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Serum levels of undercarboxylated osteocalcin are related to cardiovascular risk factors in patients with type 2 diabetes mellitus and healthy subjects

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World Journal of Diabetes 2017年第1期8卷 11-17页

作者： Sergio Sanchez-Enriquez Isabel Thalia Ballesteros-Gonzalez JoséRafael Villafán-Bernal Sara Pascoe-Gonzalez Edgar Alfonso Rivera-Leon Blanca Estela Bastidas-Ramirez Jorge David Rivas-Carrillo Juan Luis Alcala-Zermeno Juan Armendariz-Borunda Iris Monserrat Llamas-Covarrubias abraham zepeda-moreno Biochemistry Laboratory Molecular Biology and Genomics Department University Center of Health Sciences University of Guadalajara Academic Group UDG-CA-533 Multidisciplinary Study of Chronic and Degenerative Diseases Molecular Biology and Genomics Department University Center of Health Sciences University of Guadalajara Departamento de Jóvenes Investigadores y Cátedras del Consejo Nacional de Ciencia y Tecnología (CONACYT) Departamento de Cirugía Centro Universitario de Ciencias de la Salud Universidad Autónoma de Aguascalientes Physiology Department University Center of Health Sciences University of Guadalajara Institute of Degenerative Chronic Diseases Molecular Biology and Genomics Department University Center of Health Sciences University of Guadalajara Molecular Biology and Genomics Department University Center of Health SciencesUniversity of Guadalajara Institute of Cancer Research in Child and Adolescent University Center of Health Sciences University of Guadalajara

AIM To determine a potential relationship between serum undercarboxylated(uc OC) concentration and cardiovascular risk factors in type 2 diabetes(T2D) patients and healthy subjects(HS).METHODS A cross-sectional study was conducted on 140 subjects classified into two groups, 70 with T2D and 70 HS. Medical history and physical examination with anthropometric measurements were obtained from all subjects. Body fat percentage was determined by bioelectrical impendency analysis. Serum uc OC concentration was determined by enzyme immunoassay,while serum levels of insulin and hsC RP were obtained using high sensitivity enzyme-linked immunosorbent assay. Insulin resistance was determined using the homeostasis model assessment-IR. Lipid profile [triglycerides,total cholesterol(TC), high-density lipoproteins(HDL-c),low density lipoproteins(LDL-c), very low-density lipoproteins] was determined by spectrophotometry and standard formulas when applicable. RESULTS The T2D patient group showed significantly higher values of waist circumference, waist-to-hip ratio, systolic blood pressure(SBP), diastolic blood pressure(DBP),current smoking, and alcohol use when compared to the HS group(P < 0.05). We observed a significantly lower serum ucO C concentration in T2D than in HS(1.5 ± 1.4vs 2.3 ± 1.8, P < 0.05). In the whole study population,ucO C concentration was inversely correlated with body mass index(BMI)(r =-0.236, P < 0.05), fasting plasma glucose(r =-0.283, P < 0.01) and HDL-c(r =-0.255,P < 0.05); and positively correlated with LDL-c/HDL-c ratio(r = 0.306, P < 0.05) and TC/HDL-c ratio(r =0.284, P < 0.05). In the T2D group, serum uc OC concentration was inversely correlated with BMI(r =-0.310, P < 0.05) and body-fat percentage(r =-0.311,P < 0.05), and positively correlated with DBP(r = 0.450,P < 0.01). In HS group a positive correlation between serum levels of uc OC and SBP(r = 0.277, P < 0.05)was observed. CONCLUSION Serum uc OC is a potential marker for cardiovascular risk in Mex

关键词： Bone Osteocalcin Glucose metabolism Diabetes Cardiovascular risk

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SARS-CoV-2:Air pollution highly correlated to the increase in *** case of Guadalajara,Jalisco,Mexico

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Infectious Disease Modelling 2023年第2期8卷 445-457页

作者： Elizabeth Torres-Anguiano Itzel Sanchez-Lopez Angeles Garduno-Robles Jorge David Rivas-Carrillo Edgar Alfonso Rivera-Leon Sergio Sanchez-Enríquez Luis Fernando Ornelas-Hernandez Fernando Zazueta Leon-Quintero Eduardo Narciso Salazar Leon-Quintero Guillermo Enrique Juarez-Lopez Fernando Antonio Sanchez-Zubieta Mariana Ochoa-Bru abraham zepeda-moreno Onkogenetik/Mexicana de Investigacion y Biotectogía S.A.de C.V GuadalajaraJaliscoMexico Unidad de Biología Molecular Investigacion y DiagnosticoHospital San JavierGuadalajaraJaliscoMexico Departamento de Fisiología Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMexico Departamento de Biología Molecular y Genomica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMexico Departamento de Clínicas Centro Universitario de los AltosUniversidad de GuadalajaraTepatitlan de MorelosJaliscoMexico Departamento de Clínicas Medicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMexico Servicio de Hemato-Oncología Pediatrica Hospital Civil de Guadalajara“Dr.Juan I.Menchaca”GuadalajaraJaliscoMexico Hospital Civil de Guadalajara“Fray Antonio Alcalde” GuadalajaraJaliscoMexico

Objectives:To determine whether air pollution or changes in SARS-CoV-2 lineages lead to an increase in ***:Descriptive statistics were used to calculate rates of infection(2020-2021).RT ePCR was used to compare viral loads from October 2020 to February *** sequencing(NGS)(n=92)was used to examine and phylogenetically map SARS-CoV-2 lineages.A correlative“air pollution/temperature”index(I)was developed using regression ***_(2.5),PM_(10),O_(3),NO_(2),SO_(2),and CO concentrations were analyzed and compared to the ***:The mortality rate during the last year was~32%.Relative SARS-CoV-2 viral loads increased in December 2020 and January *** revealed that approximately 80%of SARS-CoV-2 linages were B.1.243(33.7%),B1.1.222(11.2%),B.1.1(9%),B.1(7%),B.1.1.159(7%),and B.1.2(7%).Two periods were analyzed,the prehigh-and high-mortality periods and no significant lineage differences or new lineages were *** correlations of air pollution/temperature index values with mortality were found for IPM_(2.5) and IPM_(10).INO_(2).ISO_(2),and ICO but not for O_(3).Using ICO,we developed a model to predict mortality with an estimated variation of~±5 deaths per day.

关键词： Air pollution COVID-19 Guadalajara Mexico SARS-CoV-2 SARS-CoV-2 lineages

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Anterior and Posterior Approach Results for Treatment of Cervical Myelopathy in the Elderly: A 10-Year Experience in a Mexican Institution

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Open Journal of Orthopedics 2021年第7期11卷 207-219页

作者： Mauricio Daniel Sánchez-Calderón María Elena Córdoba-Mosqueda José Ramón Aguilar-Calderón Carlos René Domínguez-Herz Diego Ochoa-Cacique Daniel Alejandro Vega-moreno Victor Andrés Reyes-Rodriguez Ulises García-González abraham Ibarra-de la Torre Rodrigo Efraín Hernández-Reséndiz Department of Neurosurgery Hospital Central Sur de Alta Especialidad de Alta Especialidad de PEMEX Periferico sur 4091 Fuentes del Pedregal Tlalpan México City México Department of Neurosurgery Hospital Regional de Alta Especialidad “Centenario de la Revolución Mexicana” ISSSTE Cuernavaca Palo Escrito Emiliano Zapata Department of Neurosurgery Hospital Central Norte PEMEX Mexico City México Department of Neurosurgery Hospital &Aacute ngeles Clí nica Londres Mexico City Mexico

Introduction: Degeneration of the cervical spine (CDSD) prevalence is nearly 90% by the 7th decade. This is the first research that compares the outcomes between the Anterior Approach (AA) and Posterior Approach (PA) to cervical myelopathy (CM) in the elderly. Materials and Methods: A retrospective observational study of electronic health records at the Hospital Central Sur de Alta Especialidad (HCSAE), PEMEX from January 2010 to May 2020 with patients older than 60 years submitted to cervical surgery. For the analysis we elaborated two groups according to the surgical approach: AA vs PA;we analyzed the trans-operative behavior, the immediate outcome, and after 3 months, 6 months, and 1 year. Results: As a total of 145 patients, the prevalence of CM in elderly was the 63.8% with a median age of 69 (64 - 75) years. We found statistical differences in strength outcome only in the P3m (p = 0.011), for sensitivity we found major prevalence of affection in the PA group. We didn’t report a significant difference in the Neck Disability Index (NDI) at all measures, but the PA presented a major incapacity. The Nurick scale results were significant in all stages (p . Discussion: Patients show significant improvements in outcome measures with either anterior or posterior surgery. Both approaches are highly efficacious in preventing neurolo

关键词： Cervical Spine Surgical Approach Elderly Cervical Myelopathy Cervical Degenerative Spine Disease

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