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Prediabetes: An overlooked risk factor for major adverse cardiac and cerebrovascular events in atrial fibrillation patients

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World Journal of Diabetes 2024年第1期15卷 24-33页

作者： Rupak Desai Nishanth Katukuri Sumaja Reddy Goguri Azra Kothawala Naga Ruthvika Alle Meena kuma.i Bellamkonda Debankur dey Sharmila Ganesan Minakshi Biswas Kuheli Sarkar Pramoda Prattipati Shaylika Chauhan Independent Researcher Independent ResearcherAtlantaGA 30079United States Department of Internal Medicine Mayo ClinicRochesterMN 55902United States Department of Medicine Chalmeda Anand Rao Institute of Medical SciencesTelangana 505001India Department of Medicine Jawaharlal Nehru Medical CollegeBelgaum 590010India Department of Medicine Narayana Medical CollegeAndhra PradeshNellore 524003India Department of Medicine Dr Pinnamaneni Siddhartha Institute of Medical Sciences and Research FoundationVijaywada 521286India Department of Medicine Medical College KolkataKolkata 700073India Department of Medicine P.E.S.Institute of Medical Sciences and ResearchAndhra Pradesh 517425India Department of Medicine Shaheed Ziaur Rahman Medical CollegeBogra 5800Bangladesh Department of Medicine College of Medicine and J.N.M HospitalKalyani 741235India Department of Medicine Jawaharlal Nehru Medical College IndiaKarnatakaBelagavi 590010India Department of Internal Medicine Geisinger Health SystemWikes-BarrePA 18702United States

BACKGROunD Prediabetes is a well-established risk factor for major adverse cardiac and cerebrovascular events(MACCE).However,the relationship between prediabetes and MACCE in atrial fibrillation(AF)patients has not been extensively ***,this study aimed to establish a link between prediabetes and MACCE in AF *** To investigate a link between prediabetes and MACCE in AF *** We used the National Inpatient Sample(2019)and relevant ICD-10 CM codes to identify hospitalizations with AF and categorized them into groups with and without prediabetes,excluding *** primary outcome was MACCE(all-cause inpatient mortality,cardiac arrest including ventricular fibrillation,and stroke)in AF-related *** Of the 2965875 AF-related hospitalizations for MACCE,47505(1.6%)were among patients with *** prediabetes cohort was relatively younger(median 75 vs 78 years),and often consisted of males(56.3%vs 51.4%),blacks(9.8%vs 7.9%),Hispanics(7.3%vs 4.3%),and Asians(4.7%vs 1.6%)than the non-prediabetic cohort(Ppared to the non-prediabetic cohort[18.6%vs 14.7%,odds ratio(OR)1.34,95%confidence interval 1.26-1.42,Ppared to females(aOR 1.22),whereas on the race-wise comparison,Hispanics(aOR 1.43)and Asians(aOR 1.36)had a stronger association with MACCE with prediabetes vs whites(aOR 1.33)and blacks(aOR 1.21).CONCLUSION This population-

关键词： Prediabetes Atrial fibrillation Cardiovascular disease risk Major adverse cardiovascular and cerebrovascular events Stroke Mortality

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Emergence of taurine as a therapeutic agent for neurological disorders

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Neural Regeneration Research 2024年第1期19卷 62-68页

作者： Ashok Jangra Priyanka Gola Jiten Singh Pooja Gond Swarnabha Ghosh Mahesh Rachamalla Abhijit dey Danish Iqbal Mehnaz Kamal Punya Sachdeva Saurabh kuma. Jha Shreesh Ojha Dinesh kuma. Niraj kuma. Jha Hitesh Chopra Shing Cheng Tan Department of Pharmaceutical Sciences Central University of HaryanaMahendergarhHaryanaIndia Department of Biology University of SaskatchewanSaskatoonSKCanada Department of Life Sciences Presidency UniversityKolkataWest BengalIndia Department of Health Information Management College of Applied Medical SciencesBuraydah Private CollegesBuraydahSaudi Arabia Department of Pharmaceutical Chemistry College of PharmacyPrince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia GloNeuro Vishwakarma RoadNoidaIndia Department of Biotechnology School of Engineering&Technology(SET)Sharda UniversityGreater NoidaUttar PradeshIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates School of Bioengineering&Biosciences Lovely Professional UniversityPhagwaraIndia Department of Biotechnology School of Applied&Life Sciences(SALS)Uttaranchal UniversityDehradunIndia Chitkara College of Pharmacy Chitkara UniversityPunjabIndia UKM Medical Molecular Biology Institute Universiti Kebangsaan MalaysiaKuala LumpurMalaysia

Taurine is a sulfur-containing,semi-essential amino acid that occurs naturally in the *** alternates between inflammation and oxidative stress-mediated injury in various disease *** part of its limiting functions,taurine also modulates endoplasmic reticulum stress,Ca^(2+)homeostasis,and neuronal activity at the molecular *** effectively protects against a number of neurological disorders,including stro ke,epilepsy,cerebral ischemia,memory dysfunction,and spinal cord *** various therapies are available,effective management of these disorders remains a global *** 30 million people are affected *** design of taurine fo rmation co uld lead to potential drugs/supplements for the health maintenance and treatment of central nervous system *** general neuroprotective effects of taurine and the various possible underlying mechanisms are discussed in this *** article is a good resource for understanding the general effects of taurine on various *** the strong evidence for the neuropharmacological efficacy of taurine in various experimental paradigms,it is concluded that this molecule should be considered and further investigated as a potential candidate for neurotherapeutics,with emphasis on mechanism and clinical studies to determine efficacy.

关键词： antioxidant epilepsy γ-amino butyric acid neurodegenerative disorders neuroprotection oxidative stress spinal cord injury taurine

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Biological characteristics and clinical management of uveal and conjunctival melanoma

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Oncology Research 2024年第8期32卷 1265-1285页

作者： SNJEŽANA KAŠTELAN ANA DIDOVIĆpaVIČIĆ DARIA paŠALIĆ TAMARA NIKUŠEVA-MARTIĆ SAMIRČANOVIĆ PETRA KOVAČEVIĆ SUZANA KONJEVODA School of Medicine University of ZagrebZagreb10000Croatia Department of Ophthalmology Clinical Hospital DubravaZagreb10000Croatia Department of Ophthalmology Zadar General HospitalZadar23000Croatia Department of Medical Chemistry Biochemistry and Clinical ChemistrySchool of MedicineUniversity of ZagrebZagreb10000Croatia Department of Biology and Genetics School of MedicineUniversity of ZagrebZagreb10000Croatia School of Medicine University of SplitSplit21000Croatia Department of Health Studies University of ZadarZadar23000Croatia

Uveal and conjunctival melanomas are relatively rare tumors;nonetheless,they pose a signiﬁcant risk of mortality for a large number of affected *** pathogenesis of melanoma at different sites is very similar,however,the prognosis for patients with ocular melanoma remains unfavourable,primarily due to its distinctive genetic proﬁle and tumor *** of considerable advances in understanding the genetic characteristics and biological behaviour,the treatment of uveal and conjunctival melanoma remains a formidable *** enhance the prospect of success,collaborative efforts involving medical professionals and researchers in theﬁelds of ocular biology and oncology are *** data show a lack of well-designed randomized clinical trials and limited beneﬁts in current forms of treatment for these *** advancements in the development of effective melanoma therapeutic strategies,all current treatments for uveal melanoma(UM)and conjunctival melanoma(CoM)remain unsatisfactory,resulting in a poor long-term *** trials offer hope for positive outcomes in advanced and metastatic tumors.A more comprehensive understanding of the genetic and molecular abnormalities involved in the development and progression of ocular melanomas opens the way for the development of personalized therapy,with various potential therapeutic targets currently under *** comprehension of the molecular pathogenesis of UM and CoM and their speciﬁcities may aid in the development of new and more effective systemic therapeutic agents,with the hope of improving the prognosis for patients with metastatic disease.

关键词： Uveal melanoma Conjunctival melanoma Genetic characteristics Immune checkpoint inhibitors Target molecular inhibitors

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特斯拉的增长前景面临疑问

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商业周刊（中文版） 2024年第5期 62-63页

作者： Esha dey 程玺(译) 不详

特斯拉公司(Tesla Inc.)近期发布了异常低迷的季度销售数据,这让投资者面对一个根本性问题:如果快速增长的时代已经终结,埃隆·马斯克(Elon Musk)公司的股票究竟值多少钱?

关键词：增长前景特斯拉销售数据股票根本性问题投资者

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Effect of a less permeable stronger soil layer on the stability of non-homogeneous unsaturated slopes

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Frontiers of Structural and Civil Engineering 2020年第6期14卷 1462-1475页

作者： Naba.un dey Aniruddha SENGUPTA Department of Civil Engineering Indian Institute of Technology KharagpurKharagpur 721302India

Slope failure occurs due to an increase in the saturation level and a subsequent decrease in matric suction in unsaturated *** paper presents the results of a series of centrifuge experiments and numerical analyses on a 55°inclined unsaturated sandy slope with less permeable,stronger silty sand layer inclusion within *** is observed that a less permeable,stronger silty sand layer in an otherwise homogeneous sandy soil slope hinders the infiltration of *** water content of the slope just above the stronger layer increases significantly,compared to *** shear band is found to initiate in a homogeneous sandy soil slope,whereas for a non-homogeneous slope,they initiate just above the less pervious,stronger layer.A discontinuity of the shear zone is also observed for the case of a non-homogeneous soil *** factor of safety of a non-homogeneous,unsaturated soil slope decreases because of the less permeable,stronger *** decreases significantly if this less permeable,stronger soil layer is located near the toe of the slope.

关键词： non-homogeneous slope stronger soil layer factor of safety centrifuge model test unsaturated soils

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Innovation in pathogenesis and management of aortic aneurysm

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World Journal of Experimental Medicine 2024年第2期14卷 35-45页

作者： Maryam Barkhordarian Hadrian Hoang-Vu Tran Aiswarya Menon Sai Priyanka Pulipaka Izage Kianifar Aguilar Axel Fuertes Shraboni dey Angel Ann Chacko Tanni Sethi Ayrton Bangolo Simcha Weissman Department of Internal Medicine Palisades Medical CenterNorth BergenNJ 07047United States

Aortic aneurysm(AA)refers to the persistent dilatation of the aorta,exceeding three *** the pathophysiology of this condition is important for its prevention and management,given its responsibility for more than 25000 deaths in the united *** are classified based on their location or *** pathophysiologic pathways including inflammation,the immune system and atherosclerosis have been implicated in its *** markers such as transforming growth factorβ,interleukin-1β,tumor necrosis factor-α,matrix metalloproteinase-2 and many more may contribute to this *** genetic disorders such as Marfan syndrome,Ehler-Danlos syndrome and Loeys-Dietz syndrome have also been associated with this *** years has seen the investigation of novel management of AA,exploring the implication of different immune suppressors,the role of radiation in shrinkage and prevention,as well as minimally invasive and newly hypothesized surgical *** this narrative review,we aim to present the new contributing factors involved in pathophysiology of *** also highlighted the novel management methods that have demonstrated promising benefits in clinical outcomes of the AA.

关键词： Aortic aneurysm Abdominal aneurysm Thoracic aneurysm Immunotherapy Surgical management pathophysiology Inflammation and molecular pathways

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Corrigendum to'Cancer chemotherapy and beyond:Current status,drug candidates,associated risks and progress in targeted therapeutics'[Genes&Diseases 10(2023)1367-1401]

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Genes & Diseases 2024年第4期11卷 426-427页

作者： Uttpal Anand Abhijit dey Arvind K.Singh Chandel Rupa Sanyal Amarnath Mishra Devendra kuma. pa.dey Valentina De Falco a.un Upadhyay Ramesh Kandimalla Anupama Chaudhary Jaspreet Kaur Dhanjal Saikat Dewanjee Jayalakshmi Vallamkondu Jose M.Perez de la Lastra Department of Life Sciences Ben-Gurion University of the NegevBeer-Sheva 84105Israel Department of Life Sciences Presidency UniversityKolkataWest Bengal 700073India Center for Disease Biology and Integrative Medicine Faculty of MedicineThe University of TokyoTokyo 113-0033Japan Department of Botany Bhairab Ganguly College(affliated to West Bengal State University)KolkataWest Bengal 700056India Faculty of Science and Technology Amity Institute of Forensic SciencesAmity University Uttar PradeshNoida 201313India Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwaraPunjab 144411India Institute of Endocrinology and Experimental Oncology(IEOS) National Research Council(CNR)Department of Molecular Medicine and Medical Biotechnology(DMMBM)University of Naples FedericoⅡNaples 80131Italy Department of Biochemistry School of Life SciencesCentral University of RajasthanBandar SindariKishangarhAjmerRajasthan 305817India CSiR-indian Institute of Chemical Technology HyderabadTelangana 500007India Department of Biochemistry Kakatiya Medical CollegeWarangalTelangana 506007India Orinin-BioSystems LE-52Lotus Road 4CHD CityKarnalHaryana 132001India Department of Computational Biology Indraprastha Institute of Information Technology Delhi(ⅢT-D)Okhla Industrial EstatePhaseⅢNew Delhi 110020India Advanced Pharmacognosy Research Laboratory Department of Pharmaceutical TechnologyJadavpur UniversityKolkata 700032India Department of Physics National Institute of Technology-WarangalWarangalTelangana 506004India Biotechnology of Macromolecules Research Group Instituto de Productos Naturales y AgrobiologiaIPNA-CSICSan Cristobal de La Laguna 38206TenerifeSpain

In the published article,there was an error in the affiliation information about the first author Uttpal Anand[a].Instead of"Department of Life Sciences,Ben-Gurion university of the Negev,Beer-Sheva 84105,Israel",it should be"CytoGene Research&Development LLP,K-51,UPSIDA Industrial Area,Kursi Road(Lucknow),***,225001,Uttar Pradesh,India".The authors would like to apologize for any inconvenience caused and state that this does not change the scientific conclusions of thearticle inanyway.

关键词： Cancer Cor targeted

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Chemical Reduction of CO_2 to Different Products during Photo Catalytic Reaction on TiO_2 under Diverse Conditions:an Overview

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Journal of Natural Gas Chemistry 2007年第3期16卷 217-226页

作者： G.R.dey Radiation and Photochemistry Division Bhabha Atomic Research CentreTrombayMumbai 400085India

The chemical reduction of CO2 remains a challenge with respect to the reversal of the oxidative degradation of any organic materials. The conversion of CO2 into useful substances is essential in developing alternative fuels and various raw materials for different industries. This also aids in preventing the continuous rise in tropospheric temperature due to the green house effect of CO2. In this article an overview of the growth taken place so far in the field of CO2 chemical reduction is pre- sented. The discussion comprises of photochemical methods for the development of different products, viz. CO, CH3OH and CH4, through chemical reduction of CO2. This includes the use of photo catalysts, mainly TiO2, and the role of a hole scavenger （such as 2-propanol） for this purpose.

关键词： CO2 chemical reduction H2 CH4 CO TiO2 hole scavenger photolysis

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Performance study and kinetic modeling of hybrid bioreactor for treatment of bi-substrate mixture of phenol-m-cresol in wastewater:Process optimization with response surface methodology

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Journal of Environmental Sciences 2013年第4期25卷 698-709页

作者： Sudipta dey Somnath Mukherjee Department of Biotechnology Heritage Institute of TechnologyAnandapurChowbaga RoadKolkata-700107West BengalIndia Environmental Engineering Division Civil Engineering DepartmentJadavpur UniversityRaja S.C.Mallic RoadKolkata-700032West BengalIndia

Performance of a hybrid reactor comprising of trickling filter （TF） and aeration tank （AT） unit was studied for biological treatment of wastewater containing mixture of phenol and m-cresol, using mixed microbial culture. The reactor was operated with hydraulic loading rates （HLR） and phenolics loading rates （PLR） between 0.222-1.078 m3/（m2-day） and 0.900-3.456 kg/（***）, respectively. The efficiency of substrate removal varied between 71%-100% for the range of HLR and PLR studied. The fixed film unit showed better substrate removal efficiency than the aeration tank and was more resistant to substrate inhibition. The kinetic parameters related to both units of the reactor were evaluated and their variation with HLR and PLR were monitored. It revealed the presence of substrate inhibition at high PLR both in TF and AT unit. The biofilm model established the substrate concentration profile within the film by solving differential equation of substrate mass transfer using boundary problem solver tool ＇bvp4c＇ of MATLAB 7. 1 software. Response surface methodology was used to design and optimize the biodegradation process using Design Expert 8 software, where phenol and m-cresol concentrations, residence time were chosen as input variables and percentage of removal was the response. The design of experiment showed that a quadratic model could be fitted best for the present experimental study. Significant interaction of the residence time with the substrate concentrations was observed. The optimized condition for operating the reactor as predicted by the model was 230 mg/L of phenol, 190 mg/L of m-cresol with residence time of 24.82 hr to achieve 99.92% substrate removal.

关键词： hybrid bioreactor bi-substrate phenol m-cresol response surface methodology biofilm model

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高校竞技健美操运动员落地偏侧性和稳定性的生物力学研究

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中国运动医学杂志 2024年第4期43卷 266-274页

作者：王莉莉 Wan Ahmad Munsif Bin Wan pa 王宇轩李风雷颉梦宁许春莲马来西亚国立大学教育学院吉隆坡43600 东华理工大学体育学院南昌330032 南昌交通学院体育学院南昌330100

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和... 详细信息

目的:分析竞技健美操运动员落地动作的生物力学特征,比较优势侧和非优势侧生物力学指标的偏侧性,探究影响落地稳定性的关键偏侧性因素。方法:以26名高校女性健美操运动员为研究对象,同步采集40 cm高台垂直双脚落地动作中的下肢运动学和动力学数据,比较优势侧和非优势侧的触地时刻关节角度、关节活动度(ROM)、地面反作用力(GRF)、负载率、压力中心(COP)位移和包络面积的差异,计算对称指数(代表偏侧性),并采用多元逐步回归方法分析指标偏侧性和COP包络面积的关系。结果:与非优势侧相比,优势侧在触地时刻具有更大的膝外旋和髋外展角(P<0.05),在落地过程中具有较大的踝屈伸、髋屈伸、髋内收-外展及较小的踝旋转ROM(P<0.05);优势侧的伸膝力矩峰值大于非优势侧(P<0.01);垂直方向负载率和伸膝力矩峰值的对称指数与COP包络面积呈显著正相关(P<0.05);垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以解释COP包络面积差异的83.6%。结论:竞技健美操运动员落地动作存在肢体间的偏侧性,垂直方向负载率和伸膝力矩峰值的偏侧性越大,则落地稳定性越差。此外,垂直方向负载率、伸膝力矩峰值和膝关节旋转角度的对称指数可以作为落地稳定性的预测因子。

关键词：健美操落地生物力学偏侧性稳定性

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