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International Journal of Organic Chemistry 2014年第4期4卷 247-268页

作者： Reda m. Abdel-Rahman mohammed S. T. makki abeer N. Al-Romaizan Department of Chemistry Faculty of Science King Abdul Aziz University Jeddah KSA

Novel 6-(5’-fluoro-2’-diphenylphosphorylanilido)-3-hydrazino-1,2,4-trizin-5 (2H) one (3) is achieved from hydrozinolysis of the corresponding 3-thioxo-analoges 2. Compound 2 is also obtained from phosphorylation of 6-(5’-fluoro-2’-aminophenyl)-3-thioxo-1,2,4-triazin-5(2H) one (1). Novel fluorine substituted isolated and/or fused heterobicyclic nitrogen systems bearing and/or containing, 6-phosphoryl anilido-1,2,4-trizin-5 (2H) one moiety (4 - 22) have been synthesized from ring closure reactions of compound 3 with π-acceptors activated carbon compounds in different medium and conditions. Structures of the products are characterized by mS, IR, UV-VIS, CH, N, and 1H/13CNmR spectral data. The new products have been evaluated as potential inhibitors towards HIV-1 activity.

关键词： Synthesis Fluorine Phosphorus Sulfar 1 2 4-Trizinones HIV-1

Role of endoscopic ultrasound in the characterization of solid pseudopapillary neoplasm of the pancreas

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World Journal of Gastrointestinal Endoscopy 2023年第4期15卷 273-284页

作者： Katarzyna m Pawlak Nadeem Tehami Ben maher Shujaath Asif Krishn Kant Rawal Daniel Vasile Balaban mohammed Tag-Adeen Fahd Ghalim Wael A Abbas Elsayed Ghoneem Khaled Ragab mahmoud El-Ansary Shanil Kadir Sunil Amin Keith Siau Anna Wiechowska-Kozlowska Klaus mönkemüller Dalia Abdelfatah abeer Abdellatef Sundeep Lakhtakia Hussein Hassan Okasha Endoscopy Unit Department of GastroenterologyHospital of The Ministry of Interior and AdministrationSzczecin 01-218Poland Interventional Endoscopy Unit University Hospital Southampton NHS Foundation Trust3AX POUnited Kingdom Consultant Gastroenterologist AIG HospitalsHyderabad 500032India Department of Gastroenterology Prime Institute of Digestive SciencesRajkot 360001India Department of Gastroenterology Central Military Emergency University HospitalCarol Davila University of Medicine and PharmacyBucharest 010011Romania Division of Gastroenterology and Hepatology Department of Internal MedicineQena Faculty of MedicineSouth Valley UniversityQena 83511Egypt Department of Endoscopy Shefa Al-Orman HospitalLuxor 85951Egypt Interventional Endoscopy Unit Sainte Marie HospitalOSNY 95520France Department of Internal medicine Gastroenterology UnitFaculty of MedicineAssuit UniversityAssuit 71511Egypt Department of Gastroenterology and Hepatology Faculty of MedicineMansoura UniversityMansoura 35511Egypt Department of Hepatology and Gastroenterology Theodor Bilharz Research InstituteGiza 12511Egypt Department of Hepatology&Gastroenterology Theodor Bilharz Research InstituteGiza 12511Egypt Department of Gastroenterology Liaquat National Hospital&Medical CollegeKarachi 75900Pakistan

BACKGROUND Solid pseudopapillary neoplasm(SPN)is an uncommon pathology of the pancreas with unpredictable malignant *** ultrasound(EUS)assessment plays a vital role in lesion characterization and confirmation of the tissue ***,there is a paucity of data regarding the imaging assessment of these *** To determine the characteristic EUS features of SPN and define its role in preoperative *** This was an international,multicenter,retrospective,observational study of prospective cohorts from 7 large hepatopancreaticobiliary *** cases with postoperative histology of SPN were included in the *** collected included clinical,biochemical,histological and EUS *** One hundred and six patients with the diagnosis of SPN were *** mean age was 26 years(range 9 to 70 years),with female predominance(89.6%).The most frequent clinical presentation was abdominal pain(80/106;75.5%).The mean diameter of the lesion was 53.7 mm(range 15 to 130 mm),with the slight predominant location in the head of the pancreas(44/106;41.5%).The majority of lesions presented with solid imaging features(59/106;55.7%)although 33.0%(35/106)had mixed solid/cystic characteristics and 11.3%(12/106)had cystic *** was observed in only 4(3.8%)*** pancreatic duct dilation was uncommon,evident in only 2 cases(1.9%),whilst common bile duct dilation was observed in 5(11.3%)*** patient demonstrated a double duct sign at *** and Doppler evaluation demonstrated inconsistent appearances with no emergence of a predictable *** guided biopsy was performed using three different types of needles:Fine needle aspiration(67/106;63.2%),fine needle biopsy(37/106;34.9%),and Sonar Trucut(2/106;1.9%).The diagnosis was conclusive in 103(97.2%)***-seven patients were treated surgically(91.5%)and the post-surgical SPN diagnosis was confirmed in all *** the 2-year

关键词： Solid pseudopapillary neoplasm SPN Frantz tumor Endoscopic ultrasound features EUSguided biopsy Fine needle aspiration/biopsy

Evaluation of Environmental Requirements for Sustainable Ready-mix Concrete Production in Abu Dhabi Emirate

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Journal of Environmental Protection 2014年第4期5卷 333-339页

作者： Ghanim Kashwani abeer Sajwani muhammad Al Ashram Rahma Al Yaaqoubi Abu Dhabi Company for Onshore Oil Operations Abu Dhabi UAE Department of Civil Engineering American University of Sharjah Sharjah UAE RTI-International Abu Dhabi UAE

Sustainability is the main concern for current and future construction projects in the world. In any project, attaining sustainability requires the integrity of four main elements. These elements cover economical, societal, cultural, and environmental aspects to its successful implementation and integration in an anthropogenic framework. Concrete is one of the main building materials used in current construction activities around the world;therefore, many issues pertaining to concrete long term sustainability arise. This makes issues related to environmental evaluation and assessment for the ready-mix concrete production process of vital importance. The release of particulate matter (Pm) including Pm10 and Pm2.5 could be considered the main air pollutant that is emitted from this industrial sector;where Pm can be released from different stages of ready-mix concrete production process. Another concern arising from the ready-mix concrete operations which may affect the soil and ground water quality is the spills or leaks that may occur from the storage containers used for diesel, motor oil, and chemical admixture. In 2010, Environmental Agency-Abu Dhabi (EAD) collected data pertaining to the operations of 73 ready-mix concrete facilities in the Emirate of Abu Dhabi. The data showed that the average production rate of concrete is around 250,000 m3/year, which indicates that the concrete industry is a very active industry in the Emirate. Hence, EAD has established a set of plans and requirements to minimize the environmental impacts of concrete production on the environment and public health. The environmental impact of the concrete manufacturing can be reduced by conserving use of raw material ingredients, conserving energy consumption, and following Best management Practices (BmPs) related to readymix concrete production. In this paper, a variety of BmPs are presented for ready-mix concrete manufacturing facilities in Abu Dhabi. These BmPs cover the following areas: r

关键词： Sustainability Environmental Impacts Air Quality Best management Practices

Insulin Resistance, Visceral Adiposity Index and TyG Index in Genotype-4 Chronic HCV Patients and Their Relation to Hepatic Histopathology

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Open Journal of Gastroenterology 2016年第10期6卷 249-264页

作者： Eman A. Sabet Asmaa N. mohammad Laila m. Yousef Ahmed R. H. Ahmed abeer Sheneef Department of Internal medicine Faculty of Medicine Sohag University Sohag Egypt Department of Tropical medicine and Gastroenterology Faculty of Medicine Sohag University Sohag Egypt Department of Clinical Pathology Faculty of Medicine Sohag University Sohag Egypt Department of Pathology Faculty of Medicine Sohag University Sohag Egypt Department of medical microbiology and Immunology Faculty of Medicine Sohag University Sohag Egypt

Introduction: Hepatitis C virus (HCV) genotype 4 is the most prevalent in Egypt. Vis-ceral adiposity index (VAI) and (TyG) index are newly developed indices for assess-ment of metabolic syndrome (mS) and insulin resistance (IR). We aimed at comparing their levels in HCV-patients with healthy controls and validate their use for prediction of hepatic histopathological changes. Patient and methods: 78 chronic HCV-infected patients proven by PCR, viral genotyping and hepatic histopathology, and 67 healthy controls were enrolled. Presence of mS, Homeostasis model Assessment for IR esti-mation (HOmA-IR), TyG index, and VAI were assessed. Results: HOmA-IR, TyG and frequency of mS were significantly higher in patients’ group (p p p = 0.002). Conclusion: HCV genotype 4 is significantly associated with mS and increased values of HOmA IR and TyG index. TyG index and VAI are valuable simple indices that could predict the histopathological changes in Egyptian CHC pa-tients.

关键词： HCV IR TyG VAI Steatosis Genotype 4

Study Bacteriocin Production and Optimization Using New Isolates of <i>Lactobacillus</i>spp. Isolated from Some Dairy Products under Different Culture Conditions

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Food and Nutrition Sciences 2013年第3期4卷 342-356页

作者： Hoda mahrous abeer mohamed m. Abd El-mongy A. I. El-Batal H. A. Hamza menoufiya University Shibin El Kom Egypt National Center for Radiation Research and Technology Cairo Egypt

Lactobacilli belong to the group of lactic acid bacteria (LAB), that have several distinguished abilities such as production of lactic acid, enzymes such as β-Galactosidase and natural antimicrobial substances called bacteriocins. Bacteriocin is a biopreservative agent potential of suppressing growth of some contaminant bacteria in food industry but its commercial availability is limited and costly. The study aimed to select isolates of Lactobacillus spp. potential for producing bacteriocins to suppress the growth of Escherichia coli ATCC 25922 and Bacillus subtilis NCIB3610, and to optimize the process of bacteriocin production. Results obtained in this study showed that L. acidophilus isolate CH1 was selected as the best candidate for bacteriocin among the four isolates that tested. The largest amounts of the bacteriocins were synthesized only in mRS medium was supplemented with K2HPO4 (1.0%), Tween 80 (1%), Beef extract (1%), glucose, cyctein and peptone extract (1%). The optimization of culture conditions for bacteriocin production areas showed that corn steep liquor medium was the best medium for all isolates against Bacillus subtilis while no effect was observed on Escherichia coli ATCC 25922 except when used mRS medium. The optimum conditions for bacteriocin production were pH 6.0, temperature 34?C with 4% Phenyl acetamide showing the greatest growth inhibition areas.

关键词： Lactobacillus acidophilus Lactic Acid Bacteria Bacteriocins Production

Combination of Paracetamol and the Glutathione Depleting Agent Buthionine Sulfoximine Show Differential Effect on Liver Cancer Cells and Normal Hepatocytes

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Pharmacology & Pharmacy 2016年第11期7卷 443-458页

作者： marwa E. Sayour Rania m. Abd El Salam mohamed F. Elyamany abeer m. El Sayed Raafat A. El-Awady National Cancer Institute Cairo University Cairo Egypt Department of Pharmacology & Toxicology Faculty of Pharmacy Cairo University Cairo Egypt Department of Pathology National Cancer Institute Cairo University Cairo Egypt Sharjah Institute for medical Research and College of Pharmacy University of Sharjah Sharjah UAE

Background: Paracetamol exerts toxic effects on liver cells through its metabolism into N-acetyl-p-benzoquinone imine (NAPQI), which is detoxified by conjugation with cellular glutathione (GSH). Once GSH is depleted, NAPQI stimulates a range of oxidative reactions that result in cell necrosis. The aim of the present investigation is to find a new strategy that would selectively protect normal hepatic tissues and sensitize liver cancer cells to the toxic effects of paracetamol or its metabolite. This may lead to the development of a targeted therapy for liver cancer. methods: The anti-proliferative effects of paracetamol and buthionine sulfoximine BSO (a glutathione depleting agent) alone and in combination on the liver cancer cells HepG2 and normal rat hepatocytes were investigated by sulphorhodamine-B assay. Effects on cell cycle regulation and induction of apoptosis were tested by flow cytometry. The level of prostaglandin expression was measured by ELISA. Results: The present study showed that both agents alone or in combination have anti-proliferative effects on both cell types. Surprisingly, BSO showed a cytoprotective effects on normal hepatocytes treated with high concentrations (1.75 and 2 mm) of paracetamol. This was confirmed by cell cycle analysis that recorded decreased fraction of sub-G1 cells indicating reduction of apoptosis in normal hepatocytes. Analysis of prostaglandin E2 revealed differential effects of paracetamol on normal and liver cancer cells. A significant increase in PGE2 level over the control was observed in normal hepatocytes whereas a significant decrease was seen in HepG2 cells after treatment with paracetamol. Conclusion: These results indicate that combination of paracetamol/BSO has differential effects on liver cancer cells and normal hepatocytes, which opens the avenue for a new effective and selective combination for management of liver cancer.

关键词： Paracetamol Buthionine Sufoximine (BSO) Selective GSH Depletion HepG2 Prostaglandin E2 (PGE2)

Serratia marcescens as Opportunistic Pathogen and the Importance of Continuous monitoring of Nosocomial Infection in makah City,Saudi Arabia

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Open Journal of medical microbiology 2015年第3期5卷 107-112页

作者： Hani S.Faidah Sami S.Ashgar abeer A.A.Barhameen Hamdi m.El-Said Abdelrahman Elsawy medical microbiology Department Faculty of MedicineUmm Al-Qura UniversityMakah CitySaudi Arabia Al-Noor Specialist Hospital Makah CitySaudi Arabia Department of medical microbiology Faculty of MedicineAl-Azhar UniversityCairoEgypt

The aim of this study was to the evaluation of frequency and distribution of Serratia marcescens in the hospital departments and determination of antimicrobial resistance of the isolated strains. methods: The study included 81 Serratia marcescens strains isolated from 61 patients hospitalized in the in the different hospital wards of Al-Noor Specialist Hospital within the period from 1/11/2012 to 1/11/2013. The strains were isolated from wound swabs, blood cultures, sputum, urine culture, fluid, catheter and throat swab, wound swabs, blood cultures and cerebrospinal fluid. Results: The isolates were identified by conventional method and the results and susceptibility testing were confirmed by VITEC-2 Compact. most frequently Serratia marcescens has been implicated in ICU [21%] followed by male medical [18.5%] and emergency department [12.3%]. The resistance of Serratia strains was high, excepting imipenem (15%), meropenem (27) and the resistance was higher with ampicillin (97.5%), Cefoxitin (90%) and Tetracycline (86%). Conclusion: Continuous monitoring of nosocomial infections is indispensable. Phenotypic characterization of the isolates is useful for studying the relationship of microbial pathogens.

关键词： Serratia marcescens Antimicrobial Resistance Nosocomialİnfection

mismatch repair genes (hmLH1, hPmS1, hPmS2, GTBP/hmSH6,HmSH2) in the pathogenesis of hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第20期11卷 3020-3026页

作者： Abdel-Rahman N. Zekri Gelane m. Sabry abeer A. Bahnassy Kamal A. Shalaby Sabrin A.Abdel-Wahabh Serag Zakaria Virology and Immunology Unit Cancer Biology Department National Cancer Institute Cairo University Egypt Biochemistry Department Faculty of Science Ain Shams University Egypt Pathology Department National Cancer Institute Cairo University Egypt Tropical medicine Department El-Kaser Al-Aini School of medicine Cairo University Egypt

AIm: DNA misrnatch repair (mmR) is an impotent mechanism for maintaining fidelity of genomic DNA. Abnormalities in one or more mmR genes are implicated in the development of many cancers. We investigated the role of expression of mmR genes (hmLH1, hPmS1, hPmS2, GTBP/hmSH6, hmSH2) in hepatocellular carcinogenesis. mETHODS: We evaluated the expression level of mmR genes in 33 hepatocellular carcinoma (HCC) cases using the multiplex reverse transcription (RT) PCR assays, as well as in 16 cases of normal adjacent hepatic tissues. Β-actin gene was used as an internal control and calibrator for quantification of gene expression. RESULTS: Out of the 33 studied cases, 25 were HCV positiveand 30 (90.9%) showed reduced expression in one or more of the studied mmR genes. Reduced expression was found in hmSH2 (71.9%), hmLH1 (53.3%), GTBP (51.1%), hPmS2 (33.3%) and hPmS1 (6%). A significant correlation was found between reduced expression of hPmS2(P= 0.0069) and GTBP(P= 0.0034), hPmS2and non-cirrhosis (P= 0.0197),hmLH1 and high grade. On the other hand, 57.1%, 50%, 20%, 18.8%, and 6% of the normal tissues distant to tumors showed reduced expression of hmSH2, hmLH1, GTBP, hPmS2, and hPmS1 respectively. multivariate analysis revealed a significant correlation between the expression level of hmSH2(P= 0.008), hmLH1 (P= 0.001) and GTBP (P = 0.032)and HCC, between hPmS2, GTBP and HCVassociated HCC (P＜0.001, 0.002).CONCLUSION: Reduced expression of mmR genes seemsto play an important role in HCV-associated HCC. hPmS2 islikely involved at an early stage of hepatocarcinogenesis since it was detected in normal adjacent tissues. Reduced expression of hPmS2 provides a growth advantage and stimulates proliferation which encourages malignant transformation in non-cirrhotic HCV-infected patients via acquisition of more genetic damages.

关键词：错配基因基因修复 hmLH1 hPmS1 hPmS2 GTBP/hmSH6 hmSH2 肝细胞癌病理机制

Silent Cerebral Infarctions in Type II Diabetes mellitus Patients;Could Brain mRI Be a Routine Investigation?

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Open Journal of medical Imaging 2014年第3期4卷 112-116页

作者： mohamed Hamdy Ibrahim Taha Kamel Alloush marwa Adel shaaban mohammed Khalid Abdul Rahim mohammad Ahmad m. Saad Internal medicine Department Gulf Medical University Ajman UAE Neurology Department Faculty of medicine Ain shams University Cairo Egypt Radiology Department Fayoom University Fayoom Egypt Radiology Department Misr University for Science and Technology Cairo Egypt

Objective: To study the prevalence of silent cerebral infarction in Type II diabetes mellitus. Patients and methods: The study was a prospective on 80 patients recruited from neurology, endocrine outpatient clinics. Patients were type II diabetics as described by the American Diabetes Association, 2011 criteria. All patients underwent full metabolic profiles to diagnose diabetes mellitus and mRI brain scans to detect cerebral infarction. Results: Silent cerebral infarctions were detected in 60% of patients (48/80 patients) predominately along periventricular white matter area and subcortical areas (Basal ganglia, Thalamus). Conclusion: Asymptomatic Type II diabetes mellitus patients could have vascular cerebral changes without neurological symptoms. mRI brain scans could be recommended as routine diagnosis (if possible) for early cerebral infarct detection in type II diabetic patients.

关键词： Prevalence Silent Brain Infarction Diabetes mellitus

叶面喷施腐植酸可使地表灌溉小麦的底肥量降到最低

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叶面喷施腐植酸可使地表灌溉小麦的底肥量降到最低