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Chinese Journal of Chemical Engineering 2024年第5期69卷 34-46页

作者： Jun Qiu Lu-ri bao Wei Guo Ying Yang Shu-Ying Sun National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China

Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of *** study investigated the feasibility of using manganese-based ion sieves to adsorb and extract lithium from gas-produced *** we focused on the applicability of two different granulation methods,extrusion and droplet,in gas-produced water *** types of H_(1.33)Mn_(1.67)O_(4) particles were prepared by the extrusion method(EHMO)and the droplet method(DHMO).The porosity of DHMO was much higher than that of EHMO,and the adsorption performance of DHMO increased with the decrease of binder *** prepared with a binder concentration of 0.14 g·ml^(-1)exhibited the best adsorption performance in gas-produced water,and the Li^(+)adsorption capacity could reach 25.14 mg·g^(-1).In gas-produced water,the adsorption equilibrium of DHMO only took 9 h,and the adsorption process conformed to the Langmuir model and pseudo-second-order kinetic *** pore diffusion model(PDM)could well describe its adsorption ***,DHMO showed a great selectivity to Li^(+),and the selectivity order of DHMO in gas-produced water was Li^(+)>ba^(2+)>>Mg^(2+),Ca^(2+),Sr^(2+)>>Na^(+)>>K^(+).After 20 cycles,the Li^(+)adsorption capacity was still higher than 17.30 mg·g^(-1),and the rate of manganese dissolution was less than 1%.

关键词： Gas-produced water Granulation Li_(1.33)Mn_(1.67)O_(4)

协日嘎-4味散成分组成分析及6种成分含量测定

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中成药 2024年第1期46卷 14-22页

作者：李君王跃武张谦翠平叶日贵吉日木巴图内蒙古医科大学药学院内蒙古呼和浩特010110 内蒙古医科大学新药筛选工程研究中心内蒙古呼和浩特010110 内蒙古医科大学民族医药创新中心内蒙古呼和浩特010110

目的分析协日嘎-4味散成分组成,并测定黄柏碱、绿原酸、栀子苷、小檗碱、芦丁、姜黄素的含量。方法高效液相色谱-四级杆/静电场轨道阱高分辨质谱(HPLC-Q-Exactive-MS)定性分析采用Agilent ZORbaX SB-Aq色谱柱(4.6 mm×150 mm,5μm);流... 详细信息

目的分析协日嘎-4味散成分组成,并测定黄柏碱、绿原酸、栀子苷、小檗碱、芦丁、姜黄素的含量。方法高效液相色谱-四级杆/静电场轨道阱高分辨质谱(HPLC-Q-Exactive-MS)定性分析采用Agilent ZORbaX SB-Aq色谱柱(4.6 mm×150 mm,5μm);流动相甲醇-0.1%甲酸,梯度洗脱;体积流量0.35 mL/min;柱温35℃;电喷雾离子源;正负离子扫描。高效液相色谱串联三重四级杆质谱(HPLC-MS/MS)定量分析采用Shim-pack GIST-HP C_(18)色谱柱(2.1 mm×100 mm,3μm);流动相甲醇-0.1%甲酸;体积流量0.25 mL/min;柱温35℃;电喷雾离子源;正负离子扫描;多反应监测模式。结果共鉴定出65种成分,包括19种生物碱、13种有机酸、13种黄酮、7种姜黄素、6种环烯醚萜、4种脂肪酸、2种醛、1种氨基酸。6种成分在各自范围线性关系良好(r≥0.9991),平均加样回收率96.44%~102.37%,RSD 2.05%~3.74%。结论本研究可为协日嘎-4味散的质量控制提供参考。

关键词：协日嘎-4味散成分组成化学成分含量测定高效液相色谱-四级杆/静电场轨道阱高分辨质谱(HPLC-Q-Exactive-MS) 高效液相色谱串联三重四级杆质谱(HPLC-MS/MS)

治疗早期阿尔茨海默病的潜在药物:Donanemab注射液

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中国临床药理学杂志 2024年第9期40卷 1372-1374页

作者：敖日格勒宝力高万全白国柱呼格吉乐巴图内蒙古民族大学附属医院中西医结合普外科内蒙古通辽028000 内蒙古民族大学附属医院中西医结合心内科内蒙古通辽028000 内蒙古民族大学附属医院中西医结合脑病科内蒙古通辽028000

Donanemab注射液是一种突破性Aβ靶向新药,针对抗β淀粉样蛋白的抗体药物,主要适用于早期阿尔茨海默病。临床前研究发现其能改善海马和大脑皮质层的淀粉样蛋白沉积情况,临床试验显示其能调节认知能力和日常生活活动能力方面问题。本文对... 详细信息

Donanemab注射液是一种突破性Aβ靶向新药,针对抗β淀粉样蛋白的抗体药物,主要适用于早期阿尔茨海默病。临床前研究发现其能改善海马和大脑皮质层的淀粉样蛋白沉积情况,临床试验显示其能调节认知能力和日常生活活动能力方面问题。本文对Donanemab注射液目前存在的研究进行介绍,以期增强对前沿新药的认识。

关键词：阿尔茨海默病 Donanemab注射液早期症状

More common RNAemia in the early stage of severe SARS-CoV-2 BF.7.14 infections in pediatric patients

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Biosafety and Health 2024年第1期6卷 5-11页

作者： Yu Sun Runan Zhu Yang Pan ri De Shuang Liu Liping Jia Bing Lv Xiaoyun Li Dongmei Chen Yao Yao Dong Qu Daitao Zhang Linqing Zhao Laboratory of Virology Bejing Key Laboratory of Etiology of Viral Diseases in ChildrenCapital Institute of PediatricsBejing 100020China Institute for Infectious Disease and Endemic Disease Control Bejing Center for Disease Control and Prevention Beijing 100013China Department of Intensive Care Unit Affiliated Children's Hospital of Capital Institute of PediatricsBeijing 100020China

The risk factors of severe infections in children during the severe acute respiratory syndrome coronavirus 2(SARS‐CoV‐2)outbreak in Beijing remain ***‐CoV‐2‐positive children admitted to the intensive care unit(ICU)with collected plasma specimens were enrolled and screened for common pathogens using capillary electrophoresis‐based multiplex PCR from December 12,2022,to January 24,*** SARS‐CoV‐2 subvariants were identified using next‐generation *** was positive for two(positive;P),one(suspicious;S),or no(negative;N)SARS‐CoV‐2 genes were classified as plasmatic RNA‐positive(RNAemia;P+S)or without RNAemia(N).Clinical and laboratory data of the enrolled cases were then collected and *** 34 enrolled children included 26 males and 24 younger than three *** were negative for other respiratory ***.7.14(18/29)was the predominant *** loads in respiratory specimens,hours from symptom onset to the first respiratory specimen collection(time‐variable),with comorbidities and BF.7.14 and ba.5.2 distributions were significantly different in P vs.N and RNAemia *** RNAemia *** most cases,the T lymphocyte ratios decreased,while the cytokine level and the B lymphocyte ratio *** time variables were 2.22±2.05 and 4.00±2.49 days in BF.7.14 and ba.5.2 infections,*** conclusion,SARS‐CoV‐2 was more likely to cause severe infections among males aged≤3 years old with comorbidities during the SARS‐CoV‐2 outbreak in Beijing,while RNAemia is more common in children at the early stage of severe BF.7.14 infections,and most had high cytokine levels and B‐cell activation.

关键词： Severe SARS‐CoV‐2 infection Pediatric patients risk factor RNAemia BF.7.14

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涂挂法电磁改性水泥基复合材料的吸波性能

华南理工大学学报（自然科学版） 2013年第2期41卷 135-140页

作者：国爱丽高日巴恒静北京交通大学土木建筑工程学院北京100044 哈尔滨工业大学土木工程学院黑龙江哈尔滨150090

为了获得具有吸波性能的水泥基复合材料,首先,采用涂挂法对闭孔珍珠岩和粉煤灰漂珠表面进行电磁改性.然后,通过测量各改性珍珠岩和粉煤灰漂珠与水泥基材料复合后材料的电磁波反射率,获得了吸波效果稳定的涂挂材料比例.最后,对比研究了... 详细信息

为了获得具有吸波性能的水泥基复合材料,首先,采用涂挂法对闭孔珍珠岩和粉煤灰漂珠表面进行电磁改性.然后,通过测量各改性珍珠岩和粉煤灰漂珠与水泥基材料复合后材料的电磁波反射率,获得了吸波效果稳定的涂挂材料比例.最后,对比研究了改性珍珠岩水泥基复合材料和石墨(或铁氧体)复合水泥基材料在S～C波段和X～Ku波段的电磁波反射率,并通过扫描电镜观测改性珍珠岩的微观结构.结果表明:石墨和铁氧体在连续釉化面与特殊蜂窝结构相间的珍珠岩颗粒表面分布均匀,形成有效谐振腔吸波体;涂挂法改性闭孔珍珠岩能有效提高水泥基材料的吸波性能,拓宽-10dB带宽.

关键词：水泥基复合材料涂挂法电磁改性吸波性能闭孔珍珠岩粉煤灰漂珠

The Proportional Hazards Model for Multiple Type Recurrent Gap Times

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Acta Mathematicae Applicatae Sinica 2016年第1期32卷 221-230页

作者： Ji-cai LIU Huan-bin LIU ri-quan ZHANG Department of Statistics East China Normal UniversityShanghai 200241China College of Mathematics and Computer Science Huanggang Normal University Huangzhou 438000China Department of Mathematics Shanxi Datong UniversityDatong 037009China

Recurrent events data and gap times between recurrent events are frequently encountered in many clinical and observational studies,and often more than one type of recurrent events is of *** this paper,we consider a proportional hazards model for multiple type recurrent gap times data to assess the effect of covaxiates on the censored event processes of *** estimating equation approach is used to obtain the estimators of regression coefficients and baseline cumulative hazard *** examine asymptotic properties of the proposed *** sample properties of these estimators are demonstrated by simulations.

关键词： proportional hazards model estimating equation multiple type recurrent events gap times semiparametric inference

Is convenience really king? Comparative evaluation of catastrophic costs due to tuberculosis in the public and private healthcare sectors of Viet Nam: a longitudinal patient cost study

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贫困所致传染病(英文) 2024年第2期13卷 17-28页

作者： Nguyen Hoa Binh Quang Vo Luan Nguyen Forse Rachel Jeanette Wiemers Anja Maria Christine Huynh Huy ba Dong Thuy Thi Thu Phan Yen Thi Hoang Creswell Jacob Dang Thi Minh Ha Nguyen Lan Huu Shedrawy Jad L?nnroth Knut Nguyen Tuan Dinh Van Dinh Luong Annerstedt Kristi Sidney Codlin Andrew James National Lung Hospital Ha Noi Viet Nam Friends for International TB Relief Ha Noi Viet Nam Department of Global Public Health WHO Collaboration Centre On Tuberculosis and Social Medicine Karolinska Institute Stockholm Sweden Stop TB Partnership Geneva Switzerland Pham Ngoc Thach Hospital Ho Chi Minh City Viet Nam

background In Viet Nam, tuberculosis (TB) represents a devastating life-event with an exorbitant price tag, partly due to lost income from daily directly observed therapy in public sector care. Thus, persons with TB may seek care in the private sector for its flexibility, convenience, and privacy. Our study aimed to measure income changes, costs and catastrophic cost incurrence among TB-affected households in the public and private *** Between October 2020 and March 2022, we conducted 110 longitudinal patient cost interviews, among 50 patients privately treated for TB and 60 TB patients treated by the National TB Program (NTP) in Ha Noi, Hai Phong and Ho Chi Minh City, Viet Nam. Using a local adaptation of the WHO TB patient cost survey tool, participants were interviewed during the intensive phase, continuation phase and post-treatment. We compared income levels, direct and indirect treatment costs, catastrophic costs using Wilcoxon rank-sum and chi-squared tests and associated risk factors between the two cohorts using multivariate *** The pre-treatment median monthly household income was significantly higher in the private sector versus NTP cohort (USD 868 vs USD 578;P=0.010). However, private sector treatment was also significantly costlier (USD 2075 vs USD 1313;P=0.005), driven by direct medical costs which were 4.6 times higher than costs reported by NTP participants (USD 754 vs USD 164;Private: 55% vs NTP: 52%;P=0.675). Factors associated with catastrophic cost included being a single-person household [adjusted odds ratio [(aOR=13.71; 95% confidence interval (CI): 1.36–138.14;P=0.026], unemployment during treatment (aOR=10.86; 95%CI: 2.64–44.60;Priencing TB-related stigma (aOR=37.90; 95%CI: 1.72–831.73;P=0.021).Conclusions Persons with TB in Viet Nam face similarly high risk of catastrophic costs whether treated in the

关键词： Tuberculosis Patient cost Catastrophic cost Private sector Comparative analysis Viet Nam

Two new xanthones from Lomatogonium carinthiacum

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Chinese Journal of Natural Medicines 2014年第9期12卷 693-696页

作者： ba-gen-na CHEN Yu-Lan baderihu TONG Yu-Feng Ye-ri-gui WANG Qing-Hu College of Traditional Mongolian Medicine Inner Mongolia University for Nationalities

AIM: To study the chemical constituents of Lomatogonium carinthiacum(Wulfen) Rchb. METHOD: The CHCl3-soluble fraction was separated by chromatography and the structures of the new compounds were elucidated by spectral experiments. RESULTS: Two new xanthones, 1, 8-dihydroxy-4, 5-dimethoxy-6, 7-methylenedioxyxanthone(1), 1, 4, 8-trimethoxyxanthone-6-O-β-D-glucoronyl-(1→6)O-β-D-glucoside(2) were isolated from the whole plant of Lomatogonium carinthiacum. CONCLUSION: Compounds 1 and 2 are new natural products.

关键词： dihydroxy dimethoxy glucoside elucidated separated methoxyl silica spectroscopic elucidation Gentianaceae

Investigation of Genetic Variation of B-G Gene with PCR-SSCP and RFLP in Chinese Indigenous Chickens

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Agricultural Sciences in China 2005年第8期4卷 621-628页

作者： XU ri-fu LI Kui CHEN Guo-hong QIANG-ba Yang-zong XU Hai MO De-lin LI Chang-chun FAN Bin LIU bang Laboratory of Molecular Biology and Animal Breeding College of Animal Science and Technology Huazhong Agricultural University Wuhan 430070 P.R.China Institute of Animal Science Chinese Academy of Agricultural Sciences Beijing 100094 P.R. China Department of Animal Science and Technology Yangzhou University Yangzhou 225009 P.R.China Department of Animal Husbandry and Veterinary College of Agriculture and Animal Husbandry Tibetan University Linzhi 860000 P. R. China

To reveal genetic variation of MHC B-G gene at Chinese native chickens, two PCR primer pairs were designed to hybridize specifically with conserved sequences surrounding hypervariable regions within the B-G gene and used to amplify two DNA fragments in ten Chinese indigenous chicken breeds and one introduced breed. The fragments were cloned and sequenced to assure that the expected sequences of chicken B-G gene were isolated. Of which the 189 bp fragment encompassing the most variable region within exon 2 of B-G gene was employed for PCR-SSCP assay, this method provided evidence for the presence of at least 56 B-G genotypes in the Chinese chickens sampled. It revealed a high degree of diversity in B-G genes of Chinese local breeds; particularly, high variation of B-G gene was confirmed with the presence of 48 B-G genotypes within Tibetan chicken population. Not only can the B-G genotypes be used to preliminarily screen new B-G alleles, but also they would be utilized to investigate MHC haplotypes and matched unrelated donors for bone marrow transplantation in immune researches. Another fragment of 401 bp size spanning over partial intron 1 and exon 2 of B-G gene was employed for PCR-RFLP analysis with two restriction enzymes of Msp Ⅰ and Tas Ⅰ in the breeds sampled. In this part of the gene, three novel SNPs were detected at the two restriction sites. It was more generally found the transition of two nucleotides of A294G and T295C occurred at Tas Ⅰ restriction site, and consequently led to a non-synonymous substitution of asparagine into serine at position 54 within the deduced amino acid sequence of immunoglobulin variable-region-like domain encoded by the exon 2 of B-G gene. It was observed at rare frequency that an alone mutation of A294G occurring at the site, which also caused the substitution of amino acid, asparagine 54-to-serine; and we haven＇t found only single mutation occurred at position 295 of the restriction site. At the Msp Ⅰ site, the transversion o

关键词： B-G genes PCR-SSCP assay Genetic variation Chinese indigenous chicken Genotype Allele

A comparison study of atmospheric circulations and potential vorticity anomaly between the two rapid-intensified typhoons

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Atmospheric and Oceanic Science Letters 2018年第6期11卷 481-490页

作者： Xi-ba TANG Fan PING Shuai YANG Meng-Xia LI Jing PENG Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Plateau Atmosphere and Environment Key Laboratory of Sichuan Province ChengdouChina Center of Ecological Meteorology and Satellite Remote Sensing Henan Institute of Meteorological ScienceZhengzhouChina Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

For two rapid-intensification typhoons-Mujigae(2015)and Vicente(2012)-the atmospheric circulation conditions and potential vorticity(PV)anomaly are *** similar in their rapid-intensification(ri)rate,their atmospheric circulation conditions differ considerably,with the absence or presence of an upper-tropospheric inverted trough(IT)being their main *** IT provides useful clues for the onset of ri,by estimating the interaction between the environmental upper-tropospheric IT and the typhoon based on eddy momentum flux convergence *** trough–typhoon interaction is examined by comparing the PV transport process for the two *** isolated positive PV column develops vertically near Mujigae’s onset of ri,which is not influenced by synoptic-scale PV ***,for Vicente,another source-advection from a high-latitude PV reservoir along the upper-tropospheric IT-joins the built-up high-PV anomaly in favor of ri.

关键词： Rapidly intensification upper-tropospheric inverted trough potential vorticity