检索结果-南通市图书馆

Protectivity of Freeze Dried Inactivated Rift Valley Fever Vaccine

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Veterinary Medicine 2024年第2期14卷 21-37页

作者： Diana M. Abulmagd Mohamed Hassan Atwa Noha Ezz Aldin Marwa Yehia Hammad Taradi abdel Fattah Said Rift Valley Fever Vaccine Research Department Veterinary Serum and Vaccine Research Institute Agriculture Research Center (ARC) Cairo Egypt

Background: Vaccinations for animals are crucial for food production, animal welfare, public health, and animal health. They are an affordable way to stop animal sickness, increase food production efficiency, and lessen or stop the spread of zoonotic diseases to humans. Animal vaccines that are both safe and efficacious are vital to modern culture. The vaccine should induce a strong, protective and prolonged immune response against the antigenic factor. In order to achieve these goals, novel vaccination techniques and an efficient adjuvant are required to render the vaccine immunogenically protective and trigger a strong immune response. Aim: Our study aims to promote and enhance the immunogenicity against RVF virus disease through lyophilized inactivated RVF vaccine through induction of early cellular, high and prolonged humeral immunity in vaccinated animals using cabopol as stabilizer and Saponin or normal saline as a diluent at time of vaccination. Moreover, manufacturing of these vaccines is easy to be done. Results: The gained results revealed that RVF freeze-dried vaccine with Carbopol that reconstituted using Saponin elicited better immune response than that reconstituted using normal saline (NaCl). The cell mediated immune response as represented by lymphocyte blastogenesis and phagocytic activity were markedly increased with high levels when we used Saponin as a diluent than that in group vaccinated with vaccine diluted with NaCl, on the other side the humeral immune response in group vaccinated using the Saponin as diluent is more detected and stayed within the protective level till the end of 11th month post vaccination (1.5 TCID50) while the immune response induced after using normal saline as a diluent stayed within the protective level till the end of 10th month post vaccination (1.8 TCID50). Conclusion: The use of Saponin as a diluent for reconstitution of the freeze dried RVF vaccine is preferable than the

关键词： Rift Valley Fever Saponin Cabopol Binary Ethylenemine Serum Neutralization Test

Rescue effects of aqueous seed extracts of Foeniculum vulgare and Carum carvi against cadmium-induced hepatic, renal and gonadal damage in female albino rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2017年第12期10卷 1123-1133页

作者： Ahmed abdel-wahab abdel-Razik Hashem abdel-Razik Rabie Lotfy abdel Aziz Physiology Department Faculty of Veterinary MedicineMinia University61519 El-MiniaEgypt Histology Department Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt Department of Theriogenology Faculty of Veterinary MedicineBeni-Suef University62512 Beni-SuefEgypt

Objective: To investigate the protective effects of aqueous seed extracts of fennel"Foeniculum vulgare"(FVE) and caraway "Carum carvi"(CCE) on liver, kidney and reproductive organs in female rats against cadmium chloride(CC) ***: A total of 36 adult female rats were divided into six groups, six in each *** group(fed normal diet), CC-treated group(50 mg CC/kg diet), CCE-treated group(150 mg CCE/kg diet), CCE + CC group, FVE(150 mg/kg diet) and FVE + CC. One month later, all rats were sacrificed and all samples were collected at proestrus ***: The toxic effects of CC were confirmed biochemically by significant increase of serum concentration of liver enzymes(P < 0.05), and creatinine(P < 0.001). Moreover,CC increased significantly the serum level of malondialdehyde(MDA) and decreased the total antioxidant capacity(TAC)(P < 0.001). In addition, serum concentrations of estrogen, progesterone, follicle-stimulating hormone(FSH) and luteinizing hormone(LH)were significantly decreased(P < 0.01). Histopathologically, CC-treated group revealed marked pathological changes in renal, hepatic, ovarian and uterine tissues. All toxic findings observed in liver and kidney with CC treatment were found to be ameliorated markedly after co-treatments with FVE or CCE. Furthermore, co-treatment of FVE with CC improved significantly all studied reproductive parameters(P < 0.01).Conclusions: Both FVE and CCE could be used as efficient treatments for liver and kidney against CC intoxication. Moreover, FVE could be utilized as a potent treatment to protect and improve female fertility from cadmium intoxication.

关键词： Cadmium Carum carvi Foeniculum vulgare Liver Kidney Fertility

Modulation of oxidative damage and genotoxicity of biosynthesized zinc oxide nanoparticles via supplementation with modified cinnamaldehyde-loaded chitosan nanoparticles in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Mosaad A.abdel-Wahhab Aziza A.El-Nekeety Asmaa S.Salman Zeinab K.Hamza Engy M.Akl Soher E.Aly Wenyi Kang Department of Food Toxicology & Contaminants， National Research Centre Dokki， Cairo， Egypt Genetic and Cytology Department， National Research Centre Dokki， Cairo， Egypt Department of Fats and Oils， National Research Centre Dokki， Cairo， Egypt National R & D Center for Edible Fungus Processing Technology， Henan University Joint International Research Laboratory of Food & Medicine Resource Function Functional Food Engineering Technology Research Center Henan

Synthesis of zinc oxide nanoparticles (Zn-NPs) via green method is an outstanding alternative to conventional/regular methods; however， the safety or toxicity of the biosynthesized ZnO-NPs in vivo is not fully explored. This study was conducted to evaluate the protective efficiency of cinnamaldehyde-loaded chitosan nanoparticles (Cin@CSNPs) against oxidative damage and genotoxicity of zinc oxide nanoparticles (ZnO-NPs) in mice. ZnO-NPs were biosynthesized using the extract of fresh leaves of Mentha pulegium L. Cin was extracted from cinnamon essential oil， and was loaded into chitosan nanoparticle (Cin@CSNPs). Both ZnO-NPs， Cin@CSNPs and CSNPs were characterized. The in vitro release of Cin@CSNPs was determined. In the biological study， 6 groups of male Balb/c mice were treated by gavage for 3 weeks as follows， control group， the group received ZnO-NPs (25 mg/kg b.w)， the groups received Cin@CSNPs at low dose (50 mg/kg b.w) or high dose (100 mg/kg b.w)， and the groups received ZnO-NPs plus Cin@CSNPs at the two tested doses. Blood and tissue samples were collected for different biochemical， genetical and histological studies. The particle size of ZnO-NPs， CSNPs， and Cin@CSNPs were (20.78 ± 2.6)， (170.0 ± 3.7)， and (218.23 ± 2.9) nm， and ξ-potential were (32.7 ± 4.6)， (8.32 ± 0.27) and (4.8 ± 0.21)， respectively. ZnO-NPs disturbed the biochemical and oxidative stress indices， AFP， CEA， TNF-α， chromosomal aberrations in somatic and germ cells， and sperm abnormality along with severe pathological changes in the hepatic， renal， and testicular tissues. Cin@CSNPs improved significantly all the parameters tested and the histological picture in a dose-dependent. Therefore， the biosynthesized ZnO-NPs exhibit oxidative damage and genotoxicity， and Cin@CSNPs have potential protective effects against the risks of ZnO-NPs and may be a promising tool to overcome the challenges of using Cin in food and pharmaceuticals applications.

关键词：

基于混合消能减震技术非对称双塔连体结构抗震性能研究

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

振动与冲击 2024年第6期43卷 288-300页

作者：蔡正潘文周强 Ghafar wahab Abdul 杨静昆明理工大学建筑工程学院昆明650599 云南省抗震工程技术研究中心昆明650599

以某非对称双塔连体超高层结构为研究对象,选取与建筑所在场地相匹配的地震波作为激励,通过对结构进行非线性动力时程分析,研究混合消能减震连体结构在各烈度地震作用下的消能减震效果,探讨了屈曲约束支撑(buckling-restrained brace, B... 详细信息

以某非对称双塔连体超高层结构为研究对象,选取与建筑所在场地相匹配的地震波作为激励,通过对结构进行非线性动力时程分析,研究混合消能减震连体结构在各烈度地震作用下的消能减震效果,探讨了屈曲约束支撑(buckling-restrained brace, BRB)与黏滞阻尼悬臂桁架的位置变化对结构抗震性能的影响,同时对结构进行了全面的抗震性能评估。研究结果表明:在连体结构中、上部的加强层中布设阻尼器时,结构具有更佳的减震效果;在不同水准地震作用下,BRB与黏滞阻尼悬臂桁架耗能阶段不同且具有不同的耗能效率,混合消能减震技术可以综合不同类型阻尼器的优势作用,使连体结构具有更全面的抗震性能。在控制变形方面,其能够降低连体结构的扭转效应和层间位移角;在构件耗能方面,其减轻了主体构件进入塑性的程度,降低了结构主要受力构件的应力水平。将为混合消能减震技术在连体超高层结构中的进一步研究和应用提供借鉴。

关键词：连体结构混合减震时程分析耗能机制抗震性能

维普期刊数据库

Effect of wear debris on fretting fatigue crack initiation

在线全文

学校读者我要写书评

暂无评论

Friction 2022年第6期10卷 927-943页

作者： Shengjie WANG Tongyan YUE Dagang WANG Magd abdel wahab Soete Laboratory Department of Electrical EnergyMetalsMechanical Construction&SystemsFaculty of Engineering and ArchitectureGhent UniversityGhent 9052Belgium State Grid Xinyuan Maintenance Branch Beijing 100000China School of Mechatronic Engineering China University of Mining and TechnologyXuzhou 221116China Faculty of Engineering Van Lang UniversityHo Chi Minh City 700000Vietnam Soete Laboratory Ghent UniversityGhent 9052Belgium

Both wear and fatigue occur in fretting condition,and they interact with one another during the whole *** fatigue is commonly analysed without considering the effect of wear in partial slip regime,although wear affects the lifetime of crack *** paper investigates,for the first time,the effect of wear debris on fretting fatigue crack *** investigate the effect of debris,first fretting wear characteristics in partial slip regime are analysed for loading ***,the effect of wear on fretting fatigue crack initiation is investigated using Ruiz parameters and critical plane methods without considering the debris *** the results,we can see that loading conditions affect the wear profiles in different ***,wear has a significant effect on the fatigue in partial slip regime without considering debris especially on the crack initiation ***,considering wear debris in the analysis,its effect on critical plane parameters is *** is found that by considering the wear debris effect,the frtting fatigue crack initiation location is shifted towards the trailing *** predictions of both crack initiation location and lifetime show a good agreement with the experimental data.

关键词： fretting wear fretting fatigue critical plane Ruiz parameter debris

Fatigue crack propagation across grain boundary of Al-Cu-Mg bicrystal based on crystal plasticity XFEM and cohesive zone model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2022年第31期126卷 275-287页

作者： Qi Zhao Magd abdel wahab Yong Ling Zhiyi Liu School of Materials Science and Engineering Hubei University of Automotive TechnologyShiyan 442002China Faculty of Mechanical-Electrical and Computer Engineering School of Engineering and TechnologyVan Lang UniversityHo Chi Minh CityVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903B-9052 ZwijnaardeBelgium School of Materials Science and Engineering Central South UniversityChangsha 410083China

In this paper,a methodology integrating crystal plasticity(CP),the eXtended finite element method(XFEM)and the cohesive zone model(CZM)is developed for an Al-Cu-Mg alloy to predict fatigue crack propagation(FCP)across grain boundary(GB)of Al-Cu-Mg alloy during stageІІ.One GB model is incor-porated into FCP constitutive law to describe grain interaction at GB.A bicrystal containing GB is built up to simulate FCP behavior through L participated *** features including GB characteristic,cumulative plastic strain(CPS)distribution and crystal slipping evidence can be *** numer-ical results are compared with published experimental data to check the accuracy of *** work demonstrates that the combination of CP containing GB constitutive laws,XFEM and CZM is a promising methodology in predicting twist angle-controlled crack deflection through GBs.

关键词： Grain boundary Twist angle Crystal plasticity Extended finite element method Fatigue crack propagation Cumulative plastic strain

维普期刊数据库

Thermophysical Characterization of Local Materials from a Locality in Chad for Use in Eco-Building

在线全文

学校读者我要写书评

暂无评论

Open Journal of Civil Engineering 2024年第3期14卷 486-497页

作者： Abderahman Adoum Oumar Malloum Soultan Abdallah Dadi Togdjim Jonas Mahamat Saleh abdel-Khadir Mahamoud Youssouf Khayal Salif Gaye Laboratoire de Recherche en Energtique et Matriaux (LREM) de lINSTA Institut National Suprieur des Sciences et Techniques dAbch Abch Chad Ecole Doctorale Science Technique et Environnement Universit de NDjamena NDjamena Tchad Laboratoire CABET (Construction Alternative Basse Energie au Tchad) NDjamena Chad Laboratoire de Matriaux dnergtique dlectricit et dconomie (LM3E) Universit Iba Der Thiam de This This Sngal

With the aim of enhancing the value of local building materials, the subject of this paper is a thermophysical study of natural Chadian clay from the eastern region of Chad, “Abeche”. Samples were taken from a brickwork in Abeche from a depth of 1 m, then using a clay brick-making press, 4 × 5 × 8 cm3 clay test tubes were made with 2%, 4%, 6% and 8% cow dung, and a 100% clay sample was used as a control. These samples underwent thermophysical characterization using the hot-wire method with a hot-plane option, yielding results that could improve thermophysical performance. The thermal conductivity of the test sample is in the order of 0.715 to 0.420 W/m. K, at 8% for cow dung, so the addition of cow dung as a percentage in the clay matrix enabled us to obtain various satisfactory thermal parameters.

关键词： Soils Characterization Thermophysical Local Building

Multiscale Analysis of the Effect of Debris on Fretting Wear Process Using a Semi-Concurrent Method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2020年第1期62卷 17-35页

作者： Shengjie Wang Tongyan Yue Magd abdel wahab Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityTechnologiepark Zwijnaarde 903Zwijnaarde B-9052Belgium State Grid Xinyuan Maintenance Branch BeijingChina Division of Computational Mechanics Ton Duc Thang UniversityHo Chi Minh CityVietnam Faculty of Civil Engineering Ton Duc Thang UniversityHo Chi Minh CityVietnam

Fretting wear is a phenomenon,in which wear happens between two oscillatory moving contact surfaces in microscale *** this paper,the effect of debris between pad and specimen is analyzed by using a semi-concurrent multiscale ***,the macroscale fretting wear model is ***,the part with the wear profile is imported from the macroscale model to a microscale model after running in ***,an effective pad’s radius is extracted by analyzing the contact pressure in order to take into account the effect of the ***,the effective radius is up-scaled from the microscale model to the macroscale model,which is used after running in *** this way,the effect of debris is considered by changing the radius of the pad in the macroscale *** to the smaller number of elements in the microscale model compared with the macroscale model containing the debris layer,the semi-concurrent method proposed in this paper is more computationally ***,the results of this semi-concurrent method show a better agreement with experimental data,compared to the results of the model ignoring the effect of debris.

关键词： Fretting wear debris multiscale analysis semi-concurrent

Improvement of Flat Surfaces Quality of Aluminum Alloy 6061-O By A Proposed Trajectory of Ball Burnishing Tool

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2019年第8期61卷 555-568页

作者： Ruba Alghazoul Almohanad Makki Magd abdel wahab Faculty of Mechanical and Electrical Engineering Al Baath UniversityHomsSyria Institute of Research and Development Duy Tan University03 Quang TrungDa NangVietnam Soete Laboratory Faculty of Engineering and ArchitectureGhent UniversityGentBelgium

Burnishing is a profitable process of surface finishing due to its ability to be automated,which makes burnishing method more desirable than other finishing *** obtain high surface finish,non-stop operation is required for CNC machine and we can attain that by choosing a suitable trajectory of the finishing *** other words,burnishing paths should be multidirectional rather than monotonic,in order to cover uniformly the ***,the burnishing force is also a key parameter of the burnishing process because it determines the degree of plastic deformation,and that makes determining the optimum burnishing force an essential step of the burnishing process a ***,we consider the strategy of ball burnishing path and the burnishing force as variable parameters in this *** this paper,we propose a new strategy of burnishing tool path with trochoid cycles that achieves a multidirectional burnishing of the surface according to various *** into consideration the optimum burnishing force,to improve flat surface finish of AL6061-O samples by reducing the surface roughness parameter(Rz).Experiments carried out on 3-axis milling machine show that the proposed trochoidal path is more effective than the conventional one.

关键词： Ball burnishing surface quality trajectories roughness