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hepatoprotective activity of Dypsis lutescens against D-galactosamine-induced hepatotoxicity in rats and its phytoconstituents

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Asian Pacific Journal of Tropical Biomedicine 2019年第11期9卷 467-473页

作者： Mai M.El-Ghonemy Walaa A.El-Kashak Tahia K.Mohamed Enayat A.Omara Jihan hussein abdel-razik h.farrag Mahmoud I.Nassar Mohamed Y.El-Kady Chemistry of Natural Compounds Department National Research Centre33 El-Bohouth St.Dokki12622CairoEgypt Department of Pathology National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Medical Biochemistry Department National Research Centre33 El Bohouth St.Dokki12622CairoEgypt Chemistry Department Faculty of ScienceAin Shams UniversityCairoEgypt

Objective:To isolate and identify the polyphenolic constituents of Dypsis lutescens,and evaluate the hepatoprotective activity of the ethanolic extract of Dypsis lutescens ***:hepatoprotective,antioxidant and anti-inflammatory effects of two doses of Dypsis lutescens ethanolic leaf extract were investigated in five groups of six rats each administered with the ethanolic extract of Dypsis lutescens *** function parameters were assessed,histopathological study was carried out,the anti-inflammatory mediators and the antioxidant potential in the liver tissues were *** addition,the total ethanolic extract of Dypsis lutescens leaves was subjected to different chromatographic separation techniques to yield ten phenolic *** isolated compounds structures were spectroscopically ***:hepatoprotective activity of Dypsis lutescens ethanolic extract was estimated for the first time and showed significant activity against histopathological changes induced by D-galactosamine in *** extract improved the liver *** to the D-galactosamine group,the architecture of the liver in the treated groups was improved in the histopathological *** results proved the hepatoprotective activity of Dypsis lutescens and its ability in attenuating liver oxidative damage and *** investigations of the total extract afforded ten compounds from the genus ***:The alcoholic extract of Dypsis lutescens exerted potential hepatoprotective action,maintaining liver health and functions.

关键词： Dypsis lutescens Flavonoid glycosides Phenolic acids hepatoprotective Antioxidant Anti-inflammatory

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Updates in the pathophysiological mechanisms of Parkinson's disease: Emerging role of bone marrow mesenchymal stem cells

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World Journal of Stem Cells 2016年第3期8卷 106-117页

作者： hanaa h Ahmed Ahmed M Salem hazem M Atta Emad F Eskandar abdel razik h.farrag Mohamed A Ghazy Neveen A Salem hadeer A Aglan Department Medical Research Division National Research Centre Biochemistry Department Faculty of Science Ain Shams University Clinical Biochemistry Department Faculty of Medicine King Abdulaziz University Medical Biochemistry and Molecular Biology Department Faculty of Medicine Cairo University Pathology Department Medical Research Division National Research Centre Narcotics Ergogenic aids and Poisons Department Medical Research Division National Research Centre

AIM: To explore the approaches exerted by mesenchymal stem cells (MSCs) to improve Parkinson’s disease (PD) ***: MSCs were harvested from bone marrow of femoral bones of male rats, grown and propagated in culture. Twenty four ovariectomized animals were classified into 3 groups: Group (1) was control, Groups (2) and (3) were subcutaneously administered with rotenone for 14 d after one month of ovariectomy for induction of PD. Then, Group (2) was left untreated, while Group (3) was treated with single intravenous dose of bone marrow derived MSCs (BM-MSCs). SRY gene was assessed by PCR in brain tissue of the female rats. Serum transforming growth factor beta-1 (TGF-β1), monocyte chemoattractant protein-1 (MCP-1) and brain derived neurotrophic factor (BDNF) levels were assayed by ELISA. Brain dopamine DA level was assayed fluorometrically, while brain tyrosine hydroxylase (Th) and nestin gene expression were detected by semi-quantitative real time PCR. Brain survivin expression was determined by immunohistochemical procedure. histopathological investigation of brain tissues was also ***: BM-MSCs were able to home at the injured brains and elicited significant decrease in serum TGF-β1 (489.7 ± 13.0 vs 691.2 ± 8.0, P h significant increase in serum BDNF (3663 ± 17.8 vs 2905 ± 72.9, P h (1.18 ± 0.004 vs 0.54 ± 0.009, P he number of positive cells for survivin (293.2 ± 15.9 vs 271.5 ± 15.9, P > 0.05) expression. Finally, the brain sections showed intact histologica

关键词： Parkinson’s disease Pathophysiology Bone marrow derived mesenchymal stem cells Rotenone Anti-inflammatory action Ovariectomy Anti-apoptotic effect Neurogenic potential

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Soft coral Cespitularia stolonifera:New cytotoxic ceramides and gastroprotective activity

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Chinese Journal of Natural Medicines 2017年第2期15卷 105-114页

作者： abdelsamed I.Elshamy Walaa A.El-Kashak heba M.I.Abdallah abdelrazik h.farrag Mahmoud I.Nassar Natural Compounds Chemistry Department National Research CentreGiza 12622Egypt Pharmacology Department National Research CentreGiza 12622Egypt Pathology Department National Research Centre Giza 12622Egypt

In the present study, a new ceramide, namely 2S, 3R-4E, 8E-2-(heptadecanoylamino)-heptadeca-4, 8-diene-1, 3-diol(1), along with four known steroids, including 24-methylcholesta-5, 24(28)-diene-3β-ol(2), 24-methylcholesta-5, 24(28)-diene-3β-acetate(3), 4-methyl-24-methylcholesta- 22-ene-3-ol(4), and cholesterol, was isolated and characterized from Ch2Cl2/Me Oh extract of Cespitularia stolonifera. A new acetate derivative of compound 1, termed 2S, 3R-4E, 8E-2-(heptadecanoylamino)-heptadeca-4, 8-diene-1, 3-diacetate(1a), was also prepared in the present study. All the structures were established on the basis of modern spectroscopic techniques, including FT-IR, 1D, 2D-NMR, hRESI-MS, and GC-MS, in addition of chemical methods.(-)-Alloaromadendren, ledane,(1)-alloaromadendren oxide, isoaromadendrene epoxide and(-)-caryophellen oxide were identified from the n-hexane fraction using GC-MS. The extract and the two ceramides(1) and(1a) exhibited significant cytotoxic activity against lung cancer A549 cells, while the extract and the two steroids(2) and(3) exhibited significant cytotoxic activity against breast cancer MCF-7 cells. The Ch_2Cl_2/MeOh extract exhibited significant antiulcer activity in both ethanol and acetic acid induced ulcer models in rats, as evidenced by histopathological, histochemical, and biochemical examinations.

关键词： Cespitularia stolonifera Ceramide Steroids Anticancer leading constituents Antiulcer activity

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high Gain Predictions for Ni-Like Ta Ions

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Chinese Physics Letters 2013年第11期30卷 80-83页

作者： Wessameldin S.abdelaziz A.A.farrag h.M.hamed Mai E.Ahmed National Institute of Laser Enhanced Sciences Cairo UniversityGizaEgypt Faculty of Science Cairo UniversityGizaEgypt Environmental Affairs Agency(EEAA) Egypt

Atomic structure data and effective collision strengths for 1s^(2)2s^(2)2p^(6)3s^(2)3p^(6)3d^(10) and 54 fine-structure levels are contained in the configurations 1s^(2)2s^(2)2p^(6)3s^(2)3p^(6)3d^(9)4l(l=s,p,d,f)for the nickel-like Ta *** data are used in the determination of the reduced population for the 55 fine structure levels over a wide range of electron densities(from 10^(21) to 10^(23))and at various electron plasma *** gain coefficients for those transitions with a positive population inversion factor are determined and plotted against the electron density.

关键词： density nickel structure

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Preliminary evaluation of the radiotherapeutic efficacy of 131I-atorvastatin in rats with hepatocellular carcinoma

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Nuclear Science and Techniques 2020年第11期31卷 1-11页

作者： Nourihan S.farrag Abeer M.Amin Labeled Compounds Department Hot Laboratories CentreEgyptian Atomic Energy Authority(EAEA)P.O.Box 13759CairoEgypt

As one of the most critical types of cancer,hepatocellular carcinoma(hCC)affects many people *** study demonstrated the prospective use of atorvastatin,a drug that inhibits the mevalonate pathway,causing hypolipidemia,as a carrier to deliver the iodine-131(131I)isotope to liver tissues for hCC *** atorvastatin radioiodination method was optimized for utilizing the131I *** radiochemical quality and the in vitro stability of the generated[131I]atorvastatin were *** addition,the biodistribution experiments of[131I]atorvastatin were evaluated in both normal and hCC-induced rat models.[131I]atorvastatin was produced at a maximum radiochemical yield of 86.7±0.49%.The[131I]atorvastatin solution purified via high-performance liquid chromatography showed good in vitro stability for 12 h after *** analyses revealed remarkable liver targeting capacity of[131I]atorvastatin and good localization of131I in liver ***,the encouraging biochemical profile and histopathologicalfindings have been reported,and preliminary investigations on the possible use of[131I]atorvastatin as a radiotracer and its impact on hCC radiotherapy in rats show promise.

关键词： hepatocellular carcinoma [131I]Atorvastatin Biodistribution Radiotherapy

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Discovery of Potent of New 4-oxothiazolidin-2-ylidene Derivatives Containing Piperidinyl Moiety againstAldose Reductase

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材料科学与工程（中英文A版） 2012年第2期2卷 220-231页

作者： Areal A. farrag Ali.Khalil Shaban Ibrahim Mohamed Ahmed A. EI-henaway Gameel Ahamed Mohamed El-hag Alil Yuosry Ahmed Ammar Chemistry Department Faculty of Science AI-Azhar University Nasr City（Girls） Cairo Egypt Chemistry Department Faculty of Science Ain Shams University Cairo Egypt Technology Engineering Institute Tamoh Giza Egypt Chemistry Department Faculty of Science Al-Azhar University Nasr City Cairo（boys） Egypt Chemistry Department Faculty of Science King Khaled University Saudi Arabia Abha

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