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Impact of Relative Dose Intensity (RDI) on Survival in Non-Metastatic Breast Cancer: Nigerian Experience

Journal of Biosciences and Medicines 2024年第7期12卷 120-131页

作者： Samira B. L. Makanjuola abiodun olaniyi popoola Mobolaji Adewale Oludara Department of Pharmacology College of Medicine Lagos State University (LASUCOM) Lagos Nigeria Department of Radiology & Oncology College of Medicine Lagos State University (LASUCOM) Lagos Nigeria Department of Surgery Lagos State Teaching Hospital (LASUTH) Lagos Nigeria

Background: This study was initiated to determine practices patterns in adjuvant chemotherapy for non-metastatic breast cancer and to examine the relationship between received dose intensity (RDI) and survival in patients with breast cancer Nigeria. Methods: Our study was a retrospective analysis of patients with breast cancer recruited from 2012 and 2015. A total of 204 patients were initially entered into the study, 102 were lost to follow-up leaving 102 patients who were suitable for the survival analysis. Survival time was calculated from 106 days, the scheduled end of chemotherapy. Results: The total average RDI for patients was 74%. Over the 204 patients that were reviewed, 144 (70.6%) had some reduction of RDI. This subgroup had an average RDI of 63%. On average, 79% of the intended dose of chemotherapy was given. The time to completion of chemotherapy was 1.33 times that specified by the protocol. Dose delays an overall reduction was mainly attributed to intolerability and financial constraints. Survival by RDI showed a significant decrease in survival rate for patients with RDI of >49% (Hazard Ratio = 3.473, 95% CI 1.21 - 9.91, P = 0.020);RDI of 50% - 59% (Hazard Ratio = 3.916, 95% CI 1.01 - 15.18, P = 0.048);RDI of 60% - 69% (Hazard Ratio = 4.462, 95% CI 1.65 - 12.03, P = 0.003) compared with patients who received an RDI of 100%. Although associated with poorer prognosis, there were no significant changes in the survival rate for patients with RDI of 70% - 79% (Hazard Ratio = 1.667, 95% CI 0.56 - 4.96, P = 0.359);RDI of 80% - 89% (Hazard Ratio = 1.620, 95% CI 0.47 - 5.53, P = 0.441);RDI 90% - 99% (Hazard Ratio = 1.590, 95% CI 0.53 - 4.73, P = 0.405) compared with patients who received an RDI of 100%. Conclusion: This study provides evidence that decreased RDI of <70% in non-metastatic breast cancer patients is strongly associated with decreased overall survival.

关键词： Breast Cancer Chemotherapy RDI Survival Rate

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Insight into Dynamics of Hydromagnetic Flow of Micropolar Fluid Containing Nanoparticles and Gyrotactic Microorganisms at Weak and Strong Concentrations of Microelements: Homotopy Analysis Method

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American Journal of Computational Mathematics 2022年第2期12卷 267-282页

作者： Olubode Kolade Koriko Adeola John Omowaye Amos Oladele popoola Tosin Oreyeni Abigail Ayooye Adegbite Emmanuel abiodun Oni Emmanuel Omokhuale Muhammad Muhammad Altine Department of Mathematical Sciences Federal University of Technology Akure Akure Nigeria Department of Mathematical Sciences Osun State University Osogbo Nigeria Department of Physical Sciences Precious Cornerstone University Ibadan Nigeria Department of Pure and Applied Physics Ladoke Akintola University of Technology Ogbomosho Nigeria Department of Mathematical Sciences Federal University Gusau Gusau Nigeria Department of Mathematics Federal University Birnin Kebbi Kalgo Nigeria

The mathematical model of bioconvection flow of micropolar fluid through a vertical surface containing nanoparticles and gyrotactic microorganisms is presented in this study. In the study, weak and strong concentrations of microstructures are explored. In the energy and concentration equations, the Catteneo-Christov diffusion models are used to explain temperature and concentration diffusions with thermal and solutal relaxation durations, respectively. The governing equations describing the fluid flow are transformed and parameterized through similarity variables. The approximate analytical solution is obtained by using Homotopy Analysis Method (HAM). The impacts of relevant parameters on the various distributions are investigated and illustrated. It is discovered that increasing the value of the micropolar parameter results in an increase in the microrotation distribution for strong concentrations of microstructures while decreasing the microrotation distribution for weak concentrations of microstructures.

关键词： Micropolar Fluid Bioconvection Gyrotactic Microorganisms Nanofluid Homotopy Analysis Method

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Level of Adherence to Cytotoxic Drugs by Breast Cancer Patients’ in Lagos State University Teaching Hospital

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Journal of Cancer Therapy 2015年第4期6卷 383-389页

作者： popoola abiodun Samira Makanjuola Sowunmi Anthonia Igwilo Adaeze Mobolaji Oludara Ibrahim Nasir Omodele Foluso Oncology Unit Department of Radiology Lagos State University College of Medicine Ikeja Nigeria Department of Pharmacology Lagos State University College of Medicine Ikeja Nigeria Department of Radiotherapy Lagos University Teaching Hospital Idiaraba Nigeria Department of Surgery Lagos State University Teaching Hospital Ikeja Nigeria

Background: Breast cancer is one of the most common malignant diseases in women and adjuvant combination chemotherapy has been shown to reduce mortality from this disease. Adherence to medical treatment is a multifaceted issue that can substantially alter the outcomes of therapy. Patient non-adherence to chemotherapy is the ultimate barrier to the treatment effectiveness. Objective: This study was carried out to determine the relationship between cancer chemotherapy adherence and breast cancer staging, patient’s perception of cancer care and patient’s socio-demographic characteristics. Material and method: This was a cross sectional study selection of respondents and was based on simple random sampling technique, 184 patients were interviewed and data was collected using a semi-structured questionnaire to obtain socio-demographic data, adherence data, and facility-related information. Results: There was a significant association between marital status and non-adherence (P?= 0.013). Both separated and single subjects had higher proportion of non-adherence compared with married subjects. Analysis of perception of chemotherapy care revealed a significant association between the satisfaction score and non-adherence, with non-adherent patients showing higher scores or being less satisfied. The quality of service (P?= 0.0052);rating of needs been met (P?= 0.0079);rating on whether the services helped the subject (P?= 0.0405);rating on the general satisfaction of the services provided (P?= 0.0115);and rating on whether subject would seek help again (P?= 0.0320) all had a significant association with non-adherence. Conclusion: The awareness of oncologist and patient of the problem of non-adherence and communication regarding the importance of adherence to therapy may improve health outcomes.

关键词： Chemotherapy Adherence Breast Cancer

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Modeling and Simulation of Hydrogen Storage Device for Fuel Cell Plant

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Journal of Chemistry and Chemical Engineering 2012年第7期6卷 604-612页

作者： Akanji Olaitan Lukman Obadele Babatunde abiodun Oluranti Sadiku-Agboola Patricia Abimbola popoola Emmanuel Rotimi Sadiku Department of Chemical & Metallurgical Engineering Faculty of Engineering and The Built Environment Tshwane University of Technology Pretoria West 0001 Pretoria South Africa Department of Mechanical Engineering Faculty of Engineering and Built Environment Tshwane University of Technology Lynrrwoodridge 0001 South Africa

The article reviews a brief literature on the modeling of hydrogen storage device for fuel cell. Different dimensional approaches in modeling hydrogen absorption/desorption in a metal hydride reactor for use in fuel cell are summarized. Mathematical modeling equations involved are also stated. The effect of various operating parameters such as temperature, concentration, viscosity, thermal conductivity and time on the gas is also verified. The importance of various simulation software with reference to their major functions is also identified. The review concludes on the opportunities and challenges with the use of hydrogen as an alternative renewable energy.

关键词：金属氢化物氢燃料电池存储设备仿真软件建模电厂可再生能源数学模型

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