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Autophagy as a targeted therapeutic approach for skin cancer:Evaluating natural and synthetic molecular interventions

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Cancer Pathogenesis and Therapy 2024年第4期2卷 231-245页

作者： Md.Liakot Ali Amdad Hossain Roky S.M.Asadul Karim Azad abdul Halim Shaikat Jannatul Naima Meem Emtiajul Hoque Abu mohammed Fuad Ahasan mohammed Murshedul Islam Md.Saifur Rahaman Arif Md.Saqline Mostaq Md.Zihad Mahmud Mohammad Nurul Amin MdAshiq Mahmud Department of Pharmacy University of ChittagongChattogram 4331Bangladesh Pratyasha Health Biomedical Research Center Dhaka 1230Bangladesh Department of Pharmacy International Islamic University ChittagongChattogram 4318Bangladesh Department of Pharmacy Daffodil International UniversityDhaka 1216Bangladesh Department of Pharmacy BGC Trust University BangladeshChattogram 4381Bangladesh School of Basic Pharmaceutical and Toxicological Sciences College of PharmacyUniversity of Louisiana at MonroeMonroeLA 71209-0497USA Pioneer Dental College and Hospital Dhaka 1229Bangladesh

Skin cancer,a prevalent malignancy worldwide,poses significant health concerns owing to its increasing ***,a natural cellular process,is a pivotal event in skin cancer and has advantageous and detrimental *** duality has prompted extensive investigations into medical interventions targeting autophagy modulation for their substantial therapeutic *** systematic review aimed to investigate the relationship between skin cancer and autophagy and the contribution and mechanism of autophagy modulators in skin *** outlined the effectiveness and safety of targeting autophagy as a promising therapeutic strategy for the treatment of skin *** comprehensive review identified a diverse array of autophagy modulators with promising potential for the treatment of skin *** of these compounds demonstrates efficacy through distinct physiological mechanisms that have been elucidated in ***,findings from a literature search indicated that none of the natural,synthetic,or semisynthetic compounds exhibited notable adverse effects in either human or animal ***,this review offers novel mechanistic and therapeutic perspectives on the targeted modulation of autophagy in skin cancer.

关键词： Autophagy Skin cancer Autophagy inducers Autophagy inhibitors Nature-derived compounds Synthetic compounds

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Elemental characterization of black shales of Khyber Pakthunkhawa (KPK) region of Pakistan using AAS

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Chinese Journal Of Geochemistry 2013年第3期32卷 248-251页

作者： abdul aziz Muhammad Sajjad Bashir Mohammad Central Analytical Facility Division Pakistan Institute of Nuclear Science and Technology Department of Construction Environment Engineering University of Science and Technology

Black shale samples were collected from Chimiari Khyber Pakthunkhawa region of Pakistan and were analyzed for elemental compositions. Atomic Absorption Spectrophotometry (AAS) was utilized for the determination of elements in the digested solutions. The analysis of black shale was performed precisely with relative standard deviation (RSD) lower than 2%. Results showed that the samples contained high concentrations of Ca (11.98 %), Al (7.09%), Fe (3.03%), Mg (0.59%) and Ti (0.58%).

关键词：原子吸收光谱法黑色页岩巴基斯坦元素组成表征相对标准偏差元素测定精确分析

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Earthquake induced pounding between adjacent buildings considering soil-structure interaction

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Earthquake Engineering and Engineering Vibration 2012年第3期11卷 343-358页

作者： Sadegh Naserkhaki Farah N.A.abdul aziz Hassan Pourmohammad Department of Civil Engineering Faculty of EngineeringUniversiti Putra Malaysia Department of Civil Engineering Faculty of EngineeringIslamic Azad University

Many closely located adjacent buildings have suffered from pounding during past earthquakes because they vibrated out of phase. Furthermore, buildings are usually constructed on soil; hence, there are interactions between the buildings and the underlying soil that should also be considered. This paper examines both the interaction between adjacent buildings due to pounding and the interaction between the buildings through the soil as they affect the buildings＇ seismic responses. The developed model consists of adjacent shear buildings resting on a discrete soil model and a linear visco- elastic contact force model that connects the buildings during pounding. The seismic responses of＇ adjacent buildings due to ground accelerations are obtained for two conditions： fixed-based （FB） and structure-soil-structure interaction （SSSI）. The results indicate that pounding worsens the buildings＇ condition because their seismic responses are amplified after pounding. Moreover, the underlying soil negatively impacts the buildings＇ seismic responses during pounding because the ratio of their seismic response under SSSI conditions with pounding to those without pounding is greater than that of the FB condition.

关键词： adjacent buildings underlying soil pounding seismic response fixed-based (FB) structure-soil-structureinteraction (SSSI)

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Synthesis,Characterization,Biological and Docking Simulations of 4-(Benzylideneamino) Benzoic Acids

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Chinese Journal of Structural Chemistry 2021年第3期40卷 291-300,271页

作者： HAMID aziz AAMER Saeed FARUKH Jabeen abdul Basit IRFAN Zia Qureshi abdul aziz ATIF Haroon ASHFAQ Ur Rehman Department of Chemistry Quaid-I-Azam University Islamabad 45320 Pakistan Computation ScienceResearch and Development Organization14012485 Hurontraio StreetMississaugaONCaL5A2G6 Department of Biology Laurentian University935 Ramsey Lake RoadSudburyONCanada P3E2C6 Department of Animal Sciences Quaid-I-Azam University Islamabad 45320 Pakistan Department of Microbiology Quaid-I-Azam University Islamabad 45320 Pakistan Department of Biochemistry Shankar CampusAbdul Wali Khan UniversityMardan 23200Khyber PukhtoonkhwaPakistan Department of Bioinformatics and Biostatistics Shanghai Jiaotong UniversityShanghai 200240China

The present research paper presents the synthesis, characterization, biological and computational studies of 4-(benzylideneamino) benzoic acid derivatives(3a~3g). Derivatives 3a~3c displayed best antidiabetic potential with a glucose-lowering effect compared to the reference drug Glibenclamide. Biochemical parameters including plasma glucose, serum triglycerides, cholesterol, alanine amino transferase and aspartate amino transferase levels showed significant alterations in concentrations relative to the control. Similarly, the derivatives 3a, 3d and 3e displayed potent in vitro antibacterial potential. Molecular docking simulations delineated that the ligands and complexes were stabilized at the active site by electrostatic and hydrophobic forces, consistent with the corresponding experimental results. In silico study of the binding pattern predicted that the synthesized ligands, 3d and 3a could serve as a potential surrogate for hit-to-lead generation and the design of novel antibacterial drugs.

关键词： antidiabetic biochemical cholesterol glibenclamide simulations

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Identification of potential inhibitors for Sterol C-24 reductase of Leishmania donovani through virtual screening of natural compounds

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BIOCELL 2021年第6期45卷 1601-1610页

作者： FAZLUR RAHMAN SHAMS TABREZ RAHAT ALI SAJJADUL KADIR AKAND mohammed AALAIDAROUS mohammed ALSAWEED BADER mohammed ALSHEHRI SAEED BANAWAS ABDUR RUB abdul aziz BIN DUKHYIL Infection and Immunity Laboratory(414) Department of BiotechnologyJamia Millia Islamia-A Central UniversityNew Delhi110025India Department of Medical Laboratory Sciences College of Applied Medical SciencesMajmaah UniversityAl Majmaah11952Saudi Arabia Health and Basic Sciences Research Center Majmaah UniversityAl Majmaah11952Saudi Arabia

Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different species of the genus *** is transmitted by the bite of female phlebotomies sand *** main clinical manifestations of leishmaniasis include cutaneous,visceral,and mucocutaneous *** leishmaniasis(VL)caused by Leishmania donovani,is an infection of reticuloendothelial system and fatal if ***,a sterol that is prominent in the mammalian cell membranes whereas stigmasterol and ergosterol are more prevalent in plants,yeast,and protozoa,*** which is absent in human being,is an important constituent of parasite *** C-24 reductase(LdSR)enzyme catalyzes the final step in the ergosterol biosynthesis *** inhibition of biosynthesis of ergosterol may lead to decreased cell viability and ***,we performed the molecular docking-based virtual screening of a library of natural ligands against LdSR to identify a potential inhibitor to fight ***,prenyletin,flavan-3-ol,resveratrol,and gingerol showed the top binding affinity towards *** upon ADME properties and bioactivity score,gingerol showed the best lead-likeness and drug-likeness ***,we further annotated its leishmanicidal *** found that gingerol inhibited the growth and proliferation of promastigotes as well as intra-macrophagic *** exerted its antileishmanial action through the induction of reactive oxygen species(ROS)in concentration-dependent *** induced ROS led to ***,this study described that gingerol would act as possible inhibitor to LdSR.

关键词： Leishmania Gingerol Sterol C-24 reductase Molecular docking ROS

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Mathematical models for process commonality under quality and resources breakdown in multistage production

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第11期12卷 837-848页

作者： mohammed abdul WAZED Shamsuddin AHMED Yusoff Bin NUKMAN Department of Engineering Design and Manufacture University of Malaya Department of Mechanical Engineering Chittagong University of Engineering and Technology(CUET)

It is essential to manage customers' diverse desires and to keep manufacturing costs as low as possible for survival in competition and eventually in *** resources in manufacturing for different products is a vital method of accomplishing this *** advantages of using a common process in production are stated in the ***,the mathematical models as well as simulation or conceptual models are not *** main objective of this paper is to develop mathematical models for multiproduct and multistage production under quality and breakdown *** idea of the process commonality is incorporated in the proposed *** models are validated by primary data collected from a Malaysian company and comparison of the timely requirement schedules of earlier MRP II and the proposed models under stable and perfect production *** appreciable convergence of the outcomes is ***,the proposed models are carrying additional information about the available locations of the parts in a time *** validation,the effects of process commonality on cost,capacity and the requirement schedule under uncertainties are *** is observed that the use of common processes in manufacturing is always better than the non-commonality scenario in terms of production ***,the increase in capacity requirement for commonality designs is higher for an ideal system,while it is less when the system suffers from breakdowns and a quality problem.

关键词： Process commonality Mathematical model MRP II Quality Breakdown

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Photocatalytic degradation of Chicago Sky Blue 6B and Benzopurpurin 4B using titanium dioxide thin film

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Journal of Environmental Sciences 2005年第5期17卷 869-872页

作者： abdul K. mohammed Katrina T. McKenzie Department of Chemistry Winston-Salem State UniversityDepartment of Chemistry North Carolina Agricultural and Technical State University 601 S. Martin Luther King Jr. Drive Winston-Salem North Carolina 27110 USA1601 E. Market Street Greensboro North Carolina 27411 USA

Aqueous solutions of azo dyes undergo degradation to form harmless intermediates and colorless products following irradiation by visible light in the presence of titanium dioxide thin films. The dyes that were studied in this work are： Chicago Sky Blue 6B and Benzopurpurin 4B. Results obtained indicated that complete mineralization of the dyes took place under the experimental conditions. There was an increase in conductivity after the complete mineralization experiments possibly indicating the formation of ions such as NO3^- and SO4^2-. Chemical oxygen demand（COD） measurements show a decrease in organic matter for both dyes following complete degradation. The effect of how changing experimental conditions such as pH, temperature and starting concentrations of dyes affected the rate of dye degradation was measured. There was an increase in the rate of disappearance of the dye color at lower pH. High concentrations of dye solutions reauired Iona dearadation time.

关键词： titanium dioxide photocatalysis photocatalytic degradation azo dyes

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Adoption of Improved Rice Varieties in the Global South:A Review

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Rice science 2023年第3期30卷 186-206,I0021-I0034页

作者： Julia CHECCO Fathin Ayuni azizAN Jaquie MITCHELL Ammar abdul aziz School of Agriculture and Food Sciences The University of QueenslandGatton 4343QueenslandAustralia Department of Agrotechnology Faculty of Mechanical Engineering and TechnologyUniversiti Malaysia PerlisArau 02600PerlisMalaysia

Improved rice varieties(IRVs)play a significant role in establishing food security and improving livelihood in the Global South since its introduction in the ***,the adoption of new IRVs has remained relatively *** low adoption poses a challenge to rice-producing and consuming countries as they are increasingly threatened by production shortages,malnutrition,and poor rice *** empirical studies have attempted to identify the determinants influencing the adoption of IRVs by distinguishing the characteristics between adopters and *** review showed a consensus on the important determinants influencing the adoption of IRVs in the Global *** synthesized from 99 studies suggested that variables(farm size,education,information access and farm location)examined extensively are not necessarily the most important determinants of adoption when undertaking a weighted ***,source of seed and technology-related attributes(perceived yield,maturity,ease of use,marketability and technical efficiency)are more important determinants of adoption,with determinants changing according to adoption type(probability or intensity of adoption),variety type and *** recommendations for future adoption studies include:incorporating more technology-specific variables,increasing research for overlooked regions and variety types,shifting away from predominant static analysis by capturing the dynamics of the adoption process,and considering the potential biases in *** review will facilitate the development of targeted interventions and policies that promote IRV adoption in the Global South.

关键词： technology adoption improved rice variety systematic literature review the Global South

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Effect of aggressive pH media on peat treated by cement and sodium silicate grout

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Journal of Central South University 2011年第3期18卷 840-847页

作者： S.Kazemian A.Prasad B.B.K.Huat J.Bolouri Bazaz T.A.mohammed F.N.abdul aziz Department of Civil Engineering Bojnourd BranchIslamic Azad University Department of Civil Engineering Banaras Hindu University Department of Civil Engineering University Putra Malaysia Department of Civil Engineering Ferdowsi University

The effects of aggressive peat nature (pH) on the strength of peat treated by cement and cement-sodium silicate grout were investigated by evaluating the changes in unconfined compressive strength,moisture content,and scanning electron microscopy (SEM) of samples with time in different pH *** results indicate that peats treated by cement-silicate have higher strength than peats treated by cement,due to an increase in pH value of the ***,cement and cement-silicate are highly effective in reducing the moisture content and void ratio of the treated *** microstructures of treated peats support the laboratory test results.

关键词： peat aggressive pH media cementation sodium silicate grout microstructure

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Subspace Clustering in High-Dimensional Data Streams:A Systematic Literature Review

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Computers, Materials & Continua 2023年第5期75卷 4649-4668页

作者： Nur Laila Ab Ghani Izzatdin abdul aziz Said Jadid abdulKadir Department of Computer and Information Sciences Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia Centre for Research in Data Science(CeRDAS) Universiti Teknologi PETRONASSeri Iskandar32610PerakMalaysia

Clustering high dimensional data is challenging as data dimensionality increases the distance between data points,resulting in sparse regions that degrade clustering *** clustering is a common approach for processing high-dimensional data by finding relevant features for each cluster in the data *** clustering methods extend traditional clustering to account for the constraints imposed by data *** streams are not only high-dimensional,but also unbounded and *** necessitates the development of subspace clustering algorithms that can handle high dimensionality and adapt to the unique characteristics of data *** many articles have contributed to the literature review on data stream clustering,there is currently no specific review on subspace clustering algorithms in high-dimensional data ***,this article aims to systematically review the existing literature on subspace clustering of data streams in high-dimensional streaming *** review follows a systematic methodological approach and includes 18 articles for the final *** analysis focused on two research questions related to the general clustering process and dealing with the unbounded and evolving characteristics of data *** main findings relate to six elements:clustering process,cluster search,subspace search,synopsis structure,cluster maintenance,and evaluation *** algorithms use a two-phase clustering approach consisting of an initialization stage,a refinement stage,a cluster maintenance stage,and a final clustering *** density-based top-down subspace clustering approach is more widely used than the others because it is able to distinguish true clusters and outliers using projected *** algorithms implicitly adapt to the evolving nature of the data stream by using a time fading function that is sensitive to *** work can focus on the clustering framework,parameter optimiza

关键词： Clustering subspace clustering projected clustering data stream stream clustering high dimensionality evolving data stream concept drift

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