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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Nanostructured catalyst for Fischer-Tropsch Synthesis

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chinese Journal of chemistry 2018年第9期36卷 798-808页

作者： wa Gao Qingshan Zhu Ding Ma college of chemistry and Molecular Engineering and college of Engineering Peking University Beijing 100871 China Fritz-Haber-Institut der Max-Planck-Gesellschaft Faradayweg 4-6 D-14195 Berlin Germany

Fischer-Tropsch synthesis （FTS） is a heterogeneous catalytic process for the production of fuels or chemicals from synthesis gas （cO ＋ H2）, which can be derived from nonpetroleum feedstocks such as natural gas, coal, or biomass. co, Ru, Fe and Ni are all active in FTS, but only cheaper Fe and co based catalysts are used in industry because the price of Ru is relatively high. However, the industrial Fe- and co-based FTS catalysts normally work at a relatively high temperature range of 493--623 K in order to get a reasonable space time yield. Moreover, the product selectivity of FTS is governed by the law of polymerization, i.e., a so-called Anderson-Schulz-FIory distribution holds, which restricts its industrial application. In this account, we highlight some of our progress toward the design/fabrication of nanostructured Fe, co and Ru catalysts to improve FTS activity at the low temperature and to change the product selectivity and confine the product distribution into a certain range.

关键词： catalyst Fischer-Tropsch synthesis nanostructure

MAGNETIZATION NEAR SATURATION OF IRON AND IRON-cOBALTS AT VARIOUS TEMPERATURES

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Science china Mathematics 1952年第2期 133-151页

作者： SHIAO-thur PAN Institute of Applied Physics, Academia Sinica

The approach to magnetic saturation in the cases of iron, nickel, and a number of iron-cobalt alloys at various temperatures has been studied in the range of field from a few hundred to 6,000 oersteds. It has been found that for annealed and moderately cold-worked specimens the differential susceptibility can be represented fairly accurately by a formula of the form, where I is the magnetization, H the applied field, and T the temperature. Near room temperature, the last two terms taken together are so small compared with the first two that they can be approximated by a single constant. For a specimen starting in the annealed state both the coefficients A and B increase tremendously at first with the amount of cold-work the specimen receives, but the formula fails to apply when the specimen is severely cold-worked. For annealed specimens these coefficients decrease with increasing temperature, vanishing at considerable distances below the curie point. In general, D cannot be evaluated with certainty from the present data. However, the coefficient c evaluated by neglecting D is in satisfactory agreement with the theoretical results of Holstein and Primakoff in so far as its order of magnitude and the way in which it varies with the temperature are concerned. B is undoubtedly proportional to K/Iwhere Kis the first magnetocrystalline anisotropy coefficient and Ithe saturation magnetization. However, values of Kobtained by comparing theory and experiment are satisfactory only in regard to the order of magnitude.

关键词： MAGNETIZATION NEAR SATURATION OF IRON AND IRON-cOBALTS AT VARIOUS TEMPERATURES AT

creeping fat and gut microbiota in crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen cS De Oliveira Luiz c Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of crohn’s disease(cD).cD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in cD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing cD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and cD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with cD.

关键词： creeping fat Mesenteric adipose tissue Gut microbiota crohn’s disease Inflammatory bowel disease

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Impact of climate change on outdoor design conditions and implications to peak loads

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Building Simulation 2022年第12期15卷 2051-2065页

作者： Xujie Huo Liu Yang Danny Hin wa Li Isaac Lun Siwei Lou Yuan Shi School of Architecture&Urban Planning Shenzhen UniversityShenzhen 518060China BenYuan Design and Research center Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Architecture for Health&Well-being(in preparation) Shenzhen 518060China School of Architecture Xi’an University of Architecture and TechnologyXi’an 710055China Building Energy Research Group Department of Architecture and Civil EngineeringCity University of Hong KongHong KongChina centre for Sustainable Energy Technologies University of Nottingham Ningbo ChinaNingbo 315100China School of civil Engineering Guangzhou UniversityGuangzhou 510006China

This study exams the impact of climate change on outdoor design conditions and peak loads of five chinese cities over the five major climate zones for the winter and summer *** design dry-bulb temperature(DDBT)and the coincident wet-bulb temperature(cWBT)for two 30-year periods;1971–2000 and 1984–2013 were *** was found that the DDBT of the period 1984–2013 was higher than that of the period 1971–2000,whereas the cWBT and the corresponding outdoor enthalpy of the period 1984–2013 was lower than that of 1971–2000 at the various cumulative *** trend implies that the increment in conductive heat gain through the building envelope due to the rising temperature can be lower than the reduction in fresh air load due to the lower outdoor air *** this case,the peak cooling loads may reduce in all five cities under study,and this is different from the widely held view that global warming will lead to more stringent outdoor design conditions,higher peak cooling loads and larger heating,ventilation and air conditioning(HVAc)plants than the current or historical *** implications to the“free-cooling”of HVAc systems with enthalpy control are discussed as well.

关键词： outdoor design conditions outdoor air enthalpy climate change peak loads

Reduction of residual stress in porous Ti6Al4V by in situ double scanning during laser additive manufacturing

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International Journal of Minerals,Metallurgy and Materials 2021年第11期28卷 1844-1853页

作者： Yi-wa Luo Ming-yong wang Ji-guo Tu Yu Jiang Shu-qiang Jiao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Department of Orthopedics Peking University Third HospitalBeijing 100191China

Selective laser melting(SLM)technology plays an important role in the preparation of porous titanium(Ti)implants with complex structures and precise ***,the processing characteristics of this technology,which include rapid melting and solidification,lead to products with high residual ***,an in situ method was developed to restrain the residual stress and improve the mechanical strength of porous Ti alloys during laser additive *** brief,porous Ti6Al4V was prepared by an SLM three-dimensional(3D)printer equipped with a double laser system that could rescan each layer immediately after solidification of the molten powder,thus reducing the temperature gradient and avoiding rapid melting and *** indicated that double scanning can provide stronger bonding conditions for the honeycomb structure and improve the yield strength and elastic modulus of the *** with an energy density of 75%resulted in 33.5%–38.0%reductions in residual *** porosities of double-scanned specimens were 2%–4%lower than those of singlescanned specimens,and the differences noted increased with increasing sheet *** rescanning laser power should be reduced during the preparation of porous Ti with thick cell walls to ensure dimensional accuracy.

关键词： porous titanium selective laser melting additive manufacturing residual stress mechanical properties

Serological surveillance for SARS-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R conde Sofia L costa Regina c S Sant’Anna Isa M F Antunes Mônica c carneiro Fabio S Ronzei Julia c Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio c Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele c Alexandre Karla c de Paula Márcio watanabe Antonio claudio L da Nóbrega Jackeline christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-coV-2),which led to the outbreak of coronavirus disease 2019(cOVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-coV-2 antibodies could indicate the immunoreactive profile during the cOVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-coV-2 antibodies in individuals within a university setting during the cOVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%cI:1.02-1.31](Pcontact with a cOVID-19-positive case(OR=3.49,95%cI:2.34-5.37)(Pceived the cOVID-19 vaccine(OR=2.33,95%cI:1.61-3.35)(Pcial isolation(OR=0.59,95%cI:0.41-0.84)(P<0.004).The likelihood of sho

关键词： Serological surveillance SARS-coV-2 antibodies cOVID-19 Serological rapid test Risk factors for cOVID-19