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Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis

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World Journal of Gastroenterology 2009年第20期15卷 2512-2519页

作者： Walkíria Wingester Vilas-Boas Antnio Ribeiro-oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos Laboratory of Hypertension Department of Physiology Biological Sciences institute Federal University of Minas Gerais Av. Antonio Carlos 6627 Belo Horizonte MG 31270-901 Brazil Laboratory of Endocrinology Department of Medicine Faculty of Medicine Federal University of Minas Gerais Av. Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil Hospitalar Foundation of the State of Minas Gerais FHEMIG Belo Horizonte MG Brazil Department of Pediatrics Faculty of Medicine Federal University of Minas Gerais Av.Alfredo Balena 190 Belo Horizonte MG 30130-100 Brazil

AIM： To measure circulating angiotensins at different stages of human cirrhosis and to further evaluate a possible relationship between renin angiotensin system （RAS） components and hemodynamic changes. METHODS： Patients were allocated into 4 groups： mild-to-moderate liver disease （MLD）, advanced liver disease （ALD）, patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity （PRA）, angiotensin （Ang） Ⅰ, Ang Ⅱ, and Ang-（1-7） levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components. RESULTS： PRA and angiotensins were elevated in ALD when compared to MLD and controls （P 〈 0.05）. In contrast, Ang Ⅱ was significantly reduced in MLD. Ang-（1-7）/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-（1-7）/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation （0.52 ± 0.08 vs 0.38 ±0.04, P 〈 0.02）, whereas the peripheral circulating Ang Ⅱ/Ang Ⅰ ratio was elevated in comparison to splanchnic levels （0.18 ±0.02 vs 0.13 ±0.02, P 〈 0.04）. Ang-（1-7）/ Ang Ⅱ ratios positively correlated with cardiac output （r = 0.66） and negatively correlated with systemic vascular resistance （r = -0.70）. CONCLUSION： Our findings suggest that the relationship between Ang-（1-7） and Ang Ⅱ may play a role in the hemodynamic changes of human cirrhosis.

关键词： Renin-angiotensin system Liver cirrhosis Angiotensin-(1-7) Angiotensin Ⅱ Splanchnic circulation Angiotensin converting enzyme 2

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女性便秘病因探讨

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中国肛肠病杂志 2024年第3期44卷 78-80页

作者：程爱阳樊文彬林文霞重庆市丰都县暨龙镇卫生院重庆408224 重庆中医药学院重庆402760

便秘临床比较常见,以排便受阻、排便次数减少或排便不尽感、粪质干结为主要临床表现征。史慧慧等[1]针对上海部分社区人群的流行病学调查显示,慢性便秘的患病率为4.6%,杨直等[2]通过Meta分析,结果显示,男性和女性便秘患病率分别为7.0%和... 详细信息

便秘临床比较常见,以排便受阻、排便次数减少或排便不尽感、粪质干结为主要临床表现征。史慧慧等[1]针对上海部分社区人群的流行病学调查显示,慢性便秘的患病率为4.6%,杨直等[2]通过Meta分析,结果显示,男性和女性便秘患病率分别为7.0%和11.5%。便秘可引起直肠和肛周疾病、胃肠疾病和心脑血管等疾病,严重危害女性身心健康,部分患者由于反复就医或滥用药物造成沉重的经济和心理负担[3]。

关键词：便秘女性病因综述

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Genetic Identification of Quantitative Trait Loci for Contents of Mineral Nutrients in Rice Grain

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Journal of Integrative Plant Biology 2009年第1期51卷 84-92页

作者： Ana Luisa Garcia-oliveira Department of Plant Genetics and Breeding and State Key Laboratory of Plant Physiology and Biochemistry China Agricultural University National Centre for Evaluation of Agricultural Wild Plant Rice Beijing Key Laboratory of Crop Genetic Improvement and Genome of Ministry of Agriculture

In present study, Fe, Zn, Mn, Cu, Ca, Mg, P and K contents of 85 introgression lines （ILs） derived from a cross between an elite indica cultivar Teqing and the wild rice （Oryza rufipogon） were measured by inductively coupled argon plasma （ICAP） spectrometry. Substantial variation was observed for all traits and most of the mineral elements were significantly positive correlated or independent except for Fe with Cu. A total of 31 putative quantitative trait loci （QTLs） were detected for these eight mineral elements by single point analysis. Wild rice （O. rufipogon） contributed favorable alleles for most of the QTLs （26 QTLs）, and chromosomes 1,9 and 12 exhibited 14 QTLs （45%） for these traits. One major effect of QTL for zinc content accounted for the largest proportion of phenotypic variation （11%-19%） was detected near the simple sequence repeats marker RM152 on chromosome 8. The co-locations of QTLs for some mineral elements observed in this mapping population suggested the relationship was at a molecular level among these traits and could be helpful for simultaneous improvement of these traits in rice grain by marker assisted selection.

关键词： introgression lines mineral elements Oryza sativa Oryza rufipogon quantitative trait loci.

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Application of a transversely isotropic brittle rock mass model in roof support design

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International Journal of Mining Science and Technology 2012年第5期22卷 639-643页

作者： David oliveira Coffey Geotechnics NSW 2066Australia

Accurate modelling of the potential failure modes in the rock mass is an essential task towards a robust design of roof support systems in coal *** use of generalised rock mass properties based on averaged properties(***-Brown model) has been found to limit the capability to reproduce the actual rock mass behaviour which may include a wide range of interacting and complex failure mechanisms such as shear and tension fracturing of the intact rock and shear and separation of pre-existing discontinuities,including *** studies have also shown that traditional models,such as the Mohr-Coulomb,may not accurately describe the behaviour of the intact rock,particularly for stress induced failures where spalling and slabbing are *** is mainly due to the cohesion and friction components of the shear strength of the intact rock not being mobilised at the same rate with strain-softening of the former component playing an essential role in the post peak *** addition,coal measure rocks are often transversely isotropic,both by way of the preferred orientation of clay particles within the finer grained lithology and by bedding textures and bedding partings,and this is often ignored in computer simulations.A newly developed transversely isotropic brittle rock mass model is applied in the simulation of a hypothetical and simple roadway development.A Cohesion Weakening-Friction Strengthening(CWFS) approach is adopted to describe the intact rock where the mobilisation and strain-softening of the two shear strength components are linked to plastic *** impacts of anisotropy and brittle rock on the development of the excavation disturbed zone or height of softening,as often referred to,are investigated and their implication in the roof support design discussed.

关键词： Transverse isotropy Brittle behaviour Cohesion weakening-friction strengthening Ubiquitous joints

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Atmospheric Pollutants in a Commercial Region of Fortaleza, Ceará, Brazil: Integration of Health, Environment and Economy in Urban Planning to Improve Air Quality

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Journal of Geoscience and Environment Protection 2024年第5期12卷 92-112页

作者： Mônica Giovana Alves Cardoso Ratts Brenna Kessy Silva Lima Gilvan Ribeiro dos Santos Fladimir de Lima Gondim Rinaldo Santos Araújo Mona Lisa Moura de oliveira Francisco Sales Ávila Cavalcante Daniel Silveira Serra Science and Technology Center State University of Cear&#225 Cear&#225 Brazil Department of Chemistry and Environment Federal Institute of Cear&#225 Cear&#225 Brazil Center of Technological Sciences State University of Cear&#225 Cear&#225 Brazil

The accelerated growth of the vehicular fleet, the modernization of large urban centers, and the few adjustments to the road network in Fortaleza have intensified the problems of traffic and emissions of atmospheric pollutants, highlighting the necessity for strategic urban planning initiatives to address the escalating issues of traffic and pollution. With the objective of analyzing the indices of concentrations of atmospheric pollutants and estimating how these levels can affect human health, this work consists of a study of the analysis of air quality in the intense trade region of Fortaleza. For this, the analysis zone was divided into three perimeters (Major - Medium - Minor), where each perimeter was analyzed at 7 am, 12 noon and 5 pm. Concentrations of the type of O3, particulate matter (PM2.5 and PM10), CO2 and HCHO were collected. Our results demonstrate that most of the analyses are within the limits of current legislation;however, at certain times and perimeters, the analyses of CO2 and HCHO exceeded the established limits. In view of the above, we conclude that public policies to control air quality are necessary to reduce the damage to human health and the environment caused by pollutants.

关键词： Air Quality Urban Planning Particulate Material Health Impacts

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Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production

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Acta Pharmacologica Sinica 2004年第12期25卷 74-80页

作者： Mria GEROV,Jozef TRK,Ol’ga PECHV,Jana MATUKOV Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute ofNormal and Pathological Physiology SlovakAcademy of Sciences 813 71 Bratislava Slovak Republic Institute of Pathophysiology Medical School Comenius University Bratislava Slovak Republic Now in Center for Blood Research and Department of Pathology Harvard MedicalSchool Boston USA.

AIM: To search tools of high blood pressure in the model of nitric oxide (NO)-defective hypertension, and the study focused on the effect of rilmenidine, agonist of imidazoline receptors, which was suggested to modulate central sympathetic outflow. METHODS: Three experimental groups, each consisting of 7 rats, were used: (I) rats with inhibition of NO synthase (NOS) by NG-nitro-L-arginine methyl ester (L-NAME) 40 mg·kg-1·d-1 for 4 weeks in drinking water, (II) rats with inhibited NOS as in group I , plus agonist of imidazoline receptors rilmenidine 3 mg·kg-1·d-1 for 4weeks by gavage, and(III) control rats. Systolic blood pressure wasmeasured weekly noninvasively. At the end of experiment aortic ring isometric tension was followed, NOS expression (aorta, left ventricle), and NOS activity (left ventricle and brain) were determined. RESULTS: In the group I systolic blood pressure in- creased significantly, aortic ring relaxation to acetylcholine was significantly attenuated. Rilmenidine administered simultaneously with L-NAME (group II) prevented the increase of blood pressure which did not differ significantly from control values; aortic ring relaxation to acetylcholine did not differ from control. No change in NOS expres- sion (aorta and left ventricle) was found in groups I and II. Significant decline in NOS activity (left ventricle and brain) wasfound in groups I and II. CONCLUSION: Rilmenidinehas aremarkable role inNO-defective hypertension, possibly by inhibiting central sympathetic outflow and by affecting receptors in vascular smooth muscle also. The prime cause of hypertension in this experimental model - the compromised production of NO due to inhibition of NOS - was not affected by rilmenidine.

关键词： NO deficiency hypertension imidazoline receptor nitric-oxide synthase sympathetic activity

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Geographic information technology usage in developing countries – A case study in Mozambique

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Geo-Spatial Information Science 2018年第4期21卷 331-345页

作者： Nelson Amade Marco Painho Tiago oliveira Universidade Catolica de Mocambique BeiraMozambique Nova Information Management School Universidade Nova de LisboaLisboaPortugal

Geographic information technologies(GIT)have matured,have become pervasive throughout many types of organizations over recent decades and gained a wide range of attention in diverse sectors of *** goal of this paper is to identify the main drivers and uses of GIT in organizations and to give an overview of GIT uses in developing countries with a focus on a case study developed for Mozambique by analyzing the results of a survey of 123 Mozambican organizations that are current GIT *** results show that the main drivers behind are compatibility,complexity,competitive pressure,donor pressure,government policy,intention to adopt,innovation,relative advantage,security,and technology *** of the public and private sectors use GIT for customer/resource/risk management,decision support,education,research,monitoring,prediction,simulation,suitability analysis,sustainability,use and access.

关键词： Geographic information technologies organizations remote sensing GPS geographic information systems Mozambique

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Human occupation explains species invasion better than biotic stability:evaluating Artocarpus heterophyllus Lam.(Moraceae;jackfruit)invasion in the Neotropics

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Journal of Plant Ecology 2018年第3期11卷 465-474页

作者： Guilherme de oliveira Laboratório de Biogeografia da Conservação Universidade Federal do Recôncavo da Bahia(UFRB)Centro de Ciências AgráriasAmbientais e Biológicas(CCAAB)Setor de Ciências BiológicasRua Rui Barbosa 710Centro 44380-000Cruz das AlmasBahiaBrasil

Aims Biological invasions are recognized to put native species in risk of *** this study,I tested whether the invasion of Artocarpus heterophyllus Lam.(Moraceae;jackfruit)in the Neotropics was explained by its biotic stability,an intrinsic force,or by human occupation,an extrinsic *** I used an ensemble framework combining 12 ecological niche models(ENMs)and 4 atmosphere-ocean general circulation *** were constructed for the pre-industrial time period in the Indo-Malaya biogeographic region,the native habitat of ***,and were then projected to past(last glacial maximum,21000 years ago and mid-Holocene,6000 years ago)and future(end of century,2080)*** ENMs were used to establish the biotic stability of ***-phyllus in areas where it was predicted to be present concomitantly within these four time *** biotic stability was projected onto the Neotropics,and then I used a null model and logistic regression to test what the main driver of *** *** Findings In general,the presence of *** in the Neotropics was not explained by biotic stability,tested by the null ***,human occupation explained much of its presence in the invaded habitat,once all standardized coefficients related to this driver was significant positive in the logistic *** on these results,humans sustained the presence of ***-erophyllus in the Neotropics,probably because of the additive influences of propagule pressure and habitat ***,the recommendation is that the cultivation of *** in the Neotropics must be regulated and supervised,primarily near reserve areas.

关键词： ecological niche models(ENMs) ensemble forecasting climate change habitat disturbance propagule pressure

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Shade and sapling size influence restoration of Araucaria angustifolia

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Journal of Forestry Research 2021年第5期32卷 1833-1841页

作者： Simone Aparecida Zolet Sasso JoséAbramo Marchese Amanda Pacheco Cardoso Moura Bruna Valéria Gil Anelise Tessari Perboni Joel Donazzolo Fabrícia Lorrane Rodrigues oliveira Bruno Francisco Sant’Anna-Santos Angela Rohr Moeses Andrigo Danner Agronomy Department Universidade Tecnológica Federal do Paraná(UTFPR)Campus Pato BrancoVia do Conhecimentokm 01Pato BrancoParaná85503-390Brazil UTFPR Campus Dois VizinhosEstrada para Boa Esperançakm 04Dois VizinhosParaná85660-000Brazil Biological Sciences Department Universidade Federal do Paraná(UFPR)Avenida Coronel Francisco H.dos Santos100CuritibaParaná81531-980Brazil

Toward improving reforestation of Brazilian pine(Araucaria angustifolia),two contrasting sapling sizes in either full sun or in the shade of a mixed plantation and the effect of opening the canopy were evaluated for survival,growth,gas exchange,photosynthetic pigments,and leaf anatomy 18 months after being *** 23 months after planting,a partial opening was made in the canopy in the mixed plantation,then the saplings were evaluated again after 2 months for the same morphophysiological *** 18 months,saplings planted in the full sun had higher survival,growth,pigments,and photosynthesis compared to the shaded *** saplings had higher survival and growth compared to the small *** leaves were thinner and little differentiation of palisade parenchyma and *** opening of the canopy,photo synthetically active radiation was 10 times higher,and the saplings quickly grew in height due to increased ***,although the species can tolerate shade,growth in the shade is *** recommend that for reforestation purposes of Brazilian pine,large saplings should be selected and planted in the open for better development.

关键词： Brazilian pine Luminosity Gas exchanges Photosynthetic pigments Leaf anatomy

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Fault Location Approach to Distribution Networks Based on Custom State Estimator

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1878-1889页

作者： Luis F.Ugarte Madson C.de Almeida Luís H.T.Bandória IEEE Department of Systems and Energy State University of CampinasSão Paulo 13083-970Brazil

This paper presents a properly designed branchcurrent based state estimator(BCBSE)used as the main core ofan accurate fault location approach(FLA)devoted to distribution *** to the approaches available in the literature,it uses only a limited set of conventional measurementsobtained from smart meters to accurately locate faults at busesor branches without requiring measurements provided by phasor measurement units(PMUs).This is possible due to themethods used to model the angular reference and the faultedbus,in addition to the proper choice of the weights in the stateestimator(SE).The proposed approach is based on a searchingprocedure composed of up to three stages:①the identificationof the faulted zones;②the identification of the bus closest tothe fault;and③the location of the fault itself,searching onbranches connected to the bus closest to the ***,this paper presents a comprehensive assessment of the proposedapproach,even considering the presence of distributed generation,and a sensitivity study on the proper weights required bythe SE for fault location purposes,which can not be found inthe *** show that the proposed BCBSE-basedFLA is robust,accurate,and aligned with the requirements ofthe traditional and active distribution networks.

关键词： Active distribution network branch current based state estimator fault location smart meter

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