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肝动脉双重结扎缩扎术治疗肝脏遗传性出血性毛细血管扩张症长期观察

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中国现代普通外科进展 2020年第4期23卷 277-280页

作者： Habibullah Fitrat 慕文韬郭凌宇 abdul Qahar Saleh Sayed ismail 宁尚磊徐云飞宋勰刘兆臣陈雨信山东大学齐鲁医院肝胆外科山东济南250012 山东省立医院胃肠外科山东济南250021 郑州大学第一附属医院肝胆外科河南郑州450003

目的:探讨肝脏遗传性出血性出血性毛细血管扩张症(HHHT)行肝动脉双重结扎缩扎术治疗方法及疗效。方法:2005年7月—2011年2月对6例HHHT患者行肝动脉双重结/缩扎术,并长期随访。结果:随访5~14年后,患者临床症状、实验室指标及影像学表现... 详细信息

目的:探讨肝脏遗传性出血性出血性毛细血管扩张症(HHHT)行肝动脉双重结扎缩扎术治疗方法及疗效。方法:2005年7月—2011年2月对6例HHHT患者行肝动脉双重结/缩扎术,并长期随访。结果:随访5~14年后,患者临床症状、实验室指标及影像学表现均得到不同程度的改善。结论:肝动脉起始和入肝处的双重结扎缩扎术能够有效地降低肺动脉压,减轻肝脏的损伤,是治疗HHHT的有效方法。

关键词：遗传性出血性毛细血管扩张症,肝肝动脉双重结扎缩扎术血管畸形外科治疗

Purification and identification of novel cytotoxic oligopeptides from soft coral Sarcophyton glaucum

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2019年第1期20卷 59-70页

作者： Yixian QUAH Nor Ismaliza MOHD ismail Jillian Lean Sim OOI Yang Amri AFFENDI Fazilah ABD MANAN Lai-Kuan TEH Fai-Chu WONG Tsun-Thai CHAI Department of Chemical Science Faculty of Science Universiti Tunku Abdul Rahman Department of Biological Science Faculty of Science Universiti Tunku Abdul Rahman Centre for Biodiversity Research Universiti Tunku Abdul Rahman Department of Geography Faculty of Arts and Social Sciences University of Malaya Institute of Biological Sciences Faculty of Science University of Malaya Institute of Ocean and Earth Sciences University of Malaya Department of Biosciences Faculty of Science Universiti Teknologi Malaysia Department of Biomedical Science Faculty of Science Universiti Tunku Abdul Rahman

Globally, peptide-based anticancer therapies have drawn much attention. Marine organisms are a reservoir of anticancer peptides that await discovery. In this study, we aimed to identify cytotoxic oligopeptides from Sarcophyton glaucum. Peptides were purified from among the S. glaucum hydrolysates produced by alcalase, chymotrypsin, papain, and trypsin, guided by a methylthiazolyldiphenyl-tetrazolium bromide(MTT) assay on the human cervical cancer(HeLa) cell line for cytotoxicity evaluation. Purification techniques adopted were membrane ultrafiltration, gel filtration chromatography, solid phase extraction(SPE), and reversed-phase high-performance liquid chromatography(RP-HPLC). Purified peptides were identified by de novo peptide sequencing. From papain hydrolysate, three peptide sequences were identified: AGAPGG, AERQ, and RDTQ(428.45, 502.53, and 518.53 Da, respectively). Peptides synthesized from these sequences exhibited cytotoxicity on HeLa cells with median effect concentration(EC50) values of 8.6, 4.9, and 5.6 mmol/L, respectively, up to 5.8-fold stronger than the anticancer drug 5-fluorouracil. When tested at their respective EC50, AGAPGG, AERQ, and RDTQ showed only 16%, 25%, and 11% cytotoxicity to non-cancerous Hek293 cells, respectively. In conclusion, AERQ, AGAPGG, and RDTQ are promising candidates for future development as peptide-based anticancer drugs.

关键词： Anticancer therapy Bioactive peptide Cytotoxicity HeLa cells Sarcophyton glaucum Soft coral

Response of Yield and Related Attributes of Upland Cotton to Weather Variables

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American Journal of Plant Sciences 2017年第7期8卷 1711-1720页

作者： Kalim Ullah Muhammad Idrees Khan Zahid Mahmood Toheed Iqbal Saeed Muhammad Hafiz abdul Haq Aftab Ahmad Sabahat Hussain The PCCC Cotton Research Station Dera Ismail Khan Pakistan The PCCC Central Cotton Research Institute Multan Pakistan Agricultural Research Institute Ratta Kulachi Dera Ismail Khan Pakistan Global Change Impact Study Centre Islamabad Islamabad Pakistan

Cotton growth and development is effected by various ecological issues like temperature fluctuations, distribution and quantity of rainfall, relative humidity and winds which are the climate change attributes. A field experiment was carried out to find out the response of cotton to weather variables in terms of total variation in yield and quality. The effect of planting times and thermal temperatures (cumulative heat units) on yield of 4 cotton cultivars viz;CIM-600, CIM-616, CIM-622 & CRIS-641 was evaluated. Plants were sown on 6 planting times during the year 2015-2016 and 2016-2017 in an experiment conducted in randomized complete block design having three replications. Cotton cultivars depicted significant variances for number of bolls plant-1, boll weight and seed cotton yield. The cultivar CIM-616 depicted the highest seed cotton yield of 2083.60 kg·ha-1 on interpretation of highest bolls and boll weight. Maximum seed cotton yield was noted in planting time from 1st April to 15th April whereas early and late planting decreases the seed cotton yield on account of less accretion of cumulative heat units. Regression analysis depicted that rise of one unit (15 days) from early to optimal date (15th March to 15th April) enhanced the seed cotton yield by 93.76 kg·ha-1 (y = -93.764x2 + 521.04x + 1364). Delayed planting also reduces the seed cotton yield with the same ratio. It is therefore established that cotton must be cultivated from 1st April to 1st May to harvest good production in this type of climate.

关键词： G. hirsutum Planting Time Cumulative Heat Units Cotton Cultivars

Ethnobotanical Studies on Dwarf Palm (<i>Nannorhops ritchieana</i>(Griff.) Aitchison) and Date Palm (<i>Phoenix dactylifera</i>L.) in Dera ismail Khan, KPK, Pakistan

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American Journal of Plant Sciences 2012年第8期3卷 1162-1168页

作者： Sarfaraz Khan Marwat Khalid Usman Ejaz Ahmad Khan Said Ghulam Jalaluddin Baloch abdul Manan Tauqeer Fazal Ur Rehman Department of Economics Gomal University Dera Ismail Khan Pakistan Faculty of Agriculture Gomal University Dera Ismail Khan Pakistan Faculty of Pharmacy Gomal University Dera Ismail Khan Pakistan University WENSAM College Gomal University Dera Ismail Khan Pakistan

This paper is based on research work conducted during 2008-2010 in Dera ismail Khan (D. I. Khan) District, Pakistan, to investigate Socio-Economic Impacts of Dwarf Palm (Nannorhops ritchieana) and Date Palm (Phoenix dactylifera) on the local inhabitants. A questionnaire for data collection of Dwarf Palm was designed and local people were interviewed. The main Dwarf Palm (Mazri) areas are lying between the Koh-i-Surkh and Marwat hill and yielding about 1000 tons of mazri leaves annually. Date Palm plantations are concentrated in Paniala, Paharpur, Chawdwan and Dhakki. The prominent varieties grown in the area are Dhakki, Shakri, Gulistan, Zaidi, Hillawi, Basra, Azadi and khudarawi. Dhakki Dates are well-known among all other varieties. Total area under dates cultivation in the district is 100,000 hectares, with total production of 11,000 tons dates. An average yield of Dhakki-Dates y-1 ranges from 6500 to 7000 tons i.e., 75% of the total production of dates in the area and dried dates production ranges from 800 - 1000 tons·year-1. A significant population is involved in processing of mazri and date palm leaves to prepare different products. Dates have a tremendous potential for economic uplift of the people. But growers face limitations and challenges regarding lack of information about customers and markets, harvesting, processing, and packaging techniques and infrastructure for producing good quality fresh dates. Fruit dropping in date palm particularly in Dhakki variety has become a serious concern. More than 70% date fruits drop before maturity. If production and processing constraints are properly handled, this may have significant socio-economic impact on local inhabitants.

关键词： Mazri Palm Date Palm Arecaceae Socio-Economic Impact

Factors influencing COVID-19 vaccination intention among university students:A cross-sectional study in Malaysia

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Biosafety and Health 2023年第1期5卷 37-44页

作者： Chee Yin Wong Jen Sern Tham Chai Nien Foo Foong Leng Ng Saleha Shahar Mohd Nizam Zahary Mohd Nazri ismail Cheng Siang Tan Boon Peng Hoh Subbiah Vijay Kumar Yang Mooi Lim Center for Cancer Research Universiti Tunku Abdul RahmanKajang 43000Malaysia M.Kandiah Faculty of Medicine&Health Sciences Universiti Tunku Abdul RahmanKajang 43000Malaysia Department of Communication Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia UPM-UNICEF C4D Faculty of Modern Languages and CommunicationUniversiti Putra MalaysiaSerdang 43400Malaysia Faculty of Science Universiti Teknologi MalaysiaJohor Bahru 81310Malaysia Faculty of Health Sciences Universiti Sultan Zainal AbidinKuala Nerus 21300Malaysia Analytical Biochemistry Research Centre Universiti Sains MalaysiaBayan Lepas 11900Malaysia Faculty of Medicine and Health Sciences Universiti Malaysia SarawakKota Samarahan 94300Malaysia Faculty of Medicine and Health Sciences UCSI UniversityCheras 56000Malaysia Biotechnology Research Institute Universiti Malaysia SabahKota Kinabalu 88400Malaysia

Vaccination is crucial in controlling the spread of the coronavirus disease 2019(COVID-19)that triggered the pandemic,but herd immunity can only work with high vaccination coverage in the *** study aims to measure the COVID-19 knowledge level and determine the factors influencing COVID-19 vaccination intention among university students in Malaysia.A cross-sectional online survey was carried out with 1,274 Malaysian university students in July *** and multivariate analyses were employed to examine the relationships between the study *** showed that the majority of university students had an acceptable level of knowledge of *** knowledge,risk perception of COVID-19,social norms,and perceived benefit of COVID-19 vaccination were positively associated with vaccination ***,perceived trust in information sources of COVID-19 vaccination and the government's response to COVID-19 did not affect the university students’desire to receive the *** findings are essential for health policymakers and healthcare providers to implement evidence-based interventions to increase COVID-19 vaccination uptake among university students.

关键词： Behavioral intention COVID-19 Influencing factor SARS-CoV-2 University student Vaccination