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Flow Cytometric Diagnosis of Acute Leukemia and Aberrant Antigen: Sohag University Experience

Open Journal of Blood Diseases 2018年第2期8卷 37-48页

作者： elham O. Hamed abeer fakher el-deen Departments of Clinical Pathology Faculty of Medicine Sohag University Sohag Egypt

Background: Multiparameter flow cytometry is the most important method for the lineage assignment and maturational analysis of acute leukemias (AL) cells. The multi parametric immunophenotyping analysis allows the detection of aberrant antigen expression and the analysis of heterogeneity and clonality of malignant cells in AL. The aim of the work is to study the immunophenotypes of blasts from patients with AL and determine the frequency of aberrant markers. Subjects and Methods: Retrospective study to analyze immunophenotypic data of de novo 144 AL patients who were diagnosed in Clinical Pathology Department, Sohag University. Results: We found that 61.8% of AL patients were classified as acute myeloblastic leukemia (AML) while 38.9% classified as acute lymphoblastic leukemia (ALL). The commonest FAB subtype in AML group was AML-M2 (31.8%) followed by M4-M5 27.3%. As regard ALL, there were 85.7% with B-ALL and 14.3% with T-ALL. The aberrancy expressions were found in 66 of AL cases (45.8%), CD7 was the most commonly expressed lymphoid antigen in AML (25%), CD13 was the most commonly expressed myeloid antigen in ALL (39.3%). Conclusion: The multi parametric immunophenotyping analysis of AL is sufficient for diagnosis and classification of leukemia. The frequencies of

关键词： Acute Leukemia ALL AML Immunophenotyping Aberrant Markers

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Simple Red Cell Indices in Screening and Discrimination of Iron Deficiency Anemia and Beta Thalassemia Trait in Egyptian Patients

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Open Journal of Blood Diseases 2019年第1期9卷 9-19页

作者： elham O. Hamed abeer fakher el-deen Clinical Pathology Department Faculty of Medicine Sohag University Sohag Egypt

Background: The most common causes of microcytic hypochromic anemia are iron deficiency anemia (IDA) and the beta-thalassemia trait (β-TT). The aim of the work is to compare the validity of the various simple indices to differentiate between iron deficiency anemia and β-thalassemia trait. Subjects and methods: A total of 2000 individuals were screened, by complete blood picture, measurement of serum iron, serum ferritin and hemoglobin separation;224 patients were detected as having hypochromia and microcytosis. Among them 166 cases were IDA and 58 cases were β-TT. We calculated 11 discrimination indices. The number of correctly identified cases were determined, sensitivity, specificity, positive and negative predictive value and Youden’s index (YI) of each discrimination index was calculated. Results: The percentage of correctly diagnosed patients is highest for Matos and Carvalho index (MCI) (95.5%) which is closely followed by Red cell distribution width index (RDWI) (93.7%). The third high index was Green and King (GKI) (91.9%). Sensitivity, specificity of MCI for detection of IDA was found 98.8%, 87.9% respectively. For β-TT, sensitivity and specificity was found 86.2% and 98.8% respectively. The YI of MCI was found 85.9%. It is followed by RDWI;its sensitivity and specificity for detection of IDA was found 97.6%, 85.3%. For β-TT, sensitivity and specificity was found 82.7% and 97.6% respectively. The YI of RDWI was 81.6%. Conclusion: Matos and Carvalho index and RDWI are easily available automated cell-count-based indices coming out as good discriminator between IDA and β-TT in our study.

关键词： Thalassemia Trait Iron Deficiency Anemia RBC Indices

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Effect of Natural Infection with Onion Yellow Dwarf Virus （OYDV） on Yield of Onion and Garlic Crops in Egypt

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Journal of Life Sciences 2011年第8期5卷 634-638页

作者： Salah elnagar Mohamed Abdel-Kader el-Sheikh abeer Salah E1-deen Abd E1-Wahab Department of Economic Entomology and Pesticides Faculty of Agriculture Cairo University Cairo 12613 Egypt

Present work highlights, first time in Egypt, the impact of OYDV infection on crops production. Plants grown in the field were individually labelled as either apparently healthy or diseased and were marked for harvesting. The percentage of yield loss due to viral infection was determined, on the basis of the average yield parameters of the healthy plant. The natural infection with OYDV in onion and garlic fields resulted in a substantial reduction in pseudo-stem length, number of leaves, plant weight and weight of bulb as well as number and weight of cloves. Results clearly indicate the impact of natural infection with OYDV on the crop yield of infected onion and garlic plants in comparison with the virus-free （uninfected） ones. The largest reduction in the yield of infected plants occurred in Chinese garlic （Seds40） followed by （Baladi） garlic and onion Giza 20. This information suggests that measures have to be taken to prevent natural infection with OYDV into and within onion and garlic fields in order to avoid yield loss.

关键词： Onion yellow dwarf virus (OYDV) yield reduction onion garlic.

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