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Chronic kidney disease and erectile dysfunction

World Journal of Nephrology 2014年第4期3卷 220-229页

作者： Etsu Suzuki Hiroaki Nishimatsu Shigeyoshi oba Masao Takahashi Yukio Homma Institute of Medical Science St.Marianna University School of Medicine The Department of Urology Faculty of MedicineUniversity of Tokyo The Department of Internal Medicine Faculty of MedicineUniversity of Tokyo

Erectile dysfunction(ed) is a common condition among male chronic kidney disease(CKD) *** prevalence is estimated to be approximately 80% among these *** has been well established that the production of nitric oxide from the cavernous nerve and vascular endothelium and the subsequent production of cyclic GMP are critically important in initiating and maintaining *** affecting these pathways can induce *** etiology of ed in CKD patients is *** including abnormalities in gonadal-pituitary system,disturbance in autonomic nervous system,endothelial dysfunction,anemia(and erythropoietin deficiency),secondary hyperparathyroidism,drugs,zinc deficiency,and psychological problems are implicated in the occurrence of *** improvement of general conditions is the first step of *** dialysis and adequate nutritional intake are *** addition,control of anemia and secondary hyperparathyroidism is *** of drugs that potentially affect erectile function may be ***,zinc supplementation may be necessary whenzinc deficiency is *** type 5 inhibitors(PDE5Is) are commonly used for treating ed in CKD patients,and their efficacy was confirmed by many *** replacement therapy in addition to PDE5 Is may be useful,particularly for CKD patients with *** transplantation may restore erectile *** is an early marker of cardiovascular disease(CVD),which it frequently precedes; therefore,it is crucial to examine the presence of ed in CKD patients not only for the improvement of the quality of life but also for the prevention of CVD attack.

关键词： Erectile dysfunction Chronic kidney disease Nitric oxide Phosphodiesterase type 5 Testosterone

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