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Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India

Precision Clinical medicine 2018年第2期1卷 75-87页

作者： Archana Sharma-Oates abeer m.shaaban Ian Tomlinson Luke Wynne Jean-Baptiste Cazier Sudha Sundar Centre for Computational Biology Haworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Institute of Cancer and Genomic Sciences College of Medical and Dental SciencesHaworth BuildingUniversity of BirminghamEdgbastonBirminghamB152TTUK Department of Cellular Pathology University Hospitals Birmingham NHS Foundation TrustQueen Elizabeth Hospital BirminghamMindelsohn WayBirminghamB152THUK Pan-Birmingham Gynaecological Cancer Centre City HospitalDudley RoadBirminghamWest MidlandsB187QHUK

Breast and ovarian cancers now account for one in three cancers in Indian women and their incidence is *** differences in the clinical presentation of breast and ovarian cancers exist between India and the United *** example,Indian patients with breast cancer typically present a decade earlier than in the *** for this could be multifactorial,including differences in underlying biology,environmental risks,and other systematic factors including access to *** possible explanation lies in variable incidence or penetrance of germline mutations in genes such as BRCA1 and *** performed a methodical database and literature review to investigate the prevalence and spectrum of high-risk cancer susceptibility genes in Indian patients with breast and ovarian *** identified 148 articles,but most studies were small,with inconsistent inclusion criteria and based on heterogeneous technologies,so that mutation frequency could not be reliably *** were also often lacking on penetrance,histopathology,and survival *** filtering out unsuitable studies,only 13 remained,comprising 1028 ***-scale research studies are urgently needed to determine mutation prevalence,spectra,and clinico-pathological features,and hence derive guidelines for screening,treatment,and prevention specific to the Indian population.

关键词： BRCA1 BRCA2 hereditary cancer sporadic cancer India breast cancer ovarian cancer

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Hepatic recompensation according to Baveno VII criteria via transjugular intrahepatic portosystemic shunt

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World Journal of Gastroenterology 2024年第12期30卷 1777-1779页

作者： Hossam Eldin shaaban abeer Abdellatef Hussein Hassan Okasha Department of Internal medicine and Gastroenterology NHTMRICairo 11796Egypt Department of Internal medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

Transjugular intrahepatic portosystemic shunt is a therapeutic modality done through interventional *** is aimed to decrease portal pressure in special situations for patients with decompensated liver disease with portal *** represents a potential addition to the therapeutic modalities that could achieve hepatic recompensation in those patients based on Baveno VII criteria.

关键词： Decompensated liver cirrhosis Hepatic recompensation Baveno VII Portal hypertension

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Assembly of functional carboxymethyl cellulose/polyethylene oxide/anatase TiO_(2) nanocomposites and tuning the dielectric relaxation, optical, and photoluminescence performances

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Journal of Semiconductors 2024年第7期45卷 26-38页

作者： Asmaa m.Ismail abeer A.Reffaee Fawzy G.El Desouky Spectroscopy Department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt microwave Physics and Dielectrics Department National Research CentreDokkiCairoEgypt Solid State Physics Department Physics Research InstituteNational Research CentreGizaCairo 12622Egypt

Nanocomposite films consisting of carboxymethyl cellulose,polyethylene oxide(CmC/PEO),and anatase titanium diox-ide(TO)were produced by the use of sol-gel and solution casting ***2 nanocrystals were effectively incorporated into CmC/PEO polymers,as shown by X-ray diffraction(XRD)and attenuated total reflectance fourier transform infrared(ATR-FTIR)*** roughness growth is at high levels of TO nanocrystals(TO NCs),which means increasing active sites and defects in CmC/*** differential scanning calorimetry(DSC)thermograms,the change in glass transition temperature(Tg)val-ues verifies that the polymer blend interacts with TO *** increment proportions of TO NCs have a notable impact on the dielectric performances of the nanocomposites,as *** electrical properties of the CmC/PEO/TO nanocomposite undergo significant *** nanocomposite films exhibit a red alteration in the absorption edge as the concentration of TO NCs increases in the polymer *** decline in the energy gap is readily apparent as the weight percentage of TO NCs *** photoluminescence(PL)emission spectra indicate that the sites of the luminescence peak maximums show slight variation;peaks get wider,while their intensities decrease dramatically as the concentration of TO *** nanocomposite materials show potential for multifunctional applications including optoelectronics,antireflection coatings,pho-tocatalysis,light emitting diodes,and solid polymer electrolytes.

关键词： anatase TiO_(2) CmC/PEO nanocomposites optical photoluminescent electrical optoelectronics

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Corrigendum to:Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India

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Precision Clinical medicine 2018年第3期1卷 134-134页

作者： Archana Sharma-Oates abeer m.shaaban Ian Tomlinson Luke Wynne Jean-Baptiste Cazier Sudha Sundar 不详

This is a correction notice for article pby010(Heterogeneity of germline variants in high risk breast and ovarian cancer susceptibility genes in India;DOI:https://***/10.1093/pcmedi/pby010),published on 22 September *** authors were mistakenly listed as being affiliated with the following:‘Centre for Computational Biology,Institute of Cancer and Genomic Sciences,College of medical and Dental Sciences,Haworth Building,University of Birmingham,Edgbaston,Birmingham,B152TT,UK.’Their affiliations should instead have been given as follows.

关键词： breast cancer susceptibility

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Composite Fractional Trapezoidal Rule with Romberg Integration

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Computer modeling in Engineering & Sciences 2024年第9期140卷 2729-2745页

作者： Iqbal m.Batiha Rania Saadeh Iqbal H.Jebril Ahmad Qazza abeer A.Al-Nana Shaher momani Department of mathematics Al Zaytoonah University of JordanAmman11733Jordan Nonlinear Dynamics Research Center(NDRC) Ajman UniversityAjman 346United Arab Emirates Department of mathematics Faculty of ScienceZarqa UniversityZarqa13110Jordan Department of mathematics Prince Sattam Bin Abdulaziz UniversityAlkharj11942Saudi Arabia Department of mathematics The University of JordanAmman11942Jordan

The aim of this research is to demonstrate a novel scheme for approximating the Riemann-Liouville fractional integral *** would be achieved by first establishing a fractional-order version of the 2-point Trapezoidal rule and then by proposing another fractional-order version of the(n+1)-composite Trapezoidal *** particular,the so-called divided-difference formula is typically employed to derive the 2-point Trapezoidal rule,which has accordingly been used to derive a more accurate fractional-order formula called the(n+1)-composite Trapezoidal ***,in order to increase the accuracy of the proposed approximations by reducing the true errors,we incorporate the so-called Romberg integration,which is an extrapolation formula of the Trapezoidal rule for integration,into our proposed *** numerical examples are provided and compared with a modern definition of the Riemann-Liouville fractional integral operator to illustrate the efficacy of our scheme.

关键词： Composite fractional Trapezoidal rule Romberg integration

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The impact of chemotherapy-naïve open radical cystectomy delay and perioperative transfusion on the recurrence-free survival: A perioperative parameters-based nomogram

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Asian Journal of Urology 2024年第2期11卷 294-303页

作者： Ahmed m.Harraz Ahmed Elkarta mohamed H.Zahran Ahmed mosbah Atallah A.shaaban Hassan Abol-Enein Urology and Nephrology Center Mansoura UniversityEgypt

Objective: To develop and internally validate a nomogram to predict recurrence-free survival (RFS) including the time to radical cystectomy (RC) and perioperative blood transfusion (PBT) as potential ***: Patients who underwent open RC and ileal conduit between January 1996 to December 2016 were split into developing (n=948) and validating (n=237) cohorts. The time to radical cystectomy (TTC) was defined as the interval between the onset of symptoms and RC. The regression coefficients of the independent predictors obtained by Cox regression were used to construct the nomogram. Discrimination, validation, and clinical usefulness in the validation cohort were assessed by the area under the curve, the calibration plot, and decision curve ***: In the developing dataset, the 1-, 5-, and 10-year RFS were 83.0%, 47.2%, and 44.4%, respectively. On multivariate analysis, independent predictors were TTC (hazards ratio [HR] 1.07, 95% confidence interval [CI] 1.05-1.08, pmore units: HR 1.72, 95% CI 1.29-2.29, pmous cell carcinoma (HR 0.60, 95% CI 0.45-0.81, p=0.001), pT3-T4 (HR 1.77, 95% CI 1.41-2.22, pmph node status (HR 1.53, 95% CI 1.21-1.95, pmphovascular invasion (HR 1.28, 95% CI 1.01-1.62, p=0.044). The areas under the curve in the validation dataset were 79.3%, 69.6%, and 76.2%, for 1-, 5-, and 10-year RFS, respectively. Calibration plots showed considerable correspondence between predicted and actual survival probabilities. The decision curve analysis revealed a better net benefit of the ***: A nomogram with good discrimination, validation, and clinical utility was constructed utilizing TTC and PBT in addition to standard pathological criteria.

关键词： Radicalcystectomy Blood transfusion Time to radical cystectomy Survival Nomogram

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Optimal FOPID Controllers for LFC Including Renewables by Bald Eagle Optimizer

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Computers, materials & Continua 2022年第12期73卷 5525-5541页

作者： Ahmed m.Agwa mohamed Abdeen shaaban m.shaaban Department of Electrical Engineering College of EngineeringNorthern Border UniversityArar1321Saudi Arabia Electrical Engineering Department Faculty of EngineeringAl-Azhar UniversityCairo11651Egypt Department of Engineering Basic Science Faculty of EngineeringMenoufia UniversityShebin El-Kom32511Egypt

In this study,a bald eagle optimizer(BEO)is used to get optimal parameters of the fractional-order proportional-integral-derivative(FOPID)controller for load frequency control(LFC).SinceBEOtakes only a very short time in finding the optimal solution,it is selected for designing the FOPID controller that improves the system stability and maintains the frequency within a satisfactory range at different *** and demonstrations are carried out using *** performance of the BEOFOPID controller is evaluated using a two-zone interlinked power system at different loads and under uncertainty of wind and solar *** robustness of the BEO-FOPID controller is examined by testing its performance under varying system time *** results obtained by the BEOFOPID controller are compared with those obtained by BEO-PID and PID controllers based on recent metaheuristics optimization algorithms,namely the sine-cosine approach,Jaya approach,grey wolf optimizer,genetic algorithm,bacteria foraging optimizer,and equilibrium optimization *** results confirm that the BEO-FOPID controller obtains the finest result,with the lowest frequency *** results also confirm that the BEOFOPID controller is stable and robust at different loads,under varying system time constants,and under uncertainty of wind and solar energies.

关键词： Fractional order PID control load frequency control renewable energy bald eagle optimizer

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A Review of Rechargeable Zinc-Air Batteries:Recent Progress and Future Perspectives

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Nano-micro Letters 2024年第7期16卷 358-401页

作者： Ghazanfar Nazir Adeela Rehman Jong-Hoon Lee Choong-Hee Kim Jagadis Gautam Kwang Heo Sajjad Hussain muhammad Ikram abeer AAlObaid Seul-Yi Lee Soo-Jin Park Department of Nanotechnology and Advanced materials Engineering Hybrid Materials Research Center(HMC)Sejong UniversitySeoul 05006Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Department of Chemistry Inha UniversityIncheon 22212Republic of Korea Solar Cell Applications Research Lab Department of PhysicsGovernment College University LahoreLahore 54000 PunjabPakistan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Zinc-air batteries(ZABs)are gaining attention as an ideal option for various applications requiring high-capacity batteries,such as portable electronics,electric vehicles,and renewable energy *** offer advantages such as low environmental impact,enhanced safety compared to Li-ion batteries,and cost-effectiveness due to the abundance of ***,early research faced challenges due to parasitic reactions at the zinc anode and slow oxygen redox *** advancements in restructuring the anode,utilizing alternative electrolytes,and developing bifunctional oxygen catalysts have significantly improved *** have achieved battery reversibility over thousands of cycles,introduced new electrolytes,and achieved energy efficiency records surpassing 70%.Despite these achievements,there are challenges related to lower power density,shorter lifespan,and air electrode corrosion leading to performance *** review paper discusses different battery configurations,and reaction mechanisms for electrically and mechanically rechargeable ZABs,and proposes remedies to enhance overall battery *** paper also explores recent advancements,applications,and the future prospects of electrically/mechanically rechargeable ZABs.

关键词： Zinc-air batteries Energy storage Affordability Reversibility

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Inundative field releases and evaluation of three predators for Bemisia tabaci （Hemiptera： Aleyrodidae） management in three vegetable crops

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Insect Science 2011年第2期18卷 195-202页

作者： Alvin m. Simmons shaaban Abd-Rabou USDA ARS U.S. Vegetable Laboratory Charleston South Carolina ARC PPRI Dokki Giza Egypt

The sweetpotato whitefly, Bemisia tabaci （Gennadius）（Hemiptera： Aleyrodidae）, is a global pest on numerous crops, including vegetables. Weekly inundative releases of a coccinellid predator （Coccinella undecimpunctata L. [Coleoptera： Coccinellidae]）, a common green lacewing predator （Chrysoperla carnea Stephen [Neuroptera： Chrysopidae]）, and a mirid predator （macrolophus caliginosus [Wagner] [Hemiptera： miridae]） were independently made in three vegetable crops （cabbage [Brassica oleracea var. capitata L.], cucumber [Cucumis sativus L.], and squash [Cucurbita pepo L.]） for the management of the sweetpotato whitefly. Approximately 1 million to 2.5 million larvae or nymphs of each predator were released in the vegetable crops during 20 weeks. Whitefly populations were reduced by ≈ 25%-45% during most of the season in each crop where each predator was released. The effect of each predator was similar on whitefly population reduction. Late in the season （October） when whitefly populations were low, generally no benefit was obtained from releasing the predators. Numbers of predators recovered during sampling in all crops were greatest for C. carnea, but this corresponded with the fact that more individuals of this predator were released than any other predator in the experiment. These results help define the utility of these natural enemies for managing B. tabaci in vegetable crops.

关键词： Bemisia tabaci Chrysoperla carnea Coccinella undecimpunctata macrolophus caliginosus inundative release sweetpotato whitefly

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Preliminary evaluation of the radiotherapeutic efficacy of 131I-atorvastatin in rats with hepatocellular carcinoma

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Nuclear Science and Techniques 2020年第11期31卷 1-11页

作者： Nourihan S.Farrag abeer m.Amin Labeled Compounds Department Hot Laboratories CentreEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt

As one of the most critical types of cancer,hepatocellular carcinoma(HCC)affects many people *** study demonstrated the prospective use of atorvastatin,a drug that inhibits the mevalonate pathway,causing hypolipidemia,as a carrier to deliver the iodine-131(131I)isotope to liver tissues for HCC *** atorvastatin radioiodination method was optimized for utilizing the131I *** radiochemical quality and the in vitro stability of the generated[131I]atorvastatin were *** addition,the biodistribution experiments of[131I]atorvastatin were evaluated in both normal and HCC-induced rat models.[131I]atorvastatin was produced at a maximum radiochemical yield of 86.7±0.49%.The[131I]atorvastatin solution purified via high-performance liquid chromatography showed good in vitro stability for 12 h after *** analyses revealed remarkable liver targeting capacity of[131I]atorvastatin and good localization of131I in liver ***,the encouraging biochemical profile and histopathologicalfindings have been reported,and preliminary investigations on the possible use of[131I]atorvastatin as a radiotracer and its impact on HCC radiotherapy in rats show promise.

关键词： Hepatocellular carcinoma [131I]Atorvastatin Biodistribution Radiotherapy

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