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Corneal collagen cross‑linking epithelium‑on ***‑off:a systematic review and meta‑analysis

Eye and Vision 2021年第6期8卷 338-352页

作者： Francesco D’oria Antonio Palazón Jorge L.Alio Vissum Innovation c/Cabañal103016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain

Background:The purpose of the study was to determine the advantages and disadvantages of epi-on corneal crosslinking(CXL)techniques compared with standard epi-off ***:We searched MEDLINE and EMBASE for randomized controlled trials(RCTs)and non-randomized studies of interventions(NRSIs)and we evaluated the selected papers according to the Cochrane risk of bias *** considered,as primary outcomes,average Kmax flattening,changes in uncorrected and corrected distance visual acuity(UDVA and CDVA);as secondary outcomes,we considered changes in pachymetry values and endothelial cell density(ECD).We also investigated adverse events related to the treatments and treatment ***-analysis was conducted with a fixed or random-effects model using weighted mean difference(MD)with 95%confidence interval(CI)as the effect ***:A total of 15 studies were included and among these 15 trials,9 were RCTs and 6 were NRSIs,but only 4 studies showed no high risk of bias and were included in this *** analysis revealed significant postoperative differences in CDVA(MD=0.07;95%CI 0.04 to 0.10;P0.05).Epi-on CXL protocol was found to be significantly less prompt to have risks of delay in epithelial healing(P=0.035)and persistent stromal haze(P=0.026).Conclusion:Epi-on CXL is as effective as epi-off *** for a higher significant improvement in CDVA with current epi-on protocols,our meta-analysis demonstrates that epi-on and epi-off CXL have comparable effects on visual,topographic,pachymetric,and endothelial ***-on CXL has clinical advantages in terms of comfort and avoidance of complications as it reduces the risk of developing delay in epithelial healing and persistent stromal haze.

关键词： Corneal collagen cross-linking Keratoconus Transepithelial CXL Epithelium-off CXL Epithelium-on CXL Iontophoresis

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Do supplemental perches influence electrocution risk for diurnal raptors?

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Avian Research 2020年第2期11卷 139-149页

作者： Roberto Sánchez Javier Sánchez Javier oria Francisco Guil Fundación CBD-Hábitat C/Gustavo Fernández Balbuena28002 MadridSpain Tragsa Group C/Conde de Peñalver8428006 MadridSpain Boscaje S.L. Plaza Conde de Cheste540001 SegoviaSpain Ministry for the Ecological Transition and the Demographic Challenge Plaza San Juan de la CruzS/N28071 MadridSpain

Background:Power lines are amongst the main causes of mortality for birds *** drives the population dynamics of several threatened species of raptors,at local and global *** the many solutions that have been tested to minimize this threat are supplemental perches;however,their efficiency has rarely been ***:We designed 43 transects in 4 districts in mainland Portugal to gather data from birds perching on pylons with or without supplemental *** 2015 to 2018,transects were surveyed by car at least *** analyzed the factors driving the use of these supplemental perches,and we analyzed if there were differences in the perceived risk(calculated from measurements and not from field surveys)depending on whether the perching was on pylons with or without supplemental ***:We recorded 548 perches of 14 *** conditions seemed to play a role in birds’choice of pylons with supplemental perches versus pylons without supplemental *** also indicated a strong influence of observational *** use of models showed us an important specific effect in the selection of supplemental perches where available:there are some species with a greater tendency to perch on supplemental perches,even when they use both pylons with and without supplemental *** most of the analyzed species and species groups,perceived risk was higher in pylons without supplemental perches compared to pylons with supplemental perches,but there were differences between ***:Supplemental perches may be a useful and efficient tool for mitigating raptor ***,there are many influential factors affecting their success,and their effectiveness with different species groups is not *** studies show higher electrocution rates for certain species and devices and thus,their efficacy must be *** propose a two-step validation process,first in controlled conditions and then in the

关键词： Aquila adalberti Circaetus gallicus Diurnal raptors Electrocution Power lines Pylons

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Reply to the letter to the editor

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Eye and Vision 2021年第1期8卷 462-463页

作者： Jorge L.Alio Francesco Versaci Francesco D’oria Vissum Miranza AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly

We appreciate the interest of Miguel Faria Ribeiro in our paper[1],as well as the comments made to *** interest of the topic is sound,as nowadays an enormous amount of new so-called“premium lenses”are appearing in the market,with different optical profiles which obviously lead to different light distributions and different quality of retinal *** is why our interest in this topic is longstanding and we have published extensive summaries about the outcomes and complications of multifocal lenses over the last years[2,3].

关键词： editor letter enormous

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Endoscopic hemostasis using self-expandable metal stent combinedwith PuraStat® for patient with high risk of post-endoscopicsphincterotomy bleeding (with video)

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 94-96页

作者： Takeshi Ogura Yuki uba Masahiro Yamamura Nobu Nishioka Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical UniversityOsakaJapan

To the Editor:Endoscopic sphincterotomy(EST)is an established technique for removal of bile duct stones and self-expandable metal stent(SEMS)***,bleeding can be considered an adverse event after EST,particularly for patients with high risk of bleeding such as those on *** the various techniques reported for obtaining endoscopic hemostasis[1-3].

关键词： bleeding stasis endoscopic

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Novel re-intervention device for occluded multiple uncovered self-expandable metal stent(with video)

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 434-436页

作者： Takeshi Ogura Yuki uba Mitsuki Tomita Kimi Bessho Hiroki Nishikawa 2nd Department of Internal Medicine Osaka Medical and Pharmaceutical University2-7 DaigakuchouTakatsukishiOsaka 569-8686Japan

To the Editor:Obstructive jaundice due to unresectable malignant hilar obstruction can be treated by deployment of bilateral uncovered self-expandable metal stents(UCSEMSs),which enable longer stent patency to be obtained compared with multiple plastic stents[1-3].However,re-intervention is needed if obstructive jaundice occurs after bilateral UCSEMS *** re-intervention procedures,insertion of the stent delivery system across the mesh of a UCSEMS and into the bile duct can be challenging.A novel drill dilator has recently become available in Japan(Tornus ES;Asahi Intecc,Nagoya,Japan)(Fig.1)[4].The tract is easily dilated using a clockwise *** herein describe a successful re-intervention using this device for a patient with occluded bilateral UCSEMSs.

关键词： stent struction Asahi

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Local interests meet global regime:China’s subnational politics in clean development mechanism of Kyoto Protocol

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Economic and Political Studies 2016年第3期4卷 258-277页

作者： Bo Miao Yu-wai vic Li Department of Asian and International Studies City University of Hong KongHong KongChina Department of Social Sciences The Education University of Hong KongChina

As the Kyoto Protocol enters its second commitment phase,local states are adapting to the new *** analysis of the responses of three provincial authorities(Guangdong,Zhejiang and Shanghai)demonstrates that local authorities of China have sought project development that offers capital and technological transfers from Annexe 1 parties made possible by the Clean Development Mechanism(CDM),one of the flexibility mechanisms of the global climate *** from offering technical advisory and assistance to interested firms,extending fiscal incentives and regulatory supports and leveraging their connections with central counterparts and international partners to facilitate the local market development,Guangdong and Shanghai have also been proactively responding to the changing market and policy outlook of the CDM framework,piloting carbon emissions reduction strategies at the local level to foster their *** affirm the relevance of local interests and help complete our understanding of the subnational dynamics underlying the global climate regime.

关键词： Kyoto Protocol China climate change environment local governments

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Reduction of greensand emissions by minimum 25%―Case study

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China Foundry 2010年第4期7卷 419-424页

作者： Cornelis Grefhorst Wire Senden Resat Ilman Oleg Podobed vic Lafay Werner Tilch S＆B Industrial Minerals Germany Componenta - Foundry Heerlen Netherlands S＆B Industrial Minerals North America Technische University - Bergakademie Freiberg Germany

This paper describes the development of an inorganic alternative to coal or coal replacement for bentonite bonded molds (greensand molding) and the realization in an operating foundry. Through a time period of 1.5 years, Componenta Foundry changed in many steps from a classical green sand system to a coal free system, based on ENVIBOND developed in the GO-APIC project and further development as an S&B project. At Componenta Foundry, the percentage of casting defects or scrap did not increase. There was a tendency of an increase in stress (scabbing) defects and of a decrease in penetration defects. Benzene emission is reduced by 40%, odor emission has lower values (not statistically proven). Visible is less smoke in the foundry, especially at the cooling line. The benefits for health and emissions are clearly seen.

关键词： greensand emissions bentonite bonded molds binder system coal

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Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry

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Eye and Vision 2021年第6期8卷 374-384页

作者： Jorge L.Alio Francesco D’oria Francesca Toto Joan Balgos Antonio Palazon Francesco Versaci Jorge L.Alio del Barrio Vissum Innovation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezVissum Miranzac/Cabañal103016 AlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly Department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain R&D Department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly

Background:To study and compare the clinical optical image quality following implantation with different premium IOLs by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based ***:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 LENTIS Mplus LS-313 MF30;(d)33 LENTIS Mplus LS-313 MF15;(e)17 AkkoLens Lumina;(f)31 AT LISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis *** outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(LOA)and high-order aberration(HOA)RMS measured by PWS ***:AT LISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;P<0.05),followed by SA60AT(0.41±0.11 and 0.28±0.07)and PanOptix(0.4±0.07 and 0.26±0.04).AT LISA Tri was found to provide a significantly better retinal image quality than PanOptix at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.004).Mplus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.002).Total RMS,LOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(P<0.001).Conclusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted *** LISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic.

关键词： Cataract surgery Pyramidal aberrometry Multifocal IOL Extended depth of focus Accommodative IOL

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Overgrowth of the indigenous gut microbiome and irritable bowel syndrome

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World Journal of Gastroenterology 2014年第10期20卷 2449-2455页

作者： William Bye Naveed Ishaq Terry D Bolin vic M Duncombe Stephen M Riordan Gastrointestinal and Liver Unit Prince of Wales Hospital Randwick 2031 New South Wales Australia Prince of Wales Clinical School Randwick NSW 2031 Australia

Culture-independent molecular techniques have demonstrated that the majority of the gut microbiota is *** of these molecular techniques to more accurately identify the indigenous gut microbiome has moved with great pace over recent years,leading to a substantial increase in understanding of gut microbial communities in both health and a number of disorders,including irritable bowel syndrome(IBS).Use of culture-independent molecular techniques already employed to characterise faecal and,to a lesser extent,colonic mucosal microbial populations in IBS,without reliance on insensitive,traditional microbiological culture techniques,has the potential to more accurately determine microbial composition in the small intestine of patients with this disorder,at least that occurring proximally and within reach of *** data concerning culture-based and culture-independent analyses of the small intestinal microbiome in IBS are considered here.

关键词： Gut microbiome Small intestinal bacterial overgrowth Irritable bowel syndrome

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Wafer-scale MOCVD growth of monolayer M0S2 on sapphire and SiO2

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Nano Research 2019年第10期12卷 2646-2652页

作者： Huanyao Cun Michal Macha HoKwon Kim Ke Liu Yanfei Zhao Thomas LaGrange Andras Kis Aleksa ndra Radeno vic Laboratory of Nanoscale Biology Institute of BioengineeringEcole Polytechnique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Nanoscale Electronics and Structures Electrical Engineering InstituteEcole Poly technique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Nanoscale Electronics and Structures Institute of Materials Science and EngineeringEcole Poly technique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Interdisciplinary Center for Electron Microscopy(CIME) Ecole Polytechnique Federale de Lausanne(EPFL)1015 LausanneSwitzerland

High-quality and large-scale growth of monolayer molybdenum disulfide(MoS2)has caught intensive attention because of its potential in many applications due to unique electronic ***,we report the wafer-scale growth of high-quality mono layer MoS2 on singlecrystalline sapphire and also on SiO2 substrates by a facile metal-organic chemical vapor deposit!on(MOCVD)*** to growth,an aqueous solution of sodium molybdate(Na2MoO4)is spun onto the substrates as the molybdenum precursor and diethyl sulfide((C2H5)2S)is used as the sulfur precursor duri ng the *** grown MoS2 films exhibit crystal I i nity,good electrical performa nee(electro n mobility of 22 cm2·V^-1·s^-1)and structural continuity maintained over the entire *** sapphire substrates are reusable for subsequent *** same method is applied for the synthesis of tungsten disulfide(WS2).Our work provides a facile,reproducible and cost-efficient method for the scalable fabricati on of high-quality mono layer MoS2 for versatile applicati ons,such as electro nic and optoelectr onic devices as well as the membranes for desalination and power generation.

关键词： molybdenum disulfide two-dimensional(2D)materials metal-organic chemical vapor deposition(MOCVD) wafer-scale fabrication

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