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Gastric antisecretory and antiulcer activity of bovine hemoglobin

World Journal of Gastroenterology 2013年第21期19卷 3291-3299页

作者： abdulrahman k al asmari Saud al Omani Ibrahim Elfaki Mohammad Tariq Ahmed al Malki Saeed al Asmary Research Center Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Department of Surgery Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Department of Gastroenterology Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Family and Community Medicine Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia

AIM: To investigate gastric antisecretory and gastro- protective activity of bovine hemoglobin (B-Hb) in rats. METHODS: Adult albino-Wistar rats were divided into groups of 6 animals each. B-Hb in doses of 100, 300 and 900 mg/kg body weight was tested for gastric acid secretion and antiulcer activity. Gastric secretions were measured 6 h after pylorus ligation in rats pretreated with B-Hb. The acidity was measured by titrating gastric contents against 0.01 mol/L NaOH to pH 7. Indomethacin ulcers were produced by oral administration of 30 mg/kg bw in the rats pretreated with B-Hb one hour before indomethacin. Six hours after indomethacin stomach removed and ulcer index was recorded. Ethanol ulcer were produced by 1 mL of ethanol in the rats pretreated with B-Hb 30 min before the *** hour after ethanol stomach were cut open to score ulcers. Histological examination and analysis of gastric wall mucus, non-protein sulfhydryl groups (NP-SH), and myeloperoxidase (MPO) were carried in gastric tissue following ethanol administration. RESULTS: In control rats pylorus ligation for 6 h resulted in the accumulation of 8.1 ± 0.61 mL of gastric secretion. The treatment of the rats with 100, 300 and 900 mg/kg of B-Hb produced a significant decrease in the volume of gastric secretion 5.6 ± 0.63, 5.5 ± 0.75 and 4.7 ± 0.58 mL respectively as compared to the control group [analysis of variance (ANOVA) F = 4.77, P kg (24.3 ± 3.29 mm2), 300 mg/kg (16.2 ± 1.45 mm2) and 900 mg/kg (12.6 ± 1.85 mm2) produced a dose dependent decreased the lesion scores (ANOVA F = 4.50, P kg (2.5 ± 0.42), 300 mg/kg (2.1 ± 0.4) and 900 mg/kg (0.7 ± 0.21) significantly inhibited the formation of gas

关键词： Bovine hemoglobin Gastric ulcers Indomethacin Ethanol Ischemic injury Rats

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Genetic association of apolipoprotein E polymorphisms with inflammatory bowel disease

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World Journal of Gastroenterology 2015年第3期21卷 897-904页

作者： Ebtissam Saleh al-Meghaiseeb Mulfi Mubarak al-Otaibi abdulrahman al-Robayan Reem al-Amro Ahmd Saad al-Malki Misbahul Arfin abdulrahman k al-asmari Department of Gastroenterology Prince Sultan Military Medical CityRiyadh 11159Saudi Arabia Research Center Prince Sultan Military Medical CityRiyadh 11159Suadi Arabia

AIM:To study the association of apolipoprotein E(APOE) polymorphisms with the susceptibility ofinflammatory bowel disease(IBD) in Saudi ***:APOE genotyping was performed to evaluate the allele and genotype frequencies in 378 Saudi subjects including IBD patients with ulcerative colitis(n = 84) or Crohn's disease(n = 94) and matched controls(n = 200) using polymerase chain reaction and reverse-hybridization ***:The frequencies of the APOE ε2 allele and ε2/ε3 and ε2/ε4 genotypes were significantly higher in IBD patients than in controls(P allele and its heterozygous genotypes may increase the susceptibility to *** the contrary,the frequencies of the ε3 allele and ε3/ε3 genotype were lower in IBD patients as compared to controls,suggesting a protective effect of APOE ε3 for *** prevalence of the ε4 allele was also higher in the patient group compared to controls,suggesting that the ε4 allele may also increase the risk of *** results also indicated that the APOE ε4 allele was associated with an early age of IBD *** effect of gender or type of IBD(familial or sporadic) on the frequency distribution of APOE alleles and genotypes was noticed in this ***:APOE polymorphism is associated with risk of developing IBD and early age of onset in Saudi patients,though further studies with a large-size population are warranted.

关键词： Apolipoprotein E Polymorphism Inflammatory bowel d

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Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

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Unveiling the impact:COVID-19's influence on bacterial resistance in the kingdom of Bahrain

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World Journal of Virology 2025年第1期14卷 83-98页

作者： Nermin k Saeed Safiya k almusawi Noor A albalooshi Mohammed al-Beltagi Medical Microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain Medical Microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACkGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within klebsiella pneumoniae and *** *** impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key ***

关键词： Multidrug-resistant organisms Antibiotic susceptibility COVID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya Medical Complex Bahrain

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Efficacy and safety of non-vitamin k antagonist oral anticoagulants post-kidney transplantation

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World Journal of Transplantation 2019年第6期9卷 134-144页

作者： Muhammad A Bukhari abdulrahman al-Theaby Mohammed Tawhari ali al-Shaggag Ryan Pyrke Azim Gangji Darin Treleaven Christine Ribic Department of Medicine Taif UniversityTaif 26311Saudi Arabia Department of Transplantation King Abdulaziz Medical CityRiyadh 11159Saudi Arabia Department of Nephrology and Transplantation king Fahad Specialist Hospital Dammam 15215Saudi Arabia Department of Nephrology McMaster UniversityHamiltonON L8N 4A6Canada

BACkGROUND Novel oral anticoagulants(NOACs)were developed as alternatives to vitamin k antagonists,primarily warfarin,as they do not require routine monitoring and have limited drug-drug and drug-food ***,the efficacy and safety of these agents in kidney transplantation are not well *** To assess the profile and safety of NOACs for patients who had kidney transplantation,and to provide recommendations and guidelines on therapeutic strategies in these *** This was a retrospective study carried out among adult patients who were actively on the following NOACs(apixaban,rivaroxaban or dabigatran)in our renal transplantation program from December 2015 to December *** patients were identified primarily through electronic medical record system(patient data linkage).Data on the clinical and laboratory profile of the patients were retrieved and analyzed with SPSS *** Complete data on 42 renal transplant patients were retrieved:59.5%males,90.5%were whites and 66.7%were older than 60 years *** mean duration since renal transplantation of the patients was 8.8±7.4 *** most common risk factors for the development of end-stage renal disease in the subjects were hypertension(19.0%),polycystic kidney disease(19.0%),followed by diabetic nephropathy(16.7%)and chronic glomerulonephritis(16.7%).The main indications for NOACs use in the cohort were atrial fibrillation in 25 patients(59.5%)and venous thromboembolism in 10 patients(23.8%).Overall,29 patients(69%)were treated with apixaban,10 patients(23.8%)with rivaroxaban and 3 patients(7.14%)with ***(0%)thromboembolic events were observed during the one-year period,but 3(7.1%)bleeding events occurred in the cohort consisting of 1 patient treated with rivaroxaban 15 mg daily and 2 patients who received apixaban 2.5 mg twice *** were no significant changes in serum tacrolimus level three days after the initiation of NOACs among patients treated with tacrolimus(

关键词： Novel oral anticoagulants Adult patients kidney transplantation Renal outcomes Efficacy

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Design of Machine Learning Based Smart Irrigation System for Precision Agriculture

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Computers, Materials & Continua 2022年第7期72卷 109-124页

作者： khalil Ibrahim Mohammad Abuzanouneh Fahd N.al-Wesabi Amani abdulrahman albraikan Mesfer al Duhayyim M.al-Shabi Anwer Mustafa Hilal Manar Ahmed Hamza Abu Sarwar Zamani k.Muthulakshmi Department of Information Technology College of ComputerQassim UniversityAl-Bukairiyah52571Saudi Arabia Department of Computer Science King Khalid UniversityMuhayel Aseer62529Saudi Arabia&Faculty of Computer and ITSana’a UniversitySana’a61101Yemen Department of Computer Science College of Computer and Information SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11564Saudi Arabia Department of Natural and Applied Sciences College of Community-AflajPrince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Department of Management Information System College of Business and AdministrativeTaibah UniversityMedina42353Saudi Arabia Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAl-Kharj16278Saudi Arabia Department of Electronics and Communication Engineering Dr.N.G.P Institute of TechnologyCoimbatore641048India

Agriculture 4.0,as the future of farming technology,comprises numerous key enabling technologies towards sustainable *** use of state-of-the-art technologies,such as the Internet of Things,transform traditional cultivation practices,like irrigation,to modern solutions of precision *** achieve effectivewater resource usage and automated irrigation in precision agriculture,recent technologies like machine learning(ML)can be *** this motivation,this paper design an IoT andML enabled smart irrigation system(IoTML-SIS)for precision *** proposed IoTML-SIS technique allows to sense the parameters of the farmland and make appropriate decisions for *** proposed IoTML-SIS model involves different IoT based sensors for soil moisture,humidity,temperature sensor,and ***,the sensed data are transmitted to the cloud server for processing and decision ***,artificial algae algorithm(AAA)with least squares-support vector machine(LS-SVM)model is employed for the classification process to determine the need for ***,the AAA is applied to optimally tune the parameters involved in the LS-SVM model,and thereby the classification efficiency is significantly *** performance validation of the proposed IoTML-SIS technique ensured better performance over the compared methods with the maximum accuracy of 0.975.

关键词： Automatic irrigation precision agriculture smart farming machine learning cloud computing decision making internet of things

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Intelligent Deep Convolutional Neural Network Based Object DetectionModel for Visually Challenged People

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Computer Systems Science & Engineering 2023年第9期46卷 3191-3207页

作者： S.kiruthika Devi Amani abdulrahman albraikan Fahd N.al-Wesabi Mohamed k.Nour Ahmed Ashour Anwer Mustafa Hilal Department of Computing Technology SRM Institute of Science and TechnologyIndia Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversitySaudi Arabia Department of Computer Science College of Computing and Information SystemUmm Al-Qura UniversitySaudi Arabia Department of Engineering Mathematics and Physics Faculty of Engineering and TechnologyFuture University in EgyptNew Cairo11845Egypt Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

Artificial Intelligence(AI)and Computer Vision(CV)advancements have led to many useful methodologies in recent years,particularly to help visually-challenged *** detection includes a variety of challenges,for example,handlingmultiple class images,images that get augmented when captured by a camera and so *** test images include all these variants as *** detection models alert them about their surroundings when they want to walk *** study compares four CNN-based pre-trainedmodels:ResidualNetwork(ResNet-50),Inception v3,DenseConvolutional Network(DenseNet-121),and SqueezeNet,predominantly used in image recognition *** on the analysis performed on these test images,the study infers that Inception V3 outperformed other pre-trained models in terms of accuracy and *** further improve the performance of the Inception v3 model,the thermal exchange optimization(TEO)algorithm is applied to tune the hyperparameters(number of epochs,batch size,and learning rate)showing the novelty of the *** accuracy was achieved owing to the inclusion of an auxiliary classifier as a regularizer,hyperparameter optimizer,and factorization ***,Inception V3 can handle images of different *** makes Inception V3 the optimum model for assisting visually challenged people in real-world communication when integrated with Internet of Things(IoT)-based devices.

关键词： Pre-trained models object detection visually challenged people deep learning Inception V3 DenseNet-121

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Regression analysis of squeezing-induced hybrid nanofluid flow in Darcy-Forchheimer porous medium

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 193-208页

作者： k.MUHAMMAD M.SARFRAZ Department of Humanities and Sciences School of Electrical Engineering and Computer Science National University of Sciences and Technology Department of Mathematics Quaid-i-Azam University

This article presents a mathematical model addressing a scenario involving a hybrid nanofluid flow between two infinite parallel plates. One plate remains stationary, while the other moves downward at a squeezing velocity. The space between these plates contains a Darcy-Forchheimer porous medium. A mixture of water-based fluid with gold(Au) and silicon dioxide(Si O2) nanoparticles is formulated. In contrast to the conventional Fourier's heat flux equation, this study employs the Cattaneo-Christov heat flux equation. A uniform magnetic field is applied perpendicular to the flow direction, invoking magnetohydrodynamic(MHD) effects. Further, the model accounts for Joule heating, which is the heat generated when an electric current passes through the fluid. The problem is solved via NDSolve in MATHEMATICA. Numerical and statistical analyses are conducted to provide insights into the behavior of the nanomaterials between the parallel plates with respect to the flow, energy transport, and skin *** findings of this study have potential applications in enhancing cooling systems and optimizing thermal management strategies. It is observed that the squeezing motion generates additional pressure gradients within the fluid, which enhances the flow rate but reduces the frictional drag. Consequently, the fluid is pushed more vigorously between the plates, increasing the flow velocity. As the fluid experiences higher flow rates due to the increased squeezing effect, it spends less time in the region between the plates. The thermal relaxation, however, abruptly changes the temperature, leading to a decrease in the temperature fluctuations.

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Availability, Performance and Reliability Evaluation for PV Distributed Generation

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World Journal of Engineering and Technology 2019年第3期7卷 429-454页

作者： abdulrahman k. al-Sefri Abdullah M. al-Shaalan king Saud University Riyadh KSA

Nowadays, renewable energy resources play an important role in replacing conventional energy resources such as fossil fuel by integrating solar, wind and geothermal energy. Photovoltaic energy is one?of?the very promising renewable energy resources which grew rapidly in the past few years, it can be used to produce electric energy through photovoltaic process. The primary objective of the research proposed in this paper is to facilitate the increasing penetration levels of PV systems in the electric distribution networks. In this work, the PV module electrical model is presented based on the mathematical equations and was implemented on MATLAB to simulate the non-linear characteristics I-V and P-V curves with variable input parameters which are irradiance and temperature based on Riyadh region. In addition, the reliability evaluation of distribution networks, including distributed generators of solar photovoltaic (PV) with varying output power capacity is presented also. The Monte Carlo simulation algorithm is applied to test the distribution network which is RBTS Bus 2 and the same has been conducted on the original case of distribution network substation 7029 which is located at kSA Riyadh. The two distribution networks have been modified to include the PV’s distributed generators. The distributed generators contribute to supply a part of the load during normal mode and supply the entire load during component failure or failure of grid operation supply. The PV stochastic models have been used to simulate the randomness of these resources. Moreover, the study shows that the implementation and integration of renewable resources as distributed generations have improved the reliability of the distribution networks.

关键词： Renewable Resources Photovoltaic (PV) Energy Distributed Generation (DG) Distribution Networks

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Severe autoimmune hepatitis triggered by varicella zoster infection

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World Journal of Gastroenterology 2009年第8期15卷 1004-1006页

作者： Waleed k al-Hamoudi Gastroenterology and Hepatology Unit (59) Department of Medicine King Saud University PO Box 2925 Riyadh 11461 Saudi Arabia

Autoimmune hepatitis (AIH) is a chronic disease of unknown etiology that is characterized by the presence of circulatory autoantibodies and inflammatory histological changes in the liver. although the pathogenesis of AIH is not known, it is thought that, in a genetically predisposed individual, environmental factors such as viruses can trigger the autoimmune process. Herpes simplex virus, Epstein-Barr virus, measles virus, and hepatitis viruses are thought to play a role in the etiology of AIH. Proteins belonging to these viruses may be similar to the amino acid chains of different autoantigens in the liver, this causes immune cross reactions and liver tissue damage. We report a case of severe AIH following varicella zoster infection in a 23-year-old man, and speculate that, based on the molecular mimicry hypothesis, the liver damage was caused by an immune cross reaction to the viral proteins. Varicella-zoster-induced AIH has not been reported previously.

关键词： Autoimmune liver disease Varicella zoster virus Infection

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