively of $495,970, 28.83% and 2.43. For EP （break-even point） the value of 41.08% was found, which demonstrates the minimum amount of production, so that revenue equals costs. Based on the results obtained, it was found that the reforestation model with parica proposed in this paper presents economically viable for deployment.

关键词： Amazon parica reforestation

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A Selection Process as a Game

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Management Studies 2018年第6期6卷 531-535页

作者： Manuel Alberto M.ferreira Maria Cristina Peixoto de matos Instituto Universitário de Lisboa(ISCTE-IUL) LisbonPortugal Instituto Politecnico de Viseu(IPV)-Escola Superior deTecnologia e Gestao de Viseu(ESTGV) ViseuPortugal

The aim of this paper is to exemplify how to solve the problem of selecting a candidate up to his/her acceptance trough game *** originality this paper proposes is how this problem will be approached:It will be treated as a single game which is made up of two parts,going as far as to state that the payoffs in the first part of the game will be the mediators of the second part of the game.

关键词： selection process game theory two-part game code form

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