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Prevalence of Extended-Spectrum Beta-Lactamase-Producing Strains Isolated at Zinder National Hospital (ZNH) in 2021 and Their Antibiotic Susceptibility Profile

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Open Journal of Medical Microbiology 2023年第1期13卷 43-51页

作者： Maman Sani Falissou Saïdou abdoulaye Ousmane abdoulaye inoussa abdoulaye Maman Bachir Hassane Boureima Lo Gora Alhousseini Maiga Daouda Doutchi Mahamadou Bako Saley Mahaman Laouali Sidi Maman Bacha Boukar Mamadou Saidou Faculté des Sciences de la Santé Université Dan Dicko Dankoulodo de Maradi Maradi Niger Hôpital National de Zinder Zinder Niger Centre de Recherche Médicale et Sanitaire Niamey Niger Faculté de Médecine de Pharmacie et d’odontostomatologie Université Cheikh Anta Diop de Dakar Dakar Sénégal Faculté des Sciences de la Santé Université Abdou Moumouni Niamey Niger Faculté des Sciences de la Santé Université de Zinder Zinder Niger

Purpose: Bacterial resistance to antibiotics has become a global public health problem. Enterobacteriaceae ESBL is among the most incriminated in this emergence which reduces the therapeutic possibilities. Thus, the objective of this study is to determine the prevalence of the extended-spectrum beta- lactamase (ESBL) producing Enterobacteriaceae at ZNH and their antibiotic susceptibility profile. Materials and Methods: This is a prospective study carried out over 5 months in all hospitalized and non-hospitalized patients in whom a culture was taken for the diagnosis of an infection. The search for ESBL is done by the double disc diffusion method. Results: In total, 21 out of 45 of our strains are ESBL-producing, i.e. a frequency of 46.7%. The mean age is 41.62 (±22.90) with extremes of 2.6 - 78 years. The distribution of ESBL producing species showed a predominance of E. coli with 66.7% followed by K. pneumoniae and K. oxytoca each 9.5%. All ESBL strains were resistant to Amoxicillin, Cefalotin, Pipiracillin, Piperacillin + tazobactam, Ticarcillin, Ticarcillin + clavulanic acid. Resistance to C3G and Aztreonam was each 95.5%, to Amoxicillin/clavulanic acid 9.1%. All strains were sensitive to imipenem. E. coli strains showed resistance: 85.7% to ciprofloxacin, 50% to Amikacin, 57.1% to Gentamicin. For K. pneumoniae, it is 66.7% for Gentamicin and Ciprofloxacin. Conclusion: Our study reports a high prevalence of ESBL at the HNZ. This must be taken into account in order to monitor this phenomenon which constitutes a public health problem. The study also reports sensitivity to Amoxicillin/clavulanic acid and Aminoside which can be an alternative.

关键词： Bacterial Resistance ESBL Enterobacteriaceae Zinder Niger

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Prevalence of Extended-Spectrum Beta-Lactamase-Producing Strains Isolated at Zinder National Hospital (ZNH) in 2021 and Their Antibiotic Susceptibility Profile

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Open Journal of Medical Microbiology（医学微生物学） 2023年第1期

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Secondary Stress Induced Central Serous Chorioretinopathy in Bamako: Report of Two Cases

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Open Journal of Ophthalmology 2020年第4期10卷 268-275页

作者： Rodrigue Romuald Elien Gagnan Yan Zaou Tou Adama Guindo Mahamat Adam Dicko Mohamed Kole Sidibe Aly Sylla Modibo Diarra Mohamed inoussa Lamine abdoulaye Nagnan Chieck Rahim Diabate Hamadoun Diallo Institute of African Tropical Ophthalmology University of Sciences and Technology of Bamako Bamako Mali

Introduction: Idiopathic central serous chorioretinopathy (ICSC) is characterized by the buildup of fluid leading to circumscribed elevation of the retina within the posterior pole. This condition affects young people between the ages of 20 - 50 years. The disease is seen predominantly in men as compared to women. We report the cases of two (02) patients received in consultation at IOTA-Teaching Hospital between July 2019 and February 2020. Case Presentation: We report two cases of Idiopathic stress central serous chorioretinopathy. The first case is a 37-year-old man that we received in consultation for visual acuity decrease from a sudden installation for 1 hour. The clinical and paraclinical arguments permitted us to retain the diagnosis of Idiopathic stress central serous chorioretinopathy. The patient benefited from laser treatment and the clinical evolution was good. The second case is a 42-year-old man, who consulted for a sudden reduction of visual acuity that had been evolving for 3 weeks. The clinical and paraclinical contexts were in favour of the diagnosis of Idiopathic stress central serous chorioretinopathy. The patient was treated with spironolactone. The clinical evolution was favourable. Conclusion: Our study confirms the existence of central serous chorioretinopathy (CSC) in Black African patients. Studies show the connection between CSC and stress.

关键词： Stress Central Serous Chorioretinopathy Fluorescein Angiography Bamako

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