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Mesenchymal stem cells’“garbage bags”at work:Treating radial nerve injury with mesenchymal stem cell-derived exosomes

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World Journal of Stem Cells 2024年第5期16卷 467-478页

作者： Mazhar Mushtaq Doaa hussein Zineldeen Muhammad abdul Mateen Khawaja Husnain Haider Department of Basic Sciences Sulaiman AlRajhi UniversityAlbukairiyah 52736AlQaseemSaudi Arabia Medical Biochemistry and Molecular Biology Department Faculty of MedicineTanta UniversityTanta 6632110Egypt

Unlike central nervous system injuries,peripheral nerve injuries(PNIs)are often characterized by more or less successful axonal ***,structural and functional recovery is a senile process involving multifaceted cellular and molecular *** contemporary treatment options are limited,with surgical intervention as the gold-standard method;however,each treatment option has its associated limitations,especially when the injury is severe with a large *** advancements in cell-based therapy and cell-free therapy approaches using stem cell-derived soluble and insoluble components of the cell secretome are fast-emerging therapeutic approaches to treating acute and chronic *** recent pilot study is a leap forward in the field,which is expected to pave the way for more enormous,systematic,and well-designed clinical trials to assess the therapeutic efficacy of mesenchymal stem cell-derived exosomes as a bio-drug either alone or as part of a combinatorial approach,in an attempt synergize the best of novel treatment approaches to address the complexity of the neural repair and regeneration.

关键词： Exosome Mesenchymal stem cells Nerve injury Stem cells Secretome Regeneration

Robot-assisted uretero-enteric reimplantation for uretero-enteric anastomotic strictures following robot-assisted radical cystectomy: Surgical approach and outcomes over two decades

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Asian Journal of Urology 2024年第3期11卷 384-390页

作者： abdul Wasay Mahmood Grace Harrington Zhe Jing Qiang Li Ahmed A.hussein Khurshid A.Guru Department of Urology Roswell Park Comprehensive Cancer CenterElm and Carlton StreetsBuffaloNew YorkNYUSA

Objective:We described the technique and outcomes of robot-assisted repair of uretero-enteric strictures(UES)following robot-assisted radical cystectomy(RARC)and urinary ***:Retrospective review of our RARC database from November 2005 to August 2023 at Roswell Park Comprehensive Cancer center was *** who developed UES and ultimately underwent robot-assisted uretero-enteric reimplantation(RUER)were *** method was used to compute the cumulative incidence recurrence rate of UES after RUER.A multivariable regression model was used to identify variables associated with UES ***:A total of 123(15%)out of 808 RARC patients developed UES,of whom 52 underwent reimplantation(45 patients underwent RUER[n=55 cases]and seven patients underwent open ureteroenteric reimplantation).The median time from RARC to UES was 4.4(interquartile range 3.0e7.0)months,and the median time between UES and RUER was 5.2(interquartile range 3.2e8.9)*** 3-year recurrence rate after RUER is about 29%.On multivariable analysis,longer hospital stay(hazard ratio 1.37,95%confidence interval 1.16e1.61,p<0.01)was associated with recurrent UES after ***:RUER for UES after RARC is feasible with durable outcomes although a notable subset of patients experienced postoperative complications and UES recurrence.

关键词： Stricture Cystectomy Reimplantation Robot-assisted

Disruption of sleep patterns among secondary school adolescents

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Journal of Integrative Nursing 2024年第3期6卷 145-149页

作者： Zeki Sabah MUSIHB Hasan Saud abdul hussein Alaa Mahdi Abd ALI Department of Pediatric Nursing College of NursingUniversity of KerbalaKerbalaIraq

Objectives:This study aims to assess sleep disorders among secondary school adolescents and explore the relationship between sociodemographic factors(age,gender,household income,and sleep duration)and the occurrence of these ***:A quantitative,descriptive,cross-sectional study,was conducted from November 20th,2022,to May 25th,2023,involving 200 secondary school students selected through convenience *** collection utilized a structured questionnaire divided into sociodemographic and sleep disorder *** was ensured by a panel of ten experts,and reliability was confirmed using Cronbach’s Alpha(0.77).Statistical analysis employed SPSS version ***:Findings revealed that a majority of participants(70.5%)had low-level sleep disorders,followed by moderate disorders represented(29%).Significant associations were found between sleep disorders and gender(P=0.000),economic status for family(P=0.020),and nightly sleep duration(P=0.016).However,no significant relationship was observed between sleep disorders and family structure or age(P>0.05).Conclusions:The study highlights that most secondary school students experience mild sleep disorders,followed by moderate ***,gender,income,and sleep duration showed significant correlations with sleep disorders.

关键词： Disruption of sleep secondary school adolescents sleep patterns

Principal Component Analysis and Minimum Description Length Criterion Based on Through-Wall Image Enhancement

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Chinese Physics Letters 2013年第4期30卷 45-47页

作者： Muhammad mohsin Riaz abdul Ghafoor Department of Electrical Engineering College of SignalsNational University of Sciences and Technology(NUST)IslamabadPakistan

A through-wall image enhancement scheme is proposed based on principal component analysis and minimum description length *** minimum description length criterion is used with principal component analysis to extract target eigen *** proposed scheme is capable of extracting multiple targets from heavy cluttered through-wall *** results of the proposed scheme are compared with existing schemes on the basis of quantitative analysis and visual inspection.

关键词： criterion. Image scheme

Inducing opto-electronic and spintronic trends in bilayer h-BN through TMO3 clusters incorporation: Ab-initio study

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Chinese Physics B 2019年第11期28卷 284-294页

作者： Irfan Ahmed Muhammad Rafique Mukhtiar Ahmed Mahar abdul Sattar Larik mohsin Ali Tunio Yong Shuai Mehran University of Engineering and Technology SZABCampusKhairpur Mirs’Pakistan School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Mehran University of Engineering and Technology JamshoroSindhPakistan

The band structure, magnetism, charge distribution, and optics parameters of TMO3–h-BN hybrid systems are investigated by adopting first-principles study(FPS) calculations. It is observed that the TMO3 clusters add finite magnetic moments to bilayer h-BN(BL/h-BN), thereby making it a magnetic two-dimensional(2D) material. Spin-polarized band structures for various TMO3–BL/h-BN hybrid models are calculated. After the incorporation of TMO3, BL/h-BN is converted into semimetal or conducting material in spin up/down bands, depending on the type of impurity cluster present in BL/h-BN lattice. Optics parameters are also investigated for the TMO3–BL/h-BN complex systems. The incorporation of TMO3 clusters modifies the absorption and extinction coefficient in visible range, while static reflectivity and refraction parameter increase. It can be surmised that the TMO3 substitution in BL/h-BN is a suitable technique to modify its physical parameters thus making it functional for nano/opto-electronic applications, and an experimental approach can be adapted to reinforce the outcomes of this study.

关键词： bilayer h-BN band structure density of states magnetic moments optics

CO_x-Free Hydrogen and Carbon Nanofibers Produced from Direct Decomposition of Methane on Nickel-Based Catalysts

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Journal of Natural Gas Chemistry 2006年第4期15卷 253-258页

作者： Siang-Piao Chai Sharif hussein Sharif Zein abdul Rahman Mohamed School of Chemical Engineering Universiti Sains MalaysiaEngineering Campus Seri Ampangan14300 Nibong TebalSPS Penang Malaysia

Direct decomposition of methane was carried out using a fixed-bed reactor at 700 ℃ for the production of COx-free hydrogen and carbon nanofibers. The catalytic performance of NiO-M/SiO2 catalysts （where M=AgO, CoO, CuO, FeO, MnOx and MoO） in methane decomposition was investigated. The experimental results indicate that among the tested catalysts, NiO/SiO2 promoted with CuO give the highest hydrogen yield. In addition, the examination of the most suitable catalyst support, including Al2O3, CeO2, La2O3, SiO2, and TiO2, shows that the decomposition of methane over NiO-CuO favors SiOx support. Furthermore, the optimum ratio of NiO to CuO on SiO2 support for methane decomposition was determined. The experimental results show that the optimum weight ratio of NiO to CuO fell at 8：2 （w/w） since the highest yield of hydrogen was obtained over this catalyst.

关键词： methane decomposition hydrogen carbon nanofibers supported catalyst

Label-free colorimetric nanosensor with improved sensitivity for Pb^2+ in water by using a truncated 8-17 DNAzyme

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Frontiers of Environmental Science & Engineering 2019年第1期13卷 129-134页

作者： abdul Ghaffar Memon Xiaohong Zhou Yunpeng Xing Ruoyu Wang Lanhua Liu mohsin Khan Miao He Center for Sensor Tech no logy of Environment and Health State Key Joint Laboratory of ESPC School of Environment Tsinghua University Beijing 100084 China Department of Environmental Engineering NED University of Engineering and Technology Karachi 75270. Pakistan

Water pollution accidents, such as the Flint water crisis in the United States, caused by lead contamination have raised concern on the safety of drinking water distribution systems. Thus, the routine monitoring of lead in water is highly required and demands efficient, sensitive, cost-effective, and reliable lead detection methods. This study reports a label-free colorimetric nanosensor that uses unmodified gold nanoparticles (AuNPs) as indicators to enable rapid and ultra-sensitive detection of lead in environmental water. The 8-17 DNAzyme was truncated in this study to facilitate the detachment of single-stranded DNA fragments after substrate cleavage in the presence of Pb「. The detached fragments were adsorbed over AuNPs and protected against salt concentration-induced aggregation. Accordingly, high Pb^2+ would result in rapid color change from blue to pink. The established sensing principle achieved a sensitive limit of detection of 0.2×10^-9mol/L Pb^2+. with a linear working range of two orders of magnitude from 0.5×10^-9mol/L to 5×10^-9mol/L. The selectivity of the nanosensor was demonstrated by evaluating the interfering metal ions. The developed nanosensor can serve as a substitute for the rapid analysis and monitoring of trace lead levels under the drinking water distribution system and even other environmental water samples.

关键词： Colorimetric nanosensor Truncated 8-17 DNAzyme Pb^2+ detection Unmodified AuNPs

TiO_2/Ag modified penta-bismuth hepta-oxide nitrate and its adsorption performance for azo dye removal

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Journal of Environmental Sciences 2012年第10期24卷 1876-1884页

作者： Eshraq Ahmed abdullah abdul Halim abdullah Zulkarnain Zainal Mohd Zobir hussein Tan Kar Ban Department of Chemistry Faculty of ScienceUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia. Advanced Material and Nanotechnology Laboratory Institute of Advanced TechnologyUniversiti Putra Malaysia43400UPM SerdangSelangorMalaysia

A modified hydrophilic penta-bismuth hepta-oxide nitrate （Bi5O7NO3） surface was synthesized via a precipitation method using TiO2 and Ag as modified agents. The synthesized product was characterized by different analytical techniques. The removal efficiency was evaluated using mono- and di-sulphonated azo dyes as model pollutants. Different kinetic, isotherm and diffusion models were chosen to describe the adsorption process. X-ray photoelectron spectroscopy （XPS） results revealed no noticeable differences in the chemical states of modified adsorbent when compared to pure BisOTNO3; however, the presence of hydrophilic centres such as TiO2 and Ag developed positively charged surface groups and improved its adsorption performance to a wide range of azo dyes. Dyes removal was found to be a function of adsorbent dosage, initial dye concentration, solution pH and temperature. The reduction of Langmuir 1,2-mixed order kinetics to the second or first-order kinetics could be successfully used to describe the adsorption of dyes onto the modified adsorbent. Mass transfer can be described by intra-particle diffusion at a certain stage, but it was not the rate limiting step that controlled the adsorption process. Homogenous behavior of adsorbent surface can be explored by applying Langmuir isotherm to fit the adsorption data.

关键词： Bi5O7NO3 X-ray photoelectron spectroscopy Langmuir 1,2-mixed order azo dye mass transfer

Phyto-Toxicity of Chromium in Maize： Oxidative Damage, Osmolyte Accumulation, Anti-Oxidative Defense and Chromium Uptake

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Pedosphere 2017年第2期27卷 262-273页

作者： Shakeel Ahmad ANJUM Umair ASHRAF Imran KHAN mohsin TANVEER Muhammad SHAHID abdul SHAKOOR WANG Longchang College of Agronomy and Biotechnology Southwest University/Engineering Research Center of South Upland Agriculture Ministry of Education Chongqing 400716 (China) Department of Agronomy University of Agriculture Faisalabad 38040 (Pakistan) Department of Crop Science and Technology College of Agriculture South China Agricultural University Guangzhou 510642 (China) Scientific Observing and Experimental Station of Crop Cultivation in South China Ministry of Agriculture Guangzhou 510642 (China) School of Land and Food University of Tasmania Hobart 7005 (Australia)

Agricultural production systems are immensely exposed to different environmental stresses in which heavy metal stress receives serious concerns. This study was conducted to explore the deleterious effects of different chromium （Cr） stress levels, i.e., O, 30, 60, 90, 120, and 150 μmol L^-1, on two maize genotypes, Wandan 13 and Runnong 35. Both genotypes were evaluated by measuring their growth and yield characteristics, Cr accumulation in different plant tissues, alterations in osmolyte accumulation, generation of reactive oxygen species （ROS）, and anti-oxidative enzyme activity to scavenge ROS. The results showed that Cr stress decreased the leaf area, cob formation, 100-grain weight, shoot fresh biomass, and yield formation, while Cr accumulation in different maize tissues was found in the order of roots 〉 leaves 〉 stem ~ seeds in both genotypes. The increased Cr toxicity resulted in higher free proline, soluble sugars and total phenolic contents, and lower soluble protein contents. However, enhanced lipid peroxidation was noticed in the forms of malondialdehyde, hydrogen peroxide （H2O2） and thiobarbituric acid reactive substance accumulation, and electrolyte leakage. The hyperactivity of superoxide dismutase, peroxidase, catalase, ascorbate peroxidase, especially glutathione peroxidase and glutathione reductase indicated that these anti-oxidative enzymes had a central role in protecting maize from Cr toxicity, especially for Wandan 13. Moreover, higher uptake and less translocation of Cr contents into the grains of Wandan 13 implied its importance as a potential candidate against soil Cr pollution.

关键词： agronomic characteristics anti-oxidative enzyme activity Cr accumulation Cr translocation heavy metal stress reactiveoxygen species