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Bilharzia Appendicitis: Incidence in a Commune in Mali, about 3CAS

Surgical Science 2024年第5期15卷 321-329页

作者： Souleymane Bingue dembélé Yely dianessy Moussa Samake abdou Guiré Siaka Konaté ousmane Sy Boubacar Yoro Sidibé Amadou Maïga Thiorno Nadio Boubacar Karembe Amaguiré Saye Sirama diarra dorcas Sodjiné Yede Issiaka diarra Ibrahima Maiga Mahamane dicko Moussa Konaté Aliou Bina diarra bakary Tientigui dembélé General Surgery department of the district Hospital of Commune IV of bamako Bamako Mali Kolondié ba Reference Health Centre Sikasso Mali Epidemiology and Clinical Research Bamako Mali General Surgery department of gabriel Touré University Hospital Bamako Mali ophthalmology department of the district Hospital of Commune IV of bamako Bamako Mali Gynecology and obstetrics department of the district Hospital of Commune IV of bamako Bamako Mali Commune I of the district of bamako Reference Health Centre Bamako Mali Imaging department of the district Hospital of Commune IV of bamako Bamako Mali Commune VI of the district of bamako Reference Health Centre Bamako Mali Anotomy-Pathology department of the G Point University Hospital Bamako Mali

Appendicitis bilharzia is a very rare condition and we report 3 cases of this pathology that sense clinical and biological similarities with bacterial appendicitis. The etiological diagnosis was exclusively histopathological, this allowed to highlight eggs of Schistosome in the appendicular wall in the three patients. The surgical treatment was supplemented by a specific medical treatment based on praziquantel. The surgical suites were simple for 2 patients, complicated by superficial parietal suppuration in a patient.

关键词： Bilharzial Appendicitis Endemic Histopathology Specific Antiparasitic Treatment

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Gene therapy for Parkinson’s disease and Ethical Challenges: A Systematic Review

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Advances in Parkinson's disease 2023年第2期12卷 9-28页

作者： Théodora M. Zohoncon Joseph Sawadogo abdou Azaque Zoure abdoul Karim ouattara Marie N. L. ouedraogo Luc Zongo Paul ouedraogo Florencia W. djigma Christelle W. M. Nadembèga Raphael Kabore djénéba.ouermi dorcas obiri-Yeboah Jacques Simpore Pietro Annigoni Biomolecular Research Centre (CERba) Ouagadougou Burkina Faso Faculty of Medicine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Saint Camille Hospital Ouagadougou (HOSCO) Ouagadougou Burkina Faso Molecular Biology and Genetics Laboratory (LABIoGENE) Joseph KI-ZERBO University Ouagadougou Burkina Faso National Center for Scientific and Technological Research (CNRST/IRSS) Ouagadougou Burkina Faso Norbert Zongo University/Manga University Centre Koudougou Burkina Faso department of Microbiology and Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana

background: Parkinson’s disease (Pd) is a complex, multifactorial neurodegenerative disorder with a pathophysiology deriving from the synergy of abnormal aggregation of neuroinflammation, synuclein and dysfunction of lysosomes, mitochondria and synaptic transport difficulties influenced by genetic and idiopathic factors. Worldwide, Pd has a prevalence of 2-3% in people over the age of 65. To date, there is no certified, effective treatment for Pd. Aim: The aims of this research were: (i) to present, on the basis of recent advances in molecular genetics and epigenetics, the genomic aspects and challenges of gene therapy trials for Pd;(ii) to outline the ethical principles applicable to therapeutic trials for Pd. Method: A systematic literature review was carried out to identify relevant articles reporting on genomic aspects and gene therapy in Pd from 2001 to october 2023. The search was conducted in French and/or English in three databases: PubMed, Google Scholar and Science direct. PRISMA guidelines were used in this systematic review. Results: A total of thirty-three publications were selected. An inductive thematic analysis revealed that numerous genetic mutations (SNCA, Parkin, PINK1, dJ-1, LRRK2, ATP13A2, VPS35, Parkin/PRKN, PINK1, dJ1/PARK7) and epigenetic events such as the action of certain miRNAs (miR-7, miR-153, miR-133b, miR-124, miR-137) are responsible for the onset of Pd, and that genetic therapy for this pathology raises ethical questions that need to be elucidated in the light of the bioethical principles of autonomy, beneficence, non-maleficence and justice. Conclusion: There is no zero risk in biotechnology. Then, it will be necessary to assess all the potential risks of Parkinson disease’s gene therapy to make the right decision. It is therefore essential to pursue research and, with the guidance of ethics, to advance treatment options and meet the challenges of brain manipulation and its impact on human identity. The golden rule of medicine remai

关键词： Neurodegenerative diseases Parkinson disease Molecular Mechanism Gene Therapy Gene Therapy Ethics

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Presymptomatic diagnosis and Gene Therapy for Alzheimer’s disease: Genomic, Therapeutic, and Ethical Aspects—A Systematic Review

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Advances in Alzheimer's disease 2023年第4期12卷 55-74页

作者： Théodora M. Zohoncon Joseph Sawadogo abdoul Karim ouattara abdou Azaque Zoure Marie N. L. ouedraogo Paul ouedraogo Florencia W. djigma Christelle W. M. Nadembèga Raphael Kabore djénéba.ouermi dorcas obiri-Yeboah Jacques Simpore Centre de Recherche Biomoléculaire Pietro Annigoni (CERba) Ouagadougou Burkina Faso Faculty of Medicine University Saint Thomas d’Aquin (USTA) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire H&#244pital Saint Camille de Ouagadougou (HOSCO) Ouagadougou Burkina Faso Laboratoire de Biologie Moléculaire et de Génétique (LABIoGENE) Université Joseph KI-ZERBO Ouaga Burkina département de Biochimie microbiologie Université Norbert Zongo/Centre Universitaire de Manga Koudougou Burkina Faso department of Microbiology and Immunology School of Medical Sciences University of Cape Coast Cape Coast Ghana

over the past three decades, genomic and epigenetic sciences have identified more than 70 genes involved in the molecular pathophysiology of Alzheimer’s disease (Ad). dNA methylation, abnormal histone and chromatin regulation and the action of various miRNAs induce Ad. The identification of mutated genes has paved the way for the development of diagnostic kits and the initiation of gene therapy trials. However, despite major advances in neuroscience research, there is yet no suitable treatment for Ad. Therefore, the early diagnosis of this neurodegenerative disease raises several ethical questions, including the balance between the principle of non-maleficence and the principle of beneficence. The aims of this research were to present the genomic and ethical aspects of Ad, and to highlight the ethical principles involved in its presymptomatic diagnosis and therapy. A systematic review of the literature in PubMed, Google Scholar and Science direct was carried out to outline the genomic aspects and ethical principles relating not only to the presymptomatic diagnosis of Ad, but also to its gene therapy. A total of 16 publications were selected. Ad is a multifactorial disease that can be genetically classified into Sporadic Alzheimer’s disease and Familial Alzheimer’s disease based on family history. Gene therapy targeting specific disease-causing genes is a promising therapeutic strategy. Advancements in artificial intelligence applications may enable the prediction of Ad onset several years in advance. While early diagnosis of Ad may empower patients with full decision competence for early decision-making, it also carries implications for the patient’s family members, who are at risk of developing the disease, potentially becoming a source of confusion or anxiety. Ad has a significant impact on the life of individuals at risk and their families. Given the absence of disease modifying therapy, genetic screening and early diagnosis for this condition raise ethical issue

关键词： Neurodegenerative diseases Alzheimer’s disease Molecular Mechanism Gene Therapy Presymptomatic diagnosis Ethics Gene Therapy Ethics

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