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Inferring gene regulatory networks by PCA-CMI using Hill climbing algorithm based on MIT score and SORDER method

International Journal of Biomathematics 2016年第3期9卷 139-156页

作者： Rosa Aghdam MohsenAlijanpour Mehrdad Azadi Ali Ebrahimi Changiz Eslahchit abolfazl rezvan Institute for Research in Fundamental Sciences (IPM) Iran Department of Mathematics and Computer ScienceAmirkabir University of Technology Tehran Iran Department of Mathematics Faculty of Mathematical SciencesCentral Tehran Branch Islamic Azad University Tehran Iran Department of Mathematics Faculty of Mathematical Science Shahid Beheshti University Tehran Iran Department of Computer Science Faculty of Mathematical Sciences Shahid Beheshti University Tehran Iran

Inferring gene regulatory networks （GRNs） is a challenging task in Bioinformatics. In this paper, an algorithm, PCHMS, is introduced to infer GRNs. This method applies the path consistency （PC） algorithm based on conditional mutual information test （PCA-CMI）. In the PC-based algorithms the separator set is determined to detect the dependency between variables. The PCHMS algorithm attempts to select the set in the smart way. For this purpose, the edges of resulted skeleton are directed based on PC algorithm direction rule and mutual information test （MIT） score. Then the separator set is selected according to the directed network by considering a suitable sequential order of genes. The effectiveness of this method is benchmarked through several networks from the DREAM challenge and the widely used SOS DNA repair network of Escherichia coll. Results show that applying the PCHMS algorithm improves the precision of learning the structure of the GRNs in comparison with current popular approaches.

关键词： Inferring gene regulatory networks Bayesian network PC algorithm conditional mutual independent test MIT score.

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Numerical simulation of fatigue crack propagation in heterogeneous geomaterials under varied loads using displacement discontinuity method

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 702-716页

作者： rezvan Alizadeh Mohammad Fatehi Marji abolfazl Abdollahipour Mehdi Pourghasemi Sagand Department of Mining and Metallurgical Engineering Faculty of EngineeringYazd UniversityYazdIran School of Mining Engineering College of EngineeringUniversity of TehranTehranIran

Heterogeneous brittle geomaterials are highly susceptible to cyclic *** contain inherent flaws and cracks that grow under fatigue loads and lead to *** study presents a numerical model for analyzing fatigue in these materials based on the two-dimensional(2D)boundary element method and linear elastic fracture *** process is formulated by coupling the displacement discontinuity method with the incorporation technique of dissimilar regions and the governing equations of *** heterogeneous media are assumed to consist of materials with different properties,and the interfaces are assumed to be completely *** addition,the domains include multiple cracks exposed to constant and variable amplitude cyclic *** stress intensity factor is a crucial parameter in fatigue analysis,which is determined using the displacement field around crack *** incremental crack growth scheme is applied to calculating the fatigue *** growth rate values are employed to estimate the length of crack extension when there are multiple *** interaction between cracks is considered,which also includes the coalescence ***,various structures under different cyclic loads are examined to evaluate the accuracy of this *** results demonstrate the efficiency of the proposed approach in modeling fatigue crack growth and life *** behavior of life curves for the heterogeneous domain was as *** curves illustrate the breakpoints caused by utilizing discrete incremental life *** these points,the trend of the curves changed with the material properties and fatigue characteristics of the new material around the crack tips.

关键词： Fatigue life Crack coalescence Interface Incorporation technique Variable amplitude loading

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