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Mitigating diabetes-related complications:Empowering metformin with cholecalciferol and taurine supplementation in type 2 diabetic rats

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World Journal of Diabetes 2024年第8期15卷 1778-1792页

作者： Mai s Attia Fadwa Ayman Mohamed s Attia Galal Yahya Mansour H Zahra Magdi Mohamed Ibrahim Khalil abdel aziz A Diab Department of Zoology Faculty of ScienceZagazig 44519Egypt Department of Pharmaceutics Faculty of PharmacyZagazig 44519Egypt Department of Microbiology and Immunology Faculty of PharmacyZagazig UniversityZagazig 44519Egypt Department of Biochemistry Faculty of MedicineZagazig 44519Egypt

BACKGROUND Type 2 diabetes is one of the most prevalent chronic diseases worldwide,significantly impacting patients'quality of *** treatment options like metformin(MET)effectively counteract hyperglycemia but fail to alleviate diabetes-associated complications such as retinopathy,neuropathy,nephropathy,hepatopathy,and cardiovascular *** To propose the supplementation of cholecalciferol(CHO)and taurine(TAU)to enhance MET efficacy in controlling diabetes while minimizing the risk of associated *** The study involved sixty rats,including ten non-diabetic control rats and fifty experimental rats with type 2 diabetes induced by *** experimental rats were further subdivided into positive control and treatment *** four treatment groups were randomly allocated to a single MET treatment or MET combined with supplements either CHO,TAU,or *** Diabetic rats exhibited elevated levels of glucose,insulin,Homeostasis Model Assessment of Insulin Resistance(HOMA-IR),glycated hemoglobin percentage,lipid markers,aspartate aminotransferase,and malondialdehyde,along with reduced levels of antioxidant enzymes(catalase and superoxide dismutase).The administration of CHO and TAU supplements alongside MET in diabetic rats led to a noticeable recovery of islet *** antioxidative,anti-inflammatory,and anti-apoptotic properties of the proposed combination therapy significantly ameliorated the aforementioned *** The supplementation of CHO and TAU with MET showed the potential to significantly improve metabolic parameters and protect against diabetic complications through its antioxidative,anti-inflammatory,and antiapoptotic effects.

关键词： Diabetes complications Metformin Cholecalciferol Taurine Glycated hemoglobin% Antioxidant

My Dream of Translation and Predestination With China

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China News Release 2024年第4期 24-27页

作者： abdel aziz Hamdi the Chinese language department of Al-Azhar University in Egypt

Many years later,when looking back on my decision,I can’t help but think that a few things in life seem to be coincidences,but in fact they are imperceptibly predestined,just like my dream of translation and my experience with the Chinese *** 1977,when I was 18 years old,Ain shams University in Egypt established the Chinese *** was the only Chinese department among Egyptian universities for the following two decades.

关键词： looking dream translation

Microbial,immune and antioxidant responses of Nile tilapia with dietary nano-curcumin supplements under chronic low temperatures

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Aquaculture and Fisheries 2024年第1期9卷 57-65页

作者： Mohammed F.El Basuini Mohamed A.A.Zaki abdelaziz M.El-Hais Mohamed G.Elhanafy Emad H.El-Bilawy Amr I.Zaineldin Mohamed F.A.abdel-aziz Ibrahim A.Abouelsaad Ibrahim TEl-Ratel Kumbukani Mzengereza Ronick s.shadrack Islam I.Teiba Faculty of Agriculture Tanta UniversityTanta31527Egypt King salman International University South Sinai46618Egypt Faculty of Agriculture Alexandria UniversityAlexandria21526Egypt Animal Health Research Institute(AHRI-DOKI) Agriculture Research CenterGiza12619Egypt Fish Rearing Lab. Aquaculture DivisionNational Institute of Oceanography and FisheriesAlexandria21556Egypt Horticulture Department Faculty of AgricultureDamanhour UniversityDamanhur22511Egypt Department of Poultry Production Faculty of AgricultureDamietta UniversityDamietta34517Egypt Laboratory of Aquatic Animal Nutrition Faculty of FisheriesKagoshima UniversityKagoshima890-0065Japan Department of Aquatic and Fisheries science Mzuzu UniversityMzuzuPrivate Bag 201Malawi Faculty of Aquaculture and Marine Fisheries Arish UniversityArish45516Egypt

A 56-day feeding period was performed to investigate the possible impacts of dietary nano curcumin(0,50,100,150,and 200 ppm)on the growth,nutrient utilization,non-specific immune parameters,antioxidants in Nile tilapia under chronic low temperature(21.02±0.11◦C).Fishes(n=225;Initial weight=4.39±0.08 g/fish)were randomly stocked at 15 fish/tank for five experimental groups in *** low-temperature circumstances,dietary curcumin in nano form showed no notable alteration in growth variable,nutrient efficiency,digestive enzymes efficiency,biometric indices,survival rates,and hematological ***,the serum of fishes with nano curcumin diets under low-temperature stress displayed higher total protein as well as lower glucose,cortisol,and total cholesterol compared with the control ***,fish fed nano curcumin diets displayed higher lysozyme and bactericidal activities compared to the control group and the best performance was found at dietary nano curcumin level of≥100 ***,groups fed the basal diet demonstrated the poorest antioxidant capacity,and the best superoxide dismutase(sOD)and glutathione peroxidase(GPx)existed in fish with nano curcumin diets while the best catalase(CAT)efficiency occurred at higher nano curcumin levels≥100 *** addition,higher counts of intestinal microbiota in terms of total bacterial count(TBC),total yeast and molds count(TYMC),and coliform were noticed in fish consumed the basal diet compared to groups fed on nano curcumin *** conclusion,incorporating nano curcumin at a level of≥100 mg/kg diet(particularly at 150 mg/kg)improved a non-specific immune response,antioxidant,and healthier gastrointestinal microbiota in Nile tilapia under chronic low-temperature stress.

关键词： Nano curcumin Gastrointestinal microbiota Antioxidants Non-specific immune responses Temperature stress

Ethnobotanical study of Medicinal Plants Used for Treating Urinary Tract Infections in N’Djamena (Chad)

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American Journal of Plant sciences 2024年第1期15卷 46-55页

作者： Alhadj Djidda Mahamat soudy Imar Djibrine Hamit Mht Alio Abakar Tadjadine Emmanuel Issa Issa Ramat Adam abdel-aziz Arada Baroua Abouna Elisabeth Ngo Bum Laboratory of the Faculty of Human Health sciences of the University of N’Djamena N’Djamena Chad Faculty of sciences of the University of Maroua Maroua Cameroun Food Quality Control Centre (CECOQDA) N’Djamena Chad National Reference University Hospital of N’Djamena N’Djamena Chad Lute sectorial Programme against AIDs and Hepatitis (PsLs) N’Djamena Chad Research and Livestock Institute for Development (IRED) N’Djamena Chad

Introduction: Infection disease is a real publique health problem. The rise of resistance for modern antibiotic in infections treatment imposed us order alternatives. The study objective was to contribute in the knowledge of medicinal plants uses in urinary infections treatment in N’Djamena (Chad) in view for amelioration the traditional medicine in future. Methodology: The study was conducted in the city of N’Djamena in the Republic of Chad that interviewed 60 traditherapists on using 11 plants for urinary tract infections treatment. The methodology of this study consisted of the knowledge of medicinal plants that used by traditherapists, and the plants identification was done in the laboratory of IRED at Farcha. Results: A total of 60 traditherapists was interrogated on the plants used in the treatment of urinary tract infections among the population of N’Djamena. The majority of traditherapists interrogated in this study were male with the rate of 61.67% against female with the rate of 38.33%. The age range of traditherapists was between 20 to 80 years, 25 (41.67%) from the age range between 30 - 50 years and 35 (58.33%) in age range from 50 to 70 years. For the origin of their knowledge, the study showed that 72% of traditherapists inherited the knowledge from their family, while 15% inherited from the family and from training. The ethnic groups of the traditherapists were sara (16%), Maraba (12%) and Massa (11%). According to the results, 18.33% were illiterates, 49% attended primary school and 33.34% the secondary school. Our study found that 11 species of plants belonging to 11 families were used in the treatment of urinary tract infection and the Ziziphus spina-christi was the most represented. According to traditherapists the Ziziphus spina-christi, Cassia obovata and Euphorbia hirta were the most frequent plants used in the urinary tract infections treatment. The parts of plants used in the treatment were leaves and bark, grained leaves and entire plants w

关键词： Urinary Infections Medicinal Plant and Traditherapists

Hematological Alterations in an Eastern sudanese Chronic Kidney Disease Patient Population

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Open Journal of Urology 2024年第6期14卷 359-367页

作者： Mohammed Omer Abaker Gibreel sundus Kamal Ibrahim Wijdan abdel aziz Hassan Manar Yahia Mahjoub Leyla Mohammed Kheir Hamid Hibatellah Majzoub Abbas Nuha Fouzi Mohammed secretariat of Academic Affairs Port Sudan Ahlia University Port Sudan Sudan Department of Hematology and Immunohematology College of Graduate Studies Port Sudan Ahlia University Port Sudan Sudan

Background: Chronic Kidney Disease (CKD), associated with a slow and progressive loss of kidney function over a period of several years, is an important clinical disaster with an increasing rate of morbidity and mortality especially in the least developed countries. Many hematological parameters are thought to alter dramatically during the course of the disease. These include white blood cells, red blood cells, and platelets. Methods: We tried, retrospectively, to evaluate the peripheral blood hematological alterations in a group of patients undergoing hemodialysis in an eastern sudan dialysis center to add local medical information. Results: Anemia (Low hemoglobin and hematocrit) was detected in 94% of the patients’ group. Mean Erythrocyte count (3.32vs.4.76 (×109/L)), Hemoglobin concentration (9.4vs.13 (g/dl)), Hematocrit (28.7vs.38.7 (L/L)) and platelet count (296 vs. 238 (×109/L)) were significantly lower in the patients’ group than in the control group (P-values Conclusion: Five out of eight studied parameters (Red cell count, hemoglobin, hematocrit, mean cell hemoglobin concentration, and platelets count) have shown a significant alteration in CKD patients. As the complete blood count (CBC) test is the most utilized test in clinical laboratory practice, these alterations may be considered as early indicators for CKD. Furthermore, all patients with CKD must be routinely checked for these alterations.

关键词： Chronic Kidney Disease Chronic Renal Failure Hematological Alterations CBC Eastern sudan Hemodialysis

Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij Jelle M.Blankestijn Coen R.Lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.abdel-aziz Johannes B.van Goudoever Mattijs W.Alsem Caroline L.H.Brackel Kim J.Oostrom simone Hashimoto suzanne W.J.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome

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我的翻译梦和中国缘

中国新闻发布（实务版） 2024年第4期 72-74页

作者： [埃及]阿卜杜勒·阿齐兹埃及爱资哈尔大学语言与翻译学院中文系

许多年后,当回首过去的选择,我不禁想:人生中的一些事看似偶遇,但过后想来又觉得似乎冥冥之中早有安排,正如我的翻译梦与中文的邂逅。1977年,我18岁,埃及艾因·夏姆斯大学艾尔逊学院开设了中文系,这也是此后20多年间埃及高校唯一的中文... 详细信息

许多年后,当回首过去的选择,我不禁想:人生中的一些事看似偶遇,但过后想来又觉得似乎冥冥之中早有安排,正如我的翻译梦与中文的邂逅。1977年,我18岁,埃及艾因·夏姆斯大学艾尔逊学院开设了中文系,这也是此后20多年间埃及高校唯一的中文系。第一批学生12人,我有幸成为其中的一员,并成为1979年埃及第一批送往中国留学的五名中文系学生之一。从此,我与中国和中国文化结下了不解之缘,至今已40余载。

关键词：冥冥之中中文系学生翻译埃及留学梦

Geometric Phase of a Coupled system

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Communications in Theoretical Physics 2004年第5X期42卷 672-674页

作者： H.s.abdel-aziz MathematicsDepartment FacultyofScienceSouthValleyUniversitySohagEgypt

In this contribution, my main attention is paid to the study of the geometric phase ora two-level *** expansion of the eigenvalue and analytic information are obtained. The results are illustrated with an application ... 详细信息

关键词：几何相位二平面偏微分方程量子论

some Geometric Invariants of Pseudo-spherical Evolutes in the Hyperbolic 3-space

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Computers, Materials & Continua 2018年第12期57卷 389-415页

作者： H.s.abdel-aziz M.Khalifa saad A.A.abdel-salam Mathematics Department Faculty of ScienceSohag University82524SohagEgypt Mathematics Department Faculty of ScienceIslamic University of Madinah170 El-MadinahKSA

In this paper,we study the pseudo-spherical evolutes of curves in three dimensional hyperbolic *** use techniques from singularity theory to investigate the singularities of pseudo-spherical evolutes and establish some relationships between singularities of these curves and geometric invariants of curves under the action of the Lorentz ***,we defray with illustration some computational examples in support our main results.

关键词： Pseudo-spherical evolutes evolute curves hyperbolic 3-space