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Towards Improving Predictive Statistical Learning Model Accuracy by Enhancing Learning Technique

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Computer Systems Science & Engineering 2022年第7期42卷 303-318页

作者： Ali Algarni Mahmoud Ragab Wardah alamri Samih MMostafa Statistics Department Faculty of ScienceKing Abdulaziz UniversityJeddah21589Saudi Arabia Information Technology Department Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Mathematics Department Faculty of ScienceAl-Azhar UniversityNaser City11884Egypt Centre of Artificial Intelligence for Precision Medicines King Abdulaziz UniversityJeddah21589Saudi Arabia Educational Technology Department Educational Graduate Studies FacultyKing Abdulaziz UniversityJeddah21589Saudi Arabia Computer Science Department Faculty of Computers and InformationSouth Valley UniversityQena83523Egypt

The accuracy of the statistical learning model depends on the learning technique used which in turn depends on the dataset’s *** most research studies,the existence of missing values(MVs)is a vital *** addition,any dataset with MVs cannot be used for further analysis or with any data driven tool especially when the percentage of MVs are *** this paper,the authors propose a novel algorithm for dealing with MVs depending on the feature selec-tion(FS)of similarity classiﬁer with fuzzy entropy *** proposed algo-rithm imputes MVs in cumulative *** candidate feature to be manipulated is selected using similarity classiﬁer with Parkash’s fuzzy entropy *** predictive model to predict MVs within the candidate feature is the Bayesian Ridge Regression(BRR)***,any imputed features will be incorporated within the BRR equation to impute the MVs in the next chosen incomplete *** proposed algorithm was compared against some practical state-of-the-art imputation methods by conducting an experiment on four medical datasets which were gathered from several databases repository with MVs gener-ated from the three missingness *** evaluation metrics of mean abso-lute error(MAE),root mean square error(RMSE)and coefﬁcient of determination(R2 score)were used to measure the *** results exhibited that perfor-mance vary depending on the size of the dataset,amount of MVs and the missing-ness mechanism ***,compared to other methods,the results showed that the proposed method gives better accuracy and less error in most cases.

关键词： Bayesian ridge regression fuzzy entropy measure feature selection imputation missing values missingness mechanisms similarity classiﬁer medical dataset

Solving Fractional Differential Equations via Fixed Points of Chatterjea Maps

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Computer Modeling in Engineering & Sciences 2023年第6期135卷 2617-2648页

作者： Nawab Hussain Saud M.Alsulami Hind alamri Department of Mathematics King Abdulaziz UniversityP.O.Box 80203Jeddah21589Saudi Arabia Department of Mathematics College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

In this paper,we present the existence and uniqueness of fixed points and common fixed points for Reich and Chatterjea pairs of self-maps in complete metric ***,we study fixed point theorems for Reich and Chatterjea nonexpansive mappings in a Banach space using the Krasnoselskii-Ishikawa iteration method associated withSλand consider some applications of our results to prove the existence of solutions for nonlinear integral and nonlinear fractional differential *** also establish certain interesting examples to illustrate the usability of our results.

关键词： Common fixed points Reich and Chatterjea mappings Krasnoselskii-Ishikawa iteration complete metric space Banach space integral equation nonlinear fractional differential equation

A Survey on the Role of Complex Networks in IoT and Brain Communication

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Computers, Materials & Continua 2023年第9期76卷 2573-2595页

作者： Vijey Thayananthan Aiiad Albeshri Hassan A.alamri Muhammad Bilal Qureshi Muhammad Shuaib Qureshi Cybersecurity Department Faculty of ComputingEngineering and ScienceUniversity of SouthWalesWalesUK Department of Computer Science Faculty of Computing and Information Technology(FCIT)King Abdulaziz UniversityJeddah21589Saudi Arabia Computer Science Department Umm Al-Qura UniversityMakkah21955Saudi Arabia Department of Computer Science&IT University of Lakki MarwatLakki Marwat28420KPKPakistan Department of Computer Engineering Chungnam National UniversityDaejeon34134Republic of Korea

Complex networks on the Internet of Things(IoT)and brain communication are the main focus of this *** benefits of complex networks may be applicable in the future research directions of 6G,photonic,IoT,brain,etc.,communication *** data traffic,huge capacity,minimal level of dynamic latency,*** some of the future requirements in 5G+and 6G communication *** emerging communication,technologies such as 5G+/6G-based photonic sensor communication and complex networks play an important role in improving future requirements of IoT and brain *** this paper,the state of the complex system considered as a complex network(the connection between the brain cells,neurons,etc.)needs measurement for analyzing the functions of the neurons during brain ***,we measure the state of the complex system through *** 5G+/6G-based photonic sensor nodes,finding observability influenced by the concept of contraction provides the stability of *** IoT or any sensors fail to measure the state of the connectivity in the 5G+or 6G communication due to external noise and attacks,some information about the sensor nodes during the communication will be ***,neurons considered sing the complex networks concept neuron sensors in the brain lose communication and ***,affected sensor nodes in a contraction are equivalent to compensate for maintaining stability *** this compensation,loss of observability depends on the contraction size which is a key factor for employing a complex *** analyze the observability recovery,we can use a contraction detection algorithm with complex network *** survey paper shows that contraction size will allow us to improve the performance of brain communication,stability of neurons,etc.,through the clustering coefficient considered in the contraction detection *** addition,we discuss the scalability of IoT communication using 5G+/6G

关键词： Complex networks emerging communication IoT based on 6G systems neuroscience photonic technology

Highly sensitive,scalable,and rapid SARS-CoV-2 biosensor based on In_(2)O_(3)nanoribbon transistors and phosphatase

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Nano Research 2022年第6期15卷 5510-5516页

作者： Mingrui Chen Dingzhou Cui Zhiyuan Zhao Di Kang Zhen Li Shahad Albawardi Shahla Alsageer Faisal alamri Abrar Alhazmi Moh.R.Amer Chongwu Zhou Mork Family Department of Chemical Engineering and Materials Science University of Southern CaliforniaLos AngelesCalifornia 90089USA Ming Hsieh Department of Electrical Engineering University of Southern CaliforniaLos AngelesCalifornia 90089USA Department of Physics and Astronomy University of Southern CaliforniaLos AngelesCalifornia 90089USA Center of Excellence for Green Nanotechnologies King Abdulaziz City for Science and TechnologyRiyadhSaudi Arabia Department of Electrical Engineering 420 Westwood Plaza5412 Boelter HallUniversity of CaliforniaLos AngelesLos AngelesCalifornia 90095USA eDNA Biotech PasadenaCalifornia 91107USA

Developing convenient and accurate SARS-CoV-2 antigen test and serology test is crucial in curbing the global COVID-19 *** this work,we report an improved indium oxide(In2O3)nanoribbon field-effect transistor(FET)biosensor platform detecting both SARS-CoV-2 antigen and *** FET biosensors,which were fabricated using a scalable and cost-efficient lithography-free process utilizing shadow masks,consist of an In_(2)O_(3)channel and a newly developed stable enzyme *** the biosensing process,the phosphatase enzymatic reaction generated pH change of the solution,which was then detected and converted to electrical signal by our In_(2)O_(3)*** biosensors applied phosphatase as enzyme reporter,which has a much better stability than the widely used urease in FET based *** proof-of-principle studies,we demonstrate the detection of SARS-CoV-2 spike protein in both phosphate-buffered saline(PBS)buffer and universal transport medium(UTM)(limit of detection[LoD]:100 fg/mL).Following the SARS-CoV-2 antigen tests,we developed and characterized additional sensors aimed at SARS-CoV-2 IgG antibodies,which is important to trace past infection and *** spike protein IgG antibody tests exhibit excellent detection limits in both PBS and human whole blood((LoD):1 pg/mL).Our biosensors display similar detection performance in different mediums,demonstrating that our biosensor approach is not limited by Debye screening from salts and can selectively detect biomarkers in physiological *** newly selected enzyme for our platform performs much better performance and longer shelf life which will lead our biosensor platform to be capable for real clinical diagnosis usage.

关键词： biosensor indium oxide transistor phosphatase SARS-CoV-2 spike protein SARS-CoV-2 spike IgG antibody

Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches

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Journal of Pharmaceutical Analysis 2020年第6期10卷 546-559页

作者： Mubarak A.alamri Muhammad Tahir ul Qamar Muhammad Usman Mirza Safar M.Alqahtani Matheus Froeyen Ling-Ling Chen Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAlkarjSaudi Arabia College of Life Science and Technology Guangxi UniversityNanningChina Department of Pharmaceutical and Pharmacological Sciences Rega Institute for Medical ResearchMedicinal ChemistryUniversity of LeuvenB-3000LeuvenBelgium Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan430070China

The papain-like protease(PLpro)is vital for the replication of coronaviruses(Co Vs),as well as for escaping innate-immune responses of the ***,it has emerged as an attractive antiviral *** this study,computational approaches were employed,mainly the structure-based virtual screening coupled with all-atom molecular dynamics(MD)simulations to computationally identify specific inhibitors of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)PLpro,which can be further developed as potential pan-PLprobased broad-spectrum antiviral *** sequence,structure,and functional conserveness of most deadly human Co Vs PLprowere explored,and it was revealed that functionally important catalytic triad residues are well conserved among SARS-Co V,SARS-Co V-2,and middle east respiratory syndrome coronavirus(MERS-Co V).The subsequent screening of a focused protease inhibitors database composed of^7,000 compounds resulted in the identification of three candidate compounds,ADM13083841,LMG15521745,and *** three compounds established conserved interactions which were further explored through MD simulations,free energy calculations,and residual energy contribution estimated by MM-PB(GB)SA *** these compounds showed stable conformation and interacted well with the active residues of SARS-Co V-2 PLpro,and showed consistent interaction profile with SARS-Co V PLproand MERS-Co V PLproas ***,the reported SARS-Co V-2 PLprospecific compounds could serve as seeds for developing potent pan-PLprobased broad-spectrum antiviral drugs against deadly human ***,the presented information related to binding site residual energy contribution could lead to further optimization of these compounds.

关键词： COVID-19 MERS-CoV Molecular dynamic simulation Pan-inhibitors Papain-like protease SARS-CoV SARS-CoV-2 Virtual screening

Delayed atomoxetine or fluoxetine treatment coupled with limited voluntary running promotes motor recovery in mice after ischemic stroke

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Neural Regeneration Research 2021年第7期16卷 1244-1251页

作者： Faisal F.alamri Abdullah Al Shoyaib Nausheen Syeara Anisha Paul Srinidhi Jayaraman Serob T.Karamyan Thiruma V.Arumugam Vardan T.Karamyan Department of Pharmaceutical Sciences School of PharmacyTexas Tech University Health Sciences CenterAmarilloTXUSA Department of Pharmacology Faculty of PharmacyYerevan State Medical UniversityYerevanArmenia Department of Physiology Anatomy and MicrobiologySchool of Life SciencesLa Trobe UniversityMelbourneAustralia Center for Blood Brain Barrier Research School of PharmacyTexas Tech University Health Sciences CenterAmarilloTXUSA College of Sciences and Health Profession King Saud bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research CenterJeddahSaudi Arabia

Currently, there is an unmet need for treatments promoting post-stroke functional *** aim of this study was to evaluate and compare the dose-dependent effect of delayed atomoxetine or fluoxetine therapy(starting on post-stroke day 5), coupled with limited physical exercise(2 hours daily voluntary wheel running;post-stroke days 9 to 42), on motor recovery of adult male mice after photothrombotic *** drugs are selective norepinephrine or serotonin reuptake inhibitors indicated for disorders unrelated to *** predetermined primary end-point for this study was motor function measured in two tasks of spontaneous motor behaviors in grid-walking and cylinder ***, we quantified the running distance and speed throughout the study, the number of parvalbumin-positive neurons in the medial agranular cortex and infarct *** sensorimotor tests revealed that neither limited physical exercise nor a drug treatment alone significantly facilitated motor recovery in mice after ***, combination of physical exercise with either of the drugs promoted restoration of motor function by day 42 post-stroke, with atomoxetine being a more potent *** was accompanied by a significant decrease in parvalbumin-positive inhibitory interneurons in the ipsilateral medial agranular cortex of mice with recovering motor function, while infarct volumes were comparable among experimental *** further validated in larger studies, our observations suggest that add-on atomoxetine or fluoxetine therapy coupled with limited, structured physical rehabilitation could offer therapeutic modality for stroke survivors who have difficulty to engage in early, high-intensity ***, in light of the recently completed Assessment o F Fluoxet INe In s Troke recover Y(AFFINITY) and Efficacy o F Fluoxetine-a randomis Ed Controlled Trial in Stroke(EFFECTS) trials, our observations call for newly designed studies where fluoxetine or atomoxeti

关键词： drug repurposing neural repair physical exercise physiotherapy post-stroke recovery pre-clinical trial FLAME trial selective norepinephrine reuptake inhibitor selective serotonin reuptake inhibitor stroke pharmacotherapy

Biosynthesis of raw starch degradingβ-cyclodextrin glycosyltransferase by immobilized cells of Bacillus licheniformis using potato wastewater

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BIOCELL 2021年第6期45卷 1661-1672页

作者： YASSER S.MOSTAFA SAAD A.alamri SULIMAN A.ALRUMMAN TAREK H.TAHA MOHAMED HASHEM MAHMOUD MOUSTAFA LAMIAA I.FAHMY Department of Biology College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Prince Sultan Bin abdulaziz Center for Environmental and Tourism Research and Studies King Khalid UniversityAbha9004Saudi Arabia Environmental Biotechnology Department Genetic Engineering and Biotechnology Research InstituteCity of Scientific Research&Technological ApplicationsNew Borg El-Arab City21934Egypt Department of Botany and Microbiology Faculty of ScienceAssiut UniversityAssiut71515Egypt Department of Botany and Microbiology Faculty of ScienceSouth Valley UniversityQena83523Egypt Department of Microbiology and Immunology Faculty of PharmacyOctober University for Modern Science and ArtGiza12451Egypta

The study was sought to enhance the synthesis of thermal stableβ-cyclodextrin glycosyltransferase(β-CGTase)using potato wastewater as a low-cost medium and assess the degree to which it is efficient for industrial production ofβ-cyclodextrin(β-CD)from raw potato *** bacteria producingβ-CGTase was isolated from Saudi Arabia and the promising strain was identified as Bacillus licheniformis using phylogenetic analysis of the 16S rRNA ***-encapsulated cultures exhibited twice-fold ofβ-CGTase production more than free *** electron microscopy(SEM)of polymeric capsules indicated the potential for a longer shelf-life,which promotes the restoration of activity in bacterial cells across semi-continuous fermentation ofβ-CGTase production for 252 *** optimal conditions forβ-CGTase synthesis using potato wastewater medium were at 36 h,pH of 8.0,and 50°C with 0.4%potato starch and 0.6%yeast extract as carbon and nitrogen sources,*** purified enzyme showed a specific activity of 63.90 U/mg with a molecular weight of∼84.6 kDa as determined by SDS-PAGE *** high enzyme activity was observed up to 60°C,and complete stability was achieved at 75°*** levels of activity and stability were shown at pH 8.0,and the pH range from 7.0–10.0,*** enzyme has an appreciable affinity for raw potato starch with a Km of 5.7×10−6 M and a Vmax of 87.71μmoL/mL/min.β-CD production was effective against 25 U/g of raw potato *** outcomes demonstrated its feasibility to develop a fermentation process by integrating the cost-effective production ofβ-CGTase having distinctive properties forβ-CD production with ecofriendly utilization of potato wastewater.

关键词： Potato wastewater Bacillus licheniformis β-CGTase 16S rDNA gene Semi-continuous fermentation β-cyclodextrin

Structural basis of SARS-CoV-2 3CL^pro and anti-COVID-19 drug discovery from medicinal plants

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Journal of Pharmaceutical Analysis 2020年第4期10卷 313-319页

作者： Muhammad Tahir ul Qamar Safar MAlqahtani Mubarak Aalamri Ling-Ling Chen College of Life Science and Technology Guangxi UniversityNanning530004PR China Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan430070PR China Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz University11323AlkarjSaudi Arabia

The recent pandemic of coronavirus disease 2019(COVID-19)caused by SARS-CoV-2 has raised global health *** viral 3-chymotrypsin-like cysteine protease(3CL^pro)enzyme controls coronavirus replication and is essential for its life cycle.3CL^pro is a proven drug discovery target in the case of severe acute respiratory syndrome coronavirus(SARS-CoV)and Middle East respiratory syndrome coronavirus(MERS-CoV).Recent studies revealed that the genome sequence of SARS-CoV-2 is very similar to that of ***,herein,we analysed the 3CL^pro sequence,constructed its 3D homology model,and screened it against a medicinal plant library containing 32,297 potential anti-viral phytochemicals/traditional Chinese medicinal *** analyses revealed that the top nine hits might serve as potential anti-SARS-CoV-2 lead molecules for further optimisation and drug development process to combat COVID-19.

关键词： Coronavirus SARS-CoV-2 COVID-19 Natural products Protein homology modelling Molecular docking Molecular dynamics simulation

Clinical Practice Guideline for the Management of Overweight and Obesity in Adults in Saudi Arabia

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International Journal of Clinical Medicine 2022年第12期13卷 590-649页

作者： Abdulrahman Alshaikh Ahmed Aljedai Assim Alfadda Abdulrahman Alrobayan Abdulwahab Bawahab Shaza Abou Ouf Ali Sultan Amani Alhozali Mohammed Bawazeer Eman Sheshah Fahad Alqahtani Hala Mosli Hussein Elbadawi Khaled alamri Khalid Alshali Mohammed Aldawish Mohammed Alsofiani Raed Aldahash Rasha Alfawaz Reem Alamoudi Wessam Jamal Hajer Almudaiheem Emad R. Issak Saud Alsifri King abdulaziz University Hospital Jeddah Saudi Arabia Ministry of Health Riyadh Saudi Arabia King Saud University Medical City Riyadh Saudi Arabia Prince Sultan Military Medical City Riyadh Saudi Arabia King Fahad General Hospital Jeddah Saudi Arabia International Medical Center Jeddah Saudi Arabia King Salman Hospital Riyadh Saudi Arabia King Fahad Medical Center Riyadh Saudi Arabia My Clinic Medical Center Jeddah Saudi Arabia King abdulaziz Medical City Riyadh Saudi Arabia Saudi Centre for Disease Prevention and Control Riyadh Saudi Arabia Aslam Center Cairo Egypt Al Hada Armed Forces Hospital Taif Saudi Arabia

Obesity and overweight are prevalent in Saudi Arabia (24.95% & 31.80%). Also, childhood obesity in the country is a challenge, with 6% - 10% of preschool and school-age children. The burden of being overweight and obese is disastrous. Therefore, the Saudi Diabetes Scientific Society constituted a team to develop a guideline. The team reviewed the local Clinical Practice Guidelines for the Prevention and Management of Obesity in Saudi Arabia;and conducted a rigorous review of relevant evidence-based scientific literature. After a thorough assessment, a consensus was reached to use the Australian guideline as the main guideline to be adapted and localized to be suitable for the Saudi people. To avoid duplication of efforts, the team adopted the grading of evidence used by the Australian guideline. The updated version was presented in a workshop, and the recommendation of the participants was included. The final draft was distributed for review, and comments were included. This document presents the result of such an effort as a local guideline.

关键词： Obesity Overweight Disease Burden Management Guideline Saudi Arabia