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Nanomaterials for refining tumor microenvironment and enhancing therapy in head and neck squamous cell carcinoma: a review

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Oncology and Translational Medicine 2024年第4期10卷 151-161页

作者： Kaifeng Zheng Ruibiao Song Ruifeng Li Mengli Liu Yunpeng ba Wei Jiang Kelong Fan Department of Rhinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanChina Application Center for Precision Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhouHenanChina CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules(CAS)CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijingChina Zhongyuan Nanozyme Laboratory ZhengzhouHenanChina

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal solid tumor with a high mortality rate. Conventional cancertreatments, including surgery, radiotherapy, and chemotherapy, primarily target cancer cell eradication. However, uncontrolled proliferation and metabolic activities of these cells result in abnormalities in nutrient levels, hypoxia, and immunosuppression within the tumor microenvironment (TME). These factors constrain the efficacy of traditional treatments by promoting drug resistance, recurrence, and metastasis. Nanomaterials (NMs), such as nanozymes, can exhibit enzymatic activity similar to that of natural enzymes and offer a promising avenuefor the direct modification of the TME through catalytic oxidation-reduction processes. Moreover, they can serve as sensitizers or drug deliverycarriers, enhancing the efficacy of traditional treatment methods. Recently, NMs have garnered significant attention from oncologists. Thisreview begins with an overview of the composition and unique characteristics of the TME. Subsequently, we comprehensively exploredthe application of NMs in the treatment of HNSCC. Finally, we discuss the potential prospects and challenges associated with usingNMs in biomedical research.

关键词： Nanomaterials Tumor microenvironment Antitumor therapy Tumor diagnosis Head and neck squamous cell carcinoma

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硅谷银行破产、声誉风险跨国传染与股价异动——来自中国A股上市银行的证据

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投资研究 2024年第6期43卷 4-21页

作者：邵磊巴曙松天津财经大学金融学院北京大学汇丰金融研究院

本文在对硅谷银行破产事件前因后果进行梳理的基础上,首次运用事件研究法将硅谷银行破产所引发声誉风险对A股上市银行的影响及其异质性进行识别和检验。研究发现,该影响确实存在且异质性明显。具体而言:中国国有大型银行所受到声誉风险... 详细信息

本文在对硅谷银行破产事件前因后果进行梳理的基础上,首次运用事件研究法将硅谷银行破产所引发声誉风险对A股上市银行的影响及其异质性进行识别和检验。研究发现,该影响确实存在且异质性明显。具体而言:中国国有大型银行所受到声誉风险竞争效应的影响远高于传染效应,投资者对其信心增强。与之相反,区域性农商行与城商行受到的负面冲击幅度最大也最为严重,呈现出显著的声誉风险传染效应。全国性股份制银行的表现介于二者之间。

关键词：银行破产声誉风险股票市场事件研究法

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作业车间调度的多工序精确联动邻域结构混合进化算法

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计算机集成制造系统 2024年第2期30卷 537-552页

作者：巴智勇袁逸萍裴国庆王波新疆大学机械工程学院新疆乌鲁木齐830017 卓郎新疆智能机械有限公司新疆乌鲁木齐830057

针对作业车间调度问题,以最小化最大完工时间为优化目标,提出一种基于多工序精确联动邻域结构的混合进化算法。从理论上给出了关键块中工序无效移动的判定条件,据此设计了3对工序精确联动的邻域结构。为避免算法过早收敛,引入基于邻域... 详细信息

针对作业车间调度问题,以最小化最大完工时间为优化目标,提出一种基于多工序精确联动邻域结构的混合进化算法。从理论上给出了关键块中工序无效移动的判定条件,据此设计了3对工序精确联动的邻域结构。为避免算法过早收敛,引入基于邻域惩罚的交叉父本匹配选择算子与基于动态惩罚阈值的种群更新策略。通过与其他先进算法在车间调度问题基准算例上进行对比实验,验证了所提算法的有效性与稳定性。

关键词：作业车间调度精确多工序联动邻域结构混合进化算法多样化搜索

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Evaluation of the Care of Children Aged 0 to 10 Years Hospitalized for Severe Malaria at the Tambacounda Health Center, Senegal

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Advances in Infectious Diseases 2024年第3期14卷 581-594页

作者： Tidiane Gadiaga Aminata Fall Alioune badara Gueye Siré Sagna bayal Cissé Mouhamadou Faly ba Médoune Ndiop babacar Gueye Samba Cor Sarr Sylla Thiam Elhadji ba Konko Ciré Jean Louis Abdou Ndiaye Issa Wone Directorate of Research Planning and Statistics Ministry of Health and Social Action Dakar Senegal Faculty of Medicine Assane Seck University of Ziguinchor Ziguinchor Senegal Presidents Malaria Initiative USAID Dakar Senegal Tambacounda Health District Ministry of Health and Social Action Tambacounda Senegal Institute of Health and Development Faculty of Medicine Cheikh Anta Diop University Dakar Senegal National Malaria Control Program (NMCP) Dakar Senegal UFR Sant Faculty of Medicine Iba Der Thiam University of This This Senegal

Introduction: Malaria remains a public health priority in Senegal, particularly in Tambacounda, where it is one of the main causes of child mortality. The objective of this work was to evaluate the care of children under 10 years of age hospitalized at the Tambacounda Health Center and the factors associated with recovery. Methods: An analytical, retrospective, and descriptive cross-sectional study with exhaustive recruitment of children 0 to 120 months hospitalized at the Tambacounda reference health center for severe malaria (according to WHO criteria) between 1 January 2018 and 31 December 2021 was performed. Data collection was done through a questionnaire. Records, hospitalization records, and treatment records were the sources of collection. Data entry and analysis were performed on Epi Info 7.2 and R. Results: A total of 481 children hospitalized with severe malaria were recruited. The highest number of cases was recorded in 2018 (33.05%). In the four years of the study, peaks were always observed between October and November and the highest peak in November 2020 with 95 cases. The mean age was 65.64 months with a standard deviation of 29.28 months and a predominance of male (53.43%). The majority of people were admitted from the outpatient clinic (57.79%) and the rest (42.21%) on the recommendation of a peripheral health post. All hospitalized patients had a positive RDT and/or a positive thick drop. However, the sharp decline at admission or during hospitalization was positive in 93.80% of patients in our series, negative in 5.20% and not achieved in 1.00%. Seizures and severe anemia topped the list of signs of severity with 45.94% and 8.11%, respectively. In terms of evolution, for all hospitalized patients, there were 81.29% recovery, 10.19% referral to the Tambacounda regional hospital center for hospitalization, 4.99% death, 0.83% discharge and 2.70% unknown evolution. There was a statistically significant association between recovery without referral f

关键词： Severe Malaria Children Tambacounda Senegal

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山地旅游安全事故致因研究——基于“三山五岳”的文本案例

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干旱区资源与环境 2024年第3期38卷 201-208页

作者：黄佳杰巴兆祥复旦大学旅游学系上海200433

以国内外知名的“三山五岳”景区作为研究对象,搜集其相关的178个旅游安全事故典型案例,基于扎根理论对事故致因进行分析与讨论。结果表明:1)山地旅游安全事故的致因根据比重依次为:人为因素、环境因素、设备因素以及管理因素。2)致因... 详细信息

以国内外知名的“三山五岳”景区作为研究对象,搜集其相关的178个旅游安全事故典型案例,基于扎根理论对事故致因进行分析与讨论。结果表明:1)山地旅游安全事故的致因根据比重依次为:人为因素、环境因素、设备因素以及管理因素。2)致因分别对应8个子集:游客不安全行为、当地人不安全行为、天气不安全因素、陆地不安全因素、游客装备不齐全、设施设备不安全、管理水平低以及救援水平有限。3)借鉴旅游安全事故因果连锁理论,结合分析的要素与逻辑,建构了山地旅游安全分析模型。以政府、企业和游客三个维度为切入,为山地旅游业提出对策建议。

关键词：山地旅游旅游安全旅游事故扎根理论事故致因

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基于地缘环境视角的地缘破碎带历史演进解析——以南高加索地区为例

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地理学报 2024年第6期79卷 1592-1611页

作者：巴士奇陈瑛姚宇阳李淦叶帅陕西师范大学地理科学与旅游学院西安710119 江苏理工学院文化与旅游学院常州213001

地缘破碎带是全球冲突和大国竞争的主要区域,具备外部挤压性、内部分裂性、过程动态性等基本特征,是域内外双重尺度作用下共同形成的地理区域。地缘破碎带的基本特征与发展模式契合于地缘环境研究的核心理念,在地缘环境视角下,地缘破碎... 详细信息

地缘破碎带是全球冲突和大国竞争的主要区域,具备外部挤压性、内部分裂性、过程动态性等基本特征,是域内外双重尺度作用下共同形成的地理区域。地缘破碎带的基本特征与发展模式契合于地缘环境研究的核心理念,在地缘环境视角下,地缘破碎带是一个以域内外多元行为体互动实践为核心的不断发展演化的地理区域。通过互动实践,破碎带产生的决策信息集成为制约相关行为体发生行动的物质性与理念性因素,在此约束下,这些决策行动在时序上的排列关联构成了破碎带历史演进的核心内容。选取亚欧交界处的南高加索地区为研究区域,自1991年南高加索三国独立以来,该地区历经复杂的内部冲突与外部博弈,是地缘破碎带分析的典型案例。本文构建出地缘环境视角下地缘破碎带历史演进的分析框架,从本底要素、关联要素、结构要素3类视角解析1991年南高加索地区三国独立后至2020年底的历史演进过程及阶段性特征,并从跨领域互动、跨尺度耦合和多元行为体博弈3方面分析推动演进的内在路径,以地缘政治学理论视角多维化呈现地缘破碎带的历史演进过程,尝试将地理学研究的区域性、综合性、尺度性等基本思维模式融入历史学与国际关系学研究中。

关键词：地缘破碎带地缘环境多元行为体历史演进南高加索地区

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Are all primary omental infarcts truly idiopathic?Five case reports

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World Journal of Clinical Cases 2024年第24期12卷 5596-5603页

作者： Haldun Kar Danial Khabbazazar Nihan Acar Şebnem Karasu Halis bağ Fevzi Cengiz Osman Nuri Dilek Department of General Surgery Katip Celebi University Ataturk Training and Research Hospitalİzmir 35150Türkiye Department of Radiology İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Türkiye Department of Surgery İzmir Katip Celebi UniversitySchool of Medicineİzmir 35150Türkiye

baCKGROUND Idiopathic omental infarction(IOI)is challenging to diagnose due to its low incidence and vague *** differential diagnosis also poses difficulties because it can mimic many intra-abdominal organ *** hypercoagulability and thrombosis are among the causes of omental infarction,venous thromboembolism scanning is rarely performed as an etiological *** SUMMAry The medical records of the 5 cases,who had the diagnosis of IOI by computed tomography,were *** majority of the patients were male(n=4,80%)and the mean age was 31 years(range:21-38).The patients had no previous abdominal surgery or a history of any chronic *** main complaint of all patients was persistent abdominal *** infarction was detected in all patients with contrast-enhanced computed *** treatment was initially preferred in all patients,but it failed in 1 patient(20%).After discharge,all patients were referred to the hematology department for thrombophilia *** 1 patient applied for thrombophilia screening and was homozygous for methylenetetrahydrofolate reductase(A1298C mutation)and heterozygous for a factor V Leiden *** IOI should be considered in the differential diagnosis in patients presenting with progressive and/or persistent right side abdominal *** risk factors such as hypercoagulability in patients with IOI is also important in preventing future conditions related to venous thromboembolism.

关键词： Omental infarction Acute abdominal pain Thrombophilia screening Factor V Leiden Methylenetetrahydrofolate reductase Case report

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“一带一路”沿线国家数字经济合作的基础、挑战与路径

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河南社会科学 2024年第1期32卷 43-51页

作者：巴殿君吕博尧吉林大学东北亚研究中心吉林长春130012

数字经济是重塑全球竞争格局的关键力量,给共建“一带一路”国家的合作提供新的机遇。中国在“一带一路”倡议下积极推动与多个共建国家的数字合作,加强了数字经济领域的协调,使共建国家数字综合实力不断提高。随着新兴科技的快速发展,... 详细信息

数字经济是重塑全球竞争格局的关键力量,给共建“一带一路”国家的合作提供新的机遇。中国在“一带一路”倡议下积极推动与多个共建国家的数字合作,加强了数字经济领域的协调,使共建国家数字综合实力不断提高。随着新兴科技的快速发展,推动产业数字化转型,共建国家对数字经济的政策支持不断完善,数字基础设施得到加强,数字环境持续改善,我国数字经济蓬勃发展,为进一步的合作奠定了坚实基础。然而,共建国家在数字经济合作方面仍存在数字经济发展不平衡、网络安全威胁、数字规则机制建设滞后等问题。为应对这些挑战,需因地制宜地推动数字经济协调发展,构建全面的数字安全保障体系,妥善处理中美关系和数字领域的竞争,多层次地构建数字治理体系,加强话语权建设并构建战略互信,加大金融支持人才培育、鼓励创新力度,实现共建“一带一路”国家数字经济的共同发展和互利共赢。

关键词： “一带一路” 数字经济 “数字丝绸之路” 国际合作

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计算机断层扫描在工业遗产文物保护中的应用研究

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热加工工艺 2024年第17期53卷 78-83页

作者：巴玥温瑀燕山大学河北秦皇岛066004

针对工业遗产的钢材结构表面及内部的孔隙、裂缝等微观缺陷,采用计算机断层扫描系统进行三维可视化,检测出缺陷位置,随后采用激光再制造技术以Fe-Cr-Mo+8wt%Al2O3复合粉末对缺陷位置进行精确修复。结果表明:经激光再制造后试样表面裂纹... 详细信息

针对工业遗产的钢材结构表面及内部的孔隙、裂缝等微观缺陷,采用计算机断层扫描系统进行三维可视化,检测出缺陷位置,随后采用激光再制造技术以Fe-Cr-Mo+8wt%Al2O3复合粉末对缺陷位置进行精确修复。结果表明:经激光再制造后试样表面裂纹和气孔显著减少,修复层主要由固溶体FeCr相、碳化物M(Fe,Cr,Mo)7C3、金属间化合物Fe3Al和陶瓷相Al2O3组成,显著提高了原始表面的耐腐蚀性。

关键词：工业遗产激光再制造计算机断层扫描

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From Fostering to Delusional Disorder of Filiation

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Open Journal of Psychiatry 2024年第4期14卷 283-286页

作者： Momar Camara Wissem Masmoudi El Hadji Makhtar ba Sokhna Seck Maïmouna Dieye Aïda Sylla Department of Psychiatry and Medical Psychology Cheikh Anta Diop University Dakar Senegal Thiaroye National Psychiatric Hospital Center Dakar Senegal Fann National University Hospital Center Dakar Senegal Albert Royer Childrens Hospital Dakar Senegal

Introduction: Fostering is a widespread practice in West Africa. It played an essential role in the circulation of children. The failure of its community regulation, not compensated by a legal framework, has made its practice precarious. Observation: A case study was conducted on Dior, who was hospitalised in a psychiatric ward for a delusional disorder of filiation. Dior was entrusted to her maternal grandmother and aunt at ages 2 and 9. During these fosterings, the place of the symbolic father was not substituted, causing a void that challenged her imagination. The outcome was an inscription in a genealogy where she had found herself with prestigious parents. Discussion: Fostering has strongly disrupted the family dynamics in Dior’s case. One of her options was to assume the paternal function, the use of which was perceived as a defiance or even a transgression. This same function would be a starting point of a psychosis whose filial character would only be an attempt at rectification where reality and imagination collide. Conclusion: Our study reveals the importance of stable parental figures at stake in fostering contexts, which constitute a risk factor for the development of a subsequent psychosis.

关键词： Delusional Disorder of Filiation Psychopathology Interactions Fostering Family

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