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Influence of processing history on microstructure， mechanical properties， and electrical conductivity of Cu-0.7Mg alloy

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Transactions of Nonferrous Metals Society of China 2024年

作者： Alireza KALHOR Kinga RODAK Marek TKOCZ Bartosz chmiela Ivo SCHINDLER ?ukasz POLOCZEK Krzysztof RADWA?SKI Hamed MIRZADEH Marian KAMPIK Faculty of Materials Engineering， Silesian University of Technology V?B – Technical University of Ostrava， Faculty of Materials Science and Technology Materials Research Group， ?ukasiewicz Upper Silesian Institute of Technology School of Metallurgy and Materials Engineering， College of Engineering， University of Tehran Faculty of Electrical Engineering， Silesian University of Technology

The effects of forward extrusion as well as extrusion combined with reversible torsion (KoBo extrusion)， followed by additional deformation via the MaxStrain module of the Gleeble thermomechanical simulator， on the microstructure， mechanical properties， and electrical conductivity of a Cu-0.7Mg (wt.%) alloy， were investigated in this work. The simulation results highlighted the critical influence of processing history in determining the equivalent strain distribution. The sample subjected to forward extrusion at 400 ℃and subsequent MaxStrain processing (FM sample)， possessed 76% lower grain size compared to the sample processed solely with MaxStrain (AM sample). Likewise， the KoBo-extruded and MaxStrain-processed sample (KM sample) exhibited 66% smaller grain size compared to the AM sample. Tensile test results revealed that the AM， FM， and KM samples， respectively， possessed 251%， 288%， and 360% higher yield strength， and 95%， 121%， and 169% higher tensile strength compared to the initial annealed alloy， as a result of grain refinement as well as deformation strengthening. Finally， the electrical conductivity measurements revealed that AM， FM， and KM samples， respectively， possessed electrical conductivity values of 37.9， 35.6， and 32.0 (MS/m)， which， considering their mechanical properties， makes them eligible to be categorized as high-strength and high-conductivity copper alloys.

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Molecular mimicry in Helicobacter pylori infections

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World Journal of Gastroenterology 2017年第22期23卷 3964-3977页

作者： magdalena chmiela weronika gonciarz department of immunology and infectious biology institute of microbiology biotechnology and immunology faculty of biology and environmental protection university of lodz

Gram-negative bacteria Helicobacter pylori(H. pylori) colonize gastric mucosa in humans and increase the risk of serious diseases such as gastric and duodenal ulcers, stomach cancers and mucosa associated lymphoid tissue lymphoma. The role of H. pylori infection in the pathogenesis of several extragastric diseases has been suggested including immune thrombocytopenic purpura, iron deficiency anemia, vitamin D deficiency, cardiovascular diseases,diabetes mellitus and dermatological disorders. Also neurological diseases and even lung cancer have attracted researchers concern. The relation between H. pylori infection and a growth retardation in children has also been suggested. Many mechanisms of molecular mimicry between H. pylori and the host have been proposed as a pathogen strategy to manipulate the immune system of the host in order to remain unrecognized and avoid eradication. A lot of effort has been put into the demonstration of homologous sequences between H. pylori and host compounds. However, knowledge about how often autoantibodies or autoreactive T lymphocytes induced during H. pylori infections cause pathological disorders is insufficient. This review provides data on H. pylori antigenic mimicry and possible deleterious effects due to the induction of immune response to the components common to these bacteria and the host.

关键词： Helicobacter pylori Molecular mimicry Anti-self response Extragastric effects

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Structural modifications of Helicobacter pylori lipopolysaccharide:An idea for how to live in peace

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World Journal of Gastroenterology 2014年第29期20卷 9882-9897页

作者： Magdalena chmiela Karolina Rudnicka Eliza Miszczyk Department of Immunology and Infectious Biology Faculty of Biology and Environmental ProtectionUniversity of ?ód?

In this review, we discuss the findings and concepts underlying the “persistence mechanisms” of Helicobacter pylori (H. pylori), a spiral-shaped, Gram-negative rod bacterium that was discovered as a gastric pathogen by Marshall and Warren in 1984. H. pylori colonizes the gastric mucosa of nearly half of the human population. Infections appear in early childhood and, if not treated, persist for life. The presence or absence of symptoms and their severity depend on multiple bacterial components, host susceptibility and environmental factors, which allow H. pylori to switch between pathogenicity and commensalism. Many studies have shown that H. pylori components may facilitate the colonization process and the immune response of the host during the course of H. pylori infection. These H. pylori-driven interactions might result from positive or negative modulation. Among the negative immunomodulators, a prominent position is occupied by a vacuolating toxin A (VacA) and cytotoxin-associated gene A (CagA) protein. However, in light of the recent studies that are presented in this review, it is necessary to enrich this panel with H. pylori lipopolysaccharide (LPS). Together with CagA and VacA, LPS suppresses the elimination of H. pylori bacteria from the gastric mucosa by interfering with the activity of innate and adaptive immune cells, diminishing the inflammatory response, and affecting the adaptive T lymphocyte response, thus facilitating the development of chronic infections. The complex strategy of H. pylori bacteria for survival in the gastric mucosa of the host involves both structural modifications of LPS lipid A to diminish its endotoxic properties and the expression and variation of Lewis determinants, arranged in O-specific chains of H. pylori LPS. By mimicking host components, this phenomenon leaves these bacteria “invisible” to immune cells. Together, these mechanisms allow H. pylori to survive and live for many years within the

关键词： Helicobacter pylori Lipopolysaccharide Immune response Adaptation Inflammation

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Host pathogen interactions in Helicobacter pylori related gastric cancer

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World Journal of Gastroenterology 2017年第9期23卷 1521-1540页

作者： Magdalena chmiela Zuzanna Karwowska Weronika Gonciarz Bujana Allushi Pawel Staczek Department of Immunology and Infectious Biology Institute of MicrobiologyBiotechnology and ImmunologyFaculty of Biology and Environmental ProtectionUniversity of Lodz Department of Genetics of Bacteria Institute of MicrobiologyBiotechnology and ImmunologyFaculty of Biology and Environmental ProtectionUniversity of Lodz

Helicobacter pylori (H. pylori), discovered in 1982, is a microaerophilic, spiral-shaped gram-negative bacterium that is able to colonize the human stomach. Nearly half of the world’s population is infected by this pathogen. Its ability to induce gastritis, peptic ulcers, gastric cancer and mucosa-associated lymphoid tissue lymphoma has been confirmed. The susceptibility of an individual to these clinical outcomes is multifactorial and depends on H. pylori virulence, environmental factors, the genetic susceptibility of the host and the reactivity of the host immune system. Despite the host immune response, H. pylori infection can be difficult to eradicate. H. pylori is categorized as a group I carcinogen since this bacterium is responsible for the highest rate of cancer-related deaths worldwide. Early detection of cancer can be lifesaving. The 5-year survival rate for gastric cancer patients diagnosed in the early stages is nearly 90%. Gastric cancer is asymptomatic in the early stages but always progresses over time and begins to cause symptoms when untreated. In 97% of stomach cancer cases, cancer cells metastasize to other organs. H. pylori infection is responsible for nearly 60% of the intestinal-type gastric cancer cases but also influences the development of diffuse gastric cancer. The host genetic susceptibility depends on polymorphisms of genes involved in H. pylori-related inflammation and the cytokine response of gastric epithelial and immune cells. H. pylori strains differ in their ability to induce a deleterious inflammatory response. H. pylori-driven cytokines accelerate the inflammatory response and promote malignancy. Chronic H. pylori infection induces genetic instability in gastric epithelial cells and affects the DNA damage repair systems. Therefore, H. pylori infection should always be considered a pro-cancerous factor.

关键词： Helicobacter pylori Host susceptibility Carcinogenesis Bacterial diversity

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Negative-pressure pneumatic separator:a new solution for hard-coal beneficiation

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International Journal of Coal Science & Technology 2021年第1期8卷 103-123页

作者： Kamil Stańczyk Andrzej Bajerski Marian J.Łączny Central Mining Institute Plac Gwarków 140-166KatowicePoland

Hard coal is an important source of energy *** to the imperfections of excavation technology,most run-of-mine coals must be processed before they can be utilised as *** this study,tests on the dry separation process were performed with numerous different raw hard coal and coal waste material samples,using a newly designed and constructed negative-pressure pneumatic separator(NPPS).The experiments revealed the effects of the feed-material properties and material processing *** experiments were preceded by additional tests for evaluating the influence of each device operating parameter on the process,to determine the optimal method of supplying the feed *** calorific value of the processed materials was improved by 5%–40%,while a minimal output yield of products(60%–70%)was *** trials indicated that in coal material processing,the developed NPPS can be used for not only raw coal enrichment but also coal recovery from materials stored at coal-waste *** main advantages of the device are its mobility,low material processing cost,and lack of water consumption during operation.

关键词： Dry coal beneficiation Coal enrichment Coal waste processing Aerodynamic separation Deshaling Negative-pressure system

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How rotational speed of planetary ball mill and polymer load influence the performance and water vapor sorption in solid dispersions composed of tadalafil and soluplus

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Particuology 2023年第2期73卷 37-46页

作者： Karol Kubat Anna Krupa Witold Brniak Agnieszka Węgrzyn Dorota Majda Agata Bogdał Hubert Harańczyk Department of Medical Physics Faculty of PhysicsInstitute of PhysicsJagiellonian UniversityCracowPoland Department of Pharmaceutical Technology and Biopharmaceutics Faculty of PharmacyCollegium MedicumJagiellonian UniversityCracowPoland Faculty of Chemistry Jagiellonian UniversityCracowPoland

The presence of residual water may deteriorate the performance of amorphous solid dispersions prepared by ball milling,affecting molecular mobility,crystallinity,particle size and finally,the drug dissolution *** the stability of these metastable systems depend on both formulation and process variables,the aim of this study was to assess for the first time,the impact that the polymer load and the rotational speed applied upon high energy ball milling could have on the performance of binary co-milled solid dispersions composed of tadalafil(a hydrophobic crystalline drug)and Soluplus(an amphiphilic,hygroscopic amorphous polymer).Each of these variables was tested at three *** electron microscopy,laser diffraction and X-ray powder diffraction were used to analyze morphology,particle size distribution and crystallinity of ball milled formulations *** studies were also carried *** tools of applied physics,namely solid state 1H NMR and relaxometry were used to assess the structure and water mobility upon gaseous phase hydration on *** was shown that both tested variables determined the particle size of the *** the rotational speed of 400 rpm was used,all solid dispersion were XRD-amorphous,but to ensure the immediate release of tadalafil its micellar solubilization in Soluplus was *** the formulation was exposed to water vapor,the hydration level increased with an increasing polymer load as ***,the rotational speed governed the space available for the adsorption of water molecules and their organization in a monolayer or *** behavior may have impact on the kinetics of the amorphous drug recrystallization,and finally deteriorate its dissolution.

关键词： Tadalafil Soluplus Solid dispersion Relaxation time Milling NMR

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Helicobacter pylori vs coronary heart disease-searching for connections

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World Journal of Cardiology 2015年第4期7卷 187-203页

作者： Magdalena chmiela Adrian Gajewski Karolina Rudnicka Department of Immunology and Infectious Biology Faculty of Biology and Environmental ProtectionUniversity of Lódz

In this review,we discussed the findings and concepts underlying the potential role of Helicobacter pylori(***) infections in the initiation,development or persistence of atherosclerosis and coronary heart disease(CHD).This Gram-negative bacterium was described by Marshall and Warren in *** majority of infected subjects carries and transmits *** with no symptoms; however,in some individuals these bacteria may cause peptic ulcers,and even gastric *** widespread prevalence of *** infections and the fact that frequently they remain asymptomatic may suggest that,similarly to intestinal microflora,*** may deliver antigens that stimulate not only local,but also systemic inflammatory ***,possible association between *** infection and extragastric disorders has been *** on the etiology of atherosclerosis together with current findings in the area of *** infections constitute the background for the newly proposed hypothesis that those two processes may be *** research studies confirm the indirect association between the prevalence of *** and the occurrence of *** to majority of findings the involvement of *** in this process is based on the chronic inflammation which might facilitate the CHDrelated *** needs to be elucidated,if the infection initiates or just accelerates the formation of atheromatous plaque.

关键词： Helicobacter pylori Coronary heart disease Inflammation Microbiota Lipopolysaccharide

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波兰矿山救护的组织结构与任务

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矿业安全与环保 2000年第6期27卷 54-56页

作者：窦林名 Andrzej chmiela Jan PECIAK 中国矿业大学江苏徐州221008 University Silesia

介绍了波兰矿山救护组织的组织结构及任务。矿山救护为三级系统的准军事化组织。波兰救护行动是以国家法律为依据的。

关键词：安全工作矿山救护组织波兰组织结构救护设备

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Dried fruit pomace inclusion in poultry diet:growth performance, intestinal morphology and physiology

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Journal of Animal Science and Biotechnology 2020年第4期11卷 1100-1116页

作者： Elena Colombino Ilario Ferrocino Ilaria Biasato Luca Simone Cocolin Daniel Prieto-Botella Zenon Zduńczyk Jan Jankowski Joanna Milala Monika Kosmala Bartosz Fotschki Maria Teresa Capucchio Jerzy Juśkiewicz Department of Veterinary Sciences University of TorinoLargo Paolo Braccini 2Grugliasco10095 TurinItaly Department of Agricultural Forest and Food SciencesUniversity of TorinoTorinoItaly Research Team on Occupational Therapy(InTeO) Department of Surgery and PathologyUniversity Miguel Hernandez of ElcheAlicanteSpain Polish Academy of Sciences Institute of Animal Reproduction and Food ResearchOlsztynPoland Department of Poultry Science University of Warmia and MazuryOlsztynPoland Institute of Chemical Technology of Food Lodz University of TechnologyLodzPoland.

Background: Fruit pomaces are by-products rich in polyphenol compounds and dietary fiber. They seem to play an important role in regulating the gut microbiota, morphology and physiology. The aim of this study was to assess whether apple(A), blackurrant(B) or strawberry(S) pomaces could be suitable ingredients in broiler diets and their effect on gut health. A total of 480 male broilers were randomly allotted to 8 dietary treatments with lower(3%-L) or higher(6%-H) dietary fiber content: two control groups(CL/CH), two A diets(AL/AH), two B diets(BL/BH), two S diets(SL/SH). Diet and fruit pomaces were chemically analyzed to assess polyphenol concentration and fibre fraction content. After the evaluation of growth performance, 6 birds/group were slaughtered at 35 days of age. Morphometric and histopathological investigations were performed on duodenum, jejunum and *** were collected to perform microbiota evaluation by 16 S DNA sequencing. Weight, viscosity, enzymatic activity, short chain fatty acid(SCFAs) and ammonia concentration were determined in ileum and/or ceca ***: A pomace and A diets showed the lowest polyphenol content and the highest content of soluble fibre fraction. No significant differences were observed for growth performance, gut morphometry and histopathology(P > 0.05). Dietary fruit pomace inclusion increased the weight of ileum and ceca and the ileum digesta viscosity(P 0.05). At genus level, an increase

关键词： Fruit Pomace Gut health Morphohistology Polyphenols Poultry

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The effect of the dietary inclusion of pea seeds of colored-flowered and white-flowered varieties on gastrointestinal function in turkeys

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Animal Nutrition 2022年第3期10卷 167-177页

作者： Zenon Zdunczyk Dariusz Mikulski Jan Jankowski Bogdan A.Slominski Jerzy Juskiewicz Institute of Animal Reproduction and Food Research Polish Academy of SciencesOlsztyn 10-748Poland Department of Poultry Science and Apiculture University of Warmia and MazuryOlsztyn 10-718Poland Department of Animal Science University of ManitobaWinnipeg R3T 2N2Canada

This study investigated the effects of dietary replacement of soybean meal(SBM)with graded levels of pea seeds(PS)on the gastrointestinal function of *** of 2 pea varieties,a colored-flowered variety and a white-flowered variety(CFP and WFP,respectively)were fed to 56-d-old birds for 8 wk.A total of 539 female Hybrid turkeys were allocated to 7 groups,each group consisted of 7 pens with 11 birds per *** experiment had a 2-factorial design,with 3 dietary inclusion levels of PS(100,200 and 300 g/kg)and 2 pea varieties(CFP and WFP).The control group(diets without PS)was compared with CFP and WFP treatments by simple contrast *** comparison with CFP seeds,WFP seeds contained 7-fold less tannins(0.67 vs.4.66 g/kg)and less non-starch polysaccharides(NSP,117.8 vs.132.7 g/kg),but more trypsin inhibitors(1.34 vs.0.98 g/kg)and starch(489 vs.455 g/kg).A rise in the PS content of diets from 100 to 200 and 300 g/kg increased the weight of the small intestine(P=0.031)and the dry matter(DM)content of intestinal digesta(P=0.001),but it had no effect on the pH of *** the highest PS content differentiated the concentrations of short-chain fatty acids(SCFAs)in the small intestinal digesta(WFP>CFP,P=0.008),whereas PS did not cause any changes in the morphological parameters of the small intestinal *** dietary inclusion of PS had no influence on the levels of acetate,butyrate,putrefactive SCFAs or total SCFAs in the cecal *** from increasing the activities of b-glucosidase(P=0.017)and b-galactosidase(P=0.025),pea varieties did not affect the activities of the analyzed cecal microbial ***,CFP seeds decreased the DM content(P=0.041)and increased the pH of cecal digesta,compared with WFP seeds(P=0.013).The results of this study,pointing to a few differences in the functional parameters of the small intestine and cecum,indicate that tannins are not a factor differentiating the suitability of CFP and WFP seeds in the nutrition of f

关键词： Pea Tannin Growth performance Gastrointestinal tract Turkey

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