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FHL2 deficiency aggravates Candida albicans infection through decreased myelopoiesis

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science China Life sciences 2025年

作者： Rongmei Gao Kanchao Chen Yimin Wang Rongxia Guo Xiaoyu Zhang Peng Wu Weili Wang Qingxiang Huang Xuemei Xie shangda Yang Yanling Lü Qian Ren Fei Liu song Chen Fengxia ma Tao Cheng Hui Cheng state Key Laboratory of Experimental Hematology National Clinical Research Center for Blood Diseases Haihe Laboratory of Cell Ecosystem Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College CAMs Center for stem Cell Medicine PUMC Department of Stem Cell and Regenerative Medicine

Hematopoiesis is a finely tuned process that generates all blood cell types through self-renewal and differentiation, which is crucial for maintaining homeostasis. Acute infections can prompt a hematopoietic response known as emergency myelopoiesis. In this study, using a Candida albicans (C. albicans) infection model, we demonstrated for the first time that disruption of Fhl2 led to increased fungal burden,heightened inflammatory response and reduced survival rates. Impaired myeloid hematopoiesis and immune cell production were evident, as proved by the decreased numbers of hematopoietic stem and progenitor cells (HsPCs) and granulocytes in the bone marrow of Fhl2-deficient mice. In conclusion, FHL2 regulated emergency myelopoiesis in response to C. albicans, affecting the host’s defense against pathogens.

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Online traffic-aware linked VM placement in cloud data centers

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science China(Information sciences) 2020年第7期63卷 182-204页

作者： Liwei LIN David s.L.WEI Ruhui ma Jian LI Haibing GUAN shanghai Key Laboratory of scalable Computing and systems Shanghai Jiao Tong University Department of Computer & Information sciences Fordham University

In cloud computing, virtual machine(VM) placement pla.s.a.crucial role in data center(DC)management, as different ways of VM placement may require different system resources. As Cisco research reveals that virtualization of DC increases traffic within the DC and causes network bandwidth to become scarce resource, recent researches have been focusing on traffic-aware VM placement. However, previous traffic-aware VM placement schemes treat the VM placement as a.s.a.ic process in that they do not take into account the impact of the current placement decision on the subsequent placement. In this paper,we thus propose a novel online traffic-aware VM placement scheme. Our scheme views VM placement as a context-sensitive dynamic process in that the decision of every step of the placement is made aiming at helping the subsequent steps of placement to reduce the required network bandwidth in the long run. In our scheme, we consider not only inter-VM traffic but also the bandwidth constraint of a physical machine(PM) when making a VM placement decision. To realize our objective, we put those VMs with close end time in the same or close proximity PMs so that when the VMs are terminated, one can make enough room for the future arrivals so as to not only minimize the number of active PMs but also reduce networking costs. We conduct extensive simulations to verify the superiority of our scheme in terms of networking costs and energy consumption. simulation results show that our scheme outperforms improved-best-fit-decreasing(IBFD) scheme, a revised best-fit version that takes inter-VM traffic into account, by 30%–40% on network cost under various scenarios. Our scheme also promises 10%–25% power savings compared with IBFD.

关键词： linked VMs traffic-aware online VM placement cloud data center energy efficient

Influence of Process Variables on the structure of Mechanically Alloyed Ti_3Al-base Intermetallics

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Rare Metals 1993年第4期12卷 241-249页

作者： Chen Guohao suryanarayana C.and Froes F.H.(sam)Institute for materia.s.a.d Advanced Processes,University of idaho,Moscow,id 83843-4195,U.s.A. University of idaho 美国

During mechanical alloying variables such as the type of mill,milling intensity,milling time,milling at- mosphere and ball-to-powder weight ratio(BPR)affect the morphology and constitution of the product. The effect of milling time,milling atmosphere and BPR on the nature of the product formed in mechanical- ly alloyed pure Ti and blended elemental binary Ti-Al,and ternary Ti-AI-Nb alloy powders was described. Mechanical alloying of pure titanium results,after long milling times,in the formation of an fcc *** the binary alloy,a solid solution of aluminum in titanium,an amorphous phase,and a fcc phase form with increasing milling *** fcc phase,which is probably a result of TiN formation,occurs more rapidly in air or nitrogen than in an inert *** of the B2 phase in the ternary alloys depends both on alloy composition and the milling atmosphere,with 100％ formation in all atmospheres in Ti-25Al-25Nb but not in Ti-24Al-11Nb,and an inert atmosphere favoring *** times required for the formation of the different phases decrease as the BPR increases;but their sequence is *** on this infor- mation,“milling maps”which describe phase formation as a function of the BPR and milling time are con- *** from the milling balls increased as the BPR was increased.

关键词： Mechanical alloying Titanium alloys structure evolution Process variables Milling maps

Microstructure evolution and hot deformation behavior of carbon nanotube reinforced 2009Al composite with bimodal grain structure

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Journal of materials science & Technology 2021年第11期70卷 73-82页

作者： K.ma Z.Y.Liu s.Bi X.X.Zhang B.L.Xiao Z.Y.ma shi-changxu Innovation Center for Advanced materials Institute of Metal ResearchChinese Academy of ScienceShenyang110016China school of materials science and Engineering University of Science and Technology of China72 Wenhua RoadShenyang110016China school of materials science and Engineering Guilin University of TechnologyGuilin541004China

The hot deformation behaviors of the bimodal carbon nanotube reinforced 2009Al(CNT/2009Al)composite were studied by establishing processing map and characterizing the microstructure *** results indicate that the grain size in the ultra-fine grained zones was stable during hot deformation,while the coarse grained zones were elongated with their long axis directions tending to be perpendicular to the compression *** temperature with high strain rate(LTHR),as well as high temperature with low strain rate(HTLR)could increase the length/width ratio of the coarse grained ***,LTHR and HTLR could cause the instable *** instable deformation at LTHR was induced by severe intragranular plastic deformation and the localized shear crack,while the instable deformation at HTLR resulted from the more deformation component at the coarse grained zones,and the micro-pore initiation due to CNT re-agglomeration at the boundaries between the coarse and the ultra-fine grained zones.

关键词： Carbon nanotube Bimodal Aluminum matrix composite Hot deformation Processing map

ARsENIC REMOVAL BY sULFidATION sEDIMENTATION IN maGNETIC FIELD

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中国有色金属学会会刊：英文版 1998年第3期8卷 174-177页

作者： ma, Wei ma, Wenji ma, Rongjun shen, Dianbang south China Univ of Technology Guangzhou China

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关键词： arsenic treatment of waste water sulfide magnetic field

Robust stability analysis for a cruise missile

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Journal of systems Engineering and Electronics 2008年第4期19卷 785-790页

作者： shi Yingjing ma Guangfu ma Hongzhong school of Astronautics Harbin Inst. of Technology Harbin 150001 P. R. China Third Research Academy of China Aerospace science and Industry Corporation Beijing 100074 P. R. China

A global controller design methodology for a flight stage of the cruise missile is proposed. This methodology is based on the method of least squares, To prove robust stability in the full airspace with parameter disturbances, the concepts of convex polytopic models and quadratic stability are introduced, The effect of aerodynamic parameters on system performance is analyzed. The designed controller is applied to track the overloading signal of the cruise segment of the cruise missile, avoiding system disturbance owing to controller switching, simulation results demonstrate the validity of the proposed method.

关键词： aircraft control robust control least square quadratic stabilization

Coherence evolution in two-qubit system going through amplitude damping channel

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science China(Physics,Mechanics & Astronomy) 2018年第2期61卷 12-17页

作者： MingJing Zhao Teng ma YuQuan ma school of science Beijing Information Science and Technology University state Key Laboratory of Low-Dimensional Quantum Physics and Department of Physics Tsinghua University

In this paper, we analyze the evolution of quantum coherence in a two-qubit system going through the amplitude damping channel. After they have gone through this channel many times, we analyze the systems with respect to the coherence of their output states. When only one subsystem goes through the channel, frozen coherence occurs if and only if this subsystem is incoherent and an auxiliary condition is satisfied for the other subsystem. When two subsystems go through this quantum channel, quantum coherence can be frozen if and only if the two subsystems are both incoherent. We also investigate the evolution of coherence for maximally incoherent-coherent states and derive an equation for the output states after one or two subsystems have gone through the amplitude damping channel.

关键词： quantum coherence amplitude damping channel frozen coherence

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

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Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-Luo Wang Ruo-Ran Zhang Hao Wang Peng Xu Jing-Kai Wang Bo Chen Hao Xu Deng Pan Yu-Yang ma Kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate school Jiangsu UniversityZhenjiang 212013China Graduate school Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Roll-to-roll printing trench-like metasurface film for radiative cooling

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Light(science & Applications) 2023年第12期12卷 2538-2539页

作者： Yaoguang ma state Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and EngineeringInternational ResearchCenter for Advanced PhotonicsZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global scientific and Technological Innovation Center Hangzhou 311215China Jiaxing Key Laboratory of Photonic sensing&Intelligent Imaging Intelligent Optics&Photonics Research CenterJiaxing Research InstituteZhejiang UniversityJiaxing 314000China

A Roll-to-roll technology can enable the fabrication of trench-like photonic meta-structures that are strongly absorptive in the MIR region,providing a controllable optical response for diurnal radiative cooling.

关键词： trench radiative printing