检索结果-南通市图书馆

Novel CYP1B1 mutations and a possible prognostic use for surgical management of congenital glaucoma

International Journal of Ophthalmology(English edition) 2019年第4期12卷 607-614页

作者： Mohamed M.Khafagy Nadia El-Guendy Marwa A Tantawy Mohamed A.Eldaly Hala M.Elhilali abdel hady a.abdel wahab Ophthalmology Department Faculty of Medicine Cairo University Cancer Biology Department National Cancer Institute Cairo University Research Department Children's Cancer Hospital

AIM: To identify CYP1B1 gene mutations and evaluate their possible role as a prognostic factor for success rates in the surgical management of Egyptian congenital glaucoma ***: Totally 42 eyes of 29 primary congenital glaucoma patients were operated on with combined trabeculotomy/trabeculectomy with mitomycin-C and followed up at 1 d, 1 wk, 1, 6 and 12 mo postoperatively. Genomic DNA was extracted from peripheral blood leukocytes. Coding regions of CYP1B1 gene were amplified using 13 pairs of primers, screened for mutations using single-strand conformation polymorphism followed by sequencing of both strands. Efficacy of the operation was graded as either a success [maintaining intraocular pressure(IOP) less than 21 mm Hg with or without antiglaucoma medication], or a failure(IOP more than 21 mm Hg with topical antiglaucoma medications). RESULTS: Seven novel mutations out of a total of 15 different mutations were found in the CYP1B1 genes of 14 patients(48.2%). The presence of CYP1B1 gene mutations did not correlate with the failure of the surgery(P=0.156, odds ratio=3.611, 95%CI, 0.56 to 22.89); while the positive consanguinity strongly correlated with failure of the initial procedure(P=0.016, odds ratio=11.25, 95%CI, 1.57 to 80.30). However, the Kaplan-Meier survival analysis revealed a significantly lower time of IOP control in the subgroup with mutations in CYP1B1 versus the congenital primary glaucoma group without mutations(log rank test, P=0.015).CONCLUSION: Seven new CYP1B1 mutations are identified in Egyptian patients. Patients harboring confirmed mutations suffered from early failure of the initial surgery. CYP1B1 mutations could be considered as a prognostic factor for surgery in primary congenital glaucoma.

关键词： CYP1B1 mutations primary congenital glaucoma intraocular pressure trabeculotomy/trabeculectomy with mitomycin-C.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Combining Committee-Based Semi-Supervised Learning and Active Learning

引用

Journal of Computer Science & Technology 2010年第4期25卷 681-698页

作者： Mohamed Farouk abdel hady Friedhelm Schwenker Institute of Neural Information Processing University of Ulm

Many data mining applications have a large amount of data but labeling data is usually difficult, expensive, or time consuming, as it requires human experts for annotation. Semi-supervised learning addresses this problem by using unlabeled data together with labeled data in the training process. Co-Training is a popular semi-supervised learning algorithm that has the assumptions that each example is represented by multiple sets of features （views） and these views are sufficient for learning and independent given the class. However, these assumptions axe strong and are not satisfied in many real-world domains. In this paper, a single-view variant of Co-Training, called Co-Training by Committee （CoBC） is proposed, in which an ensemble of diverse classifiers is used instead of redundant and independent views. We introduce a new labeling confidence measure for unlabeled examples based on estimating the local accuracy of the committee members on its neighborhood. Then we introduce two new learning algorithms, QBC-then-CoBC and QBC-with-CoBC, which combine the merits of committee-based semi-supervised learning and active learning. The random subspace method is applied on both C4.5 decision trees and 1-nearest neighbor classifiers to construct the diverse ensembles used for semi-supervised learning and active learning. Experiments show that these two combinations can outperform other non committee-based ones.

关键词： data mining classification active learning co-training semi-supervised learning ensemble learning randomsubspace method decision tree nearest neighbor classifier

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multi-Scale Analysis of Fretting Fatigue in Heterogeneous Materials Using Computational Homogenization

引用

Computers, Materials & Continua 2020年第1期62卷 79-97页

作者： Dimitra Papagianni Magd abdel wahab Department of Materials Science and Engineering University of IoanninaIoanninaGreece Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903Zwijnaarde B-9052Belgium Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

This paper deals with modeling of the phenomenon of fretting fatigue in heterogeneous materials using the multi-scale computational homogenization technique and finite element analysis(FEA).The heterogeneous material for the specimens consists of a single hole model(25% void/cell,16% void/cell and 10% void/cell)and a four-hole model(25%void/cell).Using a representative volume element(RVE),we try to produce the equivalent homogenized properties and work on a homogeneous specimen for the study of fretting ***,the fretting fatigue contact problem is performed for 3 new cases of models that consist of a homogeneous and a heterogeneous part(single hole cell)in the contact *** aim is to analyze the normal and shear stresses of these models and compare them with the results of the corresponding heterogeneous models based on the Direct Numerical Simulation(DNS)***,by comparing the computational time and%deviations,we draw conclusions about the reliability and effectiveness of the proposed method.

关键词： Fretting fatigue multi-scale analysis computational homogenization heterogeneous materials stress analysis finite element analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Review on Fretting Wear Mechanisms,Models and Numerical Analyses

引用

Computers, Materials & Continua 2019年第5期59卷 405-432页

作者： Tongyan Yue Magd abdel wahab State Grid Xinyuan Maintenance Branch BeijingChina Department of Electrical Energy MetalsMechanical Constructions&SystemsSoete LaboratoryFaculty of Engineering and ArchitectureGhent UniversityGhentBelgium Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

Fretting wear is a material damage in contact surfaces due to micro relative displacement between *** causes some general problems in industrial applications,such as loosening of fasteners or sticking in components supposed to move relative to each *** wear is a complicated problem involving material properties of tribosystem and working conditions of *** to these various factors,researchers have studied the process of fretting wear by experiments and numerical modelling *** paper reviews recent literature on the numerical modelling method of fretting *** a briefly introduction on the mechanism of fretting wear,numerical models,which are critical issues for fretting wear modelling,are *** paper is concluded by highlighting possible research topics for future work.

关键词： Fretting wear wear models wear mechanisms numerical modelling

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rescue effects of aqueous seed extracts of Foeniculum vulgare and Carum carvi against cadmium-induced hepatic, renal and gonadal damage in female albino rats

引用

Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1123-1133页

作者： Ahmed abdel-wahab abdel-Razik Hashem abdel-Razik Rabie Lotfy abdel Aziz Physiology Department Faculty of Veterinary MedicineMinia University61519 El-MiniaEgypt Histology Department Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt Department of Theriogenology Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt

Objective: To investigate the protective effects of aqueous seed extracts of fennel"Foeniculum vulgare"(FVE) and caraway "Carum carvi"(CCE) on liver, kidney and reproductive organs in female rats against cadmium chloride(CC) ***: A total of 36 adult female rats were divided into six groups, six in each *** group(fed normal diet), CC-treated group(50 mg CC/kg diet), CCE-treated group(150 mg CCE/kg diet), CCE + CC group, FVE(150 mg/kg diet) and FVE + CC. One month later, all rats were sacrificed and all samples were collected at proestrus ***: The toxic effects of CC were confirmed biochemically by significant increase of serum concentration of liver enzymes(P < 0.05), and creatinine(P < 0.001). Moreover,CC increased significantly the serum level of malondialdehyde(MDA) and decreased the total antioxidant capacity(TAC)(P < 0.001). In addition, serum concentrations of estrogen, progesterone, follicle-stimulating hormone(FSH) and luteinizing hormone(LH)were significantly decreased(P < 0.01). Histopathologically, CC-treated group revealed marked pathological changes in renal, hepatic, ovarian and uterine tissues. All toxic findings observed in liver and kidney with CC treatment were found to be ameliorated markedly after co-treatments with FVE or CCE. Furthermore, co-treatment of FVE with CC improved significantly all studied reproductive parameters(P < 0.01).Conclusions: Both FVE and CCE could be used as efficient treatments for liver and kidney against CC intoxication. Moreover, FVE could be utilized as a potent treatment to protect and improve female fertility from cadmium intoxication.

关键词： Cadmium Carum carvi Foeniculum vulgare Liver Kidney Fertility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Histopathological alterations in the liver and intestine of Nile tilapia Oreochromis niloticus exposed to long-term sublethal concentrations of cadmium chloride

引用

Chinese Journal of Oceanology and Limnology 2015年第4期33卷 846-852页

作者： YOUNIS Elsayed abdel-WARITH abdel-wahab AL-ASGAH Nasser EBAID Hossam Department of Zoology College of Science King Saud University Department of Animal Production Faculty of Agriculture Al-Azhar University Department of Zoology College of Science El-Minia University

Fingerlings of Nile tilapia Oreochromis niloticus were exposed to 1.68, 3.36, and 5.04 mg/L cadmium(as CdCl2), which represent 10%, 20%, and 30% of their previously determined 96-h LC5 0. After exposure for 20 days, sections of the liver and intestine of treated fish were examined histologically. Histopathological changes varied from slight to severe structural modification, depending on the exposure concentration. The hepatic tissues of fish exposed to 10% LC 50 showed markedly increased vacuolation of the hepatocytes and coarse granulation of their cytoplasm. Abundant erythrocytic infiltration among the hepatocytes was observed in fish exposed to 20% LC5 0. In the intestinal tissues of fish exposed to all doses, goblet cells proliferated and were greatly increased in size, the longitudinal muscularis mucosa was disturbed and, in the crypts of the sub-mucosal layer, apoptosis increased, indicated by large numbers of degenerated nuclei. Large numbers of inflammatory cells and dilated blood vessels were observed in the intestine of the group treated with 30% LC5 0.

关键词： fish tilapia pollutant cadmium liver intestine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fatigue crack propagation across grain boundary of Al-Cu-Mg bicrystal based on crystal plasticity XFEM and cohesive zone model

引用

Journal of Materials Science & Technology 2022年第31期126卷 275-287页

作者： Qi Zhao Magd abdel wahab Yong Ling Zhiyi Liu School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China Faculty of Mechanical-Electrical and Computer Engineering School of Engineering and TechnologyVan Lang UniversityHo Chi Minh CityVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903B-9052 ZwijnaardeBelgium School of Materials Science and Engineering Central South UniversityChangsha 410083China

In this paper,a methodology integrating crystal plasticity(CP),the eXtended finite element method(XFEM)and the cohesive zone model(CZM)is developed for an Al-Cu-Mg alloy to predict fatigue crack propagation(FCP)across grain boundary(GB)of Al-Cu-Mg alloy during stageІІ.One GB model is incor-porated into FCP constitutive law to describe grain interaction at GB.A bicrystal containing GB is built up to simulate FCP behavior through L participated *** features including GB characteristic,cumulative plastic strain(CPS)distribution and crystal slipping evidence can be *** numer-ical results are compared with published experimental data to check the accuracy of *** work demonstrates that the combination of CP containing GB constitutive laws,XFEM and CZM is a promising methodology in predicting twist angle-controlled crack deflection through GBs.

关键词： Grain boundary Twist angle Crystal plasticity Extended finite element method Fatigue crack propagation Cumulative plastic strain

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of wear debris on fretting fatigue crack initiation

引用

Friction 2022年第6期10卷 927-943页

作者： Shengjie WANG Tongyan YUE Dagang WANG Magd abdel wahab Soete Laboratory Department of Electrical EnergyMetalsMechanical Construction&SystemsFaculty of Engineering and ArchitectureGhent UniversityGhent 9052Belgium State Grid Xinyuan Maintenance Branch Beijing 100000China School of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China Faculty of Engineering Van Lang UniversityHo Chi Minh City 700000Vietnam Soete Laboratory Ghent UniversityGhent 9052Belgium

Both wear and fatigue occur in fretting condition,and they interact with one another during the whole *** fatigue is commonly analysed without considering the effect of wear in partial slip regime,although wear affects the lifetime of crack *** paper investigates,for the first time,the effect of wear debris on fretting fatigue crack *** investigate the effect of debris,first fretting wear characteristics in partial slip regime are analysed for loading ***,the effect of wear on fretting fatigue crack initiation is investigated using Ruiz parameters and critical plane methods without considering the debris *** the results,we can see that loading conditions affect the wear profiles in different ***,wear has a significant effect on the fatigue in partial slip regime without considering debris especially on the crack initiation ***,considering wear debris in the analysis,its effect on critical plane parameters is *** is found that by considering the wear debris effect,the frtting fatigue crack initiation location is shifted towards the trailing *** predictions of both crack initiation location and lifetime show a good agreement with the experimental data.

关键词： fretting wear fretting fatigue critical plane Ruiz parameter debris

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Improvement of Flat Surfaces Quality of Aluminum Alloy 6061-O By A Proposed Trajectory of Ball Burnishing Tool

引用

Computers, Materials & Continua 2019年第8期61卷 555-568页

作者： Ruba Alghazoul Almohanad Makki Magd abdel wahab Faculty of Mechanical and Electrical Engineering Al Baath UniversityHomsSyria Institute of Research and Development Duy Tan University03 Quang TrungDa NangVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityGentBelgium

Burnishing is a profitable process of surface finishing due to its ability to be automated,which makes burnishing method more desirable than other finishing *** obtain high surface finish,non-stop operation is required for CNC machine and we can attain that by choosing a suitable trajectory of the finishing *** other words,burnishing paths should be multidirectional rather than monotonic,in order to cover uniformly the ***,the burnishing force is also a key parameter of the burnishing process because it determines the degree of plastic deformation,and that makes determining the optimum burnishing force an essential step of the burnishing process a ***,we consider the strategy of ball burnishing path and the burnishing force as variable parameters in this *** this paper,we propose a new strategy of burnishing tool path with trochoid cycles that achieves a multidirectional burnishing of the surface according to various *** into consideration the optimum burnishing force,to improve flat surface finish of AL6061-O samples by reducing the surface roughness parameter(Rz).Experiments carried out on 3-axis milling machine show that the proposed trochoidal path is more effective than the conventional one.

关键词： Ball burnishing surface quality trajectories roughness

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effect of Surface Pit Treatment on Fretting Fatigue Crack Initiation

引用

Computers, Materials & Continua 2021年第1期66卷 659-673页

作者： Qingming Deng Xiaochun Yin Magd abdel wahab Department of Mechanics and Engineering Science Nanjing University of Science and TechnologyNanjing210094China Soete Laboratory Department of Electrical EnergyMetalsMechanical Constructions and SystemsFaculty of Engineering and ArchitectureGhent UniversityZwijnaarde9052Belgium Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

This paper analyses the effect of surface treatment on fretting fatigue specimen by numerical simulations using Finite Element *** processed specimen refers to artificially adding a cylindrical pit to its contact ***,the contact radius between the pad and the specimen is controlled by adjusting the radius of the *** stress distribution and slip amplitude of the contact surface under different contact geometries are *** critical plane approach is used to predict the crack initiation life and to evaluate the effect of processed specimen on its fretting fatigue *** crack initiation life and angle can be predicted by the critical plane *** parameter is used to consider the effect of contact *** is shown that the crack initial position is dependent on the tensile *** same type of model,three kinds of critical plane parameters and Ruiz method provide very similar position of crack ***,the improved sample is much safer than the flat-specimen.

关键词： Finite element analysis surface pit stress distribution fretting fatigue critical plane approach

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：