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Early Management of Nephroblastoma: A Single-Center Study in a Sub-Saharan African Country

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Open Journal of Pediatrics 2021年第4期11卷 797-803页

作者： abdoul Karim Doumbia Pierre Togo Mariam Maiga Mohamed Elmouloud Cissé Guédiouma Dembélé Oumar Coulibaly Karamoko Sacko Belco Maiga Djeneba Konaté abdou diarra Yakaria Coulibaly Fatoumata Léonie Diakité abdoul Aziz Diakité Boubacar Togo Check Bougadary Traore Adama Bah Department of Pediatrics at CHU Gabriel Touré Bamako Mali Reference Health Center of the Municipality 6 Bamako Mali Pediatric Surgery Department of the Gabriel Touré CHU Bamako Mali Pathological Anatomy and Cytology Department of the “Point G” CHU Bamako Mali

Introduction: Nephroblastoma is the most common renal cancer in pediatrics. The aim of this study was to describe the epidemiological, clinical, histological characteristics and the immediate outcome of patients with nephroblastoma. Methodology: This was a cross-sectional study of 18 cases of unilateral nephroblastoma, carried out in the pediatric oncology unit (UOP) of the CHU Gabriel Touré from January 2015 to December 2016. Results: The mean age of the patients was 33 months old. The sex ratio was 0.63. The average consultation time was 3 months. A case of malformation syndrome (aniridia and mental retardation) had been observed. The main reason for consultation was abdominal mass (100%) associated with deterioration of general condition (44%), pain (44%) and fever (17%). Stage I accounted for 61% and stage II 39%. The postoperative histological classification made it possible to find the high-risk blastematous type (33%), the regressive type of intermediate risk (11%) and the stromal type of intermediate risk (45%). Toxicities (haematological and digestive) were minimal. The 3-year overall survival was 90%. Conclusion: This study is characterized by the predominance of stages I and II and the fairly large percentage of histology at intermediate risk. These results are above all the result of multidisciplinary collaboration.

关键词： Cancer Child Nephroblastoma Diagnosis Prognosis Mali

Knowledge Practical Attitude of Health Professionals on Breast Cancer at the Hospital of the District of the Commune IV of Bamako

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Surgical Science 2024年第5期15卷 342-356页

作者： Moussa Samaké Souleymane B. Dembelé Sirama diarra Yely Dianessy abdou Guiré Dorcas Laurel Sodjiné Yede Amaguiré Saye Brahima Dembele Birama Traoré Thierno Nadio Ibrahima Maiga Mahamane Dicko Modibo diarra Siaka Konaté Amadou Maiga Bakary Tientigui Dembele Adégné Togo General Surgery Department of Bamako District IV Hospital Bamako Mali Obstetric Gynecology Department of the Bamako District IV Hospital Bamako Mali Department of Ophthalmology of the Hospital of the District of the Commune IV of Bamako Bamako Mali Imaging Service of the Bamako District IV Hospital Bamako Mali Anesthesia and Resuscitation Service of the Hospital of the District of the Commune IV of Bamako Bamako Mali Internal Medicine Department of the District Hospital of Commune IV of Bamako Bamako Mali General Surgery Department Kolondjeba Referral Health Centre Sikasso Mali General Surgery Department of the Gabriel Touré University Hospital Bamako Mali

Introduction: The level of knowledge and attitude of health professionals about breast cancer are important determinants. General objective: To study the knowledge, attitude and practice of health professionals of the hospital of the district of the commune IV on breast cancer. Methodology: This was a cross-sectional, prospective, descriptive, qualitative and quantitative study. The study period was from 01 October 2022 to December 2022. Results: In one week of survey, 110 health workers (intern, obstetrician nurse, general practitioners and specialists) received the survey sheet, 80 health workers informed it, a participation rate of 73%. The male sex was most represented at 63.75% with a sex ratio of 1.76. The average age was 39.59 years with extremes of 22 and 61 years. The clinical signs evoked by the participants were: breast nodule (81.25%), followed by breast discharge (48.75%). In relation to risk factors: interns and obstetrician nurses had no good knowledge, 51.72% of general practitioners had good knowledge, 43.48% of specialist doctors had good knowledge, and 5.88% of the wise had good knowledge. Conclusion: Breast cancer is a common pathology around the world, health professionals are at the forefront of the fight against breast cancer, and this fight cannot be effective without trained personnel.

关键词： Knowledge Attitude Practice Health Personnel Breast Cancer

Liposarcoma Retro-Peritoneal in the General Surgery Department of the Hospital of the District of the Commune IV

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Surgical Science 2024年第7期15卷 430-437页

作者： Moussa Samaké Souleymane Bingué Dembelé Yely Dianessy abdou Guiré Dorcas Laurel Sodjiné Yede Youssouf Boiré Mahamane Dicko Mantia Sara Nouhoum Sanogo Amaguiré Saye Sirama diarra Brahima Dembele Thierno Nadio Ibrahima Maiga Modibo diarra Siaka Konaté Birama Cheick Traoré Boubacar Diassana Bathio Traoré Amadou Maiga Boubacar Yoro Sidibé Adégné Togo General Surgery Department of Bamako District IV Hospital Bamako Mali Anesthesia and Resuscitation Service of the Hospital of the District of the Commune IV of Bamako Bamako Mali Anatomopathology Department of the CHU of Point G Bamako Mali Obstetric Gynecology Department of the Bamako District IV Hospital Bamako Mali Department of Ophthalmology of the Hospital of the District of the Commune IV of Bamako Bamako Mali Imaging Service of the Bamako District IV Hospital Bamako Mali Internal Medicine Department of the District Hospital of Commune IV of Bamako Bamako Mali General Surgery Department Kolondjeba Referral Health Centre Sikasso Mali Gynecology and Obstetrics Department of the San Reference Health Center Segou Mali General Surgery Department of Sikasso Hospital Sikasso Mali General Surgery Department of the Gabriel Tour University Hospital Bamako Mali

Retroperitoneal soft tissue sarcomas in the retroperitoneal/intra-abdominal regions represent 10% - 15% of all cases of soft tissue sarcoma. Liposarcomas, which are the most common histological type, account for 20% - 45% of retroperitoneal/intra-abdominal sarcoma cases, and 20% of liposarcomas cases are primary retroperitoneal liposarcomas. Surgical resection in case of malignancy remains the treatment of choice for liposarcomas, according to the guidelines of most major international companies. Our goal was to improve the management of retroperitoneal liposarcoma. This was a 65-year-old patient, with no medical or surgical history, who was referred to us for abdominal swelling, in whom clinical and paraclinical examination found retroperitoneal liposarcoma stage IV, and the surgical treatment consisted in making a tumor reduction. Conclusion: Retro-peritoneal liposarcoma is an undervalued malignant tumor, and the diagnosis is often late.

关键词： Retroperitoneal Liposarcoma Diagnostic Delay

High-dimensional supervised classification in a context of non-independence of observations to identify the determining SNPs in a phenotype

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Infectious Disease Modelling 2023年第4期8卷 1079-1087页

作者： Aboubacry Gaye abdou Ka Diongue Lionel Nanguep Komen Amadou Diallo Seydou Nourou Sylla Maryam diarra Cheikh Talla Cheikh Loucoubar Laboratory for Studies and Research in Statistics and Development Gaston Berger University of Saint LouisSenegal Epidemiology Clinical Research and Data Science UnitInstitute Pasteur de Dakar220DakarSenegal African Institute for Mathematical Sciences(AIMS) Senegal Information and Communication Technologies for Development Alioune Diop University of BambeySenegal

This work addresses the problem of supervised classification for highly correlated highdimensional data describing non-independent observations to identify SNPs related to a *** use a general penalized linear mixed model with a single random effect that performs simultaneous SNP selection and population structure adjustment in highdimensional prediction ***,the model simultaneously selects variables and estimates their effects,taking into account correlations between *** nucleotide polymorphisms(SNPs)are a type of genetic variation and each SNP represents a difference in a single DNA building block,namely a *** research has shown that SNPs can be used to identify the correct source population of an individual and can act in isolation or simultaneously to impact a *** this regard,the study of the contribution of genetics in infectious disease phenotypes is of great *** this study,we used uncorrelated variables from the construction of blocks of correlated variables done in a previous work to describe the most related observations of the *** model was trained with 90%of the observations and tested with the remaining 10%.The best model obtained with the generalized information criterion(GIC)identified the SNP named rs2493311 located on the first chromosome of the gene called PRDM16((PR/SET domain 16))as the most decisive factor in malaria attacks.

关键词： Non independence of observations Correlated variables High-dimensional supervised classification SNP Phenotype

Epidemiological, Diagnostic and Therapeutic Aspects of Breast Cancer in the Gynecology and Obstetrics Department of the CHU Gabriel Touré from 2020 to 2022

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Advances in Breast Cancer Research 2023年第3期12卷 97-113页

作者： Sirama diarra Moussa Samake Amaguiré Saye Brehima Dembélé Birama Traoré Souleymane B. Dembélé Déssé diarra Yely Dianéssy abdou Guiré Bakarou Kamate Gynecology and Obstetrics Department of the District Hospital of Commune IV Bamako Mali General Surgery Department of the Commune IV District Hospital Bamako Mali Obstetrics Gynecology Service of the CSREF of San Bamako Mali Anatomo-Pathology and Cytology Department of the Point G University Hospital Bamako Mali

In Mali, breast cancer remains a real health problem in the absence of an adequate and adapted health policy for their early diagnosis and their often late or even non-existent treatment. Objectives: This study aimed to study the epidemiological, diagnostic, and therapeutic aspects of breast cancer to write the clinical aspects of breast cancer in the gynecology-obstetrics department of the CHU Gabriel Touré from 2020 to 2022. Methodology: This was a retrospective and descriptive study of 219 cases of breast cancer that were diagnosed in the gynecology and obstetrics department of the CHU Gabriel Touré in Bamako, from 2020 to 2022. Results: The annual frequency was 77.2 cases per year, the average age 45.55 years with extremes of 16 to 85 years;housewives represented 92.7%;multiparas were reported at 57%. Considering the history, the personal history of benign breast pathology was 55.6%. Regarding the localization, the left breast was the most affected with 53.9%, and the tumor was found in the supero-external quadrant in 53.9%. The cancer was metastatic in 81.28%. The diagnosis biopsy + histology contributed to 98.6%. The histological type was invasive carcinoma of non-specific type in 95%. As for the histoprognostic grade of SBR studied, grade II was predominant at 46%, grade III at 34.95%. The therapeutic strategy was chemotherapy in 83.1%. Neoadjuvant chemotherapy followed by surgery in 10%, primary surgery in 6.4%, radiotherapy in 0.5%. Conclusion: The major challenges in the fight against breast cancer in Mali remain a better organization of the system for early diagnosis, the establishment of a screening program, early diagnosis in women from the age of 40 and also adequate care.

关键词： Epidemiology Diagnosis Therapeutics Breast Cancer Bamako (Mali)

Epidemiological and Therapeutic Aspects of Proctological Pathologies in Pregnant and Postpartum Women at the Reference Health Center of Commune IV of Bamako District

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Open Journal of Obstetrics and Gynecology 2023年第4期13卷 752-766页

作者： Seydou Mariko Amaguiré Saye Dessé diarra Sirima diarra Mariam Tangara Brahima Dembélé Fanta Doumbia Moussa Samaké abdou Guiré Yéli Dianessi abdoul Razakou Dicko Amadou Bocoum Youssouf Traoré Adégné Togo Gynecology Department of Mali Bamako Hospital Bamako Mali Department of Gynecology and Obstetrics Reference Health Center of Commune IV Bamako Mali Department of General Surgery Centre de Santé de Référence de la commune IV Bamako Mali Department of Public Health Centre de Santé de Référence de la commune IV Bamako Mali Department of Gynecology and Obstetrics Center Hospitalier Universitaire (CHU) Gabriel TOURE Bamako Bamako Mali

Introduction: Painful proctological conditions that are far less pleasant can mar pregnancy and childbirth. In Mali, few studies have been carried out on proctological pathologies in pregnant women and in the postpartum period. Objective: To determine the frequency and identify the risk factors of anal pathologies during pregnancy and in the postpartum period in the obstetric gynecology department of the Centre de Santé de Référence de la comme IV du District de Bamako. Mali. Methods and Materials: Our observational study, a cross-sectional cohort survey over a period of nine (09) months from January 1, 2020 to September 30, 2020, was conducted in the obstetrics and gynecology department of the Health Center of Reference of Type IV of the District of Bamako. Results: The frequency of anal pathologies during pregnancy and in the post partum period was 24% (36/150). The different anal pathologies found were anal fissures, hemorrhoidal disease, anal incontinence and multiple anal pathologies with respectively 10%;6.67%;5.33%;2%. Chronic constipation (p = 0.003), a newborn weight > 3500 g (p = 0.000) to the occurrence of hemorrhoidal disease. For anal fissures, risk factors were noted such as (weight of the newborn > 3500 g (p = 0.002) and duration of fetal expulsion > 20 minutes (p = 0.000). Finally, a newborn weight > 3500 g (p = 0.000) and a maternal age of up to 30 years (p = 0.001) were associated with the occurrence of anal incontinence. Conclusion: Our study shows that anal pathologies affecting women's intimacy are frequent during pregnancy and in the postpartum period and are part of the many taboos difficult to address in our society.

关键词： Anal Pathologies Delivery Pregnancy

Quality of Antenatal Care at the Referral Health Center of the Fourth Commune of Bamako District

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Open Journal of Obstetrics and Gynecology 2023年第3期13卷 609-624页

作者： Amaguiré Saye Dessé diarra Sirima diarra Brahima Dembele abdou Guire Souleymane Dembele Yéli Dianessi Moussa Samake Seydou Mariko Seydou Fomba Diakaridia Kone abdoul Razakou Dicko Pierre Coulibaly Daouda Camara Hamidou Toure Mama Sy Konake Obstetrics and Gynecology Service Commune IV Reference Health Center Bamako Mali Obstetrics and Gynecology Department of Bamako Mali Hospital Bamako Mali Department of Study and Research in Public Health Faculty of Medicine and Odontostomatology USTTB Bamako Mali Reference Health Center of Commune I Bamako Mali Obstetrics and Gynecology Department of the Somine DOLO Hospital Mopti Mali Reference Health Center of Kati Kati Mali

Purpose: To contribute to the improvement of the quality of prenatal consultation at the reference health center of the commune IV of the district of Bamako. Patients Methods: This was a qualitative cross-sectional study to assess the quality of prenatal consultation that took place from December 1, 2017 to January 31, 2018. It included 139 pregnant women whose consultations were monitored by the investigator and then the women were interviewed upon discharge from the facility to collect their opinions on the services they received. Results: The age group of 20 to 29 years was the most represented with 60.44%. In our study, 50% of our patients were managed by midwives. Among the antecedents constituting the risk factors sought in pregnant women, scar uterus was more frequent with 33.93% followed by arterial hypertension with 14.28% and multiparity with 7.14%. Conclusion: This study shows that the evaluation of the quality of services is an absolute necessity for the improvement of services in integrated reproductive health care centers.

关键词： Quality Prenatal Consultation Bamako Mali

Interest of Computed Tomography in the Diagnosis of Intestinal Obstruction Due to an Internal Hernia of Unusual Location: The Falciform Ligament

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Open Journal of Radiology 2023年第2期13卷 94-100页

作者： Diallo Moustapha Diack Aminata Ndaw Mame diarra Bousso Amar Ndeye Isseu Diop Massamba Diouf Cheikh Tidiane Fall Amath Ndiaye abdou Rahmane Soko Thierno Omar Mbengue Ababacar Department of Medical Imaging Dakar Principal Hospital Dakar Senegal

Pathological implications of the falciform ligament are rare and internal hernias are exceptional. The origin of the falciform ligament defect can be congenital or inflammatory (a satellite of acute cholecystitis) or even post-surgical. The internal hernias of the falciform ligament are most often revealed by an acute intestinal obstruction syndrome with an ischemic component. The scanner provides the benchmarking examination allowing us to conduct a positive diagnosis and see also the inherent complications, which drives us to take the appropriate and fast surgical procedures. It is an entity that must be known.

关键词： Internal Hernia Falciform Ligament Scanner

Basedowian Orbitopathy Without Thyreotoxicosis : A Case Report from Sikasso Hospital

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Open Journal of Ophthalmology 2023年第3期13卷 273-279页

作者： Cheickna Nomoko Adama Dembele Moro Sidibe Karim diarra Moussa Sidibé Niamé Touré Moussa abdou Touré Oulematou Soucko Ousmane Fané Daouda Goita Oumar Diallo Djonny Jonas Dembele Mamadou Adama Togo Kadiatou Ba Koita abdoulaye Nouhoum Coulibaly Cheick Fantamady Tounkara Nouhoum Touré abdoulaye Konaté abdoulaye Napo Nana Kadidia Fofana Regional Hospital of Sikasso Sikasso Mali Alliance for the Development of Community Ophthalmology (ADOC) Bamako Mali Referral Health Center for Commune 3 in the District of Bamako Bamako Mali African Tropical Ophthalmology Institute Bamako Mali Referral Health Center for Commune 4 in the District of Bamako Bamako Mali

Basedowian orbitopathy is an autoimmune disease representing the most frequent extra-thyroidal manifestation. Its pathophysiology is imperfectly elucidated and is the result of cross-reactivity between thyroid antigens and orbital tissue. It is most frequently seen in the context of hyperthyroidism (basedow’s disease or Graves’ disease), sometimes hypothyroidism (Hashimoto’s thyroiditis), or euthyroidism. Diagnosis is often straightforward, but management remains difficult. The introduction of simple medical treatment exposes the patient to the risk of recurrence. In Sikasso, there have been few studies of Graves’ disease. The aim of this study was to describe the clinical, therapeutic and evolutionary features of Graves’ disease in Sikasso Hospital. The patient was a 35-year-old woman with no previous history of Graves’ disease and no history of alcohol or tobacco intoxication, consulting for bilateral exophthalmos with moderate pain for 1 year. Endocrine tests were normal (euthyroidism), as was orbital-cerebral MRI, which revealed stage II exophthalmos with no sellar or supra-saltar abnormalities. The main complication was exposure to keratitis. Our patient was treated with corticosteroids. The evolution was favorable under treatment, with no recurrence after one year’s follow-up. Graves’ disease is the most common cause of hyperthyroidism, but this should not obscure the diagnosis of euthyroidism, as demonstrated in this case report. Exophthalmos remains the main ophthalmological clinical manifestation.

关键词： Euthyroidism Basedowian Orbitopathy Orbital-Cerebral MRI Corticoster-oid Therapy