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Experimental Study on Heat Storage Properties Comparison of Paraffin/Metal Foams Phase Change Material Composites

Journal of Thermal Science 2024年第2期33卷 469-478页

作者： Waqar AHMED abid hussain Hanzla SHAHID Imran ALI Hafiz Muhammad ALI Department of Mechanical Engineering University of Engineering and TechnologyTaxila47080Pakistan Department of Mechanical Engineering Institute of Space TechnologyIslamabadPakistan Department of Mechanical Mechatronics and Manufacturing EngineeringUniversity of Engineering and Technology LahoreFaisalabad CampusPunjabPakistan Mechanical Engineering Department King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Renewable Energy and Power Systems(IRC-REPS) King Fahd University of Petroleum and MineralsDhahran31261Saudi Arabia

Heat storage properties of phase change materials(PCMs) are essential characteristics that perform a key role in thermal heat energy storage *** thermal properties of PCMs can be improved by developing metal foam/PCM *** addition of metal foam in PCMs has a significant effect on the thermal characteristics of *** this paper,the heat storage properties of two different metal foam/PCM composites were experimentally *** behavior of paraffin in metal foam(copper and iron-nickel)/paraffin composites concerning pure paraffin at a constant heat flux of 1000 W/m^(2) in three directions simultaneously(x,y,and z) was *** was infiltrated into copper and iron-nickel foams to develop composite materials which resulted in enhancing the thermal conductivity of the paraffin.A comparative analysis is made on the heat storage properties of paraffin in copper and iron-nickel foams/paraffin *** temperature distribution during the phase transition process is experimentally *** comparison indicates that temperature uniformity in copper foam/paraffin composite is better than in iron-nickel foam/paraffin composite and pure paraffin at the same heat *** results show that at heat flux of 1000 W/m^(2),the heat storage time for copper foam/paraffin composite is 20.63% of that of iron-nickel foam/paraffin composite.

关键词： heat storage capacity paraffin/metal foam composite temperature uniformity heat storage rate phase transition process

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Toward sustainable waste management in small islands developing states: integrated waste-to-energy solutions in Maldives context

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Frontiers of Environmental Science & Engineering 2024年第2期18卷 133-148页

作者： Yao Wang Alejandro Ruiz-Acevedo Eemaan Rameez Vijaya Raghavan abid hussain Xunchang Fei School of Civil and Environmental Engineering Nanyang Technological University50 Nanyang AvenueSingapore 639798Singapore United Nations Office for Project Services(UNOPS) United Nations BuildingBuruzu MaguMale’20184Maldives Department of Bioresource Engineering McGill UniversitySte-Anne-De-BellevueQuebec H9X 3V9Canada Department of Civil and Environmental Engineering Carleton UniversityOttawaOntario K1S 5B6H9X 3V9Canada

Effective waste management is a major challenge for Small Island Developing States (SIDS) like Maldives due to limited land availability. Maldives exemplifies these issues as one of the most geographically dispersed countries, with a population unevenly distributed across numerous islands varying greatly in size and population density. This study provides an in-depth analysis of the unique waste management practices across different regions of Maldives in relation to its natural and socioeconomic context. Data shows Maldives has one of the highest population density and per capita waste generation among SIDS, despite its small land area and medium GDP per capita. Large disparities exist between the densely populated capital Male’ with only 5.8 km2 area generating 63% of waste and the ~194 scattered outer islands with ad hoc waste management practices. Given Male’s dense population and high calorific waste, incineration could generate up to ~30 GW/a energy and even increase Maldives’ renewable energy supply by 200%. In contrast, decentralized anaerobic digestion presents an optimal solution for outer islands to reduce waste volume while providing over 40%–100% energy supply for daily cooking in local families. This timely study delivers valuable insights into designing context-specific waste-to-energy systems and integrated waste policies tailored to Maldives’ distinct regions. The framework presented can also guide other SIDS facing similar challenges as Maldives in establishing sustainable, ecologically sound waste management strategies.

关键词： Anaerobic digestion Waste incineration Waste management Maldives Small Island Developing States Waste-to-energy

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Underestimated Methane Emissions from Solid Waste Disposal Sites Reveal Missed Greenhouse Gas Mitigation Opportunities

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Engineering 2024年第5期36卷 12-15页

作者： Yao Wang Chuanbin Zhou Ziyang Lou Houhu Zhang abid hussain Liangtong Zhan Ke Yin Mingliang Fang Xunchang Fei School of Civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Department of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Nanjing Institute of Environmental Sciences Ministry of Ecology and EnvironmentNanjing 210042China Department of Civil and Environmental Engineering Carleton UniversityOttawaON K1S 5B6Canada Ministry of Education(MOE)Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang UniversityHangzhou 310058China Department of Environmental Engineering School of Biology and the EnvironmentNanjing Forestry UniversityNanjing 210037China Department of Environmental Science and Engineering Fudan UniversityShanghai 200433China

*** Cities are responsible for approximately 70%of all anthropogenic greenhouse gas(GHG)emissions and about 60%of all anthropogenic methane(CH4)emissions[1,2].Solid waste disposal sites(including landfills and dumpsites),which are prevalent in global cities,emit CH4 generated from the anaerobic biodegradation of municipal solid waste(MSW).Notably,the proportions of CH4 emissions from disposal sites surpass 50%of the total CH4 emissions in some megalopolises[3].CH4 has a high global warming potential(GWP),being 28 times stronger than carbon dioxide(CO_(2))over a 100-year period and 80 times stronger over a 20-year period[4].Understanding and mitigating CH4 emissions from solid waste disposal sites is particularly pertinent and pressing,considering that the latest Synthesis Report from the Intergovernmental Panel on Climate Change(IPCC)emphasizes that the current pace of mitigation and adaptation policies and measures falls short of restraining global temperature rise to under 1.5℃ within the 21st century[4].More than 150 countries signed the Global Methane Pledge at the United Nations Climate Change Conference in Glasgow(COP26),which aims to reduce global annual CH4 emissions by 30%by 2030,compared with emissions in 2020[5].

关键词： landfill Solid restrain

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错失的温室气体减排机遇——被低估的生活垃圾填埋场甲烷排放量（英文）

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Engineering 2024年第5期 12-15页

作者：王曜周传斌楼紫阳张厚虎 abid hussain 詹良通殷柯方明亮费璕瑺 School of Civil and Environmental Engineering Nanyang Technological University State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Department of Environmental Science and Engineering Shanghai Jiao Tong University Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment Department of Civil and Environmental Engineering Carleton University Ministry of Education (MOE) Key Laboratory of Soft Soils and Geoenvironmental Engineering Zhejiang University Department of Environmental Engineering School of Biology and the Environment Nanjing Forestry University Department of Environmental Science and Engineering Fudan University

1. Introduction Cities are responsible for approximately 70%of all anthropogenic greenhouse gas (GHG) emissions and about 60%of all anthropogenic methane (CH4) emissions [1,2]. Solid waste disposal sites (including landfills and dumpsites), which are prevalent in global cities, emit CH4generated from the anaerobic biodegradation of municipal solid waste (MSW). Notably, the proportions of CH4emissions from disposal sites surpass 50%of the total CH4emissions in some megalopolises [3]. CH4has a high global warming potential (GWP), being 28 times stronger than carbon dioxide (CO2) over a 100-year period and 80 times stronger over a 20-year period [4]. Understanding and mitigating CH4emissions from solid waste disposal sites is particularly pertinent and pressing, considering that the latest Synthesis Report from the Intergovernmental Panel on Climate Change (IPCC) emphasizes that the current pace of mitigation and adaptation policies and measures falls short of restraining global temperature rise to under 1.5。C within the 21st century [4]. More than 150 countries signed the Global Methane Pledge at the United Nations Climate Change Conference in Glasgow (COP26), which aims to reduce global annual CH4emissions by 30%by 2030, compared with emissions in 2020 [5].

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Aptamers targeting SARS-CoV-2 nucleocapsid protein exhibit potential ant1ip1 an-coronavirus activity

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1186-1198页

作者： Minghui Yang Chunhui Li Guoguo Ye Chenguang Shen Huiping Shi Liping Zhong Yuxin Tian Mengyuan Zhao Pengfei Wu abid hussain Tian Zhang Haiyin Yang Jun Yang Yuhua Weng Xinyue Liu Zhimin Wang Lu Gan Qianyu Zhang Yingxia Liu Ge Yang Yuanyu Huang Yongxiang Zhao School of Life Science Advanced Research Institute of Multidisciplinary ScienceKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing 100081China National Clinical Research Center for infectious disease Shenzhen Third People’s HospitalSecond Hospital Affiliated to Southern University of Science and TechnologyShenzhen 518112China Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public HealthSouthern Medical UniversityGuangzhou 510515China State Key Laboratory of Targeting Oncology National Center for International Research of Biotargeting TheranosticsGuangxi Key Laboratory of Biotargeting TheranosticsCollaborative Innovation Center for Targeting Tumor Diagnosis and TherapyGuangxi Medical UniversityNanning 530021China CAMS Key Laboratory of Antiviral Drug Research Beijing Key Laboratory of Antimicrobial AgentsInstitute of Medicinal BiotechnologyChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Emerging and recurrent infectious diseases caused by human coronaviruses(HCoVs)continue to pose a significant threat to global public health *** light of this ongoing threat,the development of a broad-spectrum drug to combat HCoVs is an urgently ***,we report a series of anti-pan-coronavirus ssDNA aptamers screened using Systematic Evolution of Ligands by Exponential Enrichment(SELEX).These aptamers have nanomolar affinity with the nucleocapsid protein(NP)of Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and also show excellent binding efficiency to the N proteins of both SARS,MERS,HCoV-OC43 and-NL63 with affinity KD values of 1.31 to 135.36 *** aptamer-based therapeutics exhibited potent antiviral activity against both the authentic SARS-CoV-2 prototype strain and the Omicron variant(BA.5)with EC50 values at 2.00 nM and 41.08 nM,*** protein docking analysis also evidenced that these aptamers exhibit strong affinities for N proteins of pan-coronavirus and other HCoVs(−229E and-HKU1).In conclusion,we have identified six aptamers with a high pan-coronavirus antiviral activity,which could potentially serve as an effective strategy for preventing infections by unknown coronaviruses and addressing the ongoing global health threat.

关键词： acute threat conclusion

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mRNA-based modalities for infectious disease management

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Nano Research 2023年第1期16卷 672-691页

作者： Mengjie Zhang abid hussain Haiyin Yang Jinchao Zhang Xing-Jie Liang Yuanyu Huang School of Life Science Advanced Research Institute of Multidisciplinary ScienceSchool of Medical Technology(Institute of Engineering Medicine)Key Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China School of Materials and the Environment Beijing Institute of TechnologyZhuhai 519085China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education College of Chemistry and Environmental ScienceHebei UniversityBaoding 071002China Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology of ChinaBeijing 100190China

The novel coronavirus disease 2019(COVID-19)is still rampant all over the world,causing incalculable losses to the *** pharmaceutical organizations around the globe are focusing on vaccine research and drug development to prevent further damage caused by the *** messenger RNA(mRNA)technology has got ample of attention after the success of the two very effective mRNA vaccines during the recent pandemic of *** vaccine has been promoted to the core stage of pharmaceutical industry,and the rapid development of mRNA technology has exceeded *** COVID-19,the mRNA vaccine has been tested for various infectious diseases and undergoing clinical *** to the ability of constant mutation,the viral infections demand abrupt responses and immediate production,and therefore mRNA-based technology offers best answers to sudden *** need for mRNA-based vaccine became more obvious due to the recent emergence of new Omicron *** this review,we summarized the unique properties of mRNA-based vaccines for infectious diseases,delivery technologies,discussed current challenges,and highlighted the prospects of this promising technology in the *** also discussed various clinical studies as well preclinical studies conducted on mRNA therapeutics for diverse infectious diseases.

关键词： messenger RNA(mRNA)vaccine lipid-nanoparticle infectious disease drug delivery coronavirus disease 2019(COVID-19) virus

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A staggering rise of HIV cases in Pakistan

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Asian Pacific Journal of Tropical Medicine 2023年第3期16卷 143-144页

作者： Abdullah Riaz Muhammad Muhammad Salman abid hussain Amin Ullah Muddasir Khan Department of Health and Biological Sciences Abasyn University PeshawarKhyber PakhtunkhwaPakistan Department of Veterinary Microbiology Faculty of Veterinary SciencesChulalongkorn UniversityBangkokThailand Online Web TV and Blogging Site Mutabadil TVGermany Centre of Biotechnology and Microbiology University of PeshawarKPKPakistan

In the last decade,Pakistan has experienced multidemics of HIV in key populations,namely:injecting drug users,male sex with male,female sex workers,transgender sex workers,and *** to recent reports,in Pakistan,210000 ... 详细信息

关键词： HIV female gender

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siRNA-functionalized lanthanide nanoparticle enables efficient endosomal escape and cancer treatment

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Nano Research 2022年第10期15卷 9160-9168页

作者： Chanchan Yu Kun Li Lin Xu Bo Li Chunhui Li Shuai Guo Ziyue Li Yuquan Zhang abid hussain Hong Tan Mengyu Zhang Yongxiang Zhao Yuanyu Huang Xing-Jie Liang School of Life Science Advanced Research Institute of Multidisciplinary ScienceSchool of Medical Technology(Institute of Engineering Medicine)Key Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing 100190China National Center for International Research of Biological Targeting Diagnosis and Therapy Guangxi Key Laboratory of Biological Targeting Diagnosis and Therapy ResearchGuangxi Medical UniversityNanning 530021China

Attaching DNA/RNA to nanomaterials is the basis for nucleic acid-based assembly and drug ***,we report that small interfering RNA(siRNA)effectively coordinates with ligand-free lanthanide nanoparticles(NaGdF4 NPs),and forms siRNA/NaGdF4 spherical nucleic acids(SNA).The coordination is primarily attributed to the interaction between Gd and phosphate backbone of the ***,an efficient encapsulation and rapid endosomal escape of siRNA from the endosome/lysosome were achieved,due to its flexible ability to bound to phospholipid head of endosomal membrane,thereby disrupting the membrane *** to the dual properties of NaGdF4 NPs,siRNA loading,and endosomal escape,siRNA targeting programmed cell death-ligand 1(siPD-L1)/NaGdF4 SNA triggers significant gene silencing in vitro and in vivo,and effectively represses the tumor growth in both CT26 tumor model and 4T1 orthotopic murine model.

关键词： coordination chemistry nuclei acid lanthanide nanomaterials small interfering RNA(siRNA)delivery endosome escape

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Osteopontin targeted theranostic nanoprobes for laser-induced synergistic regression of vulnerable atherosclerotic plaques

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Acta Pharmaceutica Sinica B 2022年第4期12卷 2014-2028页

作者： Mengqi Xu Cong Mao Haoting Chen Lu Liu Yabin Wang abid hussain Sulei Li Xu Zhang Ruslan G.Tuguntaev Xing-Jie Liang Weisheng Guo Feng Cao Department of Cardiology National Clinical Research Center for Geriatric Diseases&Second Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Minimally Invasive Interventional Radiology Key Laboratory of Molecular Target&Clinical PharmacologySchool of Pharmaceutical Sciences&the Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Laboratory of Controllable Nanopharmaceuticals Chinese Academy of Sciences(CAS)Center for Excellence in Nanoscience and CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and TechnologyBeijing 100190China Department of Urology Chinese PLA General HospitalBeijing 100853China

Vulnerable atherosclerotic plaque(VASPs)is the major pathological cause of acute cardiovascular *** detection and precise intervention of VASP hold great clinical significance,yet remain a major *** therapy(PDT)realizes potent ablation efficacy under precise manipulation of laser *** this study,we constructed theranostic nanoprobes(NPs),which could precisely regress VASPs through a cascade of synergistic events triggered by local irradiation of lasers under the guidance of fluorescence/MR *** NPs were formulated from human serum albumin(HSA)conjugated with a high affinity-peptide targeting osteopontin(OPN)and encapsulated with photosensitizer IR780 and hypoxia-activatable tirapazamine(TPZ).After intravenous injection into atherosclerotic mice,the OPN-targeted NPs demonstrated high specific accumulation in VASPs due to the overexpression of OPN in activated foamy macrophages in the carotid *** the visible guidance of fluorescence and MR dual-model imaging,the precise near-infrared(NIR)laser irradiation generated massive reactive oxygen species(ROS),which resulted in efficient plaque ablation and amplified hypoxia within *** response to the elevated hypoxia,the initially inactive TPZ was successively boosted to present potent biological suppression of foamy *** therapeutic administration of the NPs for 2 weeks,the plaque area and the degree of carotid artery stenosis were markedly ***,the formulated NPs displayed excellent *** conclusion,the developed HSA-based NPs demonstrated appreciable specific identification ability of VASPs and realized precise synergistic regression of atherosclerosis.

关键词： Vulnerable atherosclerotic plaques Theranostic nanoprobe Human serum albumin Osteopontin Photodynamic therapy Hypoxia Reactive oxygen species Tirapazamine

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Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy

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Bioactive Materials 2022年第3期7卷 590-601页

作者： Chunhui Li Tongren Yang Yuhua Weng Mengjie Zhang Deyao Zhao Shuai Guo Bo Hu Wanxuan Shao Xiaoxia Wang abid hussain Xing-Jie Liang Yuanyu Huang School of Life Science Advanced Research Institute of Multidisciplinary ScienceInstitute of Engineering MedicineKey Laboratory of Molecular Medicine and BiotherapyBeijing Institute of TechnologyBeijing100081China Department of Radiation Oncology The First Affiliated Hospital of Zhengzhou UniversityErqiZhengzhou450000China Institute of Molecular Medicine College of Future TechnologyPeking UniversityBeijing100871China Chinese Academy of Sciences(CAS)Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology of ChinaBeijing100190China School of Materials and the Environment Beijing Institute of TechnologyZhuhai519085China

CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool,that relies on Cas9 protein and single guided RNA(sgRNA)to edit target ***,the lack of safe and efficient delivery carrier is one of the crucial factors restricting its clinical ***,we report an ionizable lipid nanoparticle(iLP181,pKa=6.43)based on iLY1809 lipid enabling robust gene editing in vitro and in *** iLP181 effectively encapsulate psgPLK1,the best-performing plasmid expressing for both Cas9 protein and sgRNA targeting Polo-like kinase 1(PLK1).The iLP181/psgPLK1 nanoformulation showed uniformity in size,regular nanostructure and nearly neutral zeta potential at pH *** nanoformulation effectively triggered editing of PLK1 gene with more than 30%efficiency in HepG2-Luc ***181/psgPLK1 significantly accumulated in the tumor for more than 5 days after a single intravenous *** addition,it also achieved excellent tumor growth suppression compared to other nucleic acid modalities such as siRNA,without inducing adverse effects to the main organs including the liver and *** study not only provides a clinically-applicable lipid nanocarrier for delivering CRISPR/Cas system(even other bioactive molecules),but also constitutes a potential cancer treatment regimen base on DNA editing of oncogenes.

关键词： CRISPR/Cas Gene editing Lipid nanoparticle PLK1 Cancer therapy

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